Monocrotaline_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Monocrotaline perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Monocrotaline_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.147602
BTBD9 BTB (POZ) domain containing 9 0.0931491
H1-0 H1.0 linker histone 0.0612231
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0594253
ZMYND8 zinc finger, MYND-type containing 8 0.0560643
CANX calnexin 0.0556923
AHNAK AHNAK nucleoprotein 0.0533077
PGK1 phosphoglycerate kinase 1 0.049681
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0484494
ZMYM2 zinc finger, MYM-type 2 0.0457937
CTNND1 catenin (cadherin-associated protein), delta 1 0.0444891
MBNL2 muscleblind-like splicing regulator 2 0.0444705
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0442657
APOL1 apolipoprotein L, 1 0.0437641
FNDC3A fibronectin type III domain containing 3A 0.043701
STK39 serine threonine kinase 39 0.0430635
ARHGAP26 Rho GTPase activating protein 26 0.0426886
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0423885
PRELID2 PRELI domain containing 2 0.0415039
STS steroid sulfatase (microsomal), isozyme S 0.0415005
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0403898
NPSR1 neuropeptide S receptor 1 0.040283
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0398487
ANKRD10 ankyrin repeat domain 10 0.0386323
PATJ PATJ crumbs cell polarity complex component 0.0384387
SERINC5 serine incorporator 5 0.038036
KDM3A lysine (K)-specific demethylase 3A 0.0377058
ARHGAP5 Rho GTPase activating protein 5 0.0373107
LPP LIM domain containing preferred translocation partner in lipoma 0.0368435
NKD1 naked cuticle homolog 1 (Drosophila) 0.0360345
OGA O-GlcNAcase 0.0359514
MACF1 microtubule-actin crosslinking factor 1 0.0351689
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0349
RUNX1 runt-related transcription factor 1 0.034479
TTC3 tetratricopeptide repeat domain 3 0.0343206
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0341592
PTGR1 prostaglandin reductase 1 0.0337987
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0335992
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0333653
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0330487
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0328571
MYH9 myosin, heavy chain 9, non-muscle 0.0309752
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0308596
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0306563
PTK2 protein tyrosine kinase 2 0.0301828
SBF2 SET binding factor 2 0.0301531
PTBP3 polypyrimidine tract binding protein 3 0.0298648
WDR45B WD repeat domain 45B 0.0295938
ESRP1 epithelial splicing regulatory protein 1 0.0295402
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0291873
KMT2C lysine (K)-specific methyltransferase 2C 0.0290345
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0290229
GOLGB1 golgin B1 0.0290112
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0285506
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0284367
TTC39B tetratricopeptide repeat domain 39B 0.0283903
FDPS farnesyl diphosphate synthase 0.028361
ASPH aspartate beta-hydroxylase 0.0282444
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0282188
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0282122
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.0279338
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.0279302
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.027566
ITGA1 integrin, alpha 1 0.0274836
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0272389
JAK1 Janus kinase 1 0.0271009
TXNIP thioredoxin interacting protein 0.027073
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0270261
UBC ubiquitin C 0.026999
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0268976
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0268724
XAF1 XIAP associated factor 1 0.0267854
MCTP2 multiple C2 domains, transmembrane 2 0.0266974
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.026627
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.026453
PHIP pleckstrin homology domain interacting protein 0.026288
DSCAM Down syndrome cell adhesion molecule 0.0260812
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0257918
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0256907
TMEM123 transmembrane protein 123 0.0252818
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.025171
GCLC glutamate-cysteine ligase, catalytic subunit 0.0247286
BICRAL BICRA like chromatin remodeling complex associated protein 0.0247107
ERRFI1 ERBB receptor feedback inhibitor 1 0.0245972
DOCK1 dedicator of cytokinesis 1 0.0245023
MSI2 musashi RNA-binding protein 2 0.0244498
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0243922
MED13 mediator complex subunit 13 0.0243285
DSPP dentin sialophosphoprotein 0.024308
SERINC3 serine incorporator 3 0.0241997
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.024175
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0240505
GSK3B glycogen synthase kinase 3 beta 0.0239557
ZNRF3 zinc and ring finger 3 0.0238578
CD2AP CD2-associated protein 0.0238484
AHI1 Abelson helper integration site 1 0.023772
ARGLU1 arginine and glutamate rich 1 0.0236386
ANO6 anoctamin 6 0.0233636
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0232562
RNF43 ring finger protein 43 0.023251

decreased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 -0.142761
ANXA2 annexin A2 -0.0939974
EGR1 early growth response 1 -0.0860892
B2M beta-2-microglobulin -0.0711041
C6ORF132 chromosome 6 open reading frame 132 -0.0620504
EZR ezrin -0.0616809
MX1 MX dynamin-like GTPase 1 -0.0605268
TPT1 tumor protein, translationally-controlled 1 -0.0601482
IRF1 interferon regulatory factor 1 -0.0557876
EPSTI1 epithelial stromal interaction 1 (breast) -0.0521875
IRS2 insulin receptor substrate 2 -0.0491659
P4HB prolyl 4-hydroxylase, beta polypeptide -0.047691
EXT1 exostosin glycosyltransferase 1 -0.0444063
NDRG1 N-myc downstream regulated 1 -0.0415636
MAP7 microtubule-associated protein 7 -0.0410213
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0407867
MCL1 myeloid cell leukemia 1 -0.0400657
IFI27 interferon, alpha-inducible protein 27 -0.0389435
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0382753
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0381408
RPL23 ribosomal protein L23 -0.037714
RPL35A ribosomal protein L35a -0.0377114
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0372472
FTL ferritin, light polypeptide -0.0366363
HM13 histocompatibility (minor) 13 -0.0363872
BCLAF1 BCL2-associated transcription factor 1 -0.0352902
POTEF POTE ankyrin domain family, member F -0.0347658
TMSB10 thymosin beta 10 -0.0337419
UFM1 ubiquitin-fold modifier 1 -0.0329462
RPLP1 ribosomal protein, large, P1 -0.0329301
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0327837
BLZF1 basic leucine zipper nuclear factor 1 -0.0323478
RPS19 ribosomal protein S19 -0.0321706
MCTP1 multiple C2 domains, transmembrane 1 -0.0315279
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.031189
TM4SF19 transmembrane 4 L six family member 19 -0.0296708
RAB7A RAB7A, member RAS oncogene family -0.0291919
PERP PERP, TP53 apoptosis effector -0.0291326
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0291206
ZNF292 zinc finger protein 292 -0.0287904
MORF4L2 mortality factor 4 like 2 -0.0281039
PTMA prothymosin, alpha -0.0278834
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0277463
S100A6 S100 calcium binding protein A6 -0.0274784
RPL26 ribosomal protein L26 -0.0267251
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0266461
GLS2 glutaminase 2 (liver, mitochondrial) -0.0262071
DDB1 damage-specific DNA binding protein 1, 127kDa -0.0259426
MXD1 MAX dimerization protein 1 -0.0257375
MT2A metallothionein 2A -0.0256577
PMM2 phosphomannomutase 2 -0.0256171
TFG TRK-fused gene -0.0251664
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.025028
RPL19 ribosomal protein L19 -0.0247301
VMP1 vacuole membrane protein 1 -0.024717
CCNL1 cyclin L1 -0.0246502
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0246238
RPS8 ribosomal protein S8 -0.0245258
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0240223
POU2F2 POU class 2 homeobox 2 -0.0237027
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0235641
MRPS6 mitochondrial ribosomal protein S6 -0.0235584
SETX senataxin -0.0235579
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0235088
TRIB1 tribbles pseudokinase 1 -0.0234661
PLSCR1 phospholipid scramblase 1 -0.0231395
ZNF207 zinc finger protein 207 -0.0230503
ARF4 ADP-ribosylation factor 4 -0.0230231
TNS4 tensin 4 -0.0229821
RPS6 ribosomal protein S6 -0.0228105
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0224319
SLC38A1 solute carrier family 38, member 1 -0.0220986
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0220802
RPL11 ribosomal protein L11 -0.022057
MTDH metadherin -0.0220306
POMP proteasome maturation protein -0.0219525
TRERF1 transcriptional regulating factor 1 -0.0218958
MED4 mediator complex subunit 4 -0.0218886
AREG amphiregulin -0.021781
ANKRD12 ankyrin repeat domain 12 -0.0217039
NUCB2 nucleobindin 2 -0.0216982
UGDH UDP-glucose 6-dehydrogenase -0.0214609
ANXA1 annexin A1 -0.0214575
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0213768
GPBP1 GC-rich promoter binding protein 1 -0.0212159
RPS12 ribosomal protein S12 -0.0211106
TJP1 tight junction protein 1 -0.0210203
FTH1 ferritin, heavy polypeptide 1 -0.0208857
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0208761
S100A10 S100 calcium binding protein A10 -0.0208719
RPL7A ribosomal protein L7a -0.0208263
SEC24A SEC24 family member A -0.0207934
ASXL1 additional sex combs like transcriptional regulator 1 -0.0207742
ARLN allregulin -0.0207479
HLA-B major histocompatibility complex, class I, B -0.0205772
TUFT1 tuftelin 1 -0.0205629
ZBTB43 zinc finger and BTB domain containing 43 -0.0205191
DIAPH2 diaphanous-related formin 2 -0.0205109
ZBTB7C zinc finger and BTB domain containing 7C -0.020436
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0202026