Mitoxantrone (dihydrochloride)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.112521
ASPH aspartate beta-hydroxylase 0.106621
TMEM156 transmembrane protein 156 0.0843772
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0758912
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0754487
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0705719
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0704133
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0703833
FNDC3B fibronectin type III domain containing 3B 0.0688203
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0686124
PTK2 protein tyrosine kinase 2 0.0686077
SMAD3 SMAD family member 3 0.0666608
ANKRD28 ankyrin repeat domain 28 0.0641846
GLIS3 GLIS family zinc finger 3 0.0620158
CENPF centromere protein F, 350/400kDa 0.0571934
ELL2 elongation factor, RNA polymerase II, 2 0.0565618
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0524573
RICTOR RPTOR independent companion of MTOR, complex 2 0.0514202
EPS8 epidermal growth factor receptor pathway substrate 8 0.0498647
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0491972
VEGFC vascular endothelial growth factor C 0.0491832
MYH9 myosin, heavy chain 9, non-muscle 0.04842
DST dystonin 0.0475782
NTN4 netrin 4 0.0468144
FNDC3A fibronectin type III domain containing 3A 0.0464351
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0448008
MBNL1 muscleblind-like splicing regulator 1 0.0446398
NPAS2 neuronal PAS domain protein 2 0.0443262
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0434509
AKAP12 A kinase (PRKA) anchor protein 12 0.0432042
NRIP1 nuclear receptor interacting protein 1 0.0431582
SMYD3 SET and MYND domain containing 3 0.043053
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0429277
LTBP1 latent transforming growth factor beta binding protein 1 0.0423856
RNF145 ring finger protein 145 0.0418107
MKI67 marker of proliferation Ki-67 0.0417737
SVIL supervillin 0.0416121
NRP1 neuropilin 1 0.0415967
WWTR1 WW domain containing transcription regulator 1 0.0399866
VCL vinculin 0.0383284
CD109 CD109 molecule 0.0381227
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0373443
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0373361
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0372865
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0372402
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0370906
HIPK2 homeodomain interacting protein kinase 2 0.036936
MCTP2 multiple C2 domains, transmembrane 2 0.0358735
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0352775
HELZ helicase with zinc finger 0.0340312
TPM3 tropomyosin 3 0.0339703
IL6ST interleukin 6 signal transducer 0.0333885
TPR translocated promoter region, nuclear basket protein 0.0332469
KMT2E lysine (K)-specific methyltransferase 2E 0.0330082
RAB10 RAB10, member RAS oncogene family 0.0327861
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.032724
FAT1 FAT atypical cadherin 1 0.0326956
ERBIN erbb2 interacting protein 0.0326656
NAMPT nicotinamide phosphoribosyltransferase 0.0321163
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.031889
WAC WW domain containing adaptor with coiled-coil 0.0317692
TGFB2 transforming growth factor, beta 2 0.0316142
TXNRD1 thioredoxin reductase 1 0.0314218
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.03112
MYOF myoferlin 0.0308286
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0305927
SPRED2 sprouty-related, EVH1 domain containing 2 0.0303525
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0298107
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0290173
TRIO trio Rho guanine nucleotide exchange factor 0.0289036
SHB Src homology 2 domain containing adaptor protein B 0.0287753
ZSWIM6 zinc finger, SWIM-type containing 6 0.0287581
PUM2 pumilio RNA-binding family member 2 0.0286862
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0286428
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0285818
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0283534
RASAL2 RAS protein activator like 2 0.0280119
RAB31 RAB31, member RAS oncogene family 0.0273702
ATXN1 ataxin 1 0.027312
ETNK1 ethanolamine kinase 1 0.0270975
AHR aryl hydrocarbon receptor 0.0269294
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0269221
VMP1 vacuole membrane protein 1 0.0263734
YBX3 Y box binding protein 3 0.0263393
YAP1 Yes-associated protein 1 0.026012
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0259999
ENAH enabled homolog (Drosophila) 0.0257798
AKAP13 A kinase (PRKA) anchor protein 13 0.0255727
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.025561
JMJD1C jumonji domain containing 1C 0.0254651
FOXP1 forkhead box P1 0.0253734
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0250736
SIK3 SIK family kinase 3 0.0250699
DOCK5 dedicator of cytokinesis 5 0.0249556
MSN moesin 0.0249039
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0246261
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0244666
CD44 CD44 molecule (Indian blood group) 0.0244124
SDC2 syndecan 2 0.0243905
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0242451

decreased expression

Symbol Name Standardized Value
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.234089
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.195427
NRG1 neuregulin 1 -0.177295
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.171005
HLA-B major histocompatibility complex, class I, B -0.141483
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.136165
SQSTM1 sequestosome 1 -0.134922
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.123014
FN1 fibronectin 1 -0.119396
PTMA prothymosin, alpha -0.116249
TMSB10 thymosin beta 10 -0.114257
S100A6 S100 calcium binding protein A6 -0.0959421
TPT1 tumor protein, translationally-controlled 1 -0.0922773
IFI27 interferon, alpha-inducible protein 27 -0.0908317
NDRG1 N-myc downstream regulated 1 -0.0890465
TMSB4X thymosin beta 4, X-linked -0.0682053
CANX calnexin -0.0627925
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0615163
FTL ferritin, light polypeptide -0.0586719
MRPS6 mitochondrial ribosomal protein S6 -0.0567082
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0562732
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0552596
SFTPA2 surfactant protein A2 -0.0546335
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0518413
HLA-A major histocompatibility complex, class I, A -0.0510368
RPL31 ribosomal protein L31 -0.0482983
STC2 stanniocalcin 2 -0.0482854
RPL35A ribosomal protein L35a -0.0482113
PLIN2 perilipin 2 -0.0478665
TFPI2 tissue factor pathway inhibitor 2 -0.0472392
SOX4 SRY (sex determining region Y)-box 4 -0.0466287
RPL26 ribosomal protein L26 -0.0451943
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0432182
CALR calreticulin -0.0429699
RPS24 ribosomal protein S24 -0.0421717
RPL37A ribosomal protein L37a -0.04155
IFI6 interferon, alpha-inducible protein 6 -0.0414783
B2M beta-2-microglobulin -0.0401017
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0398788
GNAS GNAS complex locus -0.0393949
RPL9 ribosomal protein L9 -0.0382326
RPL34 ribosomal protein L34 -0.0382248
ACTG1 actin gamma 1 -0.0367192
CADM1 cell adhesion molecule 1 -0.0354084
RACK1 receptor for activated C kinase 1 -0.0353088
LRRC23 leucine rich repeat containing 23 -0.0342326
CTSD cathepsin D -0.0338009
AEBP2 AE binding protein 2 -0.0327423
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0323036
RPL23 ribosomal protein L23 -0.0320789
TPI1 triosephosphate isomerase 1 -0.0314917
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0314413
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.031359
MMP13 matrix metallopeptidase 13 -0.0313461
LAMB3 laminin, beta 3 -0.030645
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0302092
EGR1 early growth response 1 -0.0300117
IGFBP3 insulin-like growth factor binding protein 3 -0.0298942
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0295662
LIMCH1 LIM and calponin homology domains 1 -0.029377
MT2A metallothionein 2A -0.0293191
RPS21 ribosomal protein S21 -0.0293128
RPS25 ribosomal protein S25 -0.0292579
LOC112694756 uncharaterized LOC112694756 -0.0291486
RPS8 ribosomal protein S8 -0.0290796
LOX lysyl oxidase -0.0290128
RPL37 ribosomal protein L37 -0.0289993
RPLP1 ribosomal protein, large, P1 -0.0288814
RPS27 ribosomal protein S27 -0.0284639
PDIA4 protein disulfide isomerase family A, member 4 -0.0282168
RAI14 retinoic acid induced 14 -0.0275937
IER3 immediate early response 3 -0.0272098
RPS27A ribosomal protein S27a -0.0271854
CD63 CD63 molecule -0.0269675
TENM4 teneurin transmembrane protein 4 -0.0263277
ENO2 enolase 2 (gamma, neuronal) -0.0262474
RPS12 ribosomal protein S12 -0.0261046
TMEM165 transmembrane protein 165 -0.0256491
FTH1 ferritin, heavy polypeptide 1 -0.0256175
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0256081
RPS6 ribosomal protein S6 -0.0255991
FAM20C family with sequence similarity 20, member C -0.025501
ARF1 ADP-ribosylation factor 1 -0.0253129
RPS3 ribosomal protein S3 -0.0251294
S100A10 S100 calcium binding protein A10 -0.0249179
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0248075
TM4SF1 transmembrane 4 L six family member 1 -0.0246432
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0245012
RPL12 ribosomal protein L12 -0.0244805
S100A9 S100 calcium binding protein A9 -0.0242641
RPL38 ribosomal protein L38 -0.0242529
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0240008
DNAH5 dynein, axonemal, heavy chain 5 -0.0239266
SPDYA speedy/RINGO cell cycle regulator family member A -0.0235771
LOC102724023 ES1 protein homolog, mitochondrial -0.0235462
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.023356
RPS16 ribosomal protein S16 -0.0233207
RPS5 ribosomal protein S5 -0.0232115
ENO1 enolase 1, (alpha) -0.023129
EIF1 eukaryotic translation initiation factor 1 -0.0227745