Mozavaptan_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mozavaptan perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mozavaptan_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.149002
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.117832
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0885171
TMSB4X thymosin beta 4, X-linked 0.0816927
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0795524
CENPF centromere protein F, 350/400kDa 0.0736579
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0691337
THBS1 thrombospondin 1 0.0625692
ADGRV1 adhesion G protein-coupled receptor V1 0.0611288
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0600301
TPM3 tropomyosin 3 0.0580338
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0577841
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0574662
NCKAP1 NCK-associated protein 1 0.0568185
CALR calreticulin 0.0567488
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.056129
HMGB2 high mobility group box 2 0.0553206
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0531155
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0521617
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0486628
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0480912
NCOR1 nuclear receptor corepressor 1 0.0472076
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0462904
COL3A1 collagen, type III, alpha 1 0.0450772
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0449875
CHD1 chromodomain helicase DNA binding protein 1 0.0443264
STAG2 stromal antigen 2 0.0440198
BZW1 basic leucine zipper and W2 domains 1 0.0430905
MKI67 marker of proliferation Ki-67 0.0422184
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0382851
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.038191
SFPQ splicing factor proline/glutamine-rich 0.0380868
CKAP5 cytoskeleton associated protein 5 0.0379516
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0376351
ANXA1 annexin A1 0.0372669
CSDE1 cold shock domain containing E1, RNA-binding 0.0362552
MRPS30 mitochondrial ribosomal protein S30 0.0353655
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0344697
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0335001
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0329631
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0328592
RPL41 ribosomal protein L41 0.0327619
MYH9 myosin, heavy chain 9, non-muscle 0.0327088
PEG10 paternally expressed 10 0.0324133
COL11A1 collagen, type XI, alpha 1 0.0318992
USP9X ubiquitin specific peptidase 9, X-linked 0.0317671
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0316474
FNDC3B fibronectin type III domain containing 3B 0.0316032
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0315538
SPAG9 sperm associated antigen 9 0.0312568
XPOT exportin, tRNA 0.0308875
RAD21 RAD21 homolog (S. pombe) 0.0307337
TSC22D2 TSC22 domain family, member 2 0.030629
ZNF217 zinc finger protein 217 0.0305258
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0302532
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0296882
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0295785
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0294811
CDC73 cell division cycle 73 0.0289115
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0286415
ENO1 enolase 1, (alpha) 0.0285433
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.028462
HSPA8 heat shock 70kDa protein 8 0.028386
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.0282004
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0278779
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0277096
PICALM phosphatidylinositol binding clathrin assembly protein 0.0272365
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0271627
ANLN anillin, actin binding protein 0.0265326
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0263129
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0262836
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0257863
SERINC1 serine incorporator 1 0.0254078
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.0253979
PGAP1 post-GPI attachment to proteins 1 0.0253192
ADAM10 ADAM metallopeptidase domain 10 0.0250191
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.024981
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0247614
LEMD3 LEM domain containing 3 0.0244956
LBR lamin B receptor 0.0244946
TOP2B topoisomerase (DNA) II beta 180kDa 0.0242422
TEX11 testis expressed 11 0.0239718
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0239694
KDM1A lysine (K)-specific demethylase 1A 0.023904
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0237862
H1-4 H1.4 linker histone, cluster member 0.0237351
MAP4 microtubule-associated protein 4 0.0236342
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0236022
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0235081
BHLHE40 basic helix-loop-helix family, member e40 0.0234109
KIF5B kinesin family member 5B 0.0233527
NUSAP1 nucleolar and spindle associated protein 1 0.0231993
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0230333
XRN2 5'-3' exoribonuclease 2 0.0228919
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0228629
ETV1 ets variant 1 0.0228399
PHF3 PHD finger protein 3 0.0228074
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0227973
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.0227248
KDM3A lysine (K)-specific demethylase 3A 0.0225437

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.275434
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.238567
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.167715
TMSB10 thymosin beta 10 -0.107813
ATP5F1B ATP synthase F1 subunit beta -0.102608
RPS6 ribosomal protein S6 -0.101969
RPS16 ribosomal protein S16 -0.0971886
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0858599
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0801574
RPS8 ribosomal protein S8 -0.0740156
RPLP1 ribosomal protein, large, P1 -0.0730661
ACTG1 actin gamma 1 -0.0720628
MDK midkine (neurite growth-promoting factor 2) -0.0710982
RPL11 ribosomal protein L11 -0.0659979
RPL19 ribosomal protein L19 -0.0646412
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0638081
GNAS GNAS complex locus -0.0629725
CADM2 cell adhesion molecule 2 -0.0626599
RPS23 ribosomal protein S23 -0.0617084
PARD3B par-3 family cell polarity regulator beta -0.0611089
RPS19 ribosomal protein S19 -0.0591527
PDE4D phosphodiesterase 4D, cAMP-specific -0.0555755
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0553733
ITGAV integrin, alpha V -0.0530664
RPLP2 ribosomal protein, large, P2 -0.0521663
FTL ferritin, light polypeptide -0.050438
RPS21 ribosomal protein S21 -0.0492331
PTMA prothymosin, alpha -0.0484782
PRTG protogenin -0.047821
PFN1 profilin 1 -0.047615
RPS12 ribosomal protein S12 -0.0474286
EIF1 eukaryotic translation initiation factor 1 -0.0470708
SYT1 synaptotagmin I -0.0463723
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.046184
RPL23 ribosomal protein L23 -0.0452817
RPL32 ribosomal protein L32 -0.0442213
CDH10 cadherin 10, type 2 (T2-cadherin) -0.044167
RPL28 ribosomal protein L28 -0.0437266
DOCK5 dedicator of cytokinesis 5 -0.0435278
RPS10 ribosomal protein S10 -0.0434967
TENM3 teneurin transmembrane protein 3 -0.0419478
RPS27A ribosomal protein S27a -0.0403704
RPS4X ribosomal protein S4, X-linked -0.0397201
ANKRD12 ankyrin repeat domain 12 -0.0394167
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0387756
RPS13 ribosomal protein S13 -0.0386992
AKAP9 A kinase (PRKA) anchor protein 9 -0.0385417
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0383207
RPL37 ribosomal protein L37 -0.0377608
RPS24 ribosomal protein S24 -0.0376268
HSPB1 heat shock 27kDa protein 1 -0.0366483
PRR16 proline rich 16 -0.0366431
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0366183
MEIS2 Meis homeobox 2 -0.0359995
NCOA2 nuclear receptor coactivator 2 -0.0359159
SRSF11 serine/arginine-rich splicing factor 11 -0.0358572
PHIP pleckstrin homology domain interacting protein -0.0352978
LOC112694756 uncharaterized LOC112694756 -0.034911
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0346821
PLPP1 phospholipid phosphatase 1 -0.0346134
MT2A metallothionein 2A -0.0345557
RBM25 RNA binding motif protein 25 -0.0342369
LOC102724023 ES1 protein homolog, mitochondrial -0.0334885
RPL7A ribosomal protein L7a -0.0334343
RPL34 ribosomal protein L34 -0.0334243
NTM neurotrimin -0.0332611
MBD5 methyl-CpG binding domain protein 5 -0.0331267
CSMD3 CUB and Sushi multiple domains 3 -0.0330176
EIF5B eukaryotic translation initiation factor 5B -0.032598
TRPS1 trichorhinophalangeal syndrome I -0.032279
RPL35A ribosomal protein L35a -0.0321504
RPS5 ribosomal protein S5 -0.0320548
DSTN destrin (actin depolymerizing factor) -0.0318899
GLI3 GLI family zinc finger 3 -0.0316435
RPL31 ribosomal protein L31 -0.0315045
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0314402
RPS15 ribosomal protein S15 -0.0313245
ANK2 ankyrin 2, neuronal -0.0311363
KTN1 kinectin 1 (kinesin receptor) -0.0310862
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0309722
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.030851
KMT2C lysine (K)-specific methyltransferase 2C -0.0306381
RPL30 ribosomal protein L30 -0.0305164
RPL5 ribosomal protein L5 -0.0300121
RCC1 regulator of chromosome condensation 1 -0.0297259
RAB2A RAB2A, member RAS oncogene family -0.0294423
FOXP2 forkhead box P2 -0.0293855
ADNP activity-dependent neuroprotector homeobox -0.0292431
COG5 component of oligomeric golgi complex 5 -0.0290776
RTN3 reticulon 3 -0.0288995
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0288315
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -0.0288245
ATP5MG ATP synthase membrane subunit g -0.0285082
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0278783
RPS14 ribosomal protein S14 -0.0275223
HMGB1 high mobility group box 1 -0.027163
CNRIP1 cannabinoid receptor interacting protein 1 -0.0269504
RPL36A ribosomal protein L36a -0.0268521
FBL fibrillarin -0.0267084
PCBP2 poly(rC) binding protein 2 -0.026694