Muscle Spasticity Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes. (Human Phenotype Ontology, HP_0001257)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D009128
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Genes

40 genes/proteins associated with the disease Muscle Spasticity from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
CNR1 cannabinoid receptor 1 (brain) 2.88009
FOS FBJ murine osteosarcoma viral oncogene homolog 1.86045
PENK proenkephalin 1.62106
TNF tumor necrosis factor 1.55921
MAPK3 mitogen-activated protein kinase 3 1.5382
MAPK1 mitogen-activated protein kinase 1 1.53036
OPRM1 opioid receptor, mu 1 1.46041
PRL prolactin 1.45936
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.40897
TH tyrosine hydroxylase 1.34664
IL6 interleukin 6 1.32251
JUN jun proto-oncogene 1.31626
POMC proopiomelanocortin 1.29564
PDYN prodynorphin 1.267
BCL2 B-cell CLL/lymphoma 2 1.26205
CCL2 chemokine (C-C motif) ligand 2 1.25525
CALCA calcitonin-related polypeptide alpha 1.25152
IL1B interleukin 1, beta 1.24275
AVP arginine vasopressin 1.21239
CAT catalase 1.19999
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.19345
DRD2 dopamine receptor D2 1.17893
BDNF brain-derived neurotrophic factor 1.16236
NPY neuropeptide Y 1.16236
IFNG interferon, gamma 1.15865
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.15425
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.14575
BCL2L1 BCL2-like 1 1.14507
GSK3B glycogen synthase kinase 3 beta 1.14302
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.11877
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 1.10493
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.09047
EGR1 early growth response 1 1.08442
IL2 interleukin 2 1.07732
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.07376
MAPK8 mitogen-activated protein kinase 8 1.03308
PRKCG protein kinase C, gamma 1.02933
MAOB monoamine oxidase B 1.01928
CDK5 cyclin-dependent kinase 5 1.01814
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.01776