Monocrotaline_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Monocrotaline perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Monocrotaline_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.143722
TXNRD1 thioredoxin reductase 1 0.13264
SOD2 superoxide dismutase 2, mitochondrial 0.11709
ANKRD10 ankyrin repeat domain 10 0.0976247
TOP1 topoisomerase (DNA) I 0.0869658
PGK1 phosphoglycerate kinase 1 0.0867385
ELL2 elongation factor, RNA polymerase II, 2 0.0845985
ASPH aspartate beta-hydroxylase 0.0754305
UBC ubiquitin C 0.072335
SPAG9 sperm associated antigen 9 0.0627122
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0605854
TBC1D22A TBC1 domain family, member 22A 0.0601798
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0576115
GLS2 glutaminase 2 (liver, mitochondrial) 0.0555455
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0555216
RUNX1 runt-related transcription factor 1 0.0554477
DSCAM Down syndrome cell adhesion molecule 0.0517402
USP9X ubiquitin specific peptidase 9, X-linked 0.0516643
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0508514
ADAM17 ADAM metallopeptidase domain 17 0.0502272
CES1 carboxylesterase 1 0.048866
AGO2 argonaute RISC catalytic component 2 0.0484669
MYH9 myosin, heavy chain 9, non-muscle 0.0477178
PUM2 pumilio RNA-binding family member 2 0.0471482
KDM6A lysine (K)-specific demethylase 6A 0.0460081
NPTN neuroplastin 0.0454124
EIF4A2 eukaryotic translation initiation factor 4A2 0.0449358
UVRAG UV radiation resistance associated 0.0449232
STAT1 signal transducer and activator of transcription 1, 91kDa 0.044896
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0441056
PDE4D phosphodiesterase 4D, cAMP-specific 0.0437785
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0436645
ECT2 epithelial cell transforming 2 0.0435226
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0396261
HOOK2 hook microtubule-tethering protein 2 0.039472
CAMTA1 calmodulin binding transcription activator 1 0.0394485
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0393662
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0388235
H1-0 H1.0 linker histone 0.0386497
NGLY1 N-glycanase 1 0.038636
NFE2L2 nuclear factor, erythroid 2-like 2 0.0385201
KIAA1217 KIAA1217 0.0381735
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0377675
ATP13A3 ATPase type 13A3 0.0377105
RICTOR RPTOR independent companion of MTOR, complex 2 0.0375196
GSK3B glycogen synthase kinase 3 beta 0.0372852
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0370436
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0369949
RBM39 RNA binding motif protein 39 0.0354917
NUP58 nucleoporin 58 0.0352342
ZC3H11A zinc finger CCCH-type containing 11A 0.0351996
RAD21 RAD21 homolog (S. pombe) 0.0351679
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0351061
NCKAP1 NCK-associated protein 1 0.0349767
ARRDC3 arrestin domain containing 3 0.0348455
KDM3A lysine (K)-specific demethylase 3A 0.0345633
LRP1B low density lipoprotein receptor-related protein 1B 0.0341857
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0338106
ZFC3H1 zinc finger, C3H1-type containing 0.0336731
ZFAND6 zinc finger, AN1-type domain 6 0.0334697
MCTP1 multiple C2 domains, transmembrane 1 0.0332866
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0326253
SLTM SAFB-like, transcription modulator 0.0325698
CDC73 cell division cycle 73 0.03255
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0323926
OGA O-GlcNAcase 0.0323471
UBA6 ubiquitin-like modifier activating enzyme 6 0.0321943
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0321023
HELZ helicase with zinc finger 0.0319576
MKI67 marker of proliferation Ki-67 0.0319228
MAP7 microtubule-associated protein 7 0.0314431
TSC22D2 TSC22 domain family, member 2 0.0311218
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0308114
DTNA dystrobrevin, alpha 0.0307224
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0306746
AKR1C1 aldo-keto reductase family 1, member C1 0.0306215
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0300999
TFG TRK-fused gene 0.0296735
GPATCH2L G patch domain containing 2-like 0.0291452
ABLIM1 actin binding LIM protein 1 0.029137
UBE2O ubiquitin-conjugating enzyme E2O 0.0287344
TM9SF3 transmembrane 9 superfamily member 3 0.0286226
ARL5B ADP-ribosylation factor-like 5B 0.0284496
USP34 ubiquitin specific peptidase 34 0.028292
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0281426
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0274541
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0272084
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0271166
MYO5B myosin VB 0.0270987
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.027027
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0268904
ARL8B ADP-ribosylation factor-like 8B 0.0267083
INSIG2 insulin induced gene 2 0.0264225
TENT2 terminal nucleotidyltransferase 2 0.0262946
ERRFI1 ERBB receptor feedback inhibitor 1 0.026181
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.025926
TKT transketolase 0.0258881
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) 0.0258138
SFPQ splicing factor proline/glutamine-rich 0.025676
SMAD3 SMAD family member 3 0.0256734

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.200815
NDRG1 N-myc downstream regulated 1 -0.180853
MT2A metallothionein 2A -0.134496
EGFR epidermal growth factor receptor -0.128974
FTL ferritin, light polypeptide -0.106165
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.105709
RPS3 ribosomal protein S3 -0.0912489
EGR1 early growth response 1 -0.0870036
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0805902
RPS12 ribosomal protein S12 -0.0724105
RPL35A ribosomal protein L35a -0.0655426
RPLP1 ribosomal protein, large, P1 -0.0548568
RPL37A ribosomal protein L37a -0.0530569
CAV1 caveolin 1, caveolae protein, 22kDa -0.0505055
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0497314
PTMA prothymosin, alpha -0.0487274
SEC61G Sec61 gamma subunit -0.0485804
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0441861
IGFBP3 insulin-like growth factor binding protein 3 -0.0437165
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0422387
PKM pyruvate kinase, muscle -0.0411737
RPS8 ribosomal protein S8 -0.0409222
CAV2 caveolin 2 -0.0408349
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0404949
S100A10 S100 calcium binding protein A10 -0.0386835
S100P S100 calcium binding protein P -0.0377064
S100A6 S100 calcium binding protein A6 -0.0374759
RPL36 ribosomal protein L36 -0.0350749
HMGA1 high mobility group AT-hook 1 -0.0349119
PFN1 profilin 1 -0.0348706
RPLP2 ribosomal protein, large, P2 -0.0346404
POTEF POTE ankyrin domain family, member F -0.0339628
RPS19 ribosomal protein S19 -0.0333337
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0330063
RPS25 ribosomal protein S25 -0.0327113
RPL31 ribosomal protein L31 -0.0319674
FTH1 ferritin, heavy polypeptide 1 -0.0314508
CST3 cystatin C -0.030758
RPS27 ribosomal protein S27 -0.0306207
RPS17 ribosomal protein S17 -0.030037
ZMYND8 zinc finger, MYND-type containing 8 -0.0297566
RPS13 ribosomal protein S13 -0.0291175
S100A11 S100 calcium binding protein A11 -0.0288766
ATF4 activating transcription factor 4 -0.0282655
TPT1 tumor protein, translationally-controlled 1 -0.0281801
MT1X metallothionein 1X -0.0277919
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0273042
THSD4 thrombospondin, type I, domain containing 4 -0.0271247
CIB1 calcium and integrin binding 1 (calmyrin) -0.0266746
ANXA1 annexin A1 -0.0260099
AKAP9 A kinase (PRKA) anchor protein 9 -0.0256118
SERF2 small EDRK-rich factor 2 -0.0255406
RPS6 ribosomal protein S6 -0.0251813
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.024952
GNAS GNAS complex locus -0.0242129
S100A9 S100 calcium binding protein A9 -0.0240733
OFD1 oral-facial-digital syndrome 1 -0.0238561
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0233987
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0232369
FLNB filamin B, beta -0.0225372
HM13 histocompatibility (minor) 13 -0.0224316
VEGFA vascular endothelial growth factor A -0.0222723
CSTB cystatin B (stefin B) -0.0221876
KRT18 keratin 18, type I -0.0221082
RPL5 ribosomal protein L5 -0.0220548
RPL30 ribosomal protein L30 -0.0220461
TPM4 tropomyosin 4 -0.0219415
ACTG1 actin gamma 1 -0.0218913
HLA-A major histocompatibility complex, class I, A -0.0218679
ESYT2 extended synaptotagmin-like protein 2 -0.0217475
SCEL sciellin -0.0211596
RPS27A ribosomal protein S27a -0.0211191
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0207653
MSN moesin -0.0206746
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0206442
ANKRD12 ankyrin repeat domain 12 -0.0203388
KRT7 keratin 7, type II -0.0201872
LOC112694756 uncharaterized LOC112694756 -0.0201626
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0201417
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.019999
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0199927
RPL12 ribosomal protein L12 -0.0198101
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.019766
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0197657
GOLGA4 golgin A4 -0.0197576
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0197413
IGFBP5 insulin-like growth factor binding protein 5 -0.0195063
PDE8A phosphodiesterase 8A -0.0193138
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0191838
GSTP1 glutathione S-transferase pi 1 -0.01913
ARF4 ADP-ribosylation factor 4 -0.0188768
GOLGB1 golgin B1 -0.0188468
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0186696
RPS29 ribosomal protein S29 -0.0186403
HDGF hepatoma-derived growth factor -0.0185493
MGAT4C MGAT4 family, member C -0.0182933
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0182477
DDIT4 DNA-damage-inducible transcript 4 -0.0181834
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0180248
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0179609