Monocrotaline_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Monocrotaline perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

143 genes differentially expressed following the Monocrotaline_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 0.145633
RPS6 ribosomal protein S6 0.0856679
DTNA dystrobrevin, alpha 0.0714806
RPLP1 ribosomal protein, large, P1 0.0709329
TMSB10 thymosin beta 10 0.0671379
LDHA lactate dehydrogenase A 0.0665658
RPL26 ribosomal protein L26 0.0652026
RPS3 ribosomal protein S3 0.0562509
TPT1 tumor protein, translationally-controlled 1 0.0557255
FTL ferritin, light polypeptide 0.0549407
GRB10 growth factor receptor-bound protein 10 0.0535552
ACTG1 actin gamma 1 0.0514456
RPL37A ribosomal protein L37a 0.0497119
RPS8 ribosomal protein S8 0.0477328
RPL27A ribosomal protein L27a 0.0467972
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0462601
GNAS GNAS complex locus 0.0446083
PSD3 pleckstrin and Sec7 domain containing 3 0.0424178
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0410622
RTN4 reticulon 4 0.0385568
FNDC3B fibronectin type III domain containing 3B 0.0376761
ELL2 elongation factor, RNA polymerase II, 2 0.036602
PDE10A phosphodiesterase 10A 0.0351002
CCNY cyclin Y 0.0347426
RACK1 receptor for activated C kinase 1 0.0339002
MACF1 microtubule-actin crosslinking factor 1 0.0336948
RPL35A ribosomal protein L35a 0.033331
SETD5 SET domain containing 5 0.0325313
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0316972
RPL36 ribosomal protein L36 0.0286723
NAP1L1 nucleosome assembly protein 1-like 1 0.0279876
ANKRD12 ankyrin repeat domain 12 0.0271725
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0271605
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0261186
PGK1 phosphoglycerate kinase 1 0.0248548
B2M beta-2-microglobulin 0.0229906
USP34 ubiquitin specific peptidase 34 0.0228184
EGFR epidermal growth factor receptor 0.0221841
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0205973
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0201484
NAMPT nicotinamide phosphoribosyltransferase 0.0194194
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0193528
THSD4 thrombospondin, type I, domain containing 4 0.0181964
SEPTIN7 septin 7 0.017483
KMT2E lysine (K)-specific methyltransferase 2E 0.0168984
RPS27A ribosomal protein S27a 0.0161575
MYO10 myosin X 0.0152045
RPL5 ribosomal protein L5 0.0151695
PDE4D phosphodiesterase 4D, cAMP-specific 0.0150947
SLC38A1 solute carrier family 38, member 1 0.0144507
JARID2 jumonji, AT rich interactive domain 2 0.0135403
RAB7A RAB7A, member RAS oncogene family 0.0130733
PRKCA protein kinase C, alpha 0.0128307
ZFAND3 zinc finger, AN1-type domain 3 0.0116032
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0110729
MSI2 musashi RNA-binding protein 2 0.0103988
BIRC6 baculoviral IAP repeat containing 6 0.00958142
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.00737591
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.00701029
KDM3A lysine (K)-specific demethylase 3A 0.00597009
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.00574404
LMO7 LIM domain 7 0.005205
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.00368043
MYOF myoferlin 0.00366806
ANXA2 annexin A2 0.00234852
RPS17 ribosomal protein S17 0.00115201
TTC3 tetratricopeptide repeat domain 3 6.75056E-4
MCL1 myeloid cell leukemia 1 5.45466E-4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 1.41498E-4

decreased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0969648
NDRG1 N-myc downstream regulated 1 -0.0756049
HMGA2 high mobility group AT-hook 2 -0.0724705
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0647134
GOLGB1 golgin B1 -0.0601421
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0589075
PTK2 protein tyrosine kinase 2 -0.0562506
RORA RAR-related orphan receptor A -0.0551638
PEG10 paternally expressed 10 -0.0545169
FN1 fibronectin 1 -0.0527624
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0521339
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0495369
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0469418
ARRDC3 arrestin domain containing 3 -0.0468525
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0433242
ANKRD17 ankyrin repeat domain 17 -0.0414029
CAMTA1 calmodulin binding transcription activator 1 -0.0401456
ATP11A ATPase, class VI, type 11A -0.0384846
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.035952
ATXN1 ataxin 1 -0.0343881
SMYD3 SET and MYND domain containing 3 -0.0333747
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0307944
EIF1 eukaryotic translation initiation factor 1 -0.0295182
DST dystonin -0.0287771
GPC6 glypican 6 -0.0283463
PKM pyruvate kinase, muscle -0.0264216
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0255927
TXNRD1 thioredoxin reductase 1 -0.0255266
GOLGA4 golgin A4 -0.0248513
TRIO trio Rho guanine nucleotide exchange factor -0.0247893
FMNL2 formin-like 2 -0.0247122
WSB1 WD repeat and SOCS box containing 1 -0.0237202
EXT1 exostosin glycosyltransferase 1 -0.0217398
STC1 stanniocalcin 1 -0.0212635
VCL vinculin -0.021071
SLTM SAFB-like, transcription modulator -0.0203997
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0199669
CALD1 caldesmon 1 -0.0194724
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0187902
NALF1 NALCN channel auxiliary factor 1 -0.0170639
ZNF292 zinc finger protein 292 -0.0169454
PTMA prothymosin, alpha -0.0168891
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0162294
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0135979
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0129343
JMJD1C jumonji domain containing 1C -0.0124015
VIM vimentin -0.0110526
RPL11 ribosomal protein L11 -0.0110145
RPL12 ribosomal protein L12 -0.0109628
MT2A metallothionein 2A -0.0106134
ZBTB20 zinc finger and BTB domain containing 20 -0.00856362
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.00739046
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.00722575
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.00696977
DSCAM Down syndrome cell adhesion molecule -0.00681899
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.00681819
AKAP9 A kinase (PRKA) anchor protein 9 -0.00667894
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.00636175
GCLC glutamate-cysteine ligase, catalytic subunit -0.00635939
ITGA6 integrin, alpha 6 -0.00617549
AKAP12 A kinase (PRKA) anchor protein 12 -0.00582278
CD44 CD44 molecule (Indian blood group) -0.00454655
KTN1 kinectin 1 (kinesin receptor) -0.00443563
ANKHD1 ankyrin repeat and KH domain containing 1 -0.00261343
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.00212337
NPAS2 neuronal PAS domain protein 2 -0.00185649
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0015503
ENO1 enolase 1, (alpha) -0.00124107
ARID4B AT rich interactive domain 4B (RBP1-like) -0.00108261
AFF4 AF4/FMR2 family, member 4 -0.00105874
PRRC2C proline-rich coiled-coil 2C -8.54747E-4
ASPH aspartate beta-hydroxylase -6.11107E-4
LPP LIM domain containing preferred translocation partner in lipoma -4.62661E-4
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -7.72351E-5