| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Mitoxantrone (dihydrochloride) perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.204415 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.170946 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.138 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.134125 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.105226 |
| FNDC3B | fibronectin type III domain containing 3B | 0.104733 |
| NAV2 | neuron navigator 2 | 0.0950103 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0949712 |
| HDAC9 | histone deacetylase 9 | 0.0947746 |
| PDE10A | phosphodiesterase 10A | 0.0928826 |
| ATXN1 | ataxin 1 | 0.0834451 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0824497 |
| FNIP1 | folliculin interacting protein 1 | 0.0803022 |
| CDH13 | cadherin 13 | 0.0750456 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0729508 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0721332 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0715507 |
| DST | dystonin | 0.0687587 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 0.0664871 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.064634 |
| CD44 | CD44 molecule (Indian blood group) | 0.0646042 |
| JMJD1C | jumonji domain containing 1C | 0.0636767 |
| PRELID2 | PRELI domain containing 2 | 0.0629172 |
| FMNL2 | formin-like 2 | 0.0622335 |
| ASPH | aspartate beta-hydroxylase | 0.0619406 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0604635 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0565789 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.054534 |
| MYOF | myoferlin | 0.0529269 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0524258 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0514488 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0511148 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0507013 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0505816 |
| TNS3 | tensin 3 | 0.0497069 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0489804 |
| TMEM132D | transmembrane protein 132D | 0.048849 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0486063 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.048262 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0468234 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0464444 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0460811 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0456195 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0455496 |
| INTS6 | integrator complex subunit 6 | 0.0448153 |
| EXOC4 | exocyst complex component 4 | 0.0447374 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.043101 |
| SMYD3 | SET and MYND domain containing 3 | 0.0423461 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0416817 |
| UTRN | utrophin | 0.0414976 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0414335 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0413896 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0410372 |
| CANX | calnexin | 0.0404437 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0402284 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.040146 |
| FRMPD4 | FERM and PDZ domain containing 4 | 0.0393053 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0391576 |
| SEPTIN9 | septin 9 | 0.0385259 |
| CADM1 | cell adhesion molecule 1 | 0.038513 |
| DUSP10 | dual specificity phosphatase 10 | 0.0383757 |
| RUNX1 | runt-related transcription factor 1 | 0.0379849 |
| RND3 | Rho family GTPase 3 | 0.0378826 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0373732 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.037355 |
| RAD51B | RAD51 paralog B | 0.0370337 |
| COL5A1 | collagen, type V, alpha 1 | 0.0370235 |
| DIAPH2 | diaphanous-related formin 2 | 0.0368871 |
| VEGFA | vascular endothelial growth factor A | 0.0366324 |
| PRKCA | protein kinase C, alpha | 0.0365073 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0362741 |
| ENO1 | enolase 1, (alpha) | 0.0361927 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0360378 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.035786 |
| MSN | moesin | 0.0356949 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0355017 |
| HELZ | helicase with zinc finger | 0.0354694 |
| NDRG1 | N-myc downstream regulated 1 | 0.0350675 |
| FBXO32 | F-box protein 32 | 0.034993 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0344735 |
| PCBP3 | poly(rC) binding protein 3 | 0.0343983 |
| SQSTM1 | sequestosome 1 | 0.0341717 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0332868 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0332303 |
| PGM3 | phosphoglucomutase 3 | 0.0330558 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0329275 |
| TNIK | TRAF2 and NCK interacting kinase | 0.0322787 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0322476 |
| GOLGA4 | golgin A4 | 0.0322143 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0321955 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0320656 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0320107 |
| ZNF638 | zinc finger protein 638 | 0.0319432 |
| MMP12 | matrix metallopeptidase 12 | 0.0316412 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0311726 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.030864 |
| VMP1 | vacuole membrane protein 1 | 0.0307931 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0307926 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.03073 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0307039 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.13118 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.107396 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.103458 |
| HLA-B | major histocompatibility complex, class I, B | -0.100744 |
| FN1 | fibronectin 1 | -0.0816547 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.065213 |
| BICC1 | BicC family RNA binding protein 1 | -0.059558 |
| HLA-A | major histocompatibility complex, class I, A | -0.0571214 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0541662 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0510498 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0461275 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0449348 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0433281 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0420477 |
| TMSB10 | thymosin beta 10 | -0.0371354 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0368277 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0357272 |
| TUBB | tubulin, beta class I | -0.0355408 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0338183 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0331607 |
| CTSD | cathepsin D | -0.0331229 |
| THBS1 | thrombospondin 1 | -0.0327313 |
| PALLD | palladin, cytoskeletal associated protein | -0.0321744 |
| UBC | ubiquitin C | -0.0311115 |
| RIGI | RNA sensor RIG-I | -0.0309219 |
| OSMR | oncostatin M receptor | -0.0306712 |
| GNAS | GNAS complex locus | -0.0283582 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0281657 |
| EGR1 | early growth response 1 | -0.0280945 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0272346 |
| VCL | vinculin | -0.0266871 |
| MKI67 | marker of proliferation Ki-67 | -0.0265659 |
| KLF6 | Kruppel-like factor 6 | -0.0258011 |
| RPL23 | ribosomal protein L23 | -0.0257256 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.025094 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0244307 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0242867 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0238804 |
| RNF213 | ring finger protein 213 | -0.0236549 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | -0.0233167 |
| FTL | ferritin, light polypeptide | -0.0230375 |
| LDHA | lactate dehydrogenase A | -0.022443 |
| TRIM22 | tripartite motif containing 22 | -0.0223266 |
| HLA-E | major histocompatibility complex, class I, E | -0.0215786 |
| IL6 | interleukin 6 | -0.0214745 |
| GLIS3 | GLIS family zinc finger 3 | -0.0210903 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0204829 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.020401 |
| PLPP6 | phospholipid phosphatase 6 | -0.0203532 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0195823 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0193845 |
| TNNC1 | troponin C type 1 (slow) | -0.0192432 |
| RUNX2 | runt-related transcription factor 2 | -0.0191577 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0191542 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0191336 |
| NRN1 | neuritin 1 | -0.0190306 |
| LOX | lysyl oxidase | -0.0188042 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0186956 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.018687 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0186303 |
| RPL12 | ribosomal protein L12 | -0.0185834 |
| PMP22 | peripheral myelin protein 22 | -0.0184315 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0183031 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0182586 |
| ASTN2 | astrotactin 2 | -0.0182463 |
| JAK2 | Janus kinase 2 | -0.0178106 |
| KYNU | kynureninase | -0.0176928 |
| RPS21 | ribosomal protein S21 | -0.0176836 |
| RTN4 | reticulon 4 | -0.0176097 |
| GOPC | golgi-associated PDZ and coiled-coil motif containing | -0.0175605 |
| SAMHD1 | SAM domain and HD domain 1 | -0.0173848 |
| RPL36A | ribosomal protein L36a | -0.0173761 |
| CFB | complement factor B | -0.0173723 |
| WDR45B | WD repeat domain 45B | -0.0173344 |
| ACTG1 | actin gamma 1 | -0.017251 |
| GBP2 | guanylate binding protein 2, interferon-inducible | -0.0170295 |
| C3 | complement component 3 | -0.0168624 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0167312 |
| THBS2 | thrombospondin 2 | -0.0167035 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0165987 |
| RPLP0 | ribosomal protein, large, P0 | -0.0164565 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0164343 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0162604 |
| CALD1 | caldesmon 1 | -0.0162493 |
| RACK1 | receptor for activated C kinase 1 | -0.0161169 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0158895 |
| ANLN | anillin, actin binding protein | -0.0158858 |
| PRR11 | proline rich 11 | -0.0155386 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | -0.0154516 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0154411 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0154394 |
| CDCP1 | CUB domain containing protein 1 | -0.0153967 |
| TMEM41B | transmembrane protein 41B | -0.0153964 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0153842 |
| MAP1B | microtubule-associated protein 1B | -0.0152556 |
| SH3RF2 | SH3 domain containing ring finger 2 | -0.0151029 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0149714 |
| HLA-C | major histocompatibility complex, class I, C | -0.0148107 |
| CDK17 | cyclin-dependent kinase 17 | -0.0145983 |
| DENND5A | DENN/MADD domain containing 5A | -0.0145596 |
