Monocrotaline_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Monocrotaline perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Monocrotaline_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.428711
COL6A3 collagen, type VI, alpha 3 0.177349
CXCL8 chemokine (C-X-C motif) ligand 8 0.166462
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.107831
CD44 CD44 molecule (Indian blood group) 0.106681
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0908279
LDHA lactate dehydrogenase A 0.0870861
MYH9 myosin, heavy chain 9, non-muscle 0.0836422
ATP13A3 ATPase type 13A3 0.0791331
TRIO trio Rho guanine nucleotide exchange factor 0.0778501
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0769187
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0723217
PABPC1 poly(A) binding protein, cytoplasmic 1 0.070137
SOD2 superoxide dismutase 2, mitochondrial 0.0679641
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0678428
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0650366
POSTN periostin, osteoblast specific factor 0.064388
ASPH aspartate beta-hydroxylase 0.0618788
LOXL2 lysyl oxidase-like 2 0.0612828
SMAD3 SMAD family member 3 0.0589039
STC1 stanniocalcin 1 0.0588132
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0570794
TMSB4X thymosin beta 4, X-linked 0.0553892
INHBA inhibin, beta A 0.0548904
LTBP1 latent transforming growth factor beta binding protein 1 0.0545464
EXT1 exostosin glycosyltransferase 1 0.0491032
CANX calnexin 0.0486899
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0480777
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0477894
COL1A2 collagen, type I, alpha 2 0.046952
WWTR1 WW domain containing transcription regulator 1 0.0460447
ENO1 enolase 1, (alpha) 0.0457237
CALU calumenin 0.0452363
VCAN versican 0.0450398
MAP1B microtubule-associated protein 1B 0.0449432
MTSS1 metastasis suppressor 1 0.044896
FBN1 fibrillin 1 0.043935
RAD21 RAD21 homolog (S. pombe) 0.0421464
FNDC3B fibronectin type III domain containing 3B 0.0421173
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0415355
TM4SF1 transmembrane 4 L six family member 1 0.0409153
ELL2 elongation factor, RNA polymerase II, 2 0.0407642
APP amyloid beta (A4) precursor protein 0.0404131
IL6ST interleukin 6 signal transducer 0.0399919
ANXA2 annexin A2 0.038166
CLIC4 chloride intracellular channel 4 0.0378766
PSD3 pleckstrin and Sec7 domain containing 3 0.0369071
ERRFI1 ERBB receptor feedback inhibitor 1 0.0363678
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0351601
ARRDC3 arrestin domain containing 3 0.0350573
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0350083
NAMPT nicotinamide phosphoribosyltransferase 0.0346003
PTK2 protein tyrosine kinase 2 0.0342833
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0326162
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0318734
ANTXR2 anthrax toxin receptor 2 0.031709
UBC ubiquitin C 0.0314274
AHNAK AHNAK nucleoprotein 0.0306782
TNIP1 TNFAIP3 interacting protein 1 0.0306068
TPM4 tropomyosin 4 0.0305285
SPAG9 sperm associated antigen 9 0.0288681
DST dystonin 0.0288607
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0287414
HMGA2 high mobility group AT-hook 2 0.0284398
PGK1 phosphoglycerate kinase 1 0.0283912
DPYSL3 dihydropyrimidinase-like 3 0.0283712
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0276816
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0274823
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0272309
ZBTB38 zinc finger and BTB domain containing 38 0.0266922
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0264017
ARHGAP29 Rho GTPase activating protein 29 0.0261136
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0254959
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0253603
BZW1 basic leucine zipper and W2 domains 1 0.0252661
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0249541
RIPK2 receptor-interacting serine-threonine kinase 2 0.0248913
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0243603
DLG1 discs, large homolog 1 (Drosophila) 0.024266
GRB10 growth factor receptor-bound protein 10 0.023929
AFAP1 actin filament associated protein 1 0.0238447
PRELID2 PRELI domain containing 2 0.0230975
PDIA6 protein disulfide isomerase family A, member 6 0.0230602
KDM7A lysine (K)-specific demethylase 7A 0.0227862
ALCAM activated leukocyte cell adhesion molecule 0.0226837
ADAM9 ADAM metallopeptidase domain 9 0.0226011
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0222922
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0220409
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0220009
RASA2 RAS p21 protein activator 2 0.0216685
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0214433
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0213284
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0211984
CSDE1 cold shock domain containing E1, RNA-binding 0.021184
NAV2 neuron navigator 2 0.0211588
NFE2L1 nuclear factor, erythroid 2-like 1 0.0208971
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0207102
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0206158
ADAM12 ADAM metallopeptidase domain 12 0.0204787
SAMD9 sterile alpha motif domain containing 9 0.0201868

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.192723
TMSB10 thymosin beta 10 -0.11686
FTL ferritin, light polypeptide -0.0956502
MT2A metallothionein 2A -0.0880906
RPL35A ribosomal protein L35a -0.0656921
PTMA prothymosin, alpha -0.0579307
TGFBI transforming growth factor, beta-induced, 68kDa -0.0542754
RPS8 ribosomal protein S8 -0.0528503
CADM1 cell adhesion molecule 1 -0.052688
RPL37A ribosomal protein L37a -0.0415269
CDH13 cadherin 13 -0.0413506
S100A9 S100 calcium binding protein A9 -0.0400488
RPS19 ribosomal protein S19 -0.0393174
RPLP2 ribosomal protein, large, P2 -0.0373314
VEGFA vascular endothelial growth factor A -0.0367762
TPT1 tumor protein, translationally-controlled 1 -0.0360457
RPS3 ribosomal protein S3 -0.0303509
ENO2 enolase 2 (gamma, neuronal) -0.030204
RPS6 ribosomal protein S6 -0.0297288
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0291183
RPL31 ribosomal protein L31 -0.028857
RPL28 ribosomal protein L28 -0.028714
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0270591
MTDH metadherin -0.0262395
RPS27A ribosomal protein S27a -0.025908
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.025459
RPS12 ribosomal protein S12 -0.0250852
RPL36 ribosomal protein L36 -0.0250344
RPS14 ribosomal protein S14 -0.0243939
RAB2A RAB2A, member RAS oncogene family -0.0243366
CYB5R3 cytochrome b5 reductase 3 -0.0243063
RPL5 ribosomal protein L5 -0.0241114
RPL9 ribosomal protein L9 -0.0240893
JARID2 jumonji, AT rich interactive domain 2 -0.023523
HILPDA hypoxia inducible lipid droplet-associated -0.0231966
RAB6A RAB6A, member RAS oncogene family -0.0231311
RPL23 ribosomal protein L23 -0.0226767
IFITM3 interferon induced transmembrane protein 3 -0.0225355
RPS13 ribosomal protein S13 -0.0222236
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0219244
RPLP1 ribosomal protein, large, P1 -0.0217064
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0215872
IARS1 isoleucyl-tRNA synthetase 1 -0.0215166
IER3 immediate early response 3 -0.0209497
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0209031
GOLGB1 golgin B1 -0.0194058
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0191849
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0188478
RPL37 ribosomal protein L37 -0.0186158
RPL36A ribosomal protein L36a -0.0185407
RPS17 ribosomal protein S17 -0.0184191
FGFR1 fibroblast growth factor receptor 1 -0.018228
RPS29 ribosomal protein S29 -0.0180392
HSPG2 heparan sulfate proteoglycan 2 -0.017938
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0175781
COL6A1 collagen, type VI, alpha 1 -0.0171066
WSB1 WD repeat and SOCS box containing 1 -0.0170579
RPL7A ribosomal protein L7a -0.0165641
RPS10 ribosomal protein S10 -0.0163961
RPS25 ribosomal protein S25 -0.0162357
RPL13A ribosomal protein L13a -0.0158359
TSC22D2 TSC22 domain family, member 2 -0.01571
HLA-A major histocompatibility complex, class I, A -0.015562
ADM adrenomedullin -0.0155095
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0151893
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0151627
INTS6 integrator complex subunit 6 -0.015149
ATF4 activating transcription factor 4 -0.0149809
HLA-B major histocompatibility complex, class I, B -0.0148373
PTPRG protein tyrosine phosphatase, receptor type, G -0.0147655
RPS21 ribosomal protein S21 -0.014605
FAM177A1 family with sequence similarity 177, member A1 -0.0145256
ARL4C ADP-ribosylation factor-like 4C -0.0144174
SEC61G Sec61 gamma subunit -0.014382
RPL27 ribosomal protein L27 -0.0142014
PFN1 profilin 1 -0.0141255
RPL38 ribosomal protein L38 -0.0138386
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.013588
RAB7A RAB7A, member RAS oncogene family -0.013331
NEK10 NIMA-related kinase 10 -0.0132794
HM13 histocompatibility (minor) 13 -0.013276
TBCA tubulin folding cofactor A -0.0131923
RPL19 ribosomal protein L19 -0.0128951
CARS1 cysteinyl-tRNA synthetase 1 -0.012881
COL6A2 collagen, type VI, alpha 2 -0.0128289
MYDGF myeloid-derived growth factor -0.0128107
GNAS GNAS complex locus -0.0127867
RPS11 ribosomal protein S11 -0.0127555
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0126017
DGKI diacylglycerol kinase, iota -0.0125932
AGO3 argonaute RISC catalytic component 3 -0.0124022
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0123945
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0123265
STC2 stanniocalcin 2 -0.0122534
SLC38A2 solute carrier family 38, member 2 -0.0122438
RPL35 ribosomal protein L35 -0.0122222
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0121863
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0121737
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0120967
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0118042