Montelukast Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
Description An aliphatic sulfide that has formula C35H36ClNO3S. (Chemical Entities of Biological Interest Ontology, CHEBI_50730)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/5281040
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Genes

200 proteins with high or low expression in Montelukast relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
KMT2B lysine (K)-specific methyltransferase 2B 1.28
GREB1 growth regulation by estrogen in breast cancer 1 1.16
DNAH6 dynein, axonemal, heavy chain 6 0.9
DIXDC1 DIX domain containing 1 0.77
NPHP3 nephronophthisis 3 (adolescent) 0.72
NECAB3 N-terminal EF-hand calcium binding protein 3 0.65
SPTA1 spectrin, alpha, erythrocytic 1 0.63
ARL4A ADP-ribosylation factor-like 4A 0.62
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.61
RWDD2B RWD domain containing 2B 0.6
ZNF175 zinc finger protein 175 0.59
B2M beta-2-microglobulin 0.54
KIF27 kinesin family member 27 0.53
METTL22 methyltransferase like 22 0.51
POTEE POTE ankyrin domain family, member E 0.51
PCTP phosphatidylcholine transfer protein 0.51
CCDC91 coiled-coil domain containing 91 0.5
THAP9 THAP domain containing 9 0.5
RBM48 RNA binding motif protein 48 0.48
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 0.48
ZWINT ZW10 interacting kinetochore protein 0.47
ZBTB43 zinc finger and BTB domain containing 43 0.46
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.46
TMOD2 tropomodulin 2 (neuronal) 0.45
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.44
ARHGAP44 Rho GTPase activating protein 44 0.44
CDCA4 cell division cycle associated 4 0.43
ACOX3 acyl-CoA oxidase 3, pristanoyl 0.43
XBP1 X-box binding protein 1 0.42
PIP prolactin-induced protein 0.42
DENND3 DENN/MADD domain containing 3 0.41
CCDC158 coiled-coil domain containing 158 0.4
BBS1 Bardet-Biedl syndrome 1 0.4
ANKRD54 ankyrin repeat domain 54 0.38
TMEM179B transmembrane protein 179B 0.38
KCTD17 potassium channel tetramerization domain containing 17 0.38
ARID3A AT rich interactive domain 3A (BRIGHT-like) 0.36
ANKRD39 ankyrin repeat domain 39 0.36
F5 coagulation factor V (proaccelerin, labile factor) 0.36
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 0.36
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 0.35
ZSWIM9 zinc finger SWIM-type containing 9 0.35
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.35
UVRAG UV radiation resistance associated 0.34
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 0.34
RAB40C RAB40C, member RAS oncogene family 0.33
CCDC150 coiled-coil domain containing 150 0.33
ANKRD36C ankyrin repeat domain 36C 0.32
RNF145 ring finger protein 145 0.32
ARL6IP6 ADP-ribosylation factor-like 6 interacting protein 6 0.32
LYST lysosomal trafficking regulator 0.31
CLASP2 cytoplasmic linker associated protein 2 0.31
HBA1 hemoglobin, alpha 1 0.3
KRIT1 KRIT1, ankyrin repeat containing 0.3
F3 coagulation factor III (thromboplastin, tissue factor) 0.3
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.3
KCTD20 potassium channel tetramerization domain containing 20 0.3
RPP21 ribonuclease P/MRP 21kDa subunit 0.3
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 0.3
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 0.29
GSTO2 glutathione S-transferase omega 2 0.29
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.29
PCNX1 pecanex 1 0.29
ZNF200 zinc finger protein 200 0.29
C20ORF27 chromosome 20 open reading frame 27 0.29
PIGX phosphatidylinositol glycan anchor biosynthesis, class X 0.28
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 0.28
DENND5A DENN/MADD domain containing 5A 0.28
DNAH14 dynein, axonemal, heavy chain 14 0.28
FBXO31 F-box protein 31 0.28
TBC1D14 TBC1 domain family, member 14 0.27
MIGA2 mitoguardin 2 0.27
CLTA clathrin, light chain A 0.27
ARMC7 armadillo repeat containing 7 0.27
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 0.27
NGFR nerve growth factor receptor 0.27
CENPH centromere protein H 0.27
SLF1 SMC5-SMC6 complex localization factor 1 0.27
AMOT angiomotin 0.26
CDPF1 cysteine-rich, DPF motif domain containing 1 0.26
KLHDC10 kelch domain containing 10 0.26
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.26
CCDC170 coiled-coil domain containing 170 0.26
RIOX1 ribosomal oxygenase 1 0.26
MLPH melanophilin 0.26
LRRC7 leucine rich repeat containing 7 0.26
FAM120C family with sequence similarity 120C 0.26
AEN apoptosis enhancing nuclease 0.26
NOMO1 NODAL modulator 1 0.25
ZNF114 zinc finger protein 114 0.25
PET117 PET117 homolog (S. cerevisiae) 0.25
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 0.24
TRIB3 tribbles pseudokinase 3 0.24
SOX12 SRY (sex determining region Y)-box 12 0.24
TMEM9 transmembrane protein 9 0.24
RARA retinoic acid receptor, alpha 0.24
CAMKMT calmodulin-lysine N-methyltransferase 0.24
PWWP2B PWWP domain containing 2B 0.24
FMNL1 formin-like 1 0.24
FRK fyn-related Src family tyrosine kinase 0.24

low expression

Symbol Name Standardized Value
ZBTB12 zinc finger and BTB domain containing 12 -0.86
CHRD chordin -0.68
TEP1 telomerase-associated protein 1 -0.68
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 -0.6
METTL26 methyltransferase like 26 -0.6
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 -0.59
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle -0.54
RNF13 ring finger protein 13 -0.54
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.44
ZNF417 zinc finger protein 417 -0.43
KHK ketohexokinase (fructokinase) -0.43
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 -0.42
HEXD hexosaminidase D -0.42
FGFBP1 fibroblast growth factor binding protein 1 -0.42
ADIRF adipogenesis regulatory factor -0.4
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.39
CCDC82 coiled-coil domain containing 82 -0.39
LRRC58 leucine rich repeat containing 58 -0.37
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 -0.37
GDF15 growth differentiation factor 15 -0.36
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa -0.35
SNRPF small nuclear ribonucleoprotein polypeptide F -0.35
DIABLO diablo, IAP-binding mitochondrial protein -0.35
CLK4 CDC-like kinase 4 -0.35
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -0.34
ADAM22 ADAM metallopeptidase domain 22 -0.34
DCLRE1A DNA cross-link repair 1A -0.33
GPRC5C G protein-coupled receptor, class C, group 5, member C -0.32
NDFIP1 Nedd4 family interacting protein 1 -0.32
S100A2 S100 calcium binding protein A2 -0.32
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -0.32
PRUNE2 prune homolog 2 (Drosophila) -0.31
GSTM5 glutathione S-transferase mu 5 -0.31
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 -0.31
FCHO1 FCH domain only 1 -0.31
AOC1 amine oxidase, copper containing 1 -0.31
SPATA7 spermatogenesis associated 7 -0.3
KLF3 Kruppel-like factor 3 (basic) -0.3
KIAA1107 KIAA1107 -0.3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.3
HIST2H2AA3 histone cluster 2, H2aa3 -0.3
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) -0.3
ICAM1 intercellular adhesion molecule 1 -0.3
ZNF525 zinc finger protein 525 -0.3
PHC1 polyhomeotic homolog 1 (Drosophila) -0.3
KIAA1324L KIAA1324-like -0.29
ZNF451 zinc finger protein 451 -0.29
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.29
CREBZF CREB/ATF bZIP transcription factor -0.29
BLZF1 basic leucine zipper nuclear factor 1 -0.29
TMSB10 thymosin beta 10 -0.29
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 -0.29
MEGF8 multiple EGF-like-domains 8 -0.29
RAD51B RAD51 paralog B -0.29
ENDOG endonuclease G -0.29
ZNF658 zinc finger protein 658 -0.29
ANAPC11 anaphase promoting complex subunit 11 -0.28
SOX13 SRY (sex determining region Y)-box 13 -0.28
ZXDC ZXD family zinc finger C -0.28
USP20 ubiquitin specific peptidase 20 -0.28
ZNF564 zinc finger protein 564 -0.28
PPCDC phosphopantothenoylcysteine decarboxylase -0.28
ADIPOR1 adiponectin receptor 1 -0.28
FANCF Fanconi anemia, complementation group F -0.28
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.28
BHLHA15 basic helix-loop-helix family, member a15 -0.27
SPOPL speckle-type POZ protein-like -0.27
METTL7A methyltransferase like 7A -0.27
LTBP1 latent transforming growth factor beta binding protein 1 -0.27
ERMARD ER membrane-associated RNA degradation -0.27
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -0.27
RGL3 ral guanine nucleotide dissociation stimulator-like 3 -0.27
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase -0.26
PLA2G12A phospholipase A2, group XIIA -0.26
SSH2 slingshot protein phosphatase 2 -0.26
DCLRE1B DNA cross-link repair 1B -0.26
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) -0.26
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 -0.26
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -0.26
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -0.26
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -0.26
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.25
ZFP37 ZFP37 zinc finger protein -0.25
GON7 GON7 subunit of KEOPS complex -0.25
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.25
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.25
ATXN1L ataxin 1-like -0.25
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase -0.25
MEAF6 MYST/Esa1-associated factor 6 -0.25
CAND2 cullin-associated and neddylation-dissociated 2 (putative) -0.25
TUFT1 tuftelin 1 -0.25
UBE2G2 ubiquitin-conjugating enzyme E2G 2 -0.25
HINT2 histidine triad nucleotide binding protein 2 -0.25
FBXL8 F-box and leucine-rich repeat protein 8 -0.25
KLF13 Kruppel-like factor 13 -0.25
ESAM endothelial cell adhesion molecule -0.24
BORCS6 BLOC-1 related complex subunit 6 -0.24
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C -0.24
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -0.24
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.24