| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Mitoxantrone (dihydrochloride) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | 0.09034 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0796039 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0697533 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.069201 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0690374 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.063617 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0626074 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0619048 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0583831 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0580714 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0576221 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0572912 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0570819 |
| HMGA2 | high mobility group AT-hook 2 | 0.0568511 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.055344 |
| FN1 | fibronectin 1 | 0.054539 |
| VCL | vinculin | 0.0530443 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0505715 |
| MT2A | metallothionein 2A | 0.0471074 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0449094 |
| ACTG1 | actin gamma 1 | 0.044748 |
| ASPH | aspartate beta-hydroxylase | 0.0419329 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0411342 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0410452 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0404516 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0399746 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.039759 |
| CALD1 | caldesmon 1 | 0.0390856 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0389339 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0379891 |
| B2M | beta-2-microglobulin | 0.0371691 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0357307 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0355197 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0352592 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0345902 |
| PTK2 | protein tyrosine kinase 2 | 0.0345689 |
| VMP1 | vacuole membrane protein 1 | 0.0341833 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0340764 |
| MCL1 | myeloid cell leukemia 1 | 0.0334103 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0333239 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0329715 |
| RPS6 | ribosomal protein S6 | 0.0327537 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0325724 |
| FTL | ferritin, light polypeptide | 0.032546 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0311896 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0310605 |
| FMNL2 | formin-like 2 | 0.0307514 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0307139 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0304466 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0296183 |
| JMJD1C | jumonji domain containing 1C | 0.0286885 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0286754 |
| JAK1 | Janus kinase 1 | 0.0285598 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.027966 |
| INTS6 | integrator complex subunit 6 | 0.0279278 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0276124 |
| CDK6 | cyclin-dependent kinase 6 | 0.0268826 |
| SMAD3 | SMAD family member 3 | 0.0267728 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0261304 |
| RUNX1 | runt-related transcription factor 1 | 0.0257294 |
| ERBIN | erbb2 interacting protein | 0.0254751 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0250461 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0249818 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0246618 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.024653 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0242683 |
| RPS8 | ribosomal protein S8 | 0.0242242 |
| BRD2 | bromodomain containing 2 | 0.0239466 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0238511 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0238394 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0236684 |
| FAT1 | FAT atypical cadherin 1 | 0.0236454 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0234857 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0232811 |
| MSN | moesin | 0.0230027 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0229825 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0229756 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0227732 |
| RAD51B | RAD51 paralog B | 0.0227697 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0227441 |
| RPL35A | ribosomal protein L35a | 0.0227436 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0227347 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0226103 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0221832 |
| DSTN | destrin (actin depolymerizing factor) | 0.022064 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0219895 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0219606 |
| ITGAV | integrin, alpha V | 0.0218103 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0215109 |
| CLIC4 | chloride intracellular channel 4 | 0.0215013 |
| NAV2 | neuron navigator 2 | 0.0214463 |
| KLF12 | Kruppel-like factor 12 | 0.0213978 |
| FERMT2 | fermitin family member 2 | 0.0212623 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0212197 |
| TPM3 | tropomyosin 3 | 0.0212047 |
| NAV1 | neuron navigator 1 | 0.0211026 |
| GOLGB1 | golgin B1 | 0.0209965 |
| IL6ST | interleukin 6 signal transducer | 0.0209811 |
| FNIP1 | folliculin interacting protein 1 | 0.0209727 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0208579 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MMP1 | matrix metallopeptidase 1 | -0.225598 |
| INHBA | inhibin, beta A | -0.225467 |
| COL6A3 | collagen, type VI, alpha 3 | -0.119115 |
| NDRG1 | N-myc downstream regulated 1 | -0.0924829 |
| VIM | vimentin | -0.0844558 |
| OXR1 | oxidation resistance 1 | -0.0811106 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0747686 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0735001 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0595338 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0590038 |
| EMP1 | epithelial membrane protein 1 | -0.0578709 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0537303 |
| COL1A2 | collagen, type I, alpha 2 | -0.0515407 |
| STC1 | stanniocalcin 1 | -0.0456667 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0440722 |
| TMEM165 | transmembrane protein 165 | -0.0438873 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0433828 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0433827 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0420149 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0407505 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0375749 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0353073 |
| MMP12 | matrix metallopeptidase 12 | -0.0348236 |
| RAI14 | retinoic acid induced 14 | -0.0337037 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0331067 |
| DACH2 | dachshund family transcription factor 2 | -0.0313541 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0301667 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0298485 |
| PRRX1 | paired related homeobox 1 | -0.0276304 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0276257 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0275107 |
| FBN1 | fibrillin 1 | -0.0269614 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0261058 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0246197 |
| HHIP | hedgehog interacting protein | -0.0245522 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | -0.0242223 |
| H1-0 | H1.0 linker histone | -0.0240844 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0227205 |
| PRSS23 | protease, serine, 23 | -0.0226752 |
| CAVIN1 | caveolae associated protein 1 | -0.0210968 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0207421 |
| LOX | lysyl oxidase | -0.020601 |
| NCKAP5 | NCK-associated protein 5 | -0.0197618 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0196196 |
| CLMP | CXADR-like membrane protein | -0.019081 |
| EHD2 | EH-domain containing 2 | -0.0189688 |
| ITPRIPL2 | inositol 1,4,5-trisphosphate receptor interacting protein-like 2 | -0.0189502 |
| S100A6 | S100 calcium binding protein A6 | -0.0185743 |
| OSMR | oncostatin M receptor | -0.0183476 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | -0.0182494 |
| TMSB10 | thymosin beta 10 | -0.0181794 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0179747 |
| COL5A1 | collagen, type V, alpha 1 | -0.0177532 |
| ATP13A3 | ATPase type 13A3 | -0.0176208 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | -0.0175427 |
| NID2 | nidogen 2 (osteonidogen) | -0.0173601 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0172897 |
| VCAN | versican | -0.0170785 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | -0.0170627 |
| C1D | C1D nuclear receptor corepressor | -0.0168175 |
| LMAN1 | lectin, mannose-binding, 1 | -0.016786 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0167724 |
| KIAA1549L | KIAA1549-like | -0.0166055 |
| PAMR1 | peptidase domain containing associated with muscle regeneration 1 | -0.0165274 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0165142 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0164912 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0161503 |
| COL1A1 | collagen, type I, alpha 1 | -0.0161335 |
| TAGLN2 | transgelin 2 | -0.0157025 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.015568 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0155211 |
| RPS27L | ribosomal protein S27-like | -0.0154368 |
| TRAM2 | translocation associated membrane protein 2 | -0.0154221 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0153871 |
| GANAB | glucosidase, alpha; neutral AB | -0.0150667 |
| XPC | xeroderma pigmentosum, complementation group C | -0.0150651 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0146529 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | -0.0146357 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0146013 |
| SEPTIN11 | septin 11 | -0.01458 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0144379 |
| TBX2 | T-box 2 | -0.0143969 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0141007 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.0140585 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0139668 |
| SMTN | smoothelin | -0.0139607 |
| AXL | AXL receptor tyrosine kinase | -0.0135116 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0133826 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.013381 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.013351 |
| COL27A1 | collagen, type XXVII, alpha 1 | -0.0131478 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0131203 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.012974 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0128688 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0127279 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0127213 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | -0.0127045 |
| ITGA11 | integrin, alpha 11 | -0.0126115 |
| CHSY3 | chondroitin sulfate synthase 3 | -0.0125152 |
| EDNRA | endothelin receptor type A | -0.0124419 |
