Monocrotaline_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Monocrotaline perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Monocrotaline_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.558097
MYH9 myosin, heavy chain 9, non-muscle 0.155271
TRIO trio Rho guanine nucleotide exchange factor 0.112994
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0857028
CADM1 cell adhesion molecule 1 0.0760885
PGK1 phosphoglycerate kinase 1 0.0718705
FNDC3B fibronectin type III domain containing 3B 0.0657789
NAV2 neuron navigator 2 0.0600423
DST dystonin 0.0597701
MYOF myoferlin 0.0596351
ZFAND3 zinc finger, AN1-type domain 3 0.0593712
FRMD4A FERM domain containing 4A 0.0544169
ZNF292 zinc finger protein 292 0.0524009
NAP1L1 nucleosome assembly protein 1-like 1 0.0522451
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0522333
SPAG9 sperm associated antigen 9 0.0505386
OGA O-GlcNAcase 0.0495888
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.047643
PDE10A phosphodiesterase 10A 0.0460261
USP9X ubiquitin specific peptidase 9, X-linked 0.0458129
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0456126
ATP13A3 ATPase type 13A3 0.0453475
TMSB4X thymosin beta 4, X-linked 0.0449555
LAMP2 lysosomal-associated membrane protein 2 0.0431408
FNIP1 folliculin interacting protein 1 0.0423937
FMNL2 formin-like 2 0.0420649
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0420438
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0415921
ELL2 elongation factor, RNA polymerase II, 2 0.0412219
APP amyloid beta (A4) precursor protein 0.0410964
COL6A3 collagen, type VI, alpha 3 0.040677
SQSTM1 sequestosome 1 0.0390533
UGCG UDP-glucose ceramide glucosyltransferase 0.0381842
CD164 CD164 molecule, sialomucin 0.0381238
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0377419
RB1CC1 RB1-inducible coiled-coil 1 0.037369
MACF1 microtubule-actin crosslinking factor 1 0.0367466
QKI QKI, KH domain containing, RNA binding 0.0367269
HDAC9 histone deacetylase 9 0.0364199
SMAD3 SMAD family member 3 0.0363088
JMJD1C jumonji domain containing 1C 0.0362406
AHNAK AHNAK nucleoprotein 0.0348102
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0345565
HELZ helicase with zinc finger 0.0344619
TNS3 tensin 3 0.0343672
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0340971
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0340372
UBA6 ubiquitin-like modifier activating enzyme 6 0.0320298
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.03175
PRELID2 PRELI domain containing 2 0.0315901
UBC ubiquitin C 0.0315229
DENND5A DENN/MADD domain containing 5A 0.0312283
STAT1 signal transducer and activator of transcription 1, 91kDa 0.030622
STAG2 stromal antigen 2 0.0304487
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0303607
ARRDC3 arrestin domain containing 3 0.0302821
KDM3A lysine (K)-specific demethylase 3A 0.0294867
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.029459
ERBIN erbb2 interacting protein 0.0293233
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0292476
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0286226
ZMIZ1 zinc finger, MIZ-type containing 1 0.0284018
NAMPT nicotinamide phosphoribosyltransferase 0.0283883
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0279742
MXI1 MAX interactor 1, dimerization protein 0.027968
TNIP1 TNFAIP3 interacting protein 1 0.0278529
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.02767
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0276475
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0273609
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0271612
WTAP Wilms tumor 1 associated protein 0.0269812
AFF4 AF4/FMR2 family, member 4 0.0269395
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0266679
IPO7 importin 7 0.0263464
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0262797
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0261671
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0261275
RPS24 ribosomal protein S24 0.0261222
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0259431
RLF rearranged L-myc fusion 0.0258791
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0258644
MATR3 matrin 3 0.0256467
PICALM phosphatidylinositol binding clathrin assembly protein 0.0255453
SDK1 sidekick cell adhesion molecule 1 0.025545
EPS8 epidermal growth factor receptor pathway substrate 8 0.0254063
RICTOR RPTOR independent companion of MTOR, complex 2 0.025164
RBM39 RNA binding motif protein 39 0.024991
IQGAP1 IQ motif containing GTPase activating protein 1 0.0247717
RND3 Rho family GTPase 3 0.0247199
PTK2 protein tyrosine kinase 2 0.0247117
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0245986
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0241868
SERINC1 serine incorporator 1 0.0240047
FOXO3 forkhead box O3 0.0239669
CERT1 ceramide transporter 1 0.0237357
TRIP12 thyroid hormone receptor interactor 12 0.023472
RHOBTB3 Rho-related BTB domain containing 3 0.0231644
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0229521
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0228639
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0224811

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.0961169
VIM vimentin -0.0836377
TMSB10 thymosin beta 10 -0.0832496
GLIS3 GLIS family zinc finger 3 -0.0453593
RPS19 ribosomal protein S19 -0.039666
MT2A metallothionein 2A -0.038642
NDRG1 N-myc downstream regulated 1 -0.0380029
HLA-B major histocompatibility complex, class I, B -0.0378942
EGR1 early growth response 1 -0.0369917
IGFBP3 insulin-like growth factor binding protein 3 -0.0361049
VEGFA vascular endothelial growth factor A -0.0340254
RPLP1 ribosomal protein, large, P1 -0.0314381
HLA-A major histocompatibility complex, class I, A -0.0297085
FTH1 ferritin, heavy polypeptide 1 -0.0291542
CTSD cathepsin D -0.0268072
RPLP2 ribosomal protein, large, P2 -0.0266403
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0257813
RPL35A ribosomal protein L35a -0.0251458
RPL36 ribosomal protein L36 -0.0237713
RPL37A ribosomal protein L37a -0.0226265
IFITM3 interferon induced transmembrane protein 3 -0.0217481
RPS13 ribosomal protein S13 -0.0202328
TGFBI transforming growth factor, beta-induced, 68kDa -0.0198376
RPL36A ribosomal protein L36a -0.0191427
S100A9 S100 calcium binding protein A9 -0.019024
IFITM1 interferon induced transmembrane protein 1 -0.0190162
GNAS GNAS complex locus -0.0177761
HMGA2 high mobility group AT-hook 2 -0.0177611
MKI67 marker of proliferation Ki-67 -0.0176095
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0172899
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0172399
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0171013
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0169876
PTMA prothymosin, alpha -0.0166272
CENPF centromere protein F, 350/400kDa -0.014802
RPS17 ribosomal protein S17 -0.0145602
RPL31 ribosomal protein L31 -0.0139998
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0139601
ENO2 enolase 2 (gamma, neuronal) -0.0138049
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0135842
RAI14 retinoic acid induced 14 -0.0135044
RPL7A ribosomal protein L7a -0.0134212
RPS8 ribosomal protein S8 -0.0132603
PALLD palladin, cytoskeletal associated protein -0.0131131
RRBP1 ribosome binding protein 1 -0.0128235
PFN1 profilin 1 -0.0127999
ASTN2 astrotactin 2 -0.0127955
BASP1 brain abundant, membrane attached signal protein 1 -0.0127857
RPS29 ribosomal protein S29 -0.0126977
INHBA inhibin, beta A -0.0124545
EEF1G eukaryotic translation elongation factor 1 gamma -0.0123049
RPS3 ribosomal protein S3 -0.012127
RPL18 ribosomal protein L18 -0.0120134
ZFHX3 zinc finger homeobox 3 -0.0117019
SEC62 SEC62 homolog (S. cerevisiae) -0.0116561
ISG15 ISG15 ubiquitin-like modifier -0.0116488
RPL5 ribosomal protein L5 -0.0115766
ZMYND8 zinc finger, MYND-type containing 8 -0.0114438
CALR calreticulin -0.0112355
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0111614
EXT1 exostosin glycosyltransferase 1 -0.0110813
SLC38A2 solute carrier family 38, member 2 -0.011013
HMGA1 high mobility group AT-hook 1 -0.0110043
MT1X metallothionein 1X -0.0109
NRP1 neuropilin 1 -0.010885
FOSL1 FOS-like antigen 1 -0.0108502
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0107672
MIS18BP1 MIS18 binding protein 1 -0.0106708
CYB5R3 cytochrome b5 reductase 3 -0.010652
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0105308
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0104958
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0104485
SMC4 structural maintenance of chromosomes 4 -0.0102168
IFI6 interferon, alpha-inducible protein 6 -0.0101917
RPL38 ribosomal protein L38 -0.0101807
LOX lysyl oxidase -0.0100693
RPS27 ribosomal protein S27 -0.0100647
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.00994766
CDCP1 CUB domain containing protein 1 -0.00962318
CDK1 cyclin-dependent kinase 1 -0.00961079
RPS21 ribosomal protein S21 -0.00959085
SEC61G Sec61 gamma subunit -0.00954931
ATF4 activating transcription factor 4 -0.00954605
PRR11 proline rich 11 -0.0094583
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.00945475
TUBB4B tubulin, beta 4B class IVb -0.00945382
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.00942051
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.00938724
SETD5 SET domain containing 5 -0.00924969
RPL9 ribosomal protein L9 -0.00906125
CNTN6 contactin 6 -0.00902683
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0089859
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.00894315
DDIT4 DNA-damage-inducible transcript 4 -0.00892123
RPS14 ribosomal protein S14 -0.00887696
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.00886683
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.00882358
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -0.00881551
NGF nerve growth factor (beta polypeptide) -0.00879952
GABARAPL2 GABA(A) receptor-associated protein-like 2 -0.00851277