Mozavaptan_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mozavaptan perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mozavaptan_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.154484
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.108048
POTEF POTE ankyrin domain family, member F 0.105344
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.104124
PKM pyruvate kinase, muscle 0.0883337
TPM3 tropomyosin 3 0.084088
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.075087
FTH1 ferritin, heavy polypeptide 1 0.0749262
ENO1 enolase 1, (alpha) 0.0718629
CALR calreticulin 0.0570567
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0551097
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0524553
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0524014
VIM vimentin 0.0514605
EEF2 eukaryotic translation elongation factor 2 0.0453469
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0431321
KTN1 kinectin 1 (kinesin receptor) 0.0427492
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0421793
LDHA lactate dehydrogenase A 0.0419112
YBX1 Y box binding protein 1 0.041842
PDIA6 protein disulfide isomerase family A, member 6 0.0401967
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0377128
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0374541
PFN1 profilin 1 0.0370741
CCNL1 cyclin L1 0.0362673
TPM4 tropomyosin 4 0.0357388
MYH9 myosin, heavy chain 9, non-muscle 0.0352582
RPL41 ribosomal protein L41 0.0346404
MCL1 myeloid cell leukemia 1 0.0338975
TAGLN2 transgelin 2 0.0334894
HYOU1 hypoxia up-regulated 1 0.0321246
HDGF hepatoma-derived growth factor 0.0316358
MSN moesin 0.0303386
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0299106
HSPA8 heat shock 70kDa protein 8 0.0295627
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0293552
RPL3 ribosomal protein L3 0.028559
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0283246
APLP2 amyloid beta (A4) precursor-like protein 2 0.027733
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0272538
TPI1 triosephosphate isomerase 1 0.0270501
FLNB filamin B, beta 0.0268443
SRRM2 serine/arginine repetitive matrix 2 0.0261089
NUP58 nucleoporin 58 0.0255575
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0254083
PFDN2 prefoldin subunit 2 0.025348
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0242722
EZR ezrin 0.0241428
EIF4A1 eukaryotic translation initiation factor 4A1 0.0239298
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0239085
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0238861
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0237061
STMN1 stathmin 1 0.0220273
PLS3 plastin 3 0.0216539
CENPF centromere protein F, 350/400kDa 0.0215214
ACTN1 actinin, alpha 1 0.0215017
ERRFI1 ERBB receptor feedback inhibitor 1 0.021321
RPS2 ribosomal protein S2 0.0212601
PCBP2 poly(rC) binding protein 2 0.0212581
RRM2 ribonucleotide reductase M2 0.0212413
APP amyloid beta (A4) precursor protein 0.0206857
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0200737
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0197389
RPS12 ribosomal protein S12 0.0192285
KIF5B kinesin family member 5B 0.0190958
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0189768
BIRC3 baculoviral IAP repeat containing 3 0.0188991
TCP1 t-complex 1 0.0184827
ANXA1 annexin A1 0.0181721
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.0180321
BCLAF1 BCL2-associated transcription factor 1 0.0180146
S100A6 S100 calcium binding protein A6 0.0179379
PA2G4 proliferation-associated 2G4, 38kDa 0.0179052
UBA6 ubiquitin-like modifier activating enzyme 6 0.0174706
RPS3 ribosomal protein S3 0.017405
RBM8A RNA binding motif protein 8A 0.01734
PRPF8 pre-mRNA processing factor 8 0.0173147
S100A11 S100 calcium binding protein A11 0.0168692
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0168223
EIF4B eukaryotic translation initiation factor 4B 0.0167997
TMSB4X thymosin beta 4, X-linked 0.0167142
SNX3 sorting nexin 3 0.0166903
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0165105
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0164415
YTHDC1 YTH domain containing 1 0.0161603
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0160603
KIF23 kinesin family member 23 0.0160134
ITGA6 integrin, alpha 6 0.0157609
SEC23A Sec23 homolog A (S. cerevisiae) 0.0156851
RPL4 ribosomal protein L4 0.0156011
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.0155233
RPL37A ribosomal protein L37a 0.0155126
UBC ubiquitin C 0.0155007
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0153701
FGB fibrinogen beta chain 0.0152492
SRRM1 serine/arginine repetitive matrix 1 0.0151935
KARS1 lysyl-tRNA synthetase 1 0.0151417
LDHB lactate dehydrogenase B 0.0151245
ATF4 activating transcription factor 4 0.0149412
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0149162

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.154508
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.140877
GRAMD1B GRAM domain containing 1B -0.111468
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.109383
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0974513
TM4SF1 transmembrane 4 L six family member 1 -0.0849377
THSD4 thrombospondin, type I, domain containing 4 -0.068133
BICC1 BicC family RNA binding protein 1 -0.0670701
TFPI2 tissue factor pathway inhibitor 2 -0.0652316
PARD3 par-3 family cell polarity regulator -0.062226
RBM39 RNA binding motif protein 39 -0.0582667
PM20D1 peptidase M20 domain containing 1 -0.058072
FNDC3B fibronectin type III domain containing 3B -0.0556261
SVIL supervillin -0.0548621
ZFAND3 zinc finger, AN1-type domain 3 -0.0544202
USP34 ubiquitin specific peptidase 34 -0.048541
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.047665
GLIS3 GLIS family zinc finger 3 -0.0464624
IER3 immediate early response 3 -0.046365
CAVIN1 caveolae associated protein 1 -0.0453505
DOCK4 dedicator of cytokinesis 4 -0.0436847
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0431
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0425583
WWOX WW domain containing oxidoreductase -0.0416438
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0403451
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0402947
NEGR1 neuronal growth regulator 1 -0.0397994
ERBIN erbb2 interacting protein -0.0388203
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.038298
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0379607
DENND4A DENN/MADD domain containing 4A -0.0373909
NIPBL Nipped-B homolog (Drosophila) -0.0365905
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0364884
KYNU kynureninase -0.0364385
HDAC9 histone deacetylase 9 -0.03598
NFE2L2 nuclear factor, erythroid 2-like 2 -0.035921
TTC28 tetratricopeptide repeat domain 28 -0.0357774
EFNA5 ephrin-A5 -0.0357589
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0356544
EXOC6B exocyst complex component 6B -0.0336747
OSMR oncostatin M receptor -0.0336254
DSCAM Down syndrome cell adhesion molecule -0.0334808
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0328308
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0328264
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0324453
IGF1R insulin-like growth factor 1 receptor -0.0322717
RAD51B RAD51 paralog B -0.032233
EIF1 eukaryotic translation initiation factor 1 -0.0316735
AHNAK AHNAK nucleoprotein -0.0314212
BABAM2 BRISC and BRCA1 A complex member 2 -0.0309911
RPS21 ribosomal protein S21 -0.0308402
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0307655
TXNRD1 thioredoxin reductase 1 -0.0307486
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0305111
PUM2 pumilio RNA-binding family member 2 -0.0303153
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0297883
FTL ferritin, light polypeptide -0.0291592
VCL vinculin -0.0290337
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0284475
PTK2 protein tyrosine kinase 2 -0.0283594
ZNF804A zinc finger protein 804A -0.0277413
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0272693
NHSL1 NHS-like 1 -0.0270988
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0270046
CAMKMT calmodulin-lysine N-methyltransferase -0.0270008
BASP1 brain abundant, membrane attached signal protein 1 -0.0268498
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0264567
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0264532
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0264192
NCOA7 nuclear receptor coactivator 7 -0.0263958
PRKN parkin RBR E3 ubiquitin protein ligase -0.0262251
ANKRD28 ankyrin repeat domain 28 -0.0254542
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.0254182
GNAS GNAS complex locus -0.0253491
BICD1 bicaudal D homolog 1 (Drosophila) -0.0252885
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0249987
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0248969
CMIP c-Maf inducing protein -0.0245263
LRMDA leucine rich melanocyte differentiation associated -0.0244266
RAB7A RAB7A, member RAS oncogene family -0.0242549
TPT1 tumor protein, translationally-controlled 1 -0.0242382
CUX1 cut-like homeobox 1 -0.0239648
RPLP1 ribosomal protein, large, P1 -0.0238031
BMP5 bone morphogenetic protein 5 -0.0235031
PCNX4 pecanex 4 -0.0234763
ALCAM activated leukocyte cell adhesion molecule -0.0229619
MAPK8 mitogen-activated protein kinase 8 -0.0227595
FBXL20 F-box and leucine-rich repeat protein 20 -0.0226536
ANKRD17 ankyrin repeat domain 17 -0.0226319
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0225437
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0225432
RPS24 ribosomal protein S24 -0.0224362
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0223692
CFDP1 craniofacial development protein 1 -0.0223139
NTN4 netrin 4 -0.0220789
WTAP Wilms tumor 1 associated protein -0.0220593
DST dystonin -0.0219884
IGF2 insulin-like growth factor 2 -0.021978
FUS FUS RNA binding protein -0.0219484
RAB1A RAB1A, member RAS oncogene family -0.0219399