Mitoxantrone (dihydrochloride)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.0762296
HMGA2 high mobility group AT-hook 2 0.074653
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0674811
SMAD3 SMAD family member 3 0.0388542
VCL vinculin 0.0368971
ATXN1 ataxin 1 0.0368709
CCSER1 coiled-coil serine-rich protein 1 0.0334876
RAD51B RAD51 paralog B 0.031431
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.02973
SGMS2 sphingomyelin synthase 2 0.0289415
RCOR1 REST corepressor 1 0.0273028
FHIT fragile histidine triad 0.0268107
HSPA8 heat shock 70kDa protein 8 0.0267409
DOCK5 dedicator of cytokinesis 5 0.0267132
SEPTIN9 septin 9 0.0260961
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0259253
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0254144
SMYD3 SET and MYND domain containing 3 0.0253498
EFNB2 ephrin-B2 0.0249834
LPP LIM domain containing preferred translocation partner in lipoma 0.0246021
PDLIM5 PDZ and LIM domain 5 0.0231647
JARID2 jumonji, AT rich interactive domain 2 0.0231627
SLC30A10 solute carrier family 30, member 10 0.0229518
WWOX WW domain containing oxidoreductase 0.0229155
CDK13 cyclin-dependent kinase 13 0.0215801
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0213694
LAMA4 laminin, alpha 4 0.0212293
ABR active BCR-related 0.0205706
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0202734
NUP50 nucleoporin 50kDa 0.0202653
OSBPL10 oxysterol binding protein-like 10 0.0201027
ZSWIM6 zinc finger, SWIM-type containing 6 0.0200496
EHBP1 EH domain binding protein 1 0.0196436
PARD3B par-3 family cell polarity regulator beta 0.0193767
FHL2 four and a half LIM domains 2 0.0192886
TRAF3 TNF receptor-associated factor 3 0.0188366
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.018779
MTUS1 microtubule associated tumor suppressor 1 0.0187553
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0185183
HOMER1 homer scaffolding protein 1 0.0179244
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0177657
LMO7 LIM domain 7 0.0175985
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0174283
EXOC4 exocyst complex component 4 0.0173966
PRELID2 PRELI domain containing 2 0.0172856
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0171839
NCEH1 neutral cholesterol ester hydrolase 1 0.0171675
DOCK1 dedicator of cytokinesis 1 0.0170836
BCAR3 breast cancer anti-estrogen resistance 3 0.01703
USP9X ubiquitin specific peptidase 9, X-linked 0.0169778
YAP1 Yes-associated protein 1 0.0166681
GATAD2A GATA zinc finger domain containing 2A 0.0164484
ARHGAP42 Rho GTPase activating protein 42 0.0163156
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0161749
DST dystonin 0.0161665
RRM2 ribonucleotide reductase M2 0.0158439
SNX9 sorting nexin 9 0.0158006
LAMB3 laminin, beta 3 0.0157974
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0154966
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0152381
AKAP13 A kinase (PRKA) anchor protein 13 0.0148726
FBXL17 F-box and leucine-rich repeat protein 17 0.0147582
ZHX2 zinc fingers and homeoboxes 2 0.0146263
ASPH aspartate beta-hydroxylase 0.0141081
ECT2 epithelial cell transforming 2 0.0140668
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0140292
GLCCI1 glucocorticoid induced 1 0.014006
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0139831
SAMD4A sterile alpha motif domain containing 4A 0.0138515
BICD1 bicaudal D homolog 1 (Drosophila) 0.0135586
CLIP2 CAP-GLY domain containing linker protein 2 0.0135112
NABP1 nucleic acid binding protein 1 0.0134467
ATL2 atlastin GTPase 2 0.0133973
DSPP dentin sialophosphoprotein 0.0133068
ADGRA3 adhesion G protein-coupled receptor A3 0.0132617
CFAP161 cilia and flagella associated protein 161 0.0131439
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0130866
MACF1 microtubule-actin crosslinking factor 1 0.0128951
SEC31A SEC31 homolog A (S. cerevisiae) 0.0126814
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0126031
INTS6 integrator complex subunit 6 0.0123621
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.012339
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0123243
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0122864
SKAP1 src kinase associated phosphoprotein 1 0.0121225
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0121159
CLDND1 claudin domain containing 1 0.0120599
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0118829
ARL15 ADP-ribosylation factor-like 15 0.0118592
CMIP c-Maf inducing protein 0.0116274
MYO5B myosin VB 0.0114236
DSCAM Down syndrome cell adhesion molecule 0.0113652
FOXP1 forkhead box P1 0.0112067
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 0.0111512
TAS2R14 taste receptor, type 2, member 14 0.0111016
RABGAP1L RAB GTPase activating protein 1-like 0.0109875
MBNL1 muscleblind-like splicing regulator 1 0.0109843
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0109458
FAT1 FAT atypical cadherin 1 0.0109316
TBC1D5 TBC1 domain family, member 5 0.0108642

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.212382
TMSB10 thymosin beta 10 -0.172963
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.161199
RPS6 ribosomal protein S6 -0.147933
RPL35A ribosomal protein L35a -0.0968426
AREG amphiregulin -0.0947659
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0896299
TPT1 tumor protein, translationally-controlled 1 -0.082574
RPS19 ribosomal protein S19 -0.0801521
RPS8 ribosomal protein S8 -0.079952
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0787513
RPS3 ribosomal protein S3 -0.0778429
RPLP1 ribosomal protein, large, P1 -0.077485
CD36 CD36 molecule (thrombospondin receptor) -0.0758513
RPL23 ribosomal protein L23 -0.0755694
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0754218
EEF2 eukaryotic translation elongation factor 2 -0.0687501
LDHA lactate dehydrogenase A -0.0682817
RPL12 ribosomal protein L12 -0.066814
RPL26 ribosomal protein L26 -0.0636868
RPL37A ribosomal protein L37a -0.0620199
RPS24 ribosomal protein S24 -0.0614051
IER3 immediate early response 3 -0.0613092
ACTG1 actin gamma 1 -0.0592009
RPLP2 ribosomal protein, large, P2 -0.0582975
RPL9 ribosomal protein L9 -0.0581153
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0578992
RPL34 ribosomal protein L34 -0.0577335
EGR1 early growth response 1 -0.0567715
RPS13 ribosomal protein S13 -0.0567459
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0558581
RPL11 ribosomal protein L11 -0.055327
RPS12 ribosomal protein S12 -0.0549836
EIF1 eukaryotic translation initiation factor 1 -0.054977
RPLP0 ribosomal protein, large, P0 -0.0549057
RPS27A ribosomal protein S27a -0.0542601
S100A6 S100 calcium binding protein A6 -0.0527244
RPS17 ribosomal protein S17 -0.0505599
RPS29 ribosomal protein S29 -0.0490521
RPL31 ribosomal protein L31 -0.0488761
RPL5 ribosomal protein L5 -0.0487674
RPS25 ribosomal protein S25 -0.0484447
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0465198
PKM pyruvate kinase, muscle -0.0454958
RPL7A ribosomal protein L7a -0.0454591
RPS14 ribosomal protein S14 -0.0442563
ENO1 enolase 1, (alpha) -0.0440516
RPS4X ribosomal protein S4, X-linked -0.0432606
RPL36 ribosomal protein L36 -0.042782
UBC ubiquitin C -0.0425911
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0422946
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0421131
MT2A metallothionein 2A -0.041792
HLA-B major histocompatibility complex, class I, B -0.0410737
HMGA1 high mobility group AT-hook 1 -0.0409784
RPL32 ribosomal protein L32 -0.0409726
RPS21 ribosomal protein S21 -0.0409717
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0408232
RPL8 ribosomal protein L8 -0.0405653
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0400711
ATP5F1B ATP synthase F1 subunit beta -0.0400589
PERP PERP, TP53 apoptosis effector -0.03918
LOC102724023 ES1 protein homolog, mitochondrial -0.0389296
NDRG1 N-myc downstream regulated 1 -0.0388605
RACK1 receptor for activated C kinase 1 -0.0387623
FOSL1 FOS-like antigen 1 -0.0379871
RPL15 ribosomal protein L15 -0.0372705
RPS5 ribosomal protein S5 -0.0372198
RPL19 ribosomal protein L19 -0.0369359
RBM25 RNA binding motif protein 25 -0.0362492
RPL35 ribosomal protein L35 -0.0361511
RPL37 ribosomal protein L37 -0.036135
EEF1G eukaryotic translation elongation factor 1 gamma -0.0361085
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.035992
PCBP2 poly(rC) binding protein 2 -0.0359325
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0354751
S100A9 S100 calcium binding protein A9 -0.0346187
RPL7 ribosomal protein L7 -0.0344178
CD9 CD9 molecule -0.0343374
POTEF POTE ankyrin domain family, member F -0.0339241
FTL ferritin, light polypeptide -0.0339199
RPS15 ribosomal protein S15 -0.0333599
FERMT1 fermitin family member 1 -0.0332719
RPL10A ribosomal protein L10a -0.0326509
RPS23 ribosomal protein S23 -0.0324625
LOC112694756 uncharaterized LOC112694756 -0.032376
CBX3 chromobox homolog 3 -0.0319563
S100A10 S100 calcium binding protein A10 -0.0316102
RPL18 ribosomal protein L18 -0.0313301
RPS28 ribosomal protein S28 -0.0312022
RPS16 ribosomal protein S16 -0.0309346
RPL28 ribosomal protein L28 -0.0301224
RPL36A ribosomal protein L36a -0.0291009
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0289886
TPI1 triosephosphate isomerase 1 -0.0289842
MT1X metallothionein 1X -0.0287485
GOLGA4 golgin A4 -0.0284948
HLA-A major histocompatibility complex, class I, A -0.028225
RPS11 ribosomal protein S11 -0.0281658
OXR1 oxidation resistance 1 -0.0277279