Monocrotaline_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Monocrotaline perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Monocrotaline_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.188156
ERRFI1 ERBB receptor feedback inhibitor 1 0.111909
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0915399
LRMDA leucine rich melanocyte differentiation associated 0.0769914
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0576257
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0434417
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0421595
DTNA dystrobrevin, alpha 0.041944
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0418138
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0414899
PABPC1 poly(A) binding protein, cytoplasmic 1 0.040285
SESTD1 SEC14 and spectrin domains 1 0.0399426
INSIG2 insulin induced gene 2 0.0397124
WDFY2 WD repeat and FYVE domain containing 2 0.0388971
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0381495
SOD2 superoxide dismutase 2, mitochondrial 0.0363617
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0352347
KDM7A lysine (K)-specific demethylase 7A 0.0349407
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0344535
GOLGA4 golgin A4 0.0337139
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0332875
AFDN afadin, adherens junction formation factor 0.0324759
ELL2 elongation factor, RNA polymerase II, 2 0.0324248
PTK2 protein tyrosine kinase 2 0.0322422
FMNL2 formin-like 2 0.0318341
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0318187
KIAA1217 KIAA1217 0.0318085
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0314003
GMDS GDP-mannose 4,6-dehydratase 0.0298581
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0295948
DDIT4 DNA-damage-inducible transcript 4 0.0292933
DENND4A DENN/MADD domain containing 4A 0.0292397
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0290952
FHIT fragile histidine triad 0.02893
PTBP3 polypyrimidine tract binding protein 3 0.0273079
MYO1B myosin IB 0.0271081
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0269624
HELZ helicase with zinc finger 0.0265016
ARHGAP12 Rho GTPase activating protein 12 0.0263628
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.026213
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0261005
ZNF292 zinc finger protein 292 0.0257006
YAP1 Yes-associated protein 1 0.0256208
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0254334
UBA6 ubiquitin-like modifier activating enzyme 6 0.0250855
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0249786
FAM13A family with sequence similarity 13, member A 0.0249021
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0246965
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0246249
BRWD1 bromodomain and WD repeat domain containing 1 0.0245714
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0242482
KMT2C lysine (K)-specific methyltransferase 2C 0.0238707
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0237248
RREB1 ras responsive element binding protein 1 0.0232096
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0230283
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0228196
MALT1 MALT1 paracaspase 0.0226384
RPLP0 ribosomal protein, large, P0 0.0225361
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0224078
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0217944
ARFGEF3 ARFGEF family member 3 0.0215276
PSD3 pleckstrin and Sec7 domain containing 3 0.0215077
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.0214287
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.0213179
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0210288
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0209442
PLIN2 perilipin 2 0.0208852
PTPRM protein tyrosine phosphatase, receptor type, M 0.0208208
MBNL2 muscleblind-like splicing regulator 2 0.0207538
CLASP1 cytoplasmic linker associated protein 1 0.0204871
BHLHE40 basic helix-loop-helix family, member e40 0.0203967
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0203363
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0202287
SBF2 SET binding factor 2 0.0198988
GRK3 G protein-coupled receptor kinase 3 0.0198549
SEC24A SEC24 family member A 0.0197252
PUM2 pumilio RNA-binding family member 2 0.0196832
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0196724
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0195374
ARHGAP26 Rho GTPase activating protein 26 0.0194312
NBAS neuroblastoma amplified sequence 0.0192201
WAC WW domain containing adaptor with coiled-coil 0.0189875
NUP58 nucleoporin 58 0.0189298
SDC4 syndecan 4 0.0188526
JMJD1C jumonji domain containing 1C 0.0188501
CCDC6 coiled-coil domain containing 6 0.0188051
LCORL ligand dependent nuclear receptor corepressor-like 0.0187933
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0187789
ESYT2 extended synaptotagmin-like protein 2 0.0187718
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0187609
AKAP13 A kinase (PRKA) anchor protein 13 0.0186845
EML4 echinoderm microtubule associated protein like 4 0.0186318
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.0182778
GLS2 glutaminase 2 (liver, mitochondrial) 0.0181584
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0180953
NAMPT nicotinamide phosphoribosyltransferase 0.0179428
TCERG1 transcription elongation regulator 1 0.0178701
AUH AU RNA binding protein/enoyl-CoA hydratase 0.017712
PHF21A PHD finger protein 21A 0.0177011
PDZD8 PDZ domain containing 8 0.0174531

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.26766
FN1 fibronectin 1 -0.117255
MT2A metallothionein 2A -0.0879405
RPS27A ribosomal protein S27a -0.0645299
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0628024
TIMP1 TIMP metallopeptidase inhibitor 1 -0.062027
TMSB10 thymosin beta 10 -0.0615488
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0577016
RPS19 ribosomal protein S19 -0.0562076
EEF2 eukaryotic translation elongation factor 2 -0.0526197
UBC ubiquitin C -0.0520686
FTL ferritin, light polypeptide -0.0492466
AKAP12 A kinase (PRKA) anchor protein 12 -0.0472837
VCL vinculin -0.0458876
RPLP1 ribosomal protein, large, P1 -0.0449021
NKD1 naked cuticle homolog 1 (Drosophila) -0.0437832
RPS8 ribosomal protein S8 -0.0432348
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0430302
C3 complement component 3 -0.0407697
TM4SF1 transmembrane 4 L six family member 1 -0.0402327
BCL2L1 BCL2-like 1 -0.0401674
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0395948
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0386497
FAM107B family with sequence similarity 107, member B -0.0377706
TPT1 tumor protein, translationally-controlled 1 -0.0368638
JUN jun proto-oncogene -0.0367945
APOE apolipoprotein E -0.0364056
FOXP1 forkhead box P1 -0.0362902
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0347938
RPLP2 ribosomal protein, large, P2 -0.0346097
NAP1L1 nucleosome assembly protein 1-like 1 -0.0345336
PTMA prothymosin, alpha -0.0341966
RPL34 ribosomal protein L34 -0.0336091
ACTN4 actinin, alpha 4 -0.0327414
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0326529
LOC112694756 uncharaterized LOC112694756 -0.0325385
RPS29 ribosomal protein S29 -0.0322429
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0321625
UBASH3B ubiquitin associated and SH3 domain containing B -0.0320477
RPS24 ribosomal protein S24 -0.0320154
RPS3 ribosomal protein S3 -0.0303416
AHNAK AHNAK nucleoprotein -0.0297883
LMCD1 LIM and cysteine-rich domains 1 -0.0296813
RPL23 ribosomal protein L23 -0.0293302
EIF1 eukaryotic translation initiation factor 1 -0.0281488
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0277317
RACK1 receptor for activated C kinase 1 -0.0276384
RPL37A ribosomal protein L37a -0.0273983
RPL5 ribosomal protein L5 -0.0269242
LAMA4 laminin, alpha 4 -0.0268102
RPL31 ribosomal protein L31 -0.026705
ITGA1 integrin, alpha 1 -0.0266356
RPS21 ribosomal protein S21 -0.0264322
RPS17 ribosomal protein S17 -0.0262932
PDLIM5 PDZ and LIM domain 5 -0.026236
RPL36A ribosomal protein L36a -0.0256637
RPS13 ribosomal protein S13 -0.0255131
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0253287
RRBP1 ribosome binding protein 1 -0.0252566
A2M alpha-2-macroglobulin -0.0249774
IGF1R insulin-like growth factor 1 receptor -0.0248288
RPL11 ribosomal protein L11 -0.0245867
FRMD5 FERM domain containing 5 -0.0242995
CALR calreticulin -0.024019
RPL37 ribosomal protein L37 -0.0239847
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0239193
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0236917
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0236839
RPL35A ribosomal protein L35a -0.0234339
RPL19 ribosomal protein L19 -0.0230796
FAT1 FAT atypical cadherin 1 -0.0230523
CANX calnexin -0.0227401
APOA2 apolipoprotein A-II -0.0227182
VMP1 vacuole membrane protein 1 -0.0223941
AOPEP aminopeptidase O (putative) -0.0217972
EGR1 early growth response 1 -0.0217824
RPS16 ribosomal protein S16 -0.0216401
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0216125
CTSB cathepsin B -0.0215982
HDLBP high density lipoprotein binding protein -0.0215302
B2M beta-2-microglobulin -0.0213534
PNISR PNN-interacting serine/arginine-rich protein -0.021312
PRRC2C proline-rich coiled-coil 2C -0.021297
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.0211905
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0211464
ACTN1 actinin, alpha 1 -0.0210249
GNAS GNAS complex locus -0.0209832
DSPP dentin sialophosphoprotein -0.0204889
RPS12 ribosomal protein S12 -0.0203149
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0202174
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0199903
RPL38 ribosomal protein L38 -0.0199057
MYH9 myosin, heavy chain 9, non-muscle -0.0197748
TGFBI transforming growth factor, beta-induced, 68kDa -0.0196889
ACTG1 actin gamma 1 -0.0194339
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0193943
DNAH17 dynein, axonemal, heavy chain 17 -0.019375
RPS15 ribosomal protein S15 -0.0192
STAU1 staufen double-stranded RNA binding protein 1 -0.0191305
RPL12 ribosomal protein L12 -0.0189795