Molindone Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/23897
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Genes

199 proteins with high or low expression in Molindone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
DIPK1B divergent protein kinase domain 1B 2.17
PIP prolactin-induced protein 2.04
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae) 1.57
SEPTIN4 septin 4 0.99
TTLL4 tubulin tyrosine ligase-like family member 4 0.78
ENO1 enolase 1, (alpha) 0.75
RPS20 ribosomal protein S20 0.7
H2AZ1 H2A.Z variant histone 1 0.68
TRIM29 tripartite motif containing 29 0.65
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.62
PACRGL PARK2 co-regulated-like 0.56
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.54
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.52
CHRD chordin 0.52
H1-2 H1.2 linker histone, cluster member 0.51
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 0.51
CNTNAP4 contactin associated protein-like 4 0.5
SH3BP2 SH3-domain binding protein 2 0.47
TBC1D32 TBC1 domain family, member 32 0.47
CBX3 chromobox homolog 3 0.47
TMEM161B transmembrane protein 161B 0.45
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.44
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.44
RPS8 ribosomal protein S8 0.44
RPL31 ribosomal protein L31 0.43
EEF1G eukaryotic translation elongation factor 1 gamma 0.43
RPL12 ribosomal protein L12 0.43
HIST2H2AA3 histone cluster 2, H2aa3 0.43
RNF146 ring finger protein 146 0.42
LDHA lactate dehydrogenase A 0.42
HIST2H3A histone cluster 2, H3a 0.42
RPL36AL ribosomal protein L36a-like 0.42
UHRF1BP1 UHRF1 binding protein 1 0.42
ZNF385B zinc finger protein 385B 0.42
SP100 SP100 nuclear antigen 0.41
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.41
DNAH14 dynein, axonemal, heavy chain 14 0.39
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.39
RPL10A ribosomal protein L10a 0.39
COMTD1 catechol-O-methyltransferase domain containing 1 0.39
TUBA1A tubulin, alpha 1a 0.39
ACTBL2 actin, beta-like 2 0.38
RPS23 ribosomal protein S23 0.38
TUBB3 tubulin, beta 3 class III 0.38
HIST2H2BF histone cluster 2, H2bf 0.38
TMEM64 transmembrane protein 64 0.37
TAZ tafazzin 0.37
WDR90 WD repeat domain 90 0.36
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.36
H1-4 H1.4 linker histone, cluster member 0.36
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 0.36
HIST2H2AB histone cluster 2, H2ab 0.35
EZR ezrin 0.35
NEK4 NIMA-related kinase 4 0.35
HMGB1 high mobility group box 1 0.35
FBXW8 F-box and WD repeat domain containing 8 0.35
KMT2B lysine (K)-specific methyltransferase 2B 0.35
RNF114 ring finger protein 114 0.34
RPS14 ribosomal protein S14 0.34
SLIRP SRA stem-loop interacting RNA binding protein 0.34
PTK6 protein tyrosine kinase 6 0.34
RGN regucalcin 0.34
DOHH deoxyhypusine hydroxylase/monooxygenase 0.34
CFL1 cofilin 1 (non-muscle) 0.34
RPS6 ribosomal protein S6 0.33
TRIR telomerase RNA component interacting RNase 0.33
MLH3 mutL homolog 3 0.33
NFYB nuclear transcription factor Y, beta 0.33
DYNLL1 dynein, light chain, LC8-type 1 0.33
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.32
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.32
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 0.32
TPI1 triosephosphate isomerase 1 0.32
RPL37A ribosomal protein L37a 0.32
RPL18A ribosomal protein L18a 0.32
ATP5IF1 ATP synthase inhibitory factor subunit 1 0.32
SERBP1 SERPINE1 mRNA binding protein 1 0.31
ANXA2 annexin A2 0.31
AEBP2 AE binding protein 2 0.31
ZNF296 zinc finger protein 296 0.31
MLF1 myeloid leukemia factor 1 0.31
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.31
NAP1L1 nucleosome assembly protein 1-like 1 0.3
HSPA8 heat shock 70kDa protein 8 0.3
PARP16 poly (ADP-ribose) polymerase family, member 16 0.3
RPL3L ribosomal protein L3-like 0.3
GVINP1 GTPase, very large interferon inducible pseudogene 1 0.29
PRRX2 paired related homeobox 2 0.29
ZBTB5 zinc finger and BTB domain containing 5 0.29
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.29
MKS1 Meckel syndrome, type 1 0.29
MARCHF7 membrane associated ring-CH-type finger 7 0.29
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.29
RPS15 ribosomal protein S15 0.29
GK5 glycerol kinase 5 (putative) 0.29
GAS6 growth arrest-specific 6 0.29
AMPD1 adenosine monophosphate deaminase 1 0.28
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 0.28
RPS11 ribosomal protein S11 0.28

low expression

Symbol Name Standardized Value
PPP1R2B PPP1R2 family member B -0.74
EPDR1 ependymin related 1 -0.72
FSTL1 follistatin-like 1 -0.72
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 -0.63
FZD2 frizzled class receptor 2 -0.59
TSPAN3 tetraspanin 3 -0.56
BID BH3 interacting domain death agonist -0.55
ARSG arylsulfatase G -0.54
ZBTB44 zinc finger and BTB domain containing 44 -0.54
C15ORF61 chromosome 15 open reading frame 61 -0.48
SLC16A6 solute carrier family 16, member 6 -0.47
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 -0.46
GKAP1 G kinase anchoring protein 1 -0.45
ZC3H6 zinc finger CCCH-type containing 6 -0.43
S100A6 S100 calcium binding protein A6 -0.42
TULP4 tubby like protein 4 -0.41
LMBR1 limb development membrane protein 1 -0.41
VWA1 von Willebrand factor A domain containing 1 -0.41
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.4
FTL ferritin, light polypeptide -0.4
METTL22 methyltransferase like 22 -0.4
CLTA clathrin, light chain A -0.4
TIGD1 tigger transposable element derived 1 -0.39
TMEM246 transmembrane protein 246 -0.39
BORA bora, aurora kinase A activator -0.39
FAM3A family with sequence similarity 3, member A -0.39
GAS8 growth arrest-specific 8 -0.39
B9D1 B9 protein domain 1 -0.39
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -0.39
TMEM135 transmembrane protein 135 -0.39
COX5B cytochrome c oxidase subunit Vb -0.39
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma -0.38
FKBP14 FK506 binding protein 14, 22 kDa -0.38
C18ORF32 chromosome 18 open reading frame 32 -0.38
RNASET2 ribonuclease T2 -0.37
GJB3 gap junction protein, beta 3, 31kDa -0.37
HINT3 histidine triad nucleotide binding protein 3 -0.37
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 -0.36
ADAP2 ArfGAP with dual PH domains 2 -0.36
XIRP1 xin actin binding repeat containing 1 -0.35
FZD1 frizzled class receptor 1 -0.34
CEP57 centrosomal protein 57kDa -0.34
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -0.34
VAMP4 vesicle-associated membrane protein 4 -0.34
PLSCR3 phospholipid scramblase 3 -0.34
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.33
ZNF250 zinc finger protein 250 -0.33
PTMS parathymosin -0.32
SLC25A38 solute carrier family 25, member 38 -0.32
CD63 CD63 molecule -0.32
SRD5A3 steroid 5 alpha-reductase 3 -0.32
L1RE1 LINE1 retrotransposable element 1 -0.32
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 -0.32
LCORL ligand dependent nuclear receptor corepressor-like -0.31
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -0.31
IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) -0.31
PLEKHA7 pleckstrin homology domain containing, family A member 7 -0.31
CSRNP2 cysteine-serine-rich nuclear protein 2 -0.31
LIME1 Lck interacting transmembrane adaptor 1 -0.31
C8ORF82 chromosome 8 open reading frame 82 -0.31
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.31
ITM2C integral membrane protein 2C -0.31
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 -0.31
FANCC Fanconi anemia, complementation group C -0.31
FGFBP1 fibroblast growth factor binding protein 1 -0.3
HACD1 3-hydroxyacyl-CoA dehydratase 1 -0.3
ARMC7 armadillo repeat containing 7 -0.3
ZNF729 zinc finger protein 729 -0.3
DMGDH dimethylglycine dehydrogenase -0.3
MT-ND5 NADH dehydrogenase, subunit 5 (complex I) -0.3
KIAA1324L KIAA1324-like -0.3
MT1L metallothionein 1L (gene/pseudogene) -0.3
FBXL15 F-box and leucine-rich repeat protein 15 -0.3
NMU neuromedin U -0.3
IER2 immediate early response 2 -0.29
NAGS N-acetylglutamate synthase -0.29
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 -0.29
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa -0.29
SLC35F6 solute carrier family 35, member F6 -0.29
C12ORF73 chromosome 12 open reading frame 73 -0.29
ZNF445 zinc finger protein 445 -0.29
BCL9 B-cell CLL/lymphoma 9 -0.29
ZFP36L1 ZFP36 ring finger protein-like 1 -0.28
IFIH1 interferon induced with helicase C domain 1 -0.28
WWOX WW domain containing oxidoreductase -0.28
ADGRE2 adhesion G protein-coupled receptor E2 -0.28
PDZD11 PDZ domain containing 11 -0.28
YBEY ybeY metallopeptidase (putative) -0.27
SERINC1 serine incorporator 1 -0.27
UNC119 unc-119 homolog (C. elegans) -0.27
ANKRD13C ankyrin repeat domain 13C -0.27
PPP1R35 protein phosphatase 1, regulatory subunit 35 -0.27
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.27
XPA xeroderma pigmentosum, complementation group A -0.27
SGTB small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta -0.27
FBXW2 F-box and WD repeat domain containing 2 -0.27
ZNF888 zinc finger protein 888 -0.27
ZFP1 ZFP1 zinc finger protein -0.27
CBR3 carbonyl reductase 3 -0.26
ABHD17A abhydrolase domain containing 17A -0.26