Mitoxantrone (dihydrochloride)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMN1 formin 1 0.154151
NAV2 neuron navigator 2 0.0701782
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0607868
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0556644
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0498547
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0425792
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0423234
FRMD5 FERM domain containing 5 0.0388592
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0380634
HDAC9 histone deacetylase 9 0.0377766
CDH13 cadherin 13 0.0344314
DST dystonin 0.0336221
FNIP1 folliculin interacting protein 1 0.0327249
RASAL2 RAS protein activator like 2 0.0314138
ATXN1 ataxin 1 0.0302078
PTK2 protein tyrosine kinase 2 0.0301828
RUNX1 runt-related transcription factor 1 0.0293842
LRMDA leucine rich melanocyte differentiation associated 0.0285253
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0276688
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0271763
FBXL17 F-box and leucine-rich repeat protein 17 0.0271333
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0267292
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0266037
AKAP13 A kinase (PRKA) anchor protein 13 0.0262575
FER fer (fps/fes related) tyrosine kinase 0.025969
DOCK5 dedicator of cytokinesis 5 0.0258403
CEP128 centrosomal protein 128kDa 0.0250275
CDK6 cyclin-dependent kinase 6 0.0245836
TBC1D5 TBC1 domain family, member 5 0.0245047
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0243069
MYH9 myosin, heavy chain 9, non-muscle 0.0241639
FNDC3B fibronectin type III domain containing 3B 0.0241383
EFNA5 ephrin-A5 0.0240587
ZCCHC7 zinc finger, CCHC domain containing 7 0.0240489
COMMD10 COMM domain containing 10 0.0239233
OSBPL10 oxysterol binding protein-like 10 0.0238818
RABGAP1L RAB GTPase activating protein 1-like 0.0238273
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0236724
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0236344
EXOC4 exocyst complex component 4 0.0234438
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0234303
ARB2A ARB2 cotranscriptional regulator A 0.0231427
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0231417
MACF1 microtubule-actin crosslinking factor 1 0.0230672
EHBP1 EH domain binding protein 1 0.0229396
ERBIN erbb2 interacting protein 0.0225355
CEMIP2 cell migration inducing hyaluronidase 2 0.0221462
VMP1 vacuole membrane protein 1 0.0220623
ZBTB38 zinc finger and BTB domain containing 38 0.0219859
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.021962
ANKRD28 ankyrin repeat domain 28 0.0219362
NOTCH2 notch 2 0.021688
OPHN1 oligophrenin 1 0.0216859
GLS2 glutaminase 2 (liver, mitochondrial) 0.0209573
PAX3 paired box 3 0.0206486
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0206121
FGGY FGGY carbohydrate kinase domain containing 0.0204713
USP34 ubiquitin specific peptidase 34 0.0203604
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0200941
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0200055
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.01993
PRELID2 PRELI domain containing 2 0.0198341
SUMF1 sulfatase modifying factor 1 0.0198145
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0197302
MSN moesin 0.0197266
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0196716
TRIO trio Rho guanine nucleotide exchange factor 0.0194942
DENND1A DENN/MADD domain containing 1A 0.0192061
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0191639
SND1 staphylococcal nuclease and tudor domain containing 1 0.0191606
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0190786
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0189698
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0189032
CYTH3 cytohesin 3 0.0185942
LINGO2 leucine rich repeat and Ig domain containing 2 0.0185132
FAM219A family with sequence similarity 219, member A 0.0184961
AFDN afadin, adherens junction formation factor 0.0181322
MED13L mediator complex subunit 13-like 0.0181293
INTS6 integrator complex subunit 6 0.018018
TCF12 transcription factor 12 0.0178445
CDK13 cyclin-dependent kinase 13 0.0175335
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0174834
KDM4C lysine (K)-specific demethylase 4C 0.017406
RAD51B RAD51 paralog B 0.0173814
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0172334
CDK19 cyclin-dependent kinase 19 0.0171255
ATP13A3 ATPase type 13A3 0.017021
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0169116
TUSC3 tumor suppressor candidate 3 0.0168465
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0168015
SOX6 SRY (sex determining region Y)-box 6 0.0167325
LPP LIM domain containing preferred translocation partner in lipoma 0.0166291
FMNL2 formin-like 2 0.0165822
STAU2 staufen double-stranded RNA binding protein 2 0.0165479
HDAC4 histone deacetylase 4 0.0163952
MBNL1 muscleblind-like splicing regulator 1 0.0163446
RASA2 RAS p21 protein activator 2 0.0162441
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0162413
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0161605
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0161338

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.316188
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.194792
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.139536
RPS3 ribosomal protein S3 -0.110574
RPS6 ribosomal protein S6 -0.106792
PTMA prothymosin, alpha -0.102616
RPL35A ribosomal protein L35a -0.101832
TMSB10 thymosin beta 10 -0.099552
RPLP1 ribosomal protein, large, P1 -0.0944181
MT2A metallothionein 2A -0.0942381
FTL ferritin, light polypeptide -0.089394
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0864201
RPL23 ribosomal protein L23 -0.0759578
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0697162
TPT1 tumor protein, translationally-controlled 1 -0.0689825
B2M beta-2-microglobulin -0.0678611
SQSTM1 sequestosome 1 -0.064731
PMEL premelanosome protein -0.0615475
SFTPA2 surfactant protein A2 -0.0612071
IFI6 interferon, alpha-inducible protein 6 -0.0606051
VDAC1 voltage-dependent anion channel 1 -0.060024
LDHA lactate dehydrogenase A -0.0599792
RPS8 ribosomal protein S8 -0.0598539
EIF1 eukaryotic translation initiation factor 1 -0.059712
RPL34 ribosomal protein L34 -0.0590687
ENO1 enolase 1, (alpha) -0.0580672
HLA-B major histocompatibility complex, class I, B -0.0563978
RPS12 ribosomal protein S12 -0.0554575
PKM pyruvate kinase, muscle -0.0543895
RPS13 ribosomal protein S13 -0.0527484
NAP1L1 nucleosome assembly protein 1-like 1 -0.0517391
RPLP2 ribosomal protein, large, P2 -0.0514534
RACK1 receptor for activated C kinase 1 -0.0510575
ACTG1 actin gamma 1 -0.0506102
KPNB1 karyopherin (importin) beta 1 -0.0501129
RPL31 ribosomal protein L31 -0.0498171
RPL36A ribosomal protein L36a -0.0489303
TPI1 triosephosphate isomerase 1 -0.04888
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0484676
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0480946
RPL38 ribosomal protein L38 -0.0474403
RPL37A ribosomal protein L37a -0.0466178
PGK1 phosphoglycerate kinase 1 -0.0464883
RPS14 ribosomal protein S14 -0.0462733
RPS21 ribosomal protein S21 -0.0457029
RPS27A ribosomal protein S27a -0.0456834
RPS4X ribosomal protein S4, X-linked -0.0452663
CCND1 cyclin D1 -0.0452473
LOC112694756 uncharaterized LOC112694756 -0.0450289
RPL11 ribosomal protein L11 -0.0447988
S100A9 S100 calcium binding protein A9 -0.0445318
WSB1 WD repeat and SOCS box containing 1 -0.0442823
APOD apolipoprotein D -0.0441299
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0433119
ICAM1 intercellular adhesion molecule 1 -0.0432529
RPL32 ribosomal protein L32 -0.0428845
RPS19 ribosomal protein S19 -0.0422352
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0422296
RPL12 ribosomal protein L12 -0.0414755
IFI16 interferon, gamma-inducible protein 16 -0.0412305
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0409477
RPS24 ribosomal protein S24 -0.0406738
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0400722
FN1 fibronectin 1 -0.0398332
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0393202
ANGPTL4 angiopoietin-like 4 -0.0391129
RPL9 ribosomal protein L9 -0.0387584
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0387443
PRAME preferentially expressed antigen in melanoma -0.0385503
RPS23 ribosomal protein S23 -0.0384311
CBX3 chromobox homolog 3 -0.0380118
LSAMP limbic system-associated membrane protein -0.0372739
GNAS GNAS complex locus -0.0367337
RPL36 ribosomal protein L36 -0.0365614
GOLGA4 golgin A4 -0.0363866
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0363039
SEPTIN7 septin 7 -0.0361332
PRRC2C proline-rich coiled-coil 2C -0.0360545
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.035911
WDR45B WD repeat domain 45B -0.0358573
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0353166
RPLP0 ribosomal protein, large, P0 -0.0351151
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0347385
RAB7A RAB7A, member RAS oncogene family -0.0343949
RPL30 ribosomal protein L30 -0.0343471
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0341061
NDRG1 N-myc downstream regulated 1 -0.0337946
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0332203
S100A10 S100 calcium binding protein A10 -0.0330553
RPL19 ribosomal protein L19 -0.0328124
LITAF lipopolysaccharide-induced TNF factor -0.0326961
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0325523
S100A6 S100 calcium binding protein A6 -0.0325471
UBC ubiquitin C -0.0324187
RPS17 ribosomal protein S17 -0.031804
RPL37 ribosomal protein L37 -0.0314588
IFITM3 interferon induced transmembrane protein 3 -0.0314438
HLA-A major histocompatibility complex, class I, A -0.0313615
TM4SF1 transmembrane 4 L six family member 1 -0.0312723
RPL26 ribosomal protein L26 -0.0309758