| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Mitoxantrone (dihydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.160357 |
| NEBL | nebulette | 0.0955469 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0948547 |
| VMP1 | vacuole membrane protein 1 | 0.0867618 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0633251 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.063113 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0619379 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0612717 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0603397 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0599423 |
| SMAD3 | SMAD family member 3 | 0.0596027 |
| DSPP | dentin sialophosphoprotein | 0.0584601 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0576878 |
| VCL | vinculin | 0.0575804 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0564433 |
| YAP1 | Yes-associated protein 1 | 0.0559113 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0544742 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0527248 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0517821 |
| MYO1E | myosin IE | 0.0517391 |
| SNX9 | sorting nexin 9 | 0.0497828 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0490886 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0467871 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0461212 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0447845 |
| FAT1 | FAT atypical cadherin 1 | 0.0447788 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0435866 |
| MED13L | mediator complex subunit 13-like | 0.0431714 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0423686 |
| DIAPH1 | diaphanous-related formin 1 | 0.0409027 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0403252 |
| TOP1 | topoisomerase (DNA) I | 0.0398029 |
| SON | SON DNA binding protein | 0.0397833 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0396464 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0396299 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.038978 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0389711 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0387915 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0383905 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0383013 |
| DST | dystonin | 0.0380855 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0379554 |
| SDC4 | syndecan 4 | 0.0372682 |
| ETV6 | ets variant 6 | 0.0371394 |
| TRIM2 | tripartite motif containing 2 | 0.0370894 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.036155 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0353361 |
| MATR3 | matrin 3 | 0.0353239 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0352577 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0351129 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0350466 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0349223 |
| KRT20 | keratin 20, type I | 0.0347891 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0346156 |
| MALT1 | MALT1 paracaspase | 0.0343139 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0336767 |
| RBM39 | RNA binding motif protein 39 | 0.0336757 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0335573 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0334823 |
| KAT6A | K(lysine) acetyltransferase 6A | 0.0334687 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0332192 |
| FAM3C | family with sequence similarity 3, member C | 0.0330941 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0330281 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0327675 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0325207 |
| NEK7 | NIMA-related kinase 7 | 0.0322008 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0319559 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.031531 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0315158 |
| NHSL1 | NHS-like 1 | 0.031484 |
| EHF | ets homologous factor | 0.0314827 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0314768 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0313861 |
| AFDN | afadin, adherens junction formation factor | 0.0310364 |
| WWC1 | WW and C2 domain containing 1 | 0.0309828 |
| NCKAP1 | NCK-associated protein 1 | 0.0307941 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0302414 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.030136 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0299497 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0299272 |
| EGFR | epidermal growth factor receptor | 0.0298364 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0292658 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0291333 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0291211 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0290524 |
| NCOA1 | nuclear receptor coactivator 1 | 0.028737 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0286619 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0286463 |
| EXOC6B | exocyst complex component 6B | 0.0285662 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0285371 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0285156 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0283754 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0282804 |
| BRD2 | bromodomain containing 2 | 0.0282634 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0280838 |
| RND3 | Rho family GTPase 3 | 0.0279247 |
| PAPOLA | poly(A) polymerase alpha | 0.0278988 |
| OXR1 | oxidation resistance 1 | 0.0278129 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0277612 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0274851 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MAML2 | mastermind-like 2 (Drosophila) | -0.174354 |
| PTMA | prothymosin, alpha | -0.160485 |
| TMSB10 | thymosin beta 10 | -0.157692 |
| FTL | ferritin, light polypeptide | -0.110514 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.107131 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.10663 |
| NDRG1 | N-myc downstream regulated 1 | -0.0923652 |
| RPS6 | ribosomal protein S6 | -0.0810514 |
| RPL35A | ribosomal protein L35a | -0.077002 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0725414 |
| EGR1 | early growth response 1 | -0.0717823 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0712366 |
| RPS21 | ribosomal protein S21 | -0.0703112 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0699301 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0666627 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0594867 |
| KRT8 | keratin 8, type II | -0.05721 |
| AHNAK | AHNAK nucleoprotein | -0.0557855 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0554596 |
| KRT18 | keratin 18, type I | -0.0541781 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0533159 |
| LDHA | lactate dehydrogenase A | -0.0527631 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0525432 |
| ITGB4 | integrin, beta 4 | -0.0521008 |
| RPLP1 | ribosomal protein, large, P1 | -0.0513959 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.049393 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.047956 |
| GNAS | GNAS complex locus | -0.0459228 |
| RPS13 | ribosomal protein S13 | -0.0456316 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0453819 |
| HM13 | histocompatibility (minor) 13 | -0.0449761 |
| RPL23 | ribosomal protein L23 | -0.0440931 |
| ACTN4 | actinin, alpha 4 | -0.0438734 |
| NFIA | nuclear factor I/A | -0.0418628 |
| RPS19 | ribosomal protein S19 | -0.0416189 |
| RPLP2 | ribosomal protein, large, P2 | -0.0401993 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0400418 |
| TPM4 | tropomyosin 4 | -0.0397118 |
| KRT19 | keratin 19, type I | -0.0384731 |
| PKM | pyruvate kinase, muscle | -0.0381871 |
| CCND1 | cyclin D1 | -0.0380636 |
| FRMD5 | FERM domain containing 5 | -0.0376593 |
| S100A6 | S100 calcium binding protein A6 | -0.0370249 |
| CTSD | cathepsin D | -0.0369972 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0369222 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0365297 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0358909 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0351477 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0350651 |
| RPL31 | ribosomal protein L31 | -0.0347303 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0340408 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0335003 |
| RPS25 | ribosomal protein S25 | -0.0332871 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0331583 |
| RPS11 | ribosomal protein S11 | -0.0330908 |
| JUP | junction plakoglobin | -0.032797 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -0.0326406 |
| IER3 | immediate early response 3 | -0.0325573 |
| HLA-A | major histocompatibility complex, class I, A | -0.0325272 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0325256 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0317788 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0317081 |
| SRRM3 | serine/arginine repetitive matrix 3 | -0.031477 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0308406 |
| CBX3 | chromobox homolog 3 | -0.0308108 |
| RPS24 | ribosomal protein S24 | -0.0307884 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | -0.0305438 |
| CADPS | Ca++-dependent secretion activator | -0.030301 |
| RPS14 | ribosomal protein S14 | -0.030001 |
| PGK1 | phosphoglycerate kinase 1 | -0.0294463 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0294379 |
| XYLT1 | xylosyltransferase I | -0.0291135 |
| MAP4 | microtubule-associated protein 4 | -0.0291116 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.028966 |
| TMEM47 | transmembrane protein 47 | -0.0289382 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0288984 |
| TMEM123 | transmembrane protein 123 | -0.0287195 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0284336 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0283935 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0278327 |
| RPL28 | ribosomal protein L28 | -0.0278251 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.027642 |
| DNM2 | dynamin 2 | -0.027642 |
| RPL34 | ribosomal protein L34 | -0.0271962 |
| RPS5 | ribosomal protein S5 | -0.0271463 |
| RPL37A | ribosomal protein L37a | -0.0270062 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0269312 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0265031 |
| RPL32 | ribosomal protein L32 | -0.0264384 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0262196 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0257716 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | -0.0257601 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0255519 |
| HMGA1 | high mobility group AT-hook 1 | -0.025468 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -0.0253808 |
| ONECUT3 | one cut homeobox 3 | -0.0253789 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.025348 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.0252628 |
| SBF2 | SET binding factor 2 | -0.0251644 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0251336 |
