Monocrotaline_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Monocrotaline perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Monocrotaline_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ADAM10 ADAM metallopeptidase domain 10 0.138453
TMSB4X thymosin beta 4, X-linked 0.137189
PDE4D phosphodiesterase 4D, cAMP-specific 0.116288
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.112435
VCL vinculin 0.10448
EGFR epidermal growth factor receptor 0.0763239
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0756963
NBEA neurobeachin 0.0740089
AHNAK AHNAK nucleoprotein 0.0728945
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0705214
SMYD3 SET and MYND domain containing 3 0.0677402
DSCAM Down syndrome cell adhesion molecule 0.0676228
PRELID2 PRELI domain containing 2 0.0674101
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0638337
PGK1 phosphoglycerate kinase 1 0.0633997
ZNF292 zinc finger protein 292 0.0620586
FLNB filamin B, beta 0.0586028
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0551935
SOX6 SRY (sex determining region Y)-box 6 0.0537225
FOXP1 forkhead box P1 0.0532027
KDM3A lysine (K)-specific demethylase 3A 0.0522249
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.05201
CAMTA1 calmodulin binding transcription activator 1 0.0511404
CPED1 cadherin-like and PC-esterase domain containing 1 0.0509852
RBM39 RNA binding motif protein 39 0.0505781
ZEB1 zinc finger E-box binding homeobox 1 0.0498814
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.049123
RTN4 reticulon 4 0.0473175
DLG1 discs, large homolog 1 (Drosophila) 0.0466401
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0460065
EIF4A2 eukaryotic translation initiation factor 4A2 0.0459635
ZFAND3 zinc finger, AN1-type domain 3 0.0452424
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0451925
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0445926
SSBP2 single-stranded DNA binding protein 2 0.0435394
LDHA lactate dehydrogenase A 0.0431727
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0430876
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.043052
EML4 echinoderm microtubule associated protein like 4 0.0423789
HDAC9 histone deacetylase 9 0.0423458
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0412097
ZBTB20 zinc finger and BTB domain containing 20 0.040363
EFNA5 ephrin-A5 0.0401303
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0395795
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.03949
CDC73 cell division cycle 73 0.0392137
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0388382
JMJD1C jumonji domain containing 1C 0.0381374
QKI QKI, KH domain containing, RNA binding 0.0379113
HDLBP high density lipoprotein binding protein 0.0376467
GSK3B glycogen synthase kinase 3 beta 0.0369156
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0369133
NBAS neuroblastoma amplified sequence 0.0362033
ECT2 epithelial cell transforming 2 0.0360554
PYGB phosphorylase, glycogen; brain 0.0359328
PTK2 protein tyrosine kinase 2 0.034872
PTBP2 polypyrimidine tract binding protein 2 0.0343576
LPP LIM domain containing preferred translocation partner in lipoma 0.0341323
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0336321
MSI2 musashi RNA-binding protein 2 0.0336306
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0331208
NFIA nuclear factor I/A 0.0328685
TBC1D5 TBC1 domain family, member 5 0.032791
NAMPT nicotinamide phosphoribosyltransferase 0.0326861
TGFBR3 transforming growth factor, beta receptor III 0.0324988
ADAM9 ADAM metallopeptidase domain 9 0.0324712
BIRC6 baculoviral IAP repeat containing 6 0.0323577
ENO1 enolase 1, (alpha) 0.0322775
TBC1D22A TBC1 domain family, member 22A 0.0322687
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0316128
EXOC6B exocyst complex component 6B 0.0315194
EXT1 exostosin glycosyltransferase 1 0.0313597
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0311776
NT5C2 5'-nucleotidase, cytosolic II 0.0310936
UBC ubiquitin C 0.030994
METTL15 methyltransferase like 15 0.0306706
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0306289
TTC3 tetratricopeptide repeat domain 3 0.0306006
NCEH1 neutral cholesterol ester hydrolase 1 0.0303725
PUM2 pumilio RNA-binding family member 2 0.0303513
PKM pyruvate kinase, muscle 0.0301413
PDGFC platelet derived growth factor C 0.0300849
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0300134
PTPRG protein tyrosine phosphatase, receptor type, G 0.0297147
TJP1 tight junction protein 1 0.0295992
ANKRD17 ankyrin repeat domain 17 0.0293955
NUP58 nucleoporin 58 0.028848
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0288102
ZMYM2 zinc finger, MYM-type 2 0.0287206
PARD3 par-3 family cell polarity regulator 0.0284136
SBF2 SET binding factor 2 0.0283786
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0282985
TAS2R14 taste receptor, type 2, member 14 0.027609
NAP1L1 nucleosome assembly protein 1-like 1 0.0275664
RAD21 RAD21 homolog (S. pombe) 0.0273762
OGA O-GlcNAcase 0.027341
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.027242
TTC28 tetratricopeptide repeat domain 28 0.0272013
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0271956
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0271794

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.153354
RPS8 ribosomal protein S8 -0.0535662
RPL35A ribosomal protein L35a -0.049376
RPLP1 ribosomal protein, large, P1 -0.0472106
RPS6 ribosomal protein S6 -0.0445777
RPL37A ribosomal protein L37a -0.0437951
RPS19 ribosomal protein S19 -0.0399694
PFN1 profilin 1 -0.0399125
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0399055
TMSB10 thymosin beta 10 -0.0381053
RPLP2 ribosomal protein, large, P2 -0.0380218
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0340006
MT2A metallothionein 2A -0.0321711
RPL31 ribosomal protein L31 -0.0302988
FTL ferritin, light polypeptide -0.0285398
HSPB1 heat shock 27kDa protein 1 -0.0241054
RPS17 ribosomal protein S17 -0.0234062
LOC102724023 ES1 protein homolog, mitochondrial -0.023392
CENPF centromere protein F, 350/400kDa -0.0231977
VIM vimentin -0.0209307
POTEF POTE ankyrin domain family, member F -0.0204194
S100A9 S100 calcium binding protein A9 -0.019709
RPL36 ribosomal protein L36 -0.0194961
RPL18 ribosomal protein L18 -0.0193323
RPL34 ribosomal protein L34 -0.0185965
RPS12 ribosomal protein S12 -0.0185749
RPL7A ribosomal protein L7a -0.0177493
RPS13 ribosomal protein S13 -0.0176171
TOP2A topoisomerase (DNA) II alpha 170kDa -0.017555
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0174431
RPS16 ribosomal protein S16 -0.0167031
RPL35 ribosomal protein L35 -0.0166263
RPS25 ribosomal protein S25 -0.0164999
RPS27 ribosomal protein S27 -0.0162392
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0161719
RPS14 ribosomal protein S14 -0.0161695
IGF2 insulin-like growth factor 2 -0.0161381
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0159312
TPI1 triosephosphate isomerase 1 -0.0158921
MKI67 marker of proliferation Ki-67 -0.0157703
PABPN1 poly(A) binding protein, nuclear 1 -0.015586
SMC4 structural maintenance of chromosomes 4 -0.0155143
S100A4 S100 calcium binding protein A4 -0.0152816
FN1 fibronectin 1 -0.0150771
RPL23 ribosomal protein L23 -0.0149026
NDRG1 N-myc downstream regulated 1 -0.0147079
RPL12 ribosomal protein L12 -0.0145252
RPL36A ribosomal protein L36a -0.0143984
HJURP Holliday junction recognition protein -0.0138189
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) -0.0134762
NAV2 neuron navigator 2 -0.0131485
GUK1 guanylate kinase 1 -0.0128021
SET SET nuclear proto-oncogene -0.012384
RPL9 ribosomal protein L9 -0.0123608
RPS3 ribosomal protein S3 -0.0122697
NUCB2 nucleobindin 2 -0.0122302
SON SON DNA binding protein -0.0121004
MYADM myeloid-associated differentiation marker -0.0120027
SRRM1 serine/arginine repetitive matrix 1 -0.0120005
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0118142
RPL36AL ribosomal protein L36a-like -0.0117928
PTMS parathymosin -0.0116542
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) -0.0116098
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0115559
EEF1G eukaryotic translation elongation factor 1 gamma -0.0111927
KIF2A kinesin heavy chain member 2A -0.0111131
COX5B cytochrome c oxidase subunit Vb -0.0110786
HMGA1 high mobility group AT-hook 1 -0.0110577
ONECUT2 one cut homeobox 2 -0.0108373
PTPRF protein tyrosine phosphatase, receptor type, F -0.0107806
HMGB1 high mobility group box 1 -0.0107593
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0107557
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0107507
BRD8 bromodomain containing 8 -0.0107184
SEC61G Sec61 gamma subunit -0.0105379
RPS10 ribosomal protein S10 -0.0103514
TPT1 tumor protein, translationally-controlled 1 -0.0101666
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0101627
RPL27 ribosomal protein L27 -0.0101292
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0100556
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0100522
VEGFA vascular endothelial growth factor A -0.0100462
CBX6 chromobox homolog 6 -0.0097255
HDGF hepatoma-derived growth factor -0.00970833
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.00960393
KIF5C kinesin family member 5C -0.00955907
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.00955194
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.00953367
CD109 CD109 molecule -0.0095178
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -0.00950396
BMP4 bone morphogenetic protein 4 -0.0094906
NKAP NFKB activating protein -0.00943472
RPL19 ribosomal protein L19 -0.00938553
ATP5MG ATP synthase membrane subunit g -0.00933074
FLNA filamin A, alpha -0.00930191
S100A11 S100 calcium binding protein A11 -0.00930029
CES2 carboxylesterase 2 -0.00927734
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.00924785
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.00923818
CDC20 cell division cycle 20 -0.00920255