Mucocutaneous Leishmaniasis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa. (Human Disease Ontology, DOID_9155)
External Link https://www.disgenet.org/browser/0/1/0/C1328252
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Genes

36 genes associated with the disease Mucocutaneous Leishmaniasis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
AIM2 absent in melanoma 2
ANXA1 annexin A1
B3GAT1 beta-1,3-glucuronyltransferase 1
CCL2 chemokine (C-C motif) ligand 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CLEC4D C-type lectin domain family 4, member D
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
FH fumarate hydratase
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FST follistatin
G6PD glucose-6-phosphate dehydrogenase
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HSPA4 heat shock 70kDa protein 4
IFNG interferon, gamma
IL10 interleukin 10
IL17A interleukin 17A
IL17D interleukin 17D
IL27 interleukin 27
IL4 interleukin 4
IL6 interleukin 6
LMLN leishmanolysin-like (metallopeptidase M8 family)
LTA lymphotoxin alpha
MMP1 matrix metallopeptidase 1
MYDGF myeloid-derived growth factor
NLRP3 NLR family, pyrin domain containing 3
PRDX2 peroxiredoxin 2
RBM45 RNA binding motif protein 45
TNF tumor necrosis factor