Mozavaptan_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mozavaptan perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mozavaptan_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.116667
GRAMD1B GRAM domain containing 1B 0.11378
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0968717
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0916645
PCBP3 poly(rC) binding protein 3 0.0867452
PDE4D phosphodiesterase 4D, cAMP-specific 0.0863709
GDA guanine deaminase 0.0860203
MCL1 myeloid cell leukemia 1 0.0844049
EFNA5 ephrin-A5 0.0836935
PDE10A phosphodiesterase 10A 0.0795743
FNDC3B fibronectin type III domain containing 3B 0.0774668
MYOF myoferlin 0.0683787
ESYT2 extended synaptotagmin-like protein 2 0.0677989
TRIO trio Rho guanine nucleotide exchange factor 0.0663582
LIMCH1 LIM and calponin homology domains 1 0.0638108
SPAG9 sperm associated antigen 9 0.0606358
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.059946
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0592691
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0582085
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0558651
DOCK4 dedicator of cytokinesis 4 0.0523679
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0501102
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0496701
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0496679
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0471898
ASPH aspartate beta-hydroxylase 0.0456364
DNER delta/notch-like EGF repeat containing 0.0447107
FLNB filamin B, beta 0.0444085
NPAS2 neuronal PAS domain protein 2 0.0442835
SMOC1 SPARC related modular calcium binding 1 0.0430691
FNDC3A fibronectin type III domain containing 3A 0.0418564
INHBA inhibin, beta A 0.0404431
VMP1 vacuole membrane protein 1 0.0399481
DST dystonin 0.0390045
SAMD4A sterile alpha motif domain containing 4A 0.037722
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.03734
USP9X ubiquitin specific peptidase 9, X-linked 0.0369725
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0366543
ELL2 elongation factor, RNA polymerase II, 2 0.0362406
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0355416
AFF4 AF4/FMR2 family, member 4 0.0342731
ADARB1 adenosine deaminase, RNA-specific, B1 0.0341792
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.034072
CFLAR CASP8 and FADD-like apoptosis regulator 0.0337851
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0334534
APP amyloid beta (A4) precursor protein 0.033445
NCAM1 neural cell adhesion molecule 1 0.0332928
ADGRD1 adhesion G protein-coupled receptor D1 0.0331456
PRELID2 PRELI domain containing 2 0.032892
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0319197
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0317228
MACF1 microtubule-actin crosslinking factor 1 0.0313793
ERRFI1 ERBB receptor feedback inhibitor 1 0.0306684
KMT2C lysine (K)-specific methyltransferase 2C 0.0305849
COL4A6 collagen, type IV, alpha 6 0.0305269
FMNL2 formin-like 2 0.0304177
RPL41 ribosomal protein L41 0.0302841
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0295506
PICALM phosphatidylinositol binding clathrin assembly protein 0.0293551
ZC3H11A zinc finger CCCH-type containing 11A 0.0286158
NBAS neuroblastoma amplified sequence 0.0285853
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0284805
AGFG1 ArfGAP with FG repeats 1 0.0283859
FAM13A family with sequence similarity 13, member A 0.0282677
PYGL phosphorylase, glycogen, liver 0.0277465
DGKD diacylglycerol kinase, delta 130kDa 0.027507
EIF4B eukaryotic translation initiation factor 4B 0.0273544
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0272043
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0269576
ANO6 anoctamin 6 0.0269065
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0267843
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0267705
ITPRID2 ITPR interacting domain containing 2 0.0266714
WSB1 WD repeat and SOCS box containing 1 0.0261076
ZFC3H1 zinc finger, C3H1-type containing 0.0259239
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0253971
BCAR3 breast cancer anti-estrogen resistance 3 0.0253392
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0251225
KDM6A lysine (K)-specific demethylase 6A 0.0246313
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0244251
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0244207
PPP1R3C protein phosphatase 1, regulatory subunit 3C 0.0243251
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0241853
TGFBR1 transforming growth factor, beta receptor 1 0.024147
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0241374
AVL9 AVL9 homolog (S. cerevisiase) 0.0240465
MFF mitochondrial fission factor 0.0240342
FNIP1 folliculin interacting protein 1 0.0235001
TGFBI transforming growth factor, beta-induced, 68kDa 0.0233882
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0232931
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.023047
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0230461
BMERB1 bMERB domain containing 1 0.0227626
TM4SF1 transmembrane 4 L six family member 1 0.0226309
SNX9 sorting nexin 9 0.0226306
CD109 CD109 molecule 0.0221442
GPC6 glypican 6 0.0220697
CREB5 cAMP responsive element binding protein 5 0.0218915
WWTR1 WW domain containing transcription regulator 1 0.021657
NRCAM neuronal cell adhesion molecule 0.0215329

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.123522
VIM vimentin -0.110728
TMSB10 thymosin beta 10 -0.109558
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.089219
IGFBP3 insulin-like growth factor binding protein 3 -0.0886981
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0833652
RPS12 ribosomal protein S12 -0.0794701
FTL ferritin, light polypeptide -0.0787885
RPLP1 ribosomal protein, large, P1 -0.0770402
RPL26 ribosomal protein L26 -0.0714569
FTH1 ferritin, heavy polypeptide 1 -0.069639
RPL12 ribosomal protein L12 -0.0676056
RPS6 ribosomal protein S6 -0.0664429
RPL35A ribosomal protein L35a -0.0650609
S100A6 S100 calcium binding protein A6 -0.0641556
RPS8 ribosomal protein S8 -0.0640823
RPL37A ribosomal protein L37a -0.0632508
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0631911
COL8A1 collagen, type VIII, alpha 1 -0.060116
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0586687
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0574623
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0511158
RPS3 ribosomal protein S3 -0.0510064
GNAS GNAS complex locus -0.0486877
RPL9 ribosomal protein L9 -0.0468729
RACK1 receptor for activated C kinase 1 -0.0468282
RPL23 ribosomal protein L23 -0.0451263
B2M beta-2-microglobulin -0.0419707
COL5A2 collagen, type V, alpha 2 -0.0415733
RPL34 ribosomal protein L34 -0.0415075
RPS4X ribosomal protein S4, X-linked -0.0414689
RPS19 ribosomal protein S19 -0.0407588
EIF1 eukaryotic translation initiation factor 1 -0.0367685
RPL13A ribosomal protein L13a -0.0354566
YBX1 Y box binding protein 1 -0.0352931
RPL19 ribosomal protein L19 -0.0346463
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0338612
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0334877
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0328278
RPS2 ribosomal protein S2 -0.0323725
RPL31 ribosomal protein L31 -0.0319581
ACTG1 actin gamma 1 -0.0314035
RPS27 ribosomal protein S27 -0.0312111
S100A9 S100 calcium binding protein A9 -0.0303594
NF1 neurofibromin 1 -0.0302702
RPL36 ribosomal protein L36 -0.0296581
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0296427
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0293958
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0282982
RPS27A ribosomal protein S27a -0.0282077
RPS14 ribosomal protein S14 -0.0279776
EEF1G eukaryotic translation elongation factor 1 gamma -0.0279042
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0276495
PFN1 profilin 1 -0.0276048
RPLP0 ribosomal protein, large, P0 -0.0267059
SMYD3 SET and MYND domain containing 3 -0.026418
PDIA3 protein disulfide isomerase family A, member 3 -0.0258086
RPL18 ribosomal protein L18 -0.025772
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0257331
RPL11 ribosomal protein L11 -0.0255702
RPS13 ribosomal protein S13 -0.0254547
TFPI2 tissue factor pathway inhibitor 2 -0.0252151
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0246346
SLF1 SMC5-SMC6 complex localization factor 1 -0.024615
TBCA tubulin folding cofactor A -0.0242718
RPL5 ribosomal protein L5 -0.0238932
ATP5F1E ATP synthase F1 subunit epsilon -0.0238578
PCDH15 protocadherin-related 15 -0.0238083
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0232737
RPL35 ribosomal protein L35 -0.0232244
RPS28 ribosomal protein S28 -0.0232007
ISG15 ISG15 ubiquitin-like modifier -0.0229103
ANTXR1 anthrax toxin receptor 1 -0.0227945
TPI1 triosephosphate isomerase 1 -0.0225194
KIAA0825 KIAA0825 -0.0225047
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0220463
NCAM2 neural cell adhesion molecule 2 -0.0219874
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0215623
HMGA1 high mobility group AT-hook 1 -0.0215606
LDHB lactate dehydrogenase B -0.0214087
ANXA2 annexin A2 -0.0213578
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0211385
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -0.0208976
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0208952
MAP1B microtubule-associated protein 1B -0.0208436
RTN1 reticulon 1 -0.02083
RBM25 RNA binding motif protein 25 -0.0205983
RPLP2 ribosomal protein, large, P2 -0.0203551
KPNB1 karyopherin (importin) beta 1 -0.019573
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0191544
TMX4 thioredoxin-related transmembrane protein 4 -0.0191073
P3H2 prolyl 3-hydroxylase 2 -0.0190386
ATP5F1B ATP synthase F1 subunit beta -0.0187868
SRGN serglycin -0.0186861
KRT19 keratin 19, type I -0.0185653
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0181822
FAM120A family with sequence similarity 120A -0.0181729
PTGR1 prostaglandin reductase 1 -0.0180466
CBX3 chromobox homolog 3 -0.0180141
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0179128