Monocrotaline_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Monocrotaline perturbation in SW 1271 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Monocrotaline_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.109913
HILPDA hypoxia inducible lipid droplet-associated 0.0839721
SOD2 superoxide dismutase 2, mitochondrial 0.0787265
VIM vimentin 0.075171
NUP58 nucleoporin 58 0.0631284
TRIO trio Rho guanine nucleotide exchange factor 0.0627254
BIRC3 baculoviral IAP repeat containing 3 0.061893
NAMPT nicotinamide phosphoribosyltransferase 0.0612475
WAC WW domain containing adaptor with coiled-coil 0.0601684
SNX14 sorting nexin 14 0.0585391
YBX3 Y box binding protein 3 0.0575694
LDHA lactate dehydrogenase A 0.0572023
FNDC3B fibronectin type III domain containing 3B 0.0544017
CXCL8 chemokine (C-X-C motif) ligand 8 0.0534992
ENO1 enolase 1, (alpha) 0.0519072
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0489214
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0482988
NAV2 neuron navigator 2 0.0469159
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0466386
SDC4 syndecan 4 0.0463376
PKM pyruvate kinase, muscle 0.0462981
RBM39 RNA binding motif protein 39 0.0457471
UBC ubiquitin C 0.0453874
MATR3 matrin 3 0.0449447
ITCH itchy E3 ubiquitin protein ligase 0.0449126
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0441281
SPAG9 sperm associated antigen 9 0.0439567
DGKD diacylglycerol kinase, delta 130kDa 0.0433803
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0429969
MAP1B microtubule-associated protein 1B 0.0428249
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0428197
SLMAP sarcolemma associated protein 0.0408247
MCTP1 multiple C2 domains, transmembrane 1 0.040271
MORF4L1 mortality factor 4 like 1 0.0400939
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0397801
PCBP2 poly(rC) binding protein 2 0.0395399
PRKCE protein kinase C, epsilon 0.0390534
BIRC6 baculoviral IAP repeat containing 6 0.0390066
SEPTIN2 septin 2 0.0383662
ANXA1 annexin A1 0.0380893
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0380172
ATXN1 ataxin 1 0.0377533
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0376927
ZNF292 zinc finger protein 292 0.0370182
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0358696
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0356084
AKAP13 A kinase (PRKA) anchor protein 13 0.0351635
ACTN1 actinin, alpha 1 0.0349447
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0344037
DNER delta/notch-like EGF repeat containing 0.0343255
TRA2A transformer 2 alpha homolog (Drosophila) 0.0339839
CDCP1 CUB domain containing protein 1 0.0335548
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0334107
TFG TRK-fused gene 0.0332425
ECT2 epithelial cell transforming 2 0.0329056
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0328031
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0327322
RTN4 reticulon 4 0.0326821
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0321947
NAP1L1 nucleosome assembly protein 1-like 1 0.0318964
PBX3 pre-B-cell leukemia homeobox 3 0.0317304
TPST1 tyrosylprotein sulfotransferase 1 0.0316464
ANKRD37 ankyrin repeat domain 37 0.031359
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.0313557
SRPK2 SRSF protein kinase 2 0.0310193
SGO2 shugoshin 2 0.0309627
MCL1 myeloid cell leukemia 1 0.0308933
GSK3B glycogen synthase kinase 3 beta 0.0308738
MIS18BP1 MIS18 binding protein 1 0.0307781
TPD52 tumor protein D52 0.0304332
PDE8A phosphodiesterase 8A 0.0300356
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0298537
NGLY1 N-glycanase 1 0.0298496
CAPRIN2 caprin family member 2 0.0295618
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0295143
BIRC2 baculoviral IAP repeat containing 2 0.0294752
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0293183
ATP13A3 ATPase type 13A3 0.0293139
CKAP2 cytoskeleton associated protein 2 0.0291761
USP37 ubiquitin specific peptidase 37 0.0289056
TPX2 TPX2, microtubule-associated 0.0287189
RAB1A RAB1A, member RAS oncogene family 0.028512
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0284729
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0281897
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0279689
SMAD5 SMAD family member 5 0.0274724
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0269892
PUM2 pumilio RNA-binding family member 2 0.0266274
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0262372
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0260686
HBP1 HMG-box transcription factor 1 0.0260276
INSIG1 insulin induced gene 1 0.0258423
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0258406
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.025658
PDGFA platelet-derived growth factor alpha polypeptide 0.025635
UGCG UDP-glucose ceramide glucosyltransferase 0.0255483
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0252402
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0248636
CCNB1 cyclin B1 0.0248031
HOOK2 hook microtubule-tethering protein 2 0.0247884

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0662824
TPT1 tumor protein, translationally-controlled 1 -0.0624489
FTL ferritin, light polypeptide -0.0579881
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0512337
RPS25 ribosomal protein S25 -0.0431673
RPS6 ribosomal protein S6 -0.0406799
INTS6 integrator complex subunit 6 -0.0397408
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.037999
RPL19 ribosomal protein L19 -0.0372734
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.033664
RSRP1 arginine/serine-rich protein 1 -0.0319949
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0306415
RPS13 ribosomal protein S13 -0.0303097
RPS20 ribosomal protein S20 -0.0301593
RPL34 ribosomal protein L34 -0.0301328
OSMR oncostatin M receptor -0.0287426
RPS29 ribosomal protein S29 -0.0286267
RPLP2 ribosomal protein, large, P2 -0.0281802
TBCA tubulin folding cofactor A -0.027053
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0269768
ACTG1 actin gamma 1 -0.0269587
GPATCH8 G patch domain containing 8 -0.0266823
SMC4 structural maintenance of chromosomes 4 -0.0262957
GPHN gephyrin -0.0262498
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0257121
FUS FUS RNA binding protein -0.0255864
LOC112694756 uncharaterized LOC112694756 -0.0249508
EGR1 early growth response 1 -0.0248668
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0248144
EEF2 eukaryotic translation elongation factor 2 -0.0247813
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0247589
EIF5B eukaryotic translation initiation factor 5B -0.0247451
SAMD4A sterile alpha motif domain containing 4A -0.024721
WWTR1 WW domain containing transcription regulator 1 -0.0246002
SLC38A2 solute carrier family 38, member 2 -0.0243354
USP34 ubiquitin specific peptidase 34 -0.0238937
MT2A metallothionein 2A -0.023699
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0234927
ZNF721 zinc finger protein 721 -0.0230668
TUBB4B tubulin, beta 4B class IVb -0.0229402
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0224758
KIF16B kinesin family member 16B -0.0223639
BICD1 bicaudal D homolog 1 (Drosophila) -0.0222819
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0222205
ATF7IP activating transcription factor 7 interacting protein -0.0220297
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0218454
CMIP c-Maf inducing protein -0.0218116
RPL9 ribosomal protein L9 -0.0217675
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.021756
RPL35A ribosomal protein L35a -0.0217168
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0217135
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0215988
GCC2 GRIP and coiled-coil domain containing 2 -0.0215189
MORF4L2 mortality factor 4 like 2 -0.0214821
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0213997
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0212846
RAB2A RAB2A, member RAS oncogene family -0.0212211
JUN jun proto-oncogene -0.0211034
ZNF644 zinc finger protein 644 -0.0210797
CEP290 centrosomal protein 290kDa -0.0210479
RPL32 ribosomal protein L32 -0.0210164
PHF14 PHD finger protein 14 -0.020957
DST dystonin -0.020916
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.020874
RPS14 ribosomal protein S14 -0.020824
CUX1 cut-like homeobox 1 -0.0208167
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0207758
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit -0.0206712
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0206642
PLEK2 pleckstrin 2 -0.0205609
DYM dymeclin -0.0205522
POMP proteasome maturation protein -0.0204827
TRIM44 tripartite motif containing 44 -0.0204283
DDIT4 DNA-damage-inducible transcript 4 -0.0203541
RTN3 reticulon 3 -0.0202573
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0201949
ARHGAP5 Rho GTPase activating protein 5 -0.0200225
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0198202
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0198133
PARD3 par-3 family cell polarity regulator -0.0197546
EPB41L4A erythrocyte membrane protein band 4.1 like 4A -0.0197082
GGNBP2 gametogenetin binding protein 2 -0.0196544
SERF2 small EDRK-rich factor 2 -0.0195919
BCAR3 breast cancer anti-estrogen resistance 3 -0.0194761
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0194597
TSC22D2 TSC22 domain family, member 2 -0.0193286
IGF2 insulin-like growth factor 2 -0.0193136
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0193068
TCF12 transcription factor 12 -0.019249
RPS17 ribosomal protein S17 -0.0192438
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.019179
SPAG16 sperm associated antigen 16 -0.0190549
HIP1 huntingtin interacting protein 1 -0.0190287
MZT2B mitotic spindle organizing protein 2B -0.0189571
GOLGB1 golgin B1 -0.0188589
MED13L mediator complex subunit 13-like -0.0188261
OAZ1 ornithine decarboxylase antizyme 1 -0.0188039
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0187731
FOXP1 forkhead box P1 -0.0187487
ANO6 anoctamin 6 -0.0185809