Mitoxantrone (dihydrochloride)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 0.0422124
BIRC3 baculoviral IAP repeat containing 3 0.0415224
SMAD3 SMAD family member 3 0.0350513
SDC4 syndecan 4 0.0333829
LPP LIM domain containing preferred translocation partner in lipoma 0.0331167
FNDC3B fibronectin type III domain containing 3B 0.0308757
INTS6 integrator complex subunit 6 0.0308521
FMNL2 formin-like 2 0.0292608
CAPRIN2 caprin family member 2 0.0277912
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0254053
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0252294
SVIL supervillin 0.0246739
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0243145
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0238928
PBX3 pre-B-cell leukemia homeobox 3 0.022802
BICD1 bicaudal D homolog 1 (Drosophila) 0.0225718
CDK6 cyclin-dependent kinase 6 0.0224175
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0217465
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0216024
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0209662
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0207903
IRAK2 interleukin-1 receptor-associated kinase 2 0.0206635
SIK2 salt-inducible kinase 2 0.0198789
SKIL SKI-like proto-oncogene 0.0194011
BCAR3 breast cancer anti-estrogen resistance 3 0.0192932
COL5A1 collagen, type V, alpha 1 0.0192642
DYM dymeclin 0.0190165
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0186638
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0184244
NAV3 neuron navigator 3 0.0184214
IFRD1 interferon-related developmental regulator 1 0.0182485
FERMT2 fermitin family member 2 0.0181411
MAMLD1 mastermind-like domain containing 1 0.0167945
DERA deoxyribose-phosphate aldolase (putative) 0.0167235
ARHGAP21 Rho GTPase activating protein 21 0.016596
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.016543
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0163066
TASOR transcription activation suppressor 0.0162855
AAGAB alpha- and gamma-adaptin binding protein 0.0162404
RAP1A RAP1A, member of RAS oncogene family 0.0160738
GPR39 G protein-coupled receptor 39 0.0160612
NSRP1 nuclear speckle splicing regulatory protein 1 0.015874
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0158268
PCNX4 pecanex 4 0.0157551
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.015753
ANXA2 annexin A2 0.0157252
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0153098
PARD3B par-3 family cell polarity regulator beta 0.0152679
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0151395
BICC1 BicC family RNA binding protein 1 0.0151208
ANXA4 annexin A4 0.0149778
ZC3H12C zinc finger CCCH-type containing 12C 0.0149059
FOS FBJ murine osteosarcoma viral oncogene homolog 0.014821
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.014804
CEP112 centrosomal protein 112kDa 0.0146134
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0145328
KLF12 Kruppel-like factor 12 0.0144631
MYSM1 Myb-like, SWIRM and MPN domains 1 0.0144022
TRIO trio Rho guanine nucleotide exchange factor 0.0142873
VEGFC vascular endothelial growth factor C 0.0141806
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.014108
PIAS2 protein inhibitor of activated STAT, 2 0.0140852
MGLL monoglyceride lipase 0.0139849
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0139846
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.0138601
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0138218
EFCAB13 EF-hand calcium binding domain 13 0.0137889
ZFAT zinc finger and AT hook domain containing 0.013696
LRRC28 leucine rich repeat containing 28 0.0136769
LIPH lipase, member H 0.0136145
FBXL4 F-box and leucine-rich repeat protein 4 0.0136062
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.0135133
PCBP3 poly(rC) binding protein 3 0.0134876
NPHP3 nephronophthisis 3 (adolescent) 0.0133536
SCRN3 secernin 3 0.0133513
NPAS2 neuronal PAS domain protein 2 0.0133481
DNM1L dynamin 1-like 0.0133064
LRRC1 leucine rich repeat containing 1 0.0132345
RHBDD1 rhomboid domain containing 1 0.0131998
CEMIP cell migration inducing protein, hyaluronan binding 0.013094
PRPF38A pre-mRNA processing factor 38A 0.013012
ARTN artemin 0.0130087
RAB18 RAB18, member RAS oncogene family 0.0129767
FKBP5 FK506 binding protein 5 0.0129547
LARP4B La ribonucleoprotein domain family, member 4B 0.0129333
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 0.0129271
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0129146
PHKB phosphorylase kinase, beta 0.0129061
EPB41L4A erythrocyte membrane protein band 4.1 like 4A 0.0129049
SOX9 SRY (sex determining region Y)-box 9 0.0129019
ADGRG6 adhesion G protein-coupled receptor G6 0.0128788
OGFRL1 opioid growth factor receptor-like 1 0.0128454
MSRA methionine sulfoxide reductase A 0.0128295
COMMD10 COMM domain containing 10 0.012816
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0128152
RYBP RING1 and YY1 binding protein 0.0127759
DOCK3 dedicator of cytokinesis 3 0.0127613
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0127164
WDR20 WD repeat domain 20 0.0127117
MCUB mitochondrial calcium uniporter dominant negative subunit beta 0.0126795

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.440219
VIM vimentin -0.171134
PTMA prothymosin, alpha -0.168243
TMSB10 thymosin beta 10 -0.13283
TPT1 tumor protein, translationally-controlled 1 -0.109571
LDHA lactate dehydrogenase A -0.0935721
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0899396
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0893648
RBM39 RNA binding motif protein 39 -0.0761051
RPLP1 ribosomal protein, large, P1 -0.0747555
GOLGA4 golgin A4 -0.0733649
YBX3 Y box binding protein 3 -0.0728338
PKM pyruvate kinase, muscle -0.0685571
RPL15 ribosomal protein L15 -0.0631284
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0589473
SMYD3 SET and MYND domain containing 3 -0.0584687
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0578326
RPL23 ribosomal protein L23 -0.0561244
NAP1L1 nucleosome assembly protein 1-like 1 -0.0557444
CENPF centromere protein F, 350/400kDa -0.0547307
TPX2 TPX2, microtubule-associated -0.0541984
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0538816
GNAS GNAS complex locus -0.0522524
ENO1 enolase 1, (alpha) -0.0506375
RPS3 ribosomal protein S3 -0.0498276
RPS12 ribosomal protein S12 -0.0496812
PHF20 PHD finger protein 20 -0.0496642
PDE4D phosphodiesterase 4D, cAMP-specific -0.0490452
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0488287
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0486802
RPS17 ribosomal protein S17 -0.0483962
PRRC2C proline-rich coiled-coil 2C -0.0471866
RPL37 ribosomal protein L37 -0.0465304
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0465141
SETD5 SET domain containing 5 -0.0461221
NUP58 nucleoporin 58 -0.0460573
ANKRD12 ankyrin repeat domain 12 -0.0459719
CHD1 chromodomain helicase DNA binding protein 1 -0.0457401
NCOR1 nuclear receptor corepressor 1 -0.0456869
PNISR PNN-interacting serine/arginine-rich protein -0.0454757
NDRG1 N-myc downstream regulated 1 -0.0449019
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0447154
IGF2 insulin-like growth factor 2 -0.0442769
RPL31 ribosomal protein L31 -0.0440868
RPL35A ribosomal protein L35a -0.0420918
RDX radixin -0.0420727
BASP1 brain abundant, membrane attached signal protein 1 -0.0415187
RPL26 ribosomal protein L26 -0.0413621
NIPBL Nipped-B homolog (Drosophila) -0.0413167
RPL37A ribosomal protein L37a -0.0411459
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0408093
ANKRD11 ankyrin repeat domain 11 -0.040677
RPS13 ribosomal protein S13 -0.0400711
RBM25 RNA binding motif protein 25 -0.0398955
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0395227
SPAG9 sperm associated antigen 9 -0.0391013
RPLP2 ribosomal protein, large, P2 -0.0390538
RPL12 ribosomal protein L12 -0.0389765
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0387828
B2M beta-2-microglobulin -0.0384711
GOLGB1 golgin B1 -0.0384613
WSB1 WD repeat and SOCS box containing 1 -0.0384361
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0382001
EIF1 eukaryotic translation initiation factor 1 -0.0380652
KIF5B kinesin family member 5B -0.0379692
RPS20 ribosomal protein S20 -0.0379167
UBE2B ubiquitin-conjugating enzyme E2B -0.0375663
RPS6 ribosomal protein S6 -0.0375462
ZNF207 zinc finger protein 207 -0.0374829
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0368754
LOC112694756 uncharaterized LOC112694756 -0.036797
RB1CC1 RB1-inducible coiled-coil 1 -0.0367712
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.036629
POTEF POTE ankyrin domain family, member F -0.0366122
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0356473
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0356034
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0355203
RSRC2 arginine/serine-rich coiled-coil 2 -0.0354358
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0353326
RTN4 reticulon 4 -0.0352771
VDAC1 voltage-dependent anion channel 1 -0.0350049
ENO2 enolase 2 (gamma, neuronal) -0.0349682
NKTR natural killer cell triggering receptor -0.0347887
MATR3 matrin 3 -0.0344839
RAB7A RAB7A, member RAS oncogene family -0.034178
RPL9 ribosomal protein L9 -0.0341635
H3-3B H3.3 histone B -0.0338771
RPLP0 ribosomal protein, large, P0 -0.0337517
MT2A metallothionein 2A -0.0336039
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0332333
AFF4 AF4/FMR2 family, member 4 -0.0331627
BCAS3 breast carcinoma amplified sequence 3 -0.0328533
RPL36 ribosomal protein L36 -0.0323868
EIF5B eukaryotic translation initiation factor 5B -0.0319787
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0317714
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0317109
S100A9 S100 calcium binding protein A9 -0.0315411
RPS23 ribosomal protein S23 -0.0313904
RPS8 ribosomal protein S8 -0.031326
WAC WW domain containing adaptor with coiled-coil -0.0312365