Mitoxantrone (dihydrochloride)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) 0.14737
SYT1 synaptotagmin I 0.131275
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.119407
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.101309
WWOX WW domain containing oxidoreductase 0.0977943
TNS3 tensin 3 0.0966858
VCL vinculin 0.0889673
NAV2 neuron navigator 2 0.0883286
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0877202
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0826682
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0801621
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0730171
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0693273
GMDS GDP-mannose 4,6-dehydratase 0.0674214
YAP1 Yes-associated protein 1 0.0653034
CDK6 cyclin-dependent kinase 6 0.0651878
ASPH aspartate beta-hydroxylase 0.0634189
INTS6 integrator complex subunit 6 0.0625997
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0617664
MSI2 musashi RNA-binding protein 2 0.0566258
RAD51B RAD51 paralog B 0.0557565
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0542432
PDE4D phosphodiesterase 4D, cAMP-specific 0.052857
DST dystonin 0.0525993
WNK1 WNK lysine deficient protein kinase 1 0.0514953
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0497945
EXOC4 exocyst complex component 4 0.0480567
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0477423
ADGRL2 adhesion G protein-coupled receptor L2 0.0470765
SMYD3 SET and MYND domain containing 3 0.0465321
COBL cordon-bleu WH2 repeat protein 0.045733
DSPP dentin sialophosphoprotein 0.0451878
CENPF centromere protein F, 350/400kDa 0.0447218
PDLIM5 PDZ and LIM domain 5 0.0446808
CDH13 cadherin 13 0.0446198
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0442039
MAML2 mastermind-like 2 (Drosophila) 0.044089
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0438712
ITPRID2 ITPR interacting domain containing 2 0.043377
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0433211
HDAC4 histone deacetylase 4 0.0423564
DIAPH2 diaphanous-related formin 2 0.0422964
LPP LIM domain containing preferred translocation partner in lipoma 0.0418869
SPATA13 spermatogenesis associated 13 0.0417724
SMAD3 SMAD family member 3 0.0409845
ATXN1 ataxin 1 0.0409732
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0408845
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0406576
LMO7 LIM domain 7 0.0405034
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0403852
SFPQ splicing factor proline/glutamine-rich 0.0397222
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0395113
BMP5 bone morphogenetic protein 5 0.0394502
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0391877
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0391009
RUNX1 runt-related transcription factor 1 0.0389694
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0384707
SKAP1 src kinase associated phosphoprotein 1 0.0381244
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0380621
GRIK5 glutamate receptor, ionotropic, kainate 5 0.037967
SPIDR scaffolding protein involved in DNA repair 0.037933
FAF1 Fas (TNFRSF6) associated factor 1 0.0366483
GPHN gephyrin 0.0366363
TAS2R14 taste receptor, type 2, member 14 0.0361198
SLC38A2 solute carrier family 38, member 2 0.0361053
FAT1 FAT atypical cadherin 1 0.0357498
TCF12 transcription factor 12 0.0353513
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0348756
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0345081
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0344568
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0338737
TRIO trio Rho guanine nucleotide exchange factor 0.033803
ARHGAP32 Rho GTPase activating protein 32 0.0336313
MYH9 myosin, heavy chain 9, non-muscle 0.0334398
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0333945
PUM2 pumilio RNA-binding family member 2 0.0333613
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0330155
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0329053
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0327027
MED13 mediator complex subunit 13 0.0326924
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0326746
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0319032
HSPA8 heat shock 70kDa protein 8 0.0316874
MACF1 microtubule-actin crosslinking factor 1 0.0313788
TMEM163 transmembrane protein 163 0.0313405
NCEH1 neutral cholesterol ester hydrolase 1 0.0310488
DOCK5 dedicator of cytokinesis 5 0.0309576
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 0.0307139
RCOR1 REST corepressor 1 0.0307033
ANKRD17 ankyrin repeat domain 17 0.030217
WDR43 WD repeat domain 43 0.0299118
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0297952
PUM1 pumilio RNA-binding family member 1 0.0296503
ECT2 epithelial cell transforming 2 0.029565
STK38L serine/threonine kinase 38 like 0.0291327
PCM1 pericentriolar material 1 0.0288305
GLI3 GLI family zinc finger 3 0.0288017
CEMIP2 cell migration inducing hyaluronidase 2 0.0282734
KLF12 Kruppel-like factor 12 0.0278756
PHF14 PHD finger protein 14 0.0278126

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.135213
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.131993
RPL35A ribosomal protein L35a -0.112268
TMSB10 thymosin beta 10 -0.110908
RPS6 ribosomal protein S6 -0.11017
PTMA prothymosin, alpha -0.107506
AKAP12 A kinase (PRKA) anchor protein 12 -0.0919792
VIM vimentin -0.0637241
RPL23 ribosomal protein L23 -0.0600136
RPS24 ribosomal protein S24 -0.0586377
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0568062
RPLP1 ribosomal protein, large, P1 -0.0561909
RPS19 ribosomal protein S19 -0.0527943
KRT18 keratin 18, type I -0.0527502
RPL26 ribosomal protein L26 -0.0523893
AHNAK AHNAK nucleoprotein -0.0507172
RPS13 ribosomal protein S13 -0.0502443
RPL12 ribosomal protein L12 -0.0500194
RPS3 ribosomal protein S3 -0.0483247
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0482433
RPL37A ribosomal protein L37a -0.0468238
RPS8 ribosomal protein S8 -0.044775
RPL36A ribosomal protein L36a -0.0421992
S100A6 S100 calcium binding protein A6 -0.0419966
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0408368
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0407992
TPI1 triosephosphate isomerase 1 -0.0399217
RPL31 ribosomal protein L31 -0.0391299
FTL ferritin, light polypeptide -0.0389363
NDRG1 N-myc downstream regulated 1 -0.0387386
RPLP2 ribosomal protein, large, P2 -0.0383165
RPS21 ribosomal protein S21 -0.0381803
KRT8 keratin 8, type II -0.0370748
RPLP0 ribosomal protein, large, P0 -0.0366729
RPL34 ribosomal protein L34 -0.0364986
RPL37 ribosomal protein L37 -0.0363989
RPS12 ribosomal protein S12 -0.0360523
GNAS GNAS complex locus -0.0357847
S100A10 S100 calcium binding protein A10 -0.035721
RPS27A ribosomal protein S27a -0.0348688
ACTG1 actin gamma 1 -0.0347637
EIF1 eukaryotic translation initiation factor 1 -0.0340847
KRT19 keratin 19, type I -0.0335443
RPL19 ribosomal protein L19 -0.0332041
ANO1 anoctamin 1, calcium activated chloride channel -0.0330049
ESYT2 extended synaptotagmin-like protein 2 -0.0329936
KDM3A lysine (K)-specific demethylase 3A -0.0315546
RPS25 ribosomal protein S25 -0.03136
RPL38 ribosomal protein L38 -0.0308656
PFN1 profilin 1 -0.0306374
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0303298
MORF4L2 mortality factor 4 like 2 -0.0302608
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0300702
RPS14 ribosomal protein S14 -0.028897
HMGA1 high mobility group AT-hook 1 -0.0286064
GOLGA4 golgin A4 -0.0285485
TMSB4X thymosin beta 4, X-linked -0.0279326
RPL7A ribosomal protein L7a -0.0279102
RPS5 ribosomal protein S5 -0.0278244
H1-0 H1.0 linker histone -0.0274854
RPL11 ribosomal protein L11 -0.0272096
RPL9 ribosomal protein L9 -0.0272064
H3-3B H3.3 histone B -0.026757
S100A9 S100 calcium binding protein A9 -0.0263617
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0263394
RACK1 receptor for activated C kinase 1 -0.0262292
ITGB4 integrin, beta 4 -0.0260718
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0259047
RPL35 ribosomal protein L35 -0.0258176
RPL32 ribosomal protein L32 -0.025494
RPL28 ribosomal protein L28 -0.025428
ZMYND8 zinc finger, MYND-type containing 8 -0.0254151
RPL27A ribosomal protein L27a -0.0253947
CANX calnexin -0.0251862
TPM4 tropomyosin 4 -0.0244939
RPL8 ribosomal protein L8 -0.0242365
RPS11 ribosomal protein S11 -0.0241652
PDGFA platelet-derived growth factor alpha polypeptide -0.0240901
MYL12B myosin, light chain 12B, regulatory -0.0239528
FLNB filamin B, beta -0.0237391
PERP PERP, TP53 apoptosis effector -0.023418
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0233931
RPS16 ribosomal protein S16 -0.0231922
RPS23 ribosomal protein S23 -0.0231615
RPS29 ribosomal protein S29 -0.023144
RPL36 ribosomal protein L36 -0.0230871
LDHA lactate dehydrogenase A -0.0228782
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0220718
GCC2 GRIP and coiled-coil domain containing 2 -0.0220429
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0220064
MT2A metallothionein 2A -0.0219655
RPS4X ribosomal protein S4, X-linked -0.0219447
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0218496
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0216363
RBP1 retinol binding protein 1, cellular -0.0215419
UBB ubiquitin B -0.0213824
KPNB1 karyopherin (importin) beta 1 -0.0213553
LOC112694756 uncharaterized LOC112694756 -0.0209104
PGK1 phosphoglycerate kinase 1 -0.0206422
RPL18 ribosomal protein L18 -0.0206411