Morphine Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy). (Chemical Entities of Biological Interest Ontology, CHEBI_17303)
External Link http://ctdbase.org/detail.go?type=chem&acc=D009020
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Genes

196 genes/proteins interacting with the chemical Morphine from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
ADCY1 adenylate cyclase 1 (brain)
ADCY8 adenylate cyclase 8 (brain)
ADORA1 adenosine A1 receptor
ADORA2A adenosine A2a receptor
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ANXA6 annexin A6
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOE apolipoprotein E
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARRB2 arrestin, beta 2
ART3 ADP-ribosyltransferase 3
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
BAG3 BCL2-associated athanogene 3
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BECN1 beclin 1, autophagy related
CALCA calcitonin-related polypeptide alpha
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CCKBR cholecystokinin B receptor
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES2 carboxylesterase 2
CHRM5 cholinergic receptor, muscarinic 5
CMBL carboxymethylenebutenolidase homolog (Pseudomonas)
CNBP CCHC-type zinc finger, nucleic acid binding protein
COMT catechol-O-methyltransferase
COQ9 coenzyme Q9
CREB1 cAMP responsive element binding protein 1
CRHR1 corticotropin releasing hormone receptor 1
CRP C-reactive protein, pentraxin-related
CRYAB crystallin, alpha B
CSTB cystatin B (stefin B)
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYBB cytochrome b-245, beta polypeptide
CYCS cytochrome c, somatic
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DCXR dicarbonyl/L-xylulose reductase
DDAH2 dimethylarginine dimethylaminohydrolase 2
DLG4 discs, large homolog 4 (Drosophila)
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
DRD2 dopamine receptor D2
ECH1 enoyl CoA hydratase 1, peroxisomal
EGR4 early growth response 4
EHD1 EH-domain containing 1
ELK1 ELK1, member of ETS oncogene family
EML2 echinoderm microtubule associated protein like 2
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3
F2 coagulation factor II (thrombin)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FAS Fas cell surface death receptor
FBLIM1 filamin binding LIM protein 1
FGF2 fibroblast growth factor 2 (basic)
FH fumarate hydratase
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GFM1 G elongation factor, mitochondrial 1
GH1 growth hormone 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAS GNAS complex locus
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIK1 glutamate receptor, ionotropic, kainate 1
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GSK3B glycogen synthase kinase 3 beta
HINT1 histidine triad nucleotide binding protein 1
HMOX1 heme oxygenase 1
HMOX2 heme oxygenase 2
HP haptoglobin
HRH2 histamine receptor H2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPB1 heat shock 27kDa protein 1
HSPE1 heat shock 10kDa protein 1
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IDH3B isocitrate dehydrogenase 3 (NAD+) beta
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL6 interleukin 6
JUN jun proto-oncogene
KLF7 Kruppel-like factor 7 (ubiquitous)
KRT1 keratin 1, type II
KRT10 keratin 10, type I
KRT2 keratin 2, type II
KRT33A keratin 33A, type I
KRT5 keratin 5, type II
KRT8 keratin 8, type II
LHB luteinizing hormone beta polypeptide
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MAVS mitochondrial antiviral signaling protein
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
NCAM1 neural cell adhesion molecule 1
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTSR1 neurotensin receptor 1 (high affinity)
OPRD1 opioid receptor, delta 1
OPRK1 opioid receptor, kappa 1
OPRL1 opiate receptor-like 1
OPRM1 opioid receptor, mu 1
OXCT1 3-oxoacid CoA transferase 1
PDCD5 programmed cell death 5
PDGFB platelet-derived growth factor beta polypeptide
PDHB pyruvate dehydrogenase (lipoamide) beta
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PDYN prodynorphin
PENK proenkephalin
PER2 period circadian clock 2
PERM1 PPARGC1 and ESRR induced regulator, muscle 1
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCD1 phospholipase C, delta 1
PLG plasminogen
PNOC prepronociceptin
POMC proopiomelanocortin
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCG protein kinase C, gamma
PRKG1 protein kinase, cGMP-dependent, type I
PRL prolactin
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB3A RAB3A, member RAS oncogene family
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RGS17 regulator of G-protein signaling 17
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SELL selectin L
SEPT7 septin 7
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC25A46 solute carrier family 25, member 46
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SMPX small muscle protein, X-linked
SOD2 superoxide dismutase 2, mitochondrial
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUCLG1 succinate-CoA ligase, alpha subunit
TAC1 tachykinin, precursor 1
TACR1 tachykinin receptor 1
TACR2 tachykinin receptor 2
TGFB1 transforming growth factor, beta 1
TH tyrosine hydroxylase
TKT transketolase
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TP53 tumor protein p53
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTR transthyretin
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
USP15 ubiquitin specific peptidase 15
VEGFA vascular endothelial growth factor A
VIM vimentin
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon