Mozavaptan_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mozavaptan perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mozavaptan_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.234172
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.155551
TMSB4X thymosin beta 4, X-linked 0.135213
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.122483
RPS3 ribosomal protein S3 0.103433
RPL35A ribosomal protein L35a 0.102842
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.101683
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0892618
ENO1 enolase 1, (alpha) 0.0865015
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0850484
LDHA lactate dehydrogenase A 0.0796018
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0786921
MT2A metallothionein 2A 0.0763101
RPL12 ribosomal protein L12 0.0741172
RPL26 ribosomal protein L26 0.0729375
RPS12 ribosomal protein S12 0.0708226
S100A6 S100 calcium binding protein A6 0.069629
EEF2 eukaryotic translation elongation factor 2 0.0695083
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0675242
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0672345
EZR ezrin 0.0662661
GOLGA4 golgin A4 0.0660728
RPL37A ribosomal protein L37a 0.0651575
RPL34 ribosomal protein L34 0.0639913
RACK1 receptor for activated C kinase 1 0.0609966
RPL13A ribosomal protein L13a 0.0604726
RPS8 ribosomal protein S8 0.0604663
CALR calreticulin 0.0595317
RPL4 ribosomal protein L4 0.0589059
PKM pyruvate kinase, muscle 0.0574326
SRRM2 serine/arginine repetitive matrix 2 0.0551804
RPS19 ribosomal protein S19 0.0540527
GARS1 glycyl-tRNA synthetase 1 0.0538706
SMC3 structural maintenance of chromosomes 3 0.0514802
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0501026
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0486695
RPL11 ribosomal protein L11 0.0469808
PGK1 phosphoglycerate kinase 1 0.0465167
RPL9 ribosomal protein L9 0.0462418
NAP1L1 nucleosome assembly protein 1-like 1 0.0456569
TXNIP thioredoxin interacting protein 0.0455835
FTL ferritin, light polypeptide 0.0444372
RPL36 ribosomal protein L36 0.0435246
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0431417
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0424593
YBX1 Y box binding protein 1 0.0422771
RPS27A ribosomal protein S27a 0.0418311
ZNF292 zinc finger protein 292 0.040073
TMSB10 thymosin beta 10 0.0391846
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0391165
RPS6 ribosomal protein S6 0.0388254
ECT2 epithelial cell transforming 2 0.0380497
RPL31 ribosomal protein L31 0.0377718
NACA nascent polypeptide-associated complex alpha subunit 0.037444
CANX calnexin 0.0374247
LOC112694756 uncharaterized LOC112694756 0.0372982
RPL18 ribosomal protein L18 0.0369309
ATF4 activating transcription factor 4 0.0366672
EIF1 eukaryotic translation initiation factor 1 0.0361224
TTC3 tetratricopeptide repeat domain 3 0.0358694
COPA coatomer protein complex, subunit alpha 0.0357592
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0354847
RPLP0 ribosomal protein, large, P0 0.0350043
RSRC2 arginine/serine-rich coiled-coil 2 0.0348691
SEC31A SEC31 homolog A (S. cerevisiae) 0.0342767
KMT2E lysine (K)-specific methyltransferase 2E 0.0340786
RPLP1 ribosomal protein, large, P1 0.0339612
TPI1 triosephosphate isomerase 1 0.0337351
SSR1 signal sequence receptor, alpha 0.0335557
RPL19 ribosomal protein L19 0.0334969
EIF4A1 eukaryotic translation initiation factor 4A1 0.0329595
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0328787
RPL7 ribosomal protein L7 0.0328197
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0326356
HMGB2 high mobility group box 2 0.032471
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0316865
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0316801
RPL41 ribosomal protein L41 0.0313325
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0309036
TMF1 TATA element modulatory factor 1 0.0289151
PRDX2 peroxiredoxin 2 0.0288686
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0285835
KDM3A lysine (K)-specific demethylase 3A 0.0282615
RNF145 ring finger protein 145 0.0281879
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0272494
PNISR PNN-interacting serine/arginine-rich protein 0.026948
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0268473
RPS17 ribosomal protein S17 0.0266758
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0264003
AKAP9 A kinase (PRKA) anchor protein 9 0.0263064
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 0.0262586
EIF4A2 eukaryotic translation initiation factor 4A2 0.0262487
COG6 component of oligomeric golgi complex 6 0.0262166
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0259563
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0259024
WDR43 WD repeat domain 43 0.025891
PHF3 PHD finger protein 3 0.0258765
RPL5 ribosomal protein L5 0.0258073
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0256767
NAMPT nicotinamide phosphoribosyltransferase 0.0253211

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.125633
AHNAK AHNAK nucleoprotein -0.116513
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0978158
VCL vinculin -0.0857101
EGFR epidermal growth factor receptor -0.085504
FOXP1 forkhead box P1 -0.0784508
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0740188
NBEA neurobeachin -0.0737024
ADAM10 ADAM metallopeptidase domain 10 -0.0709191
BMP10 bone morphogenetic protein 10 -0.0694455
GSE1 Gse1 coiled-coil protein -0.0623754
TTC28 tetratricopeptide repeat domain 28 -0.0581638
PTPRG protein tyrosine phosphatase, receptor type, G -0.0550247
CCND1 cyclin D1 -0.0547995
GLI3 GLI family zinc finger 3 -0.0542119
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.050324
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0484138
PARD3 par-3 family cell polarity regulator -0.0471683
GLI2 GLI family zinc finger 2 -0.0466393
FLNB filamin B, beta -0.0440496
BMP2K BMP2 inducible kinase -0.0387675
PYGB phosphorylase, glycogen; brain -0.0384134
PRUNE2 prune homolog 2 (Drosophila) -0.0383069
CUX1 cut-like homeobox 1 -0.0382454
DLG1 discs, large homolog 1 (Drosophila) -0.0380698
USP34 ubiquitin specific peptidase 34 -0.0375319
SDK1 sidekick cell adhesion molecule 1 -0.036944
TXNRD1 thioredoxin reductase 1 -0.0366155
ZNF438 zinc finger protein 438 -0.0365935
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0357869
SPIDR scaffolding protein involved in DNA repair -0.0355391
ARL4C ADP-ribosylation factor-like 4C -0.0354629
SOX6 SRY (sex determining region Y)-box 6 -0.0351528
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0342539
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0342019
MYO5C myosin VC -0.0339535
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0331138
NPAS2 neuronal PAS domain protein 2 -0.033103
DPYD dihydropyrimidine dehydrogenase -0.0326208
PDE4B phosphodiesterase 4B, cAMP-specific -0.0324797
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0316214
EML4 echinoderm microtubule associated protein like 4 -0.0314333
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -0.031269
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0312316
EVI5 ecotropic viral integration site 5 -0.0307206
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0306519
TAS2R14 taste receptor, type 2, member 14 -0.0302218
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0300767
DOCK3 dedicator of cytokinesis 3 -0.0298698
MACROD2 MACRO domain containing 2 -0.0291917
GPHN gephyrin -0.0291818
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.029103
SPRY4 sprouty homolog 4 (Drosophila) -0.0288147
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0287283
EXOC6B exocyst complex component 6B -0.0287271
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0287102
TBC1D5 TBC1 domain family, member 5 -0.0284169
NF1 neurofibromin 1 -0.0280831
FAF1 Fas (TNFRSF6) associated factor 1 -0.0274721
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0274306
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0267925
CRPPA CDP-L-ribitol pyrophosphorylase A -0.026678
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0266282
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0265169
ECPAS Ecm29 proteasome adaptor and scaffold -0.0264094
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0263346
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.026111
TSC22D1 TSC22 domain family, member 1 -0.0261078
SRPK2 SRSF protein kinase 2 -0.0254894
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.025239
ZMYND8 zinc finger, MYND-type containing 8 -0.0252076
SMYD3 SET and MYND domain containing 3 -0.0249015
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.02485
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0244991
BICD1 bicaudal D homolog 1 (Drosophila) -0.0243857
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0243311
PKP4 plakophilin 4 -0.0242439
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0242153
DGKH diacylglycerol kinase, eta -0.0241963
PRRC2B proline-rich coiled-coil 2B -0.0240773
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0240295
TBC1D22A TBC1 domain family, member 22A -0.0237236
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0236303
PDE7B phosphodiesterase 7B -0.0233556
ZNF609 zinc finger protein 609 -0.0230404
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.022982
RABGAP1L RAB GTPase activating protein 1-like -0.022981
DARS1 aspartyl-tRNA synthetase 1 -0.022729
XKR6 XK, Kell blood group complex subunit-related family, member 6 -0.0226977
COMMD10 COMM domain containing 10 -0.0226558
OSMR oncostatin M receptor -0.0224596
TCF12 transcription factor 12 -0.0221001
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.021994
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0217991
METTL15 methyltransferase like 15 -0.0217076
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -0.0216078
TRIP12 thyroid hormone receptor interactor 12 -0.0214133
ZMYM4 zinc finger, MYM-type 4 -0.0211055
FER fer (fps/fes related) tyrosine kinase -0.0208774
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -0.0208149