Monocrotaline_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Monocrotaline perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Monocrotaline_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.202107
FN1 fibronectin 1 0.145853
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.143401
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.143014
NAMPT nicotinamide phosphoribosyltransferase 0.106136
SOD2 superoxide dismutase 2, mitochondrial 0.102031
PGK1 phosphoglycerate kinase 1 0.101901
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.101322
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.072829
DNER delta/notch-like EGF repeat containing 0.0727514
UBC ubiquitin C 0.0702857
ESYT2 extended synaptotagmin-like protein 2 0.070158
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0688161
CXCL8 chemokine (C-X-C motif) ligand 8 0.0664601
ASPH aspartate beta-hydroxylase 0.0657955
SPAG9 sperm associated antigen 9 0.063886
LDHA lactate dehydrogenase A 0.0627026
CANX calnexin 0.0607911
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0607637
ENO1 enolase 1, (alpha) 0.0603954
MCL1 myeloid cell leukemia 1 0.0602639
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0601024
FNDC3B fibronectin type III domain containing 3B 0.059366
PCBP3 poly(rC) binding protein 3 0.0575885
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0546757
BZW1 basic leucine zipper and W2 domains 1 0.0513184
CDH13 cadherin 13 0.0508809
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.048655
PRELID2 PRELI domain containing 2 0.047078
ERRFI1 ERBB receptor feedback inhibitor 1 0.0467358
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0442926
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0441554
RBM39 RNA binding motif protein 39 0.0439786
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.04391
OGA O-GlcNAcase 0.0437687
BIRC6 baculoviral IAP repeat containing 6 0.0437012
PM20D1 peptidase M20 domain containing 1 0.0432514
KMT2C lysine (K)-specific methyltransferase 2C 0.0432079
ANXA2 annexin A2 0.0405008
ZNF292 zinc finger protein 292 0.0404585
PDIA6 protein disulfide isomerase family A, member 6 0.0403882
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0398284
DGKD diacylglycerol kinase, delta 130kDa 0.0388245
TM4SF1 transmembrane 4 L six family member 1 0.0386322
PSD3 pleckstrin and Sec7 domain containing 3 0.0383233
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0382838
PTPRM protein tyrosine phosphatase, receptor type, M 0.0374862
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.037363
AKAP13 A kinase (PRKA) anchor protein 13 0.037207
KDM6A lysine (K)-specific demethylase 6A 0.0371834
USP9X ubiquitin specific peptidase 9, X-linked 0.037046
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0368899
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0363382
ANKRD11 ankyrin repeat domain 11 0.0363026
APP amyloid beta (A4) precursor protein 0.0360204
MYOF myoferlin 0.0359304
TPT1 tumor protein, translationally-controlled 1 0.0354932
COL5A2 collagen, type V, alpha 2 0.0351512
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0349145
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0348294
HSPA8 heat shock 70kDa protein 8 0.0348123
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0347219
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0346952
FAM13A family with sequence similarity 13, member A 0.0344681
BBX bobby sox homolog (Drosophila) 0.0344559
USP34 ubiquitin specific peptidase 34 0.0343977
HELZ helicase with zinc finger 0.0343912
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0342942
PKM pyruvate kinase, muscle 0.0339692
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0333306
CTBP2 C-terminal binding protein 2 0.0332818
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0332708
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0331006
PDIA3 protein disulfide isomerase family A, member 3 0.0329814
AGFG1 ArfGAP with FG repeats 1 0.0323729
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0323437
PTEN phosphatase and tensin homolog 0.0322553
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0322103
WARS1 tryptophanyl-tRNA synthetase 1 0.0320217
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0319641
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0315346
EZR ezrin 0.0313657
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0312199
KDM3A lysine (K)-specific demethylase 3A 0.031097
PDE10A phosphodiesterase 10A 0.0307705
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0307295
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0301886
HILPDA hypoxia inducible lipid droplet-associated 0.0300322
CUL4B cullin 4B 0.0298848
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0296815
TRIO trio Rho guanine nucleotide exchange factor 0.0295707
NUP58 nucleoporin 58 0.0293782
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0293022
ELL2 elongation factor, RNA polymerase II, 2 0.0290419
ZC3H11A zinc finger CCCH-type containing 11A 0.0287266
SQSTM1 sequestosome 1 0.0284243
EFNA5 ephrin-A5 0.0284025
PTK2 protein tyrosine kinase 2 0.0282429
CHD1 chromodomain helicase DNA binding protein 1 0.028238
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0280878

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.133072
PDLIM5 PDZ and LIM domain 5 -0.0833743
RPLP1 ribosomal protein, large, P1 -0.0770315
RPL26 ribosomal protein L26 -0.0738192
FTL ferritin, light polypeptide -0.069948
GDA guanine deaminase -0.0662148
RPL37A ribosomal protein L37a -0.0635578
RPS12 ribosomal protein S12 -0.0632295
RPS3 ribosomal protein S3 -0.0527591
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0523703
RPL12 ribosomal protein L12 -0.050946
RPS19 ribosomal protein S19 -0.0481931
RPS8 ribosomal protein S8 -0.0437838
MT2A metallothionein 2A -0.0434035
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0370902
RPL36 ribosomal protein L36 -0.0361178
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0361118
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.035079
RPL35A ribosomal protein L35a -0.0350239
RPL23 ribosomal protein L23 -0.0349748
RTN1 reticulon 1 -0.0345661
RPL19 ribosomal protein L19 -0.0332718
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0326648
KYNU kynureninase -0.0321394
RPL18 ribosomal protein L18 -0.032075
S100A6 S100 calcium binding protein A6 -0.0310221
NTN4 netrin 4 -0.0309064
TFPI2 tissue factor pathway inhibitor 2 -0.0297893
ISG15 ISG15 ubiquitin-like modifier -0.0295146
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0282633
RPS17 ribosomal protein S17 -0.0279462
RPL35 ribosomal protein L35 -0.027622
SAMD4A sterile alpha motif domain containing 4A -0.0272081
RPL31 ribosomal protein L31 -0.0270279
TGFBI transforming growth factor, beta-induced, 68kDa -0.0268282
RPLP2 ribosomal protein, large, P2 -0.0266489
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0265695
RPL13A ribosomal protein L13a -0.0265361
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0261162
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0257473
COL4A5 collagen, type IV, alpha 5 -0.0256313
PFN1 profilin 1 -0.0249217
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0248918
RBMS2 RNA binding motif, single stranded interacting protein 2 -0.0245736
RACK1 receptor for activated C kinase 1 -0.0232941
VIM vimentin -0.0226795
RPS16 ribosomal protein S16 -0.0222772
TBCA tubulin folding cofactor A -0.0221992
EVA1C eva-1 homolog C (C. elegans) -0.0220426
POTEF POTE ankyrin domain family, member F -0.0219796
RPL32 ribosomal protein L32 -0.0215489
HLA-A major histocompatibility complex, class I, A -0.0208261
RPS27A ribosomal protein S27a -0.0207734
RPL30 ribosomal protein L30 -0.020698
NT5C2 5'-nucleotidase, cytosolic II -0.0206622
CTSC cathepsin C -0.0202847
PTMA prothymosin, alpha -0.020035
RPL9 ribosomal protein L9 -0.0197729
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0195206
COL8A1 collagen, type VIII, alpha 1 -0.0191203
EIF5B eukaryotic translation initiation factor 5B -0.0189689
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0188563
DDIT4 DNA-damage-inducible transcript 4 -0.0186905
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0184315
RPL5 ribosomal protein L5 -0.0183397
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0181038
RPS27 ribosomal protein S27 -0.0179638
PHF14 PHD finger protein 14 -0.0179311
PRRC2C proline-rich coiled-coil 2C -0.0175379
PLCB4 phospholipase C, beta 4 -0.0174211
KIFC3 kinesin family member C3 -0.0170874
RPL37 ribosomal protein L37 -0.0169628
RPS4X ribosomal protein S4, X-linked -0.0169191
RPL36A ribosomal protein L36a -0.0169083
VMP1 vacuole membrane protein 1 -0.0164097
MAML2 mastermind-like 2 (Drosophila) -0.0163819
NPAS2 neuronal PAS domain protein 2 -0.0161429
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0161176
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0161114
ARHGAP29 Rho GTPase activating protein 29 -0.016103
LAMA5 laminin, alpha 5 -0.0158648
NDUFA4 NDUFA4, mitochondrial complex associated -0.0157755
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0157088
CCL5 chemokine (C-C motif) ligand 5 -0.0154827
PDE7B phosphodiesterase 7B -0.0154723
DOCK5 dedicator of cytokinesis 5 -0.0154716
CCL3 chemokine (C-C motif) ligand 3 -0.015407
CD109 CD109 molecule -0.0153317
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0152947
RPL7A ribosomal protein L7a -0.015028
NABP1 nucleic acid binding protein 1 -0.0148921
YBX1 Y box binding protein 1 -0.0148701
EXOC6B exocyst complex component 6B -0.0148285
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0144347
GRAMD1B GRAM domain containing 1B -0.0144242
SDCCAG8 serologically defined colon cancer antigen 8 -0.0142164
OSMR oncostatin M receptor -0.0140477
MT1X metallothionein 1X -0.0136718
MAML3 mastermind-like 3 (Drosophila) -0.0135119
COX6C cytochrome c oxidase subunit VIc -0.0132819