Monocrotaline_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Monocrotaline perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Monocrotaline_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ALCAM activated leukocyte cell adhesion molecule 0.0762605
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0732578
POTEF POTE ankyrin domain family, member F 0.07183
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0639034
UBC ubiquitin C 0.0593068
TMSB4X thymosin beta 4, X-linked 0.0548603
PGK1 phosphoglycerate kinase 1 0.0515751
TPT1 tumor protein, translationally-controlled 1 0.0501194
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0494795
COPA coatomer protein complex, subunit alpha 0.0472119
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0460458
IGF2 insulin-like growth factor 2 0.0429584
ITGA6 integrin, alpha 6 0.0404448
PICALM phosphatidylinositol binding clathrin assembly protein 0.0402655
MSN moesin 0.0387387
TRIO trio Rho guanine nucleotide exchange factor 0.0379139
CALU calumenin 0.0369001
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0360203
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0339189
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0332865
KRT6A keratin 6A, type II 0.0319855
B2M beta-2-microglobulin 0.0319663
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0311929
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.0305388
IQGAP1 IQ motif containing GTPase activating protein 1 0.0303952
ARRDC3 arrestin domain containing 3 0.029409
CLINT1 clathrin interactor 1 0.0293684
SPINK5 serine peptidase inhibitor, Kazal type 5 0.0293501
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0292839
TGM2 transglutaminase 2 0.0290729
LDHA lactate dehydrogenase A 0.0290643
RBM39 RNA binding motif protein 39 0.028944
KIAA1217 KIAA1217 0.0288558
S100A10 S100 calcium binding protein A10 0.0285886
ACTG1 actin gamma 1 0.0284627
ASPH aspartate beta-hydroxylase 0.0283991
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0283737
DOCK5 dedicator of cytokinesis 5 0.0281434
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0274693
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0273391
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0272625
KDM3A lysine (K)-specific demethylase 3A 0.0270337
FNIP1 folliculin interacting protein 1 0.0270057
FOXO1 forkhead box O1 0.0268313
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0256115
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0252875
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0250961
TNRC6A trinucleotide repeat containing 6A 0.0250852
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 0.0250542
USP9X ubiquitin specific peptidase 9, X-linked 0.0249756
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0249586
VCL vinculin 0.0248284
MYOF myoferlin 0.0247017
TES testin LIM domain protein 0.0243252
AKAP9 A kinase (PRKA) anchor protein 9 0.0242495
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.0241254
SNX9 sorting nexin 9 0.0240688
SUCO SUN domain containing ossification factor 0.0239973
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0239255
UBA6 ubiquitin-like modifier activating enzyme 6 0.0236986
LUZP1 leucine zipper protein 1 0.0236188
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0234429
HSPH1 heat shock 105kDa/110kDa protein 1 0.0233039
PLAT plasminogen activator, tissue 0.0232941
ENO1 enolase 1, (alpha) 0.0230732
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0230316
RPS23 ribosomal protein S23 0.0228198
TFG TRK-fused gene 0.0227003
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0226346
CUL4B cullin 4B 0.0223362
CSMD2 CUB and Sushi multiple domains 2 0.0220253
CRY1 cryptochrome circadian clock 1 0.0219282
ITCH itchy E3 ubiquitin protein ligase 0.0218695
PRRC1 proline-rich coiled-coil 1 0.0217768
RLIM ring finger protein, LIM domain interacting 0.0217589
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0212669
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0212261
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0211933
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0206194
PLK2 polo-like kinase 2 0.0205027
SKIC3 SKI3 subunit of superkiller complex 0.0202727
F3 coagulation factor III (thromboplastin, tissue factor) 0.0202636
EMP1 epithelial membrane protein 1 0.0202443
CCNL1 cyclin L1 0.0202311
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0201105
ARHGAP29 Rho GTPase activating protein 29 0.0194616
DIAPH1 diaphanous-related formin 1 0.0194001
PDIA6 protein disulfide isomerase family A, member 6 0.0193232
APLP2 amyloid beta (A4) precursor-like protein 2 0.01919
OSBPL3 oxysterol binding protein-like 3 0.0191707
BZW1 basic leucine zipper and W2 domains 1 0.019104
SLK STE20-like kinase 0.0190088
SEC23A Sec23 homolog A (S. cerevisiae) 0.0188305
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0188014
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0187715
SCFD1 sec1 family domain containing 1 0.0187165
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0187156
COG6 component of oligomeric golgi complex 6 0.0187131
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0186021
DENND4C DENN/MADD domain containing 4C 0.0185653

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.184885
FLNB filamin B, beta -0.136034
RPS3 ribosomal protein S3 -0.127889
NDRG1 N-myc downstream regulated 1 -0.106979
RPLP2 ribosomal protein, large, P2 -0.104617
RPLP1 ribosomal protein, large, P1 -0.104354
LMNA lamin A/C -0.0989427
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0964374
RPS12 ribosomal protein S12 -0.0939275
PTMA prothymosin, alpha -0.0896763
RPS19 ribosomal protein S19 -0.0802781
HSPG2 heparan sulfate proteoglycan 2 -0.0783692
SULF1 sulfatase 1 -0.0778095
RPS21 ribosomal protein S21 -0.0756031
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.073249
MT2A metallothionein 2A -0.07313
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0717102
S100A2 S100 calcium binding protein A2 -0.0678663
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0668814
RIGI RNA sensor RIG-I -0.0660654
AHNAK AHNAK nucleoprotein -0.064609
RPS6 ribosomal protein S6 -0.062206
GNAS GNAS complex locus -0.061942
RPL37A ribosomal protein L37a -0.0616282
MTSS1 metastasis suppressor 1 -0.0602307
GRB10 growth factor receptor-bound protein 10 -0.0593727
RPL36 ribosomal protein L36 -0.0580969
RPS13 ribosomal protein S13 -0.0563706
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0550099
RPS8 ribosomal protein S8 -0.0537685
SULF2 sulfatase 2 -0.0513964
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0509858
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0501762
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0479004
S100A9 S100 calcium binding protein A9 -0.0462334
PRSS23 protease, serine, 23 -0.0461364
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0459368
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0447117
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0438639
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0437984
RPL37 ribosomal protein L37 -0.0437009
RPS20 ribosomal protein S20 -0.0428137
HM13 histocompatibility (minor) 13 -0.0426241
S100A6 S100 calcium binding protein A6 -0.0423694
RPL7A ribosomal protein L7a -0.0417678
SRRM2 serine/arginine repetitive matrix 2 -0.041085
RPS27 ribosomal protein S27 -0.0409987
RPL12 ribosomal protein L12 -0.0408941
NF1 neurofibromin 1 -0.0407704
H1-0 H1.0 linker histone -0.0407548
YBX1 Y box binding protein 1 -0.0406503
RAI14 retinoic acid induced 14 -0.0403667
SMYD3 SET and MYND domain containing 3 -0.0394043
RPL18 ribosomal protein L18 -0.0393467
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0391724
ZEB1 zinc finger E-box binding homeobox 1 -0.0387117
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0386182
RPL35 ribosomal protein L35 -0.0385964
RPS29 ribosomal protein S29 -0.0383929
RACK1 receptor for activated C kinase 1 -0.0381873
ITGB4 integrin, beta 4 -0.0378558
ACTN4 actinin, alpha 4 -0.0376666
PODXL podocalyxin-like -0.0376508
MECOM MDS1 and EVI1 complex locus -0.037613
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0375737
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0374348
FTL ferritin, light polypeptide -0.037229
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0364258
LMO7 LIM domain 7 -0.0360988
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0360668
FSCN1 fascin actin-bundling protein 1 -0.0356862
CAVIN1 caveolae associated protein 1 -0.0352044
PLEC plectin -0.0349987
PTK2 protein tyrosine kinase 2 -0.0342566
MBNL1 muscleblind-like splicing regulator 1 -0.0341011
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0336812
EGFR epidermal growth factor receptor -0.0333362
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0331492
RPS27A ribosomal protein S27a -0.0331117
ZNFX1 zinc finger, NFX1-type containing 1 -0.0327236
ADAR adenosine deaminase, RNA-specific -0.032463
ZMYND8 zinc finger, MYND-type containing 8 -0.0323858
ARHGAP26 Rho GTPase activating protein 26 -0.0321472
GARS1 glycyl-tRNA synthetase 1 -0.0320999
IFITM3 interferon induced transmembrane protein 3 -0.0320825
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0320054
RPL5 ribosomal protein L5 -0.0317126
ABI3BP ABI family, member 3 (NESH) binding protein -0.0315901
OXR1 oxidation resistance 1 -0.0315878
UBE2B ubiquitin-conjugating enzyme E2B -0.0313418
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0312998
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0312648
CNTNAP3 contactin associated protein-like 3 -0.0312558
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0311944
MEIS2 Meis homeobox 2 -0.0311895
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0308741
HMGA2 high mobility group AT-hook 2 -0.030698
SEC61G Sec61 gamma subunit -0.0306402
KTN1 kinectin 1 (kinesin receptor) -0.0303303
UTRN utrophin -0.0302813