Mitoxantrone (dihydrochloride)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.255154
AHNAK AHNAK nucleoprotein 0.134577
PDE4B phosphodiesterase 4B, cAMP-specific 0.128904
EGFR epidermal growth factor receptor 0.0859229
VCL vinculin 0.0847881
HDAC9 histone deacetylase 9 0.0797608
PDGFC platelet derived growth factor C 0.0721227
SOX6 SRY (sex determining region Y)-box 6 0.0685883
ZEB1 zinc finger E-box binding homeobox 1 0.0655326
ZNF608 zinc finger protein 608 0.0630242
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0612077
MYO5C myosin VC 0.0597978
GLI3 GLI family zinc finger 3 0.0541191
TJP1 tight junction protein 1 0.0515706
DSCAM Down syndrome cell adhesion molecule 0.0487328
CPED1 cadherin-like and PC-esterase domain containing 1 0.0465103
EFNA5 ephrin-A5 0.0462823
LPP LIM domain containing preferred translocation partner in lipoma 0.0433574
SAMD4A sterile alpha motif domain containing 4A 0.0430977
EML4 echinoderm microtubule associated protein like 4 0.0418896
FOXP1 forkhead box P1 0.0383703
NBEA neurobeachin 0.0381504
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0380583
MACROD2 MACRO domain containing 2 0.0350799
SMYD3 SET and MYND domain containing 3 0.0345328
PRELID2 PRELI domain containing 2 0.0338651
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0327731
NFE2L2 nuclear factor, erythroid 2-like 2 0.032712
ECT2 epithelial cell transforming 2 0.0324138
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0321595
TSC22D1 TSC22 domain family, member 1 0.0314695
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0304232
NPAS2 neuronal PAS domain protein 2 0.0298605
UBC ubiquitin C 0.0297374
TRIO trio Rho guanine nucleotide exchange factor 0.02937
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0291979
ZFAND3 zinc finger, AN1-type domain 3 0.0288843
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0274664
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0269077
EXT1 exostosin glycosyltransferase 1 0.0255092
FAT1 FAT atypical cadherin 1 0.0252139
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.025134
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0247876
IGF1R insulin-like growth factor 1 receptor 0.0246623
FNIP1 folliculin interacting protein 1 0.024543
TMEM65 transmembrane protein 65 0.0243636
GLI2 GLI family zinc finger 2 0.0240816
TGFBR3 transforming growth factor, beta receptor III 0.0240579
INTS6 integrator complex subunit 6 0.0240139
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0239644
SPTBN1 spectrin, beta, non-erythrocytic 1 0.023417
DST dystonin 0.0233389
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0232875
FER1L6 fer-1-like family member 6 0.0230137
ZNF638 zinc finger protein 638 0.0229536
MACF1 microtubule-actin crosslinking factor 1 0.0225173
BMP2K BMP2 inducible kinase 0.0223782
PARD3 par-3 family cell polarity regulator 0.0220324
ZSWIM6 zinc finger, SWIM-type containing 6 0.0216464
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.021599
SSBP2 single-stranded DNA binding protein 2 0.0214461
PTPRG protein tyrosine phosphatase, receptor type, G 0.0212291
IFI16 interferon, gamma-inducible protein 16 0.0211714
ADAM10 ADAM metallopeptidase domain 10 0.021147
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.021146
MLIP muscular LMNA-interacting protein 0.021087
CTBP2 C-terminal binding protein 2 0.0210441
APP amyloid beta (A4) precursor protein 0.0208438
ZMYND8 zinc finger, MYND-type containing 8 0.0208091
EIF4B eukaryotic translation initiation factor 4B 0.0205025
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0200306
ZNF438 zinc finger protein 438 0.0198727
PDE7B phosphodiesterase 7B 0.0196639
EZR ezrin 0.0195287
PARD3B par-3 family cell polarity regulator beta 0.0193132
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0192699
ANKRD36 ankyrin repeat domain 36 0.019188
TAS2R14 taste receptor, type 2, member 14 0.0190995
TRERF1 transcriptional regulating factor 1 0.0190422
CORO1C coronin, actin binding protein, 1C 0.0188504
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0188336
TTC28 tetratricopeptide repeat domain 28 0.0183247
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.018295
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0180087
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0179895
TACC2 transforming, acidic coiled-coil containing protein 2 0.0178214
WDFY3 WD repeat and FYVE domain containing 3 0.0176897
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0176417
PYGB phosphorylase, glycogen; brain 0.0176285
SFPQ splicing factor proline/glutamine-rich 0.0175786
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0173118
FAF1 Fas (TNFRSF6) associated factor 1 0.0171895
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.0171084
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0171082
PRKCE protein kinase C, epsilon 0.0171044
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0168945
SGMS2 sphingomyelin synthase 2 0.0166841
CRPPA CDP-L-ribitol pyrophosphorylase A 0.0165762
SMAD6 SMAD family member 6 0.0164891
AEBP2 AE binding protein 2 0.0161973

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.321642
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.303101
RPS6 ribosomal protein S6 -0.149993
TPT1 tumor protein, translationally-controlled 1 -0.12167
RPS8 ribosomal protein S8 -0.106358
RPL35A ribosomal protein L35a -0.105685
ACTG1 actin gamma 1 -0.0649021
RPS19 ribosomal protein S19 -0.0638274
RPL34 ribosomal protein L34 -0.062726
RPL26 ribosomal protein L26 -0.062149
RPL9 ribosomal protein L9 -0.0608543
RPLP0 ribosomal protein, large, P0 -0.0572653
RPL19 ribosomal protein L19 -0.0565893
RPL31 ribosomal protein L31 -0.0564998
RPL12 ribosomal protein L12 -0.0559226
RPS13 ribosomal protein S13 -0.0553869
RPS23 ribosomal protein S23 -0.0551157
RPLP1 ribosomal protein, large, P1 -0.0543257
PFN1 profilin 1 -0.0542027
POTEF POTE ankyrin domain family, member F -0.0537076
HSPB1 heat shock 27kDa protein 1 -0.0530447
RPL11 ribosomal protein L11 -0.0528201
S100A4 S100 calcium binding protein A4 -0.0521129
RPLP2 ribosomal protein, large, P2 -0.0511373
RPL37A ribosomal protein L37a -0.0509446
RPL7A ribosomal protein L7a -0.0500979
RPS3 ribosomal protein S3 -0.0492488
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0491511
RPS2 ribosomal protein S2 -0.0488147
RPS25 ribosomal protein S25 -0.0480935
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0465811
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0454271
ARL4C ADP-ribosylation factor-like 4C -0.0450079
EIF1 eukaryotic translation initiation factor 1 -0.0428182
S100A6 S100 calcium binding protein A6 -0.0427869
RPS14 ribosomal protein S14 -0.0415939
RPL32 ribosomal protein L32 -0.040518
B2M beta-2-microglobulin -0.0399893
RPL36 ribosomal protein L36 -0.0398407
CCND1 cyclin D1 -0.0392133
FTL ferritin, light polypeptide -0.0380443
RPS12 ribosomal protein S12 -0.0377212
S100A9 S100 calcium binding protein A9 -0.0367708
RACK1 receptor for activated C kinase 1 -0.0365536
RPL8 ribosomal protein L8 -0.0359215
ENO2 enolase 2 (gamma, neuronal) -0.035327
MYL12B myosin, light chain 12B, regulatory -0.0347051
RPS17 ribosomal protein S17 -0.0346173
TPI1 triosephosphate isomerase 1 -0.0345982
RPS21 ribosomal protein S21 -0.0341588
GOLGA4 golgin A4 -0.033669
LDHA lactate dehydrogenase A -0.0331038
RPL30 ribosomal protein L30 -0.0326192
RPL27A ribosomal protein L27a -0.032574
RPL23 ribosomal protein L23 -0.0324537
RPS16 ribosomal protein S16 -0.0322815
RPL37 ribosomal protein L37 -0.0318819
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.031769
RPS24 ribosomal protein S24 -0.0316457
RPL36A ribosomal protein L36a -0.0316297
RPS27 ribosomal protein S27 -0.0315606
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0313446
RPL28 ribosomal protein L28 -0.0309177
SMC3 structural maintenance of chromosomes 3 -0.030667
PRDX2 peroxiredoxin 2 -0.0306059
RPS29 ribosomal protein S29 -0.0304579
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0303315
RPL7 ribosomal protein L7 -0.0301846
RPL5 ribosomal protein L5 -0.0300685
RPS5 ribosomal protein S5 -0.0299642
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0298851
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0298645
RPS11 ribosomal protein S11 -0.0294262
GNAS GNAS complex locus -0.0293544
RPL10A ribosomal protein L10a -0.0291329
RPS15 ribosomal protein S15 -0.028668
RPL13A ribosomal protein L13a -0.0285912
S100A10 S100 calcium binding protein A10 -0.0284315
TPM4 tropomyosin 4 -0.02754
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.027515
KPNB1 karyopherin (importin) beta 1 -0.0269971
HMGA1 high mobility group AT-hook 1 -0.02679
FAM162A family with sequence similarity 162, member A -0.0267043
PKM pyruvate kinase, muscle -0.026695
WSB1 WD repeat and SOCS box containing 1 -0.0259298
RPS10 ribosomal protein S10 -0.02567
TUBB4B tubulin, beta 4B class IVb -0.0254492
RPL35 ribosomal protein L35 -0.0253015
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0252284
EMP3 epithelial membrane protein 3 -0.0251651
MKI67 marker of proliferation Ki-67 -0.0247546
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0246928
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0245575
TMSB4X thymosin beta 4, X-linked -0.0245466
EIF5B eukaryotic translation initiation factor 5B -0.0244637
DSTN destrin (actin depolymerizing factor) -0.0244619
HLA-B major histocompatibility complex, class I, B -0.0242299
MT2A metallothionein 2A -0.0238699
ATF4 activating transcription factor 4 -0.0234805
CCNI cyclin I -0.02344