Monocrotaline_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Monocrotaline perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Monocrotaline_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.191159
NAMPT nicotinamide phosphoribosyltransferase 0.188324
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.117511
TRIO trio Rho guanine nucleotide exchange factor 0.101229
SOD2 superoxide dismutase 2, mitochondrial 0.100438
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0992215
CXCL8 chemokine (C-X-C motif) ligand 8 0.09508
CANX calnexin 0.0867109
CD109 CD109 molecule 0.0854715
FN1 fibronectin 1 0.0851528
FNDC3B fibronectin type III domain containing 3B 0.0821662
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0744014
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0715768
SPAG9 sperm associated antigen 9 0.067657
ASPH aspartate beta-hydroxylase 0.0670225
PTK2 protein tyrosine kinase 2 0.0630208
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0609987
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0588033
BIRC6 baculoviral IAP repeat containing 6 0.0587052
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0572101
SQSTM1 sequestosome 1 0.0550008
HELZ helicase with zinc finger 0.0545249
FAM13A family with sequence similarity 13, member A 0.0529387
AHR aryl hydrocarbon receptor 0.0512653
ZNF292 zinc finger protein 292 0.0510046
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0493753
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0482768
SPTBN1 spectrin, beta, non-erythrocytic 1 0.048157
RBM39 RNA binding motif protein 39 0.0477151
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0471423
RICTOR RPTOR independent companion of MTOR, complex 2 0.0467165
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0453404
MYH9 myosin, heavy chain 9, non-muscle 0.0452168
CALU calumenin 0.0445792
TMEM156 transmembrane protein 156 0.0444538
CDC73 cell division cycle 73 0.0442544
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0439673
GRB10 growth factor receptor-bound protein 10 0.0429062
PGK1 phosphoglycerate kinase 1 0.0421172
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0412995
TXNIP thioredoxin interacting protein 0.040566
TAS2R14 taste receptor, type 2, member 14 0.0403452
RAD21 RAD21 homolog (S. pombe) 0.0401027
APP amyloid beta (A4) precursor protein 0.0399909
TXNRD1 thioredoxin reductase 1 0.039798
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0397705
UBA6 ubiquitin-like modifier activating enzyme 6 0.0392041
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0387171
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.03847
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0382183
TMSB4X thymosin beta 4, X-linked 0.0376673
ESYT2 extended synaptotagmin-like protein 2 0.0369675
SMYD3 SET and MYND domain containing 3 0.036785
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0364125
KDM3A lysine (K)-specific demethylase 3A 0.0355899
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0352304
DST dystonin 0.0350629
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0348563
MARCHF6 membrane associated ring-CH-type finger 6 0.0345199
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0343664
CENPF centromere protein F, 350/400kDa 0.0336624
KDM5B lysine (K)-specific demethylase 5B 0.0330948
USP34 ubiquitin specific peptidase 34 0.0323591
DENND5B DENN/MADD domain containing 5B 0.0320352
SEC23A Sec23 homolog A (S. cerevisiae) 0.0319686
TPR translocated promoter region, nuclear basket protein 0.0318873
UBC ubiquitin C 0.0311074
RANBP2 RAN binding protein 2 0.0309721
XPO1 exportin 1 0.0308021
ANKRD11 ankyrin repeat domain 11 0.0307239
TPM3 tropomyosin 3 0.0307193
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0303448
PRELID2 PRELI domain containing 2 0.0303012
OGA O-GlcNAcase 0.0302841
YME1L1 YME1-like 1 ATPase 0.0302302
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0300692
ENO1 enolase 1, (alpha) 0.0299908
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0299896
FAT1 FAT atypical cadherin 1 0.0296277
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0295725
SUCO SUN domain containing ossification factor 0.0294703
APLP2 amyloid beta (A4) precursor-like protein 2 0.0289007
LIFR leukemia inhibitory factor receptor alpha 0.0288436
PLIN2 perilipin 2 0.0287825
LCORL ligand dependent nuclear receptor corepressor-like 0.0286033
ERRFI1 ERBB receptor feedback inhibitor 1 0.0285863
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0283371
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0282883
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0281141
COPA coatomer protein complex, subunit alpha 0.0280905
BZW1 basic leucine zipper and W2 domains 1 0.0278642
AFF4 AF4/FMR2 family, member 4 0.0277895
TTC3 tetratricopeptide repeat domain 3 0.0277836
MACF1 microtubule-actin crosslinking factor 1 0.0275883
INSIG2 insulin induced gene 2 0.0275486
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0275056
SMAD3 SMAD family member 3 0.0274946
PDIA6 protein disulfide isomerase family A, member 6 0.0273746
NBAS neuroblastoma amplified sequence 0.0273251
ANXA5 annexin A5 0.0272615

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.105516
TMSB10 thymosin beta 10 -0.0908341
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0776559
MT2A metallothionein 2A -0.0750064
RPL37A ribosomal protein L37a -0.0644834
RPS19 ribosomal protein S19 -0.0588199
RPL35A ribosomal protein L35a -0.0558021
NTN4 netrin 4 -0.0533279
RPS12 ribosomal protein S12 -0.0524048
RPL26 ribosomal protein L26 -0.0466292
RPLP2 ribosomal protein, large, P2 -0.0449645
RPS27 ribosomal protein S27 -0.0440035
RPL31 ribosomal protein L31 -0.0425455
RPLP1 ribosomal protein, large, P1 -0.0419281
RPL36 ribosomal protein L36 -0.0404692
PTMA prothymosin, alpha -0.0386358
RPL9 ribosomal protein L9 -0.0382542
VCL vinculin -0.0377833
EXT1 exostosin glycosyltransferase 1 -0.037491
RPS8 ribosomal protein S8 -0.0364651
RPL23 ribosomal protein L23 -0.0360928
RPL12 ribosomal protein L12 -0.0337454
RPL19 ribosomal protein L19 -0.0334627
RPS3 ribosomal protein S3 -0.0333823
NRP1 neuropilin 1 -0.033311
VIM vimentin -0.0327511
HLA-B major histocompatibility complex, class I, B -0.0319791
S100A9 S100 calcium binding protein A9 -0.0317914
RPS21 ribosomal protein S21 -0.0292137
PALLD palladin, cytoskeletal associated protein -0.0288996
AKAP9 A kinase (PRKA) anchor protein 9 -0.0283313
RPS27A ribosomal protein S27a -0.0280482
RPL28 ribosomal protein L28 -0.0278924
HMGA1 high mobility group AT-hook 1 -0.0273087
KSR1 kinase suppressor of ras 1 -0.0272761
RPL37 ribosomal protein L37 -0.026505
TPT1 tumor protein, translationally-controlled 1 -0.026358
ENO2 enolase 2 (gamma, neuronal) -0.0261591
RPS17 ribosomal protein S17 -0.0259612
RPS6 ribosomal protein S6 -0.0257907
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0255594
RACK1 receptor for activated C kinase 1 -0.0253001
RPL18 ribosomal protein L18 -0.0252781
RPS25 ribosomal protein S25 -0.0250023
FTH1 ferritin, heavy polypeptide 1 -0.0245485
IFI27 interferon, alpha-inducible protein 27 -0.0242109
LOC102724023 ES1 protein homolog, mitochondrial -0.024198
RPL36A ribosomal protein L36a -0.023805
RPL5 ribosomal protein L5 -0.0236345
EGR1 early growth response 1 -0.0233746
RPL35 ribosomal protein L35 -0.0231881
RPS16 ribosomal protein S16 -0.0219834
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0207895
GNAS GNAS complex locus -0.0204681
RPS14 ribosomal protein S14 -0.0203677
RPL11 ribosomal protein L11 -0.0203423
FHL2 four and a half LIM domains 2 -0.0201943
RPS29 ribosomal protein S29 -0.0201368
RPL34 ribosomal protein L34 -0.0199294
RPL36AL ribosomal protein L36a-like -0.0196013
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0189686
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0189177
RPL27 ribosomal protein L27 -0.0188031
NDUFA4 NDUFA4, mitochondrial complex associated -0.0186057
RPS20 ribosomal protein S20 -0.0183381
PFN1 profilin 1 -0.0180122
INTS6 integrator complex subunit 6 -0.0172053
GLCCI1 glucocorticoid induced 1 -0.0170855
SEPTIN9 septin 9 -0.0165037
VMP1 vacuole membrane protein 1 -0.0164425
ATP5F1E ATP synthase F1 subunit epsilon -0.016237
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0161782
RAB10 RAB10, member RAS oncogene family -0.016157
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0160168
RPL30 ribosomal protein L30 -0.0160119
SERF2 small EDRK-rich factor 2 -0.0158777
ADAM8 ADAM metallopeptidase domain 8 -0.0157399
RPS13 ribosomal protein S13 -0.0157235
DUSP16 dual specificity phosphatase 16 -0.0156604
SSR4 signal sequence receptor, delta -0.0155429
RPL7A ribosomal protein L7a -0.015171
AOPEP aminopeptidase O (putative) -0.0148726
LIMA1 LIM domain and actin binding 1 -0.0146978
ETV1 ets variant 1 -0.0143215
RPS11 ribosomal protein S11 -0.0142438
RPL21 ribosomal protein L21 -0.0142316
NACA nascent polypeptide-associated complex alpha subunit -0.0141871
SOX4 SRY (sex determining region Y)-box 4 -0.0138587
GPX4 glutathione peroxidase 4 -0.0135626
RPL38 ribosomal protein L38 -0.0134268
ACTG1 actin gamma 1 -0.0133398
RIGI RNA sensor RIG-I -0.0132872
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -0.0132475
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) -0.0130606
AHRR aryl-hydrocarbon receptor repressor -0.0129696
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0128068
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0127116
VEGFA vascular endothelial growth factor A -0.0126756
MX2 MX dynamin-like GTPase 2 -0.0126503
CST3 cystatin C -0.0126344