| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Mitoxantrone (dihydrochloride) perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.133472 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.128342 |
| GLIS3 | GLIS family zinc finger 3 | 0.0923904 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0909686 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0866153 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0847012 |
| KYNU | kynureninase | 0.0838577 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0835719 |
| COL1A1 | collagen, type I, alpha 1 | 0.0767069 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0755126 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0741196 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0727213 |
| EGFR | epidermal growth factor receptor | 0.0723518 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0716122 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0672333 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0661767 |
| ASPH | aspartate beta-hydroxylase | 0.0658076 |
| HMGA2 | high mobility group AT-hook 2 | 0.0647252 |
| ERBIN | erbb2 interacting protein | 0.064027 |
| VCL | vinculin | 0.0640064 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0639751 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0620818 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0620735 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0601257 |
| VEGFC | vascular endothelial growth factor C | 0.058051 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0574838 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0556797 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0535558 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0527925 |
| HDAC9 | histone deacetylase 9 | 0.0508482 |
| RUNX1 | runt-related transcription factor 1 | 0.0507289 |
| NF1 | neurofibromin 1 | 0.0493599 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.048492 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0481346 |
| AHR | aryl hydrocarbon receptor | 0.0480194 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0470858 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0470291 |
| SETBP1 | SET binding protein 1 | 0.0468834 |
| CD44 | CD44 molecule (Indian blood group) | 0.0466157 |
| EXOC4 | exocyst complex component 4 | 0.0465645 |
| CENPF | centromere protein F, 350/400kDa | 0.0462739 |
| CDK6 | cyclin-dependent kinase 6 | 0.0461643 |
| INTS6 | integrator complex subunit 6 | 0.0461617 |
| DPYD | dihydropyrimidine dehydrogenase | 0.045517 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0446197 |
| NAV1 | neuron navigator 1 | 0.0445974 |
| VMP1 | vacuole membrane protein 1 | 0.0445242 |
| SMAD3 | SMAD family member 3 | 0.0440785 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0438388 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.043744 |
| NRXN3 | neurexin 3 | 0.0433158 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0430961 |
| AOPEP | aminopeptidase O (putative) | 0.0429425 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0426645 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0424315 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0421786 |
| NABP1 | nucleic acid binding protein 1 | 0.0420547 |
| PTK2 | protein tyrosine kinase 2 | 0.0417954 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0416711 |
| DNAH11 | dynein, axonemal, heavy chain 11 | 0.0415688 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0414843 |
| DIAPH3 | diaphanous-related formin 3 | 0.0405684 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0400108 |
| RNF145 | ring finger protein 145 | 0.0399401 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0393037 |
| FRMD4A | FERM domain containing 4A | 0.0388407 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0386683 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0377702 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0377541 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0376058 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0375721 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0371995 |
| FAT1 | FAT atypical cadherin 1 | 0.0368933 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0366895 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0363382 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0347801 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0342121 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0339951 |
| BICC1 | BicC family RNA binding protein 1 | 0.0331784 |
| ENO1 | enolase 1, (alpha) | 0.0329155 |
| QKI | QKI, KH domain containing, RNA binding | 0.032729 |
| FTO | fat mass and obesity associated | 0.0324491 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0317435 |
| PKM | pyruvate kinase, muscle | 0.0314815 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | 0.0313555 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0311211 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0305737 |
| MSN | moesin | 0.0305705 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0305527 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0303857 |
| ZNF638 | zinc finger protein 638 | 0.030354 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0303089 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0301773 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0296531 |
| USP34 | ubiquitin specific peptidase 34 | 0.029635 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0295512 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0294335 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0293143 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0292696 |
| PGK1 | phosphoglycerate kinase 1 | 0.02924 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HLA-B | major histocompatibility complex, class I, B | -0.186555 |
| MT2A | metallothionein 2A | -0.140061 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.129296 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.128589 |
| TMSB10 | thymosin beta 10 | -0.112117 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0882531 |
| NDRG1 | N-myc downstream regulated 1 | -0.0865986 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0785442 |
| B2M | beta-2-microglobulin | -0.077051 |
| IL6 | interleukin 6 | -0.07413 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0697177 |
| HLA-A | major histocompatibility complex, class I, A | -0.0675024 |
| MT1X | metallothionein 1X | -0.0564097 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0550756 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0503985 |
| VIM | vimentin | -0.0478944 |
| CALR | calreticulin | -0.0466152 |
| S100A6 | S100 calcium binding protein A6 | -0.0457603 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0449961 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0432971 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0429926 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0404406 |
| HLA-C | major histocompatibility complex, class I, C | -0.0403388 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0392841 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0391848 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0389462 |
| PRSS23 | protease, serine, 23 | -0.0379132 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0377819 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -0.0371023 |
| UBC | ubiquitin C | -0.0348804 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0345883 |
| ZNF395 | zinc finger protein 395 | -0.0338365 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0334554 |
| FTL | ferritin, light polypeptide | -0.0332505 |
| CADM1 | cell adhesion molecule 1 | -0.0332315 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0318744 |
| RPL26 | ribosomal protein L26 | -0.0316212 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.0315553 |
| STC1 | stanniocalcin 1 | -0.030973 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0308522 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0303428 |
| H3-3B | H3.3 histone B | -0.0298564 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0296131 |
| RPL36 | ribosomal protein L36 | -0.0293026 |
| RPL12 | ribosomal protein L12 | -0.0291394 |
| TMSB4X | thymosin beta 4, X-linked | -0.0287065 |
| SYNJ2 | synaptojanin 2 | -0.0286948 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0285872 |
| RPL11 | ribosomal protein L11 | -0.0285137 |
| LOXL2 | lysyl oxidase-like 2 | -0.0284843 |
| FRMD6 | FERM domain containing 6 | -0.0281626 |
| DUSP6 | dual specificity phosphatase 6 | -0.0278707 |
| SFTPA2 | surfactant protein A2 | -0.0277899 |
| RPS19 | ribosomal protein S19 | -0.0276498 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0275499 |
| GNAS | GNAS complex locus | -0.0275141 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.0274355 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0273084 |
| RACK1 | receptor for activated C kinase 1 | -0.0272573 |
| RPS2 | ribosomal protein S2 | -0.0269291 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.026812 |
| PURA | purine-rich element binding protein A | -0.0267981 |
| NSD3 | nuclear receptor binding SET domain protein 3 | -0.0263492 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0259957 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0257703 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0255471 |
| BCAR1 | breast cancer anti-estrogen resistance 1 | -0.0251963 |
| NIBAN2 | niban apoptosis regulator 2 | -0.0251682 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0248267 |
| INHBA | inhibin, beta A | -0.0248249 |
| RPL31 | ribosomal protein L31 | -0.0245334 |
| NUCB2 | nucleobindin 2 | -0.0234414 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.023289 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.023175 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0231125 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0228683 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0228243 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0225503 |
| BSG | basigin (Ok blood group) | -0.0223654 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0221079 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0217591 |
| ITM2C | integral membrane protein 2C | -0.0216816 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0215722 |
| PFN1 | profilin 1 | -0.02153 |
| COG6 | component of oligomeric golgi complex 6 | -0.021515 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0214168 |
| CTSA | cathepsin A | -0.0213553 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0213213 |
| LMNA | lamin A/C | -0.0209475 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0208591 |
| RPL35A | ribosomal protein L35a | -0.020575 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0205513 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0202252 |
| RPS3 | ribosomal protein S3 | -0.0201644 |
| GBP1 | guanylate binding protein 1, interferon-inducible | -0.0200527 |
| LAMB3 | laminin, beta 3 | -0.0199509 |
| TNNT1 | troponin T type 1 (skeletal, slow) | -0.0198283 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0198176 |
| RBM15 | RNA binding motif protein 15 | -0.019756 |
| RPS21 | ribosomal protein S21 | -0.0197392 |
