Monocrotaline_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Monocrotaline perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Monocrotaline_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.130743
SOD2 superoxide dismutase 2, mitochondrial 0.121724
FNDC3B fibronectin type III domain containing 3B 0.109674
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.104735
FAM13A family with sequence similarity 13, member A 0.100401
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0914744
PCBP2 poly(rC) binding protein 2 0.0894752
GOLGA4 golgin A4 0.0855775
SMAD3 SMAD family member 3 0.0800754
TRIO trio Rho guanine nucleotide exchange factor 0.0758441
NAV2 neuron navigator 2 0.073782
GRB10 growth factor receptor-bound protein 10 0.0697969
USP34 ubiquitin specific peptidase 34 0.06588
KDM2A lysine (K)-specific demethylase 2A 0.0655608
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0624248
PRELID2 PRELI domain containing 2 0.0614704
ZNF292 zinc finger protein 292 0.0602276
CXCL8 chemokine (C-X-C motif) ligand 8 0.0589969
SDK1 sidekick cell adhesion molecule 1 0.0569925
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0560469
RBM39 RNA binding motif protein 39 0.0553047
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0540728
NBAS neuroblastoma amplified sequence 0.052781
HELZ helicase with zinc finger 0.0505511
RUNX1 runt-related transcription factor 1 0.0493929
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0487064
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0484414
UBA6 ubiquitin-like modifier activating enzyme 6 0.0480618
EFNA5 ephrin-A5 0.0465733
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0450139
RICTOR RPTOR independent companion of MTOR, complex 2 0.0443776
FBXL13 F-box and leucine-rich repeat protein 13 0.04415
DLG1 discs, large homolog 1 (Drosophila) 0.043589
ANXA1 annexin A1 0.0435824
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0413045
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0410381
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0409823
KMT2C lysine (K)-specific methyltransferase 2C 0.0409276
NGLY1 N-glycanase 1 0.0396731
COG5 component of oligomeric golgi complex 5 0.0390616
BIRC6 baculoviral IAP repeat containing 6 0.0375862
LIMCH1 LIM and calponin homology domains 1 0.0371258
ESYT2 extended synaptotagmin-like protein 2 0.0368748
TAS2R14 taste receptor, type 2, member 14 0.0355918
ATP13A3 ATPase type 13A3 0.0354696
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0346316
MAP2K1 mitogen-activated protein kinase kinase 1 0.0345562
PIAS2 protein inhibitor of activated STAT, 2 0.034393
OGA O-GlcNAcase 0.0340093
DSCAM Down syndrome cell adhesion molecule 0.0337822
EGFR epidermal growth factor receptor 0.0334279
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0330417
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0329825
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0326709
DOCK5 dedicator of cytokinesis 5 0.0325244
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0324421
FLNB filamin B, beta 0.0320963
LRRC49 leucine rich repeat containing 49 0.030997
AKAP12 A kinase (PRKA) anchor protein 12 0.0309903
SEC23A Sec23 homolog A (S. cerevisiae) 0.0305369
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.030525
SPAG9 sperm associated antigen 9 0.030049
YEATS2 YEATS domain containing 2 0.0299614
SIK3 SIK family kinase 3 0.0298831
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0297511
SRP54 signal recognition particle 54kDa 0.0296124
PICALM phosphatidylinositol binding clathrin assembly protein 0.0295942
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0294474
MCL1 myeloid cell leukemia 1 0.0288915
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0288386
WDPCP WD repeat containing planar cell polarity effector 0.028608
GPC6 glypican 6 0.0285634
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0285602
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0285367
LDHA lactate dehydrogenase A 0.0284243
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0282095
RB1CC1 RB1-inducible coiled-coil 1 0.0280536
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0279792
SEC24A SEC24 family member A 0.0274824
SUCO SUN domain containing ossification factor 0.0273158
GPHN gephyrin 0.0273036
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0272659
CTNND1 catenin (cadherin-associated protein), delta 1 0.0271345
SBF2 SET binding factor 2 0.0271094
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0270715
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0269483
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0268794
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0268237
ITCH itchy E3 ubiquitin protein ligase 0.0266686
MYOF myoferlin 0.0262608
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0261285
COPA coatomer protein complex, subunit alpha 0.0260863
AKAP9 A kinase (PRKA) anchor protein 9 0.0260093
UBC ubiquitin C 0.0259296
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.025876
SETD5 SET domain containing 5 0.0258565
TENT4A terminal nucleotidyltransferase 4A 0.0256554
PDE4D phosphodiesterase 4D, cAMP-specific 0.0255947
ZFAND3 zinc finger, AN1-type domain 3 0.0255786
RAB8B RAB8B, member RAS oncogene family 0.0255012

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.195868
FN1 fibronectin 1 -0.116746
GLCCI1 glucocorticoid induced 1 -0.115182
FTL ferritin, light polypeptide -0.114505
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0760056
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0741636
PTMA prothymosin, alpha -0.0707343
RPLP1 ribosomal protein, large, P1 -0.0642592
HMGA2 high mobility group AT-hook 2 -0.0608778
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0541491
RPS19 ribosomal protein S19 -0.0537443
NRG1 neuregulin 1 -0.0535335
NTN4 netrin 4 -0.0513757
MT2A metallothionein 2A -0.049694
RPL36 ribosomal protein L36 -0.0466418
NRP1 neuropilin 1 -0.0460678
RPLP2 ribosomal protein, large, P2 -0.044917
TFPI2 tissue factor pathway inhibitor 2 -0.0448197
TPT1 tumor protein, translationally-controlled 1 -0.0444067
RPL35A ribosomal protein L35a -0.0438685
VIM vimentin -0.0434804
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0427006
LOX lysyl oxidase -0.0426058
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0410728
DPYD dihydropyrimidine dehydrogenase -0.0400045
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0399517
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0397385
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0370081
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0368309
RPS29 ribosomal protein S29 -0.0367751
ANTXR2 anthrax toxin receptor 2 -0.036538
S100A6 S100 calcium binding protein A6 -0.0358297
ARHGAP5 Rho GTPase activating protein 5 -0.0357268
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0351445
WSB1 WD repeat and SOCS box containing 1 -0.0336978
VRK2 vaccinia related kinase 2 -0.0326793
SYT1 synaptotagmin I -0.0306651
LTBP1 latent transforming growth factor beta binding protein 1 -0.0306422
RPL31 ribosomal protein L31 -0.0305212
CLMP CXADR-like membrane protein -0.0304943
IER3 immediate early response 3 -0.0301594
PSD3 pleckstrin and Sec7 domain containing 3 -0.0301594
RPS21 ribosomal protein S21 -0.0288123
RAI14 retinoic acid induced 14 -0.0280945
CDH13 cadherin 13 -0.0278463
RPL37A ribosomal protein L37a -0.0273645
RPL34 ribosomal protein L34 -0.02731
S100A9 S100 calcium binding protein A9 -0.0271468
TPST1 tyrosylprotein sulfotransferase 1 -0.0266343
PRRX1 paired related homeobox 1 -0.0264497
C15ORF48 chromosome 15 open reading frame 48 -0.0263007
ZNF804A zinc finger protein 804A -0.0253932
WLS wntless Wnt ligand secretion mediator -0.0252914
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0249633
EGR1 early growth response 1 -0.0248539
RAB27B RAB27B, member RAS oncogene family -0.0247923
RPS3 ribosomal protein S3 -0.024751
SOX4 SRY (sex determining region Y)-box 4 -0.0239142
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0238878
OSMR oncostatin M receptor -0.0237363
RNF213 ring finger protein 213 -0.023354
LOC102724023 ES1 protein homolog, mitochondrial -0.0233275
RPL19 ribosomal protein L19 -0.0229842
GLIS3 GLIS family zinc finger 3 -0.0229829
ZEB2 zinc finger E-box binding homeobox 2 -0.0229369
HLA-B major histocompatibility complex, class I, B -0.0229035
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.022793
BMERB1 bMERB domain containing 1 -0.022626
MECOM MDS1 and EVI1 complex locus -0.0226156
HIPK2 homeodomain interacting protein kinase 2 -0.0223425
RASAL2 RAS protein activator like 2 -0.02222
TRPS1 trichorhinophalangeal syndrome I -0.0221806
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.021317
RPL32 ribosomal protein L32 -0.0202666
RPL12 ribosomal protein L12 -0.0199059
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0199035
PTGIS prostaglandin I2 (prostacyclin) synthase -0.0196684
HEG1 heart development protein with EGF-like domains 1 -0.0195724
RAB13 RAB13, member RAS oncogene family -0.0195349
EIF1 eukaryotic translation initiation factor 1 -0.0195208
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0194589
RPL18 ribosomal protein L18 -0.0192135
RPL36AL ribosomal protein L36a-like -0.0191996
RPS25 ribosomal protein S25 -0.0191836
AHNAK AHNAK nucleoprotein -0.0191699
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0190758
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0188125
RPL36A ribosomal protein L36a -0.0187907
CUX1 cut-like homeobox 1 -0.018645
FBN1 fibrillin 1 -0.018634
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 -0.0186159
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0185907
PRSS23 protease, serine, 23 -0.0185658
H1-0 H1.0 linker histone -0.018204
RPS13 ribosomal protein S13 -0.0181629
CDK14 cyclin-dependent kinase 14 -0.017996
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0179882
RPS12 ribosomal protein S12 -0.0179303
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0178059
TBL1X transducin (beta)-like 1X-linked -0.0178042