Mitoxantrone (dihydrochloride)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRIK1 glutamate receptor, ionotropic, kainate 1 0.0890066
CNKSR3 CNKSR family member 3 0.0850205
FNDC3A fibronectin type III domain containing 3A 0.0782202
SNAP25 synaptosomal-associated protein, 25kDa 0.0780121
RIMS2 regulating synaptic membrane exocytosis 2 0.0687915
NCKAP5 NCK-associated protein 5 0.068684
TENM1 teneurin transmembrane protein 1 0.0678289
PDE4B phosphodiesterase 4B, cAMP-specific 0.0557809
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0549344
FGF14 fibroblast growth factor 14 0.0542953
TOX thymocyte selection-associated high mobility group box 0.0533854
GMDS GDP-mannose 4,6-dehydratase 0.0521131
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 0.0496777
PDE10A phosphodiesterase 10A 0.048688
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0480637
NBEA neurobeachin 0.0475421
ARHGAP26 Rho GTPase activating protein 26 0.0468953
INHBA inhibin, beta A 0.0468386
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 0.0460844
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0448594
SMYD3 SET and MYND domain containing 3 0.0441948
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.043453
PDE4D phosphodiesterase 4D, cAMP-specific 0.0431933
ARB2A ARB2 cotranscriptional regulator A 0.0431606
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0425164
RIT2 Ras-like without CAAX 2 0.0420573
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0405794
PEG10 paternally expressed 10 0.0393104
FHIT fragile histidine triad 0.0387176
LCOR ligand dependent nuclear receptor corepressor 0.0385743
PCSK1 proprotein convertase subtilisin/kexin type 1 0.0384132
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0378961
SMOC1 SPARC related modular calcium binding 1 0.0363807
SASH1 SAM and SH3 domain containing 1 0.0361707
TCF12 transcription factor 12 0.0353593
FAT1 FAT atypical cadherin 1 0.035355
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.033613
GPC5 glypican 5 0.0334678
LSAMP limbic system-associated membrane protein 0.0321924
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.0318066
JAZF1 JAZF zinc finger 1 0.0314636
ATF6 activating transcription factor 6 0.0310288
CREB5 cAMP responsive element binding protein 5 0.0309081
NPAS3 neuronal PAS domain protein 3 0.0303843
ZNF804A zinc finger protein 804A 0.0301281
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0298963
ST18 suppression of tumorigenicity 18, zinc finger 0.0298961
SYT1 synaptotagmin I 0.0297813
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0295224
PARM1 prostate androgen-regulated mucin-like protein 1 0.0290954
ANKRD17 ankyrin repeat domain 17 0.028993
ASIC2 acid sensing (proton gated) ion channel 2 0.0289809
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0284073
AOPEP aminopeptidase O (putative) 0.0281761
KIF26B kinesin family member 26B 0.0280322
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.027931
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.0276757
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0275465
NAV2 neuron navigator 2 0.0268052
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0267501
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.0266596
CADM1 cell adhesion molecule 1 0.0257725
TTC28 tetratricopeptide repeat domain 28 0.0256999
EPHA4 EPH receptor A4 0.0255722
SYT4 synaptotagmin IV 0.0254676
PBX3 pre-B-cell leukemia homeobox 3 0.025429
GDAP1 ganglioside induced differentiation associated protein 1 0.0253842
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0252094
SIK2 salt-inducible kinase 2 0.0250176
WWOX WW domain containing oxidoreductase 0.0242193
MACF1 microtubule-actin crosslinking factor 1 0.0240264
STAU2 staufen double-stranded RNA binding protein 2 0.0236035
PEX5L peroxisomal biogenesis factor 5-like 0.0235623
AUTS2 autism susceptibility candidate 2 0.023039
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0230332
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.022312
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0221341
CPE carboxypeptidase E 0.0219255
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.0218276
ASPH aspartate beta-hydroxylase 0.0216576
VCL vinculin 0.0216461
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0214498
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.021398
CLIC4 chloride intracellular channel 4 0.0213819
TXNRD1 thioredoxin reductase 1 0.0211339
HSPH1 heat shock 105kDa/110kDa protein 1 0.0211337
ARHGAP24 Rho GTPase activating protein 24 0.0207952
PALLD palladin, cytoskeletal associated protein 0.0206582
RNF213 ring finger protein 213 0.0206043
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0205543
SLC38A2 solute carrier family 38, member 2 0.0205227
SERGEF secretion regulating guanine nucleotide exchange factor 0.020519
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0200882
LPP LIM domain containing preferred translocation partner in lipoma 0.0200309
GPHN gephyrin 0.0199663
MCL1 myeloid cell leukemia 1 0.0199543
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 0.0197867
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0197459
NOVA1 neuro-oncological ventral antigen 1 0.0197052
GLCCI1 glucocorticoid induced 1 0.0196697

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.152241
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0907388
RPL26 ribosomal protein L26 -0.0492571
RPS3 ribosomal protein S3 -0.0465729
DTNA dystrobrevin, alpha -0.046428
WSB1 WD repeat and SOCS box containing 1 -0.0412132
RPS21 ribosomal protein S21 -0.0406135
MAP1B microtubule-associated protein 1B -0.0397116
RPS6 ribosomal protein S6 -0.0394252
STC1 stanniocalcin 1 -0.0389829
RPS2 ribosomal protein S2 -0.0355377
IGFBP5 insulin-like growth factor binding protein 5 -0.0354968
ZNF292 zinc finger protein 292 -0.0354638
LOC112694756 uncharaterized LOC112694756 -0.0339394
PTMA prothymosin, alpha -0.033842
KTN1 kinectin 1 (kinesin receptor) -0.0334246
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.03196
VEGFA vascular endothelial growth factor A -0.0316448
WDR45B WD repeat domain 45B -0.0310313
ZNF395 zinc finger protein 395 -0.0295241
RPL37 ribosomal protein L37 -0.0288948
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0282252
RPL38 ribosomal protein L38 -0.0277063
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0276898
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0268065
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0267052
GNAS GNAS complex locus -0.0266214
CAMTA1 calmodulin binding transcription activator 1 -0.0261273
RPS12 ribosomal protein S12 -0.0260993
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0258619
VGF VGF nerve growth factor inducible -0.0249257
KPNB1 karyopherin (importin) beta 1 -0.0246651
PCBP3 poly(rC) binding protein 3 -0.024479
KDM3A lysine (K)-specific demethylase 3A -0.0243729
ISG15 ISG15 ubiquitin-like modifier -0.0242631
RPLP1 ribosomal protein, large, P1 -0.0242095
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0242056
TSHZ2 teashirt zinc finger homeobox 2 -0.0240423
SET SET nuclear proto-oncogene -0.0240392
ACTG1 actin gamma 1 -0.0239084
CCDC88A coiled-coil domain containing 88A -0.0233791
RPL12 ribosomal protein L12 -0.0232605
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0230701
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0230591
RPS27A ribosomal protein S27a -0.0226251
XPO1 exportin 1 -0.0224026
MIS18BP1 MIS18 binding protein 1 -0.0223962
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0217843
AHR aryl hydrocarbon receptor -0.0217838
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0217008
TMSB4X thymosin beta 4, X-linked -0.0216592
S100A9 S100 calcium binding protein A9 -0.0215391
RPS16 ribosomal protein S16 -0.0214788
FAM13A family with sequence similarity 13, member A -0.0211072
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0207941
ATP5F1E ATP synthase F1 subunit epsilon -0.0206939
ONECUT2 one cut homeobox 2 -0.0206346
RPL36A ribosomal protein L36a -0.0199798
DGKD diacylglycerol kinase, delta 130kDa -0.0199132
TFF3 trefoil factor 3 (intestinal) -0.0197241
RPL37A ribosomal protein L37a -0.0196586
GRB10 growth factor receptor-bound protein 10 -0.0195957
RORA RAR-related orphan receptor A -0.0195576
CHD1L chromodomain helicase DNA binding protein 1-like -0.0193747
RPL11 ribosomal protein L11 -0.0192536
TMSB10 thymosin beta 10 -0.0190907
OXR1 oxidation resistance 1 -0.0189742
RPS17 ribosomal protein S17 -0.0189435
RPS8 ribosomal protein S8 -0.0189304
NUF2 NUF2, NDC80 kinetochore complex component -0.0188655
RPH3AL rabphilin 3A-like (without C2 domains) -0.018772
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0187493
RACK1 receptor for activated C kinase 1 -0.0185413
NOP58 NOP58 ribonucleoprotein -0.0182051
SOX4 SRY (sex determining region Y)-box 4 -0.0181682
AKAP10 A kinase (PRKA) anchor protein 10 -0.0180994
PAEP progestagen-associated endometrial protein -0.0179573
H1-4 H1.4 linker histone, cluster member -0.0178488
MATR3 matrin 3 -0.0177905
PABPN1 poly(A) binding protein, nuclear 1 -0.0177813
BMERB1 bMERB domain containing 1 -0.0177516
PNISR PNN-interacting serine/arginine-rich protein -0.0177248
PGK1 phosphoglycerate kinase 1 -0.0176238
IFI6 interferon, alpha-inducible protein 6 -0.0174679
SREBF2 sterol regulatory element binding transcription factor 2 -0.0174367
RPL31 ribosomal protein L31 -0.0174297
TPT1 tumor protein, translationally-controlled 1 -0.0173983
ANKRD12 ankyrin repeat domain 12 -0.0172949
EIF1 eukaryotic translation initiation factor 1 -0.0171254
TPD52 tumor protein D52 -0.0170241
MYH10 myosin, heavy chain 10, non-muscle -0.0170171
RPL32 ribosomal protein L32 -0.0169338
ERBIN erbb2 interacting protein -0.0169176
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0167921
AVL9 AVL9 homolog (S. cerevisiase) -0.0167842
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.0167406
SEC61G Sec61 gamma subunit -0.0167293
ARGLU1 arginine and glutamate rich 1 -0.0165628
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0164996
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0164231