Mozavaptan_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mozavaptan perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mozavaptan_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.192355
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.1781
POTEF POTE ankyrin domain family, member F 0.168933
ENO1 enolase 1, (alpha) 0.131571
CALR calreticulin 0.113254
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.109204
BHLHE40 basic helix-loop-helix family, member e40 0.107789
FN1 fibronectin 1 0.105698
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.104618
PABPC1 poly(A) binding protein, cytoplasmic 1 0.104252
PKM pyruvate kinase, muscle 0.0974315
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0935321
FTL ferritin, light polypeptide 0.093307
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0874435
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0813955
RPS3 ribosomal protein S3 0.0802872
MYH9 myosin, heavy chain 9, non-muscle 0.0802718
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0799742
DSPP dentin sialophosphoprotein 0.0762673
TPM3 tropomyosin 3 0.0727093
ASPH aspartate beta-hydroxylase 0.0676143
LDHA lactate dehydrogenase A 0.067177
HMGB2 high mobility group box 2 0.0645309
EEF2 eukaryotic translation elongation factor 2 0.0600441
HSPA8 heat shock 70kDa protein 8 0.0599845
RPS12 ribosomal protein S12 0.0582796
FTH1 ferritin, heavy polypeptide 1 0.0575552
TMSB4X thymosin beta 4, X-linked 0.05519
ADAM9 ADAM metallopeptidase domain 9 0.0535963
NUP58 nucleoporin 58 0.0532668
FAM13A family with sequence similarity 13, member A 0.053058
PCBP2 poly(rC) binding protein 2 0.0525339
NAMPT nicotinamide phosphoribosyltransferase 0.0516645
RNF145 ring finger protein 145 0.0513904
G0S2 G0/G1 switch 2 0.0512818
FXR1 fragile X mental retardation, autosomal homolog 1 0.0505292
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0502838
CANX calnexin 0.0480397
APLP2 amyloid beta (A4) precursor-like protein 2 0.0479831
MSN moesin 0.046125
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0457151
UBA6 ubiquitin-like modifier activating enzyme 6 0.0457083
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0456385
YBX1 Y box binding protein 1 0.0455237
SQSTM1 sequestosome 1 0.044986
RACK1 receptor for activated C kinase 1 0.0444177
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0436571
RPL4 ribosomal protein L4 0.043324
CCNL1 cyclin L1 0.0426749
CD9 CD9 molecule 0.0417312
RPL12 ribosomal protein L12 0.0416367
CENPF centromere protein F, 350/400kDa 0.0414997
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0405329
GPX4 glutathione peroxidase 4 0.0401124
MT2A metallothionein 2A 0.0400884
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0384384
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0379008
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0376947
RPLP0 ribosomal protein, large, P0 0.0374223
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.037126
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0369276
S100A6 S100 calcium binding protein A6 0.0367315
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0365849
AREG amphiregulin 0.0355928
RPS17 ribosomal protein S17 0.035451
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0351324
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0350229
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0348078
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0346248
EZR ezrin 0.0340428
TAGLN2 transgelin 2 0.0337091
PTMA prothymosin, alpha 0.0333361
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0329871
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0328926
PDIA6 protein disulfide isomerase family A, member 6 0.0327143
KTN1 kinectin 1 (kinesin receptor) 0.0326543
MKI67 marker of proliferation Ki-67 0.0324712
GARS1 glycyl-tRNA synthetase 1 0.032108
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0318853
RPL35A ribosomal protein L35a 0.0316923
FOSL1 FOS-like antigen 1 0.0316606
CBX3 chromobox homolog 3 0.0316087
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0311496
RAD23B RAD23 homolog B (S. cerevisiae) 0.0308949
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.030632
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0301616
RPS8 ribosomal protein S8 0.0300635
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0300245
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0297353
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0297236
RPL37 ribosomal protein L37 0.0296761
PGK1 phosphoglycerate kinase 1 0.0296595
DDIT4 DNA-damage-inducible transcript 4 0.0295544
RPS19 ribosomal protein S19 0.0293492
SET SET nuclear proto-oncogene 0.0291896
MATR3 matrin 3 0.0290914
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0289169
ANLN anillin, actin binding protein 0.0288862
TFG TRK-fused gene 0.0288357
RPS27 ribosomal protein S27 0.0287109

decreased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.158676
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.143814
ACTG1 actin gamma 1 -0.11231
EXT1 exostosin glycosyltransferase 1 -0.103709
SAMD4A sterile alpha motif domain containing 4A -0.0916024
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0829814
LMO7 LIM domain 7 -0.0676656
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0630792
ERBIN erbb2 interacting protein -0.0624143
IGFBP3 insulin-like growth factor binding protein 3 -0.0586319
EFNA5 ephrin-A5 -0.055849
LIMCH1 LIM and calponin homology domains 1 -0.0549193
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0545299
FBXO32 F-box protein 32 -0.0534376
MYO1E myosin IE -0.0527223
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0514467
UBE2H ubiquitin-conjugating enzyme E2H -0.0495177
TM4SF1 transmembrane 4 L six family member 1 -0.0481308
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0465575
ARHGAP5 Rho GTPase activating protein 5 -0.0448982
VCL vinculin -0.0447723
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0432892
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0430349
SH3KBP1 SH3-domain kinase binding protein 1 -0.0427956
RASAL2 RAS protein activator like 2 -0.0414584
FNIP1 folliculin interacting protein 1 -0.0410729
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0388304
CDCP1 CUB domain containing protein 1 -0.0374205
NIPBL Nipped-B homolog (Drosophila) -0.0368082
FBXL2 F-box and leucine-rich repeat protein 2 -0.0368005
AHNAK AHNAK nucleoprotein -0.0366328
FBXO34 F-box protein 34 -0.035905
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0358098
ALCAM activated leukocyte cell adhesion molecule -0.0358043
BLZF1 basic leucine zipper nuclear factor 1 -0.0356732
TMEM165 transmembrane protein 165 -0.035432
STRN3 striatin, calmodulin binding protein 3 -0.0354287
SOX4 SRY (sex determining region Y)-box 4 -0.0349495
S100A10 S100 calcium binding protein A10 -0.0344117
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0342678
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0336768
ANTXR2 anthrax toxin receptor 2 -0.0331018
KDM2A lysine (K)-specific demethylase 2A -0.0326007
LPP LIM domain containing preferred translocation partner in lipoma -0.0323299
NUMB numb homolog (Drosophila) -0.0322407
CDK13 cyclin-dependent kinase 13 -0.0316944
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0315105
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0313996
ANKRD17 ankyrin repeat domain 17 -0.0311865
RAB1A RAB1A, member RAS oncogene family -0.0309256
JMJD1C jumonji domain containing 1C -0.0305121
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0303127
CCND1 cyclin D1 -0.0302473
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0302284
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0294972
CEP350 centrosomal protein 350kDa -0.0293613
VGLL3 vestigial-like family member 3 -0.0292452
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0291851
PATJ PATJ crumbs cell polarity complex component -0.0288616
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0287894
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.028027
SH3RF1 SH3 domain containing ring finger 1 -0.0280173
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0277831
PLSCR1 phospholipid scramblase 1 -0.0273277
BASP1 brain abundant, membrane attached signal protein 1 -0.0270515
MCU mitochondrial calcium uniporter -0.0270427
PDLIM5 PDZ and LIM domain 5 -0.0267486
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0266456
MON2 MON2 homolog (S. cerevisiae) -0.026557
EGFR epidermal growth factor receptor -0.0264978
NF1 neurofibromin 1 -0.0263212
RAB7A RAB7A, member RAS oncogene family -0.0262603
TJP1 tight junction protein 1 -0.0261896
TMEM263 transmembrane protein 263 -0.0261722
TPT1 tumor protein, translationally-controlled 1 -0.0261513
ARHGAP20 Rho GTPase activating protein 20 -0.026104
CD2AP CD2-associated protein -0.0260227
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0259423
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0259323
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0255574
MCTP2 multiple C2 domains, transmembrane 2 -0.0254814
NPEPPS aminopeptidase puromycin sensitive -0.0253247
GNAS GNAS complex locus -0.0249934
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0246231
WWTR1 WW domain containing transcription regulator 1 -0.0243446
LOC112694756 uncharaterized LOC112694756 -0.0243085
FCHO2 FCH domain only 2 -0.0242236
AFF1 AF4/FMR2 family, member 1 -0.0242212
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0242018
FBXO11 F-box protein 11 -0.0241879
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0241564
UBAP1 ubiquitin associated protein 1 -0.0241284
ATP11A ATPase, class VI, type 11A -0.0234409
SVIL supervillin -0.0233944
ELL2 elongation factor, RNA polymerase II, 2 -0.0233236
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0233035
PALLD palladin, cytoskeletal associated protein -0.0232604
IFI6 interferon, alpha-inducible protein 6 -0.0231875
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0231631
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0230185