Muscle contraction Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
Description A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. (Gene Ontology, GO_0006936)
External Link https://reactome.org/PathwayBrowser/#/R-HSA-397014
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Genes

203 proteins participating in the Muscle contraction pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ACTA1 actin, alpha 1, skeletal muscle
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTC1 actin, alpha, cardiac muscle 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN2 actinin, alpha 2
ACTN3 actinin, alpha 3 (gene/pseudogene)
AHCYL1 adenosylhomocysteinase-like 1
AKAP9 A kinase (PRKA) anchor protein 9
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA1 annexin A1
ANXA2 annexin A2
ANXA6 annexin A6
ASPH aspartate beta-hydroxylase
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CACNG6 calcium channel, voltage-dependent, gamma subunit 6
CACNG7 calcium channel, voltage-dependent, gamma subunit 7
CACNG8 calcium channel, voltage-dependent, gamma subunit 8
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle)
CASQ2 calsequestrin 2 (cardiac muscle)
CAV3 caveolin 3
CES1 carboxylesterase 1
CLIC2 chloride intracellular channel 2
CORIN corin, serine peptidase
DES desmin
DMD dystrophin
DMPK dystrophia myotonica-protein kinase
DYSF dysferlin
FGF11 fibroblast growth factor 11
FGF12 fibroblast growth factor 12
FGF13 fibroblast growth factor 13
FGF14 fibroblast growth factor 14
FKBP1B FK506 binding protein 1B, 12.6 kDa
FXYD1 FXYD domain containing ion transport regulator 1
FXYD2 FXYD domain containing ion transport regulator 2
FXYD3 FXYD domain containing ion transport regulator 3
FXYD4 FXYD domain containing ion transport regulator 4
FXYD6 FXYD domain containing ion transport regulator 6
FXYD7 FXYD domain containing ion transport regulator 7
GATA4 GATA binding protein 4
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1
HIPK1 homeodomain interacting protein kinase 1
HIPK2 homeodomain interacting protein kinase 2
ITGA1 integrin, alpha 1
ITGB5 integrin, beta 5
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KAT2B K(lysine) acetyltransferase 2B
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNIP1 Kv channel interacting protein 1
KCNIP2 Kv channel interacting protein 2
KCNIP3 Kv channel interacting protein 3, calsenilin
KCNIP4 Kv channel interacting protein 4
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNK13 potassium channel, two pore domain subfamily K, member 13
KCNK15 potassium channel, two pore domain subfamily K, member 15
KCNK16 potassium channel, two pore domain subfamily K, member 16
KCNK17 potassium channel, two pore domain subfamily K, member 17
KCNK18 potassium channel, two pore domain subfamily K, member 18
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNK4 potassium channel, two pore domain subfamily K, member 4
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCNK6 potassium channel, two pore domain subfamily K, member 6
KCNK7 potassium channel, two pore domain subfamily K, member 7
KCNK9 potassium channel, two pore domain subfamily K, member 9
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
LMOD1 leiomodin 1 (smooth muscle)
MME membrane metallo-endopeptidase
MYBPC1 myosin binding protein C, slow type
MYBPC2 myosin binding protein C, fast type
MYBPC3 myosin binding protein C, cardiac
MYH11 myosin, heavy chain 11, smooth muscle
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYL10 myosin, light chain 10, regulatory
MYL11 myosin light chain 11
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL12B myosin, light chain 12B, regulatory
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYL5 myosin, light chain 5, regulatory
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYL7 myosin, light chain 7, regulatory
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
NEB nebulin
NKX2-5 NK2 homeobox 5
NOS1 nitric oxide synthase 1 (neuronal)
NPPA natriuretic peptide A
NPPC natriuretic peptide C
NPR1 natriuretic peptide receptor 1
NPR2 natriuretic peptide receptor 2
ORAI1 ORAI calcium release-activated calcium modulator 1
ORAI2 ORAI calcium release-activated calcium modulator 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PDE5A phosphodiesterase 5A, cGMP-specific
PLN phospholamban
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PXN paxillin
RANGRF RAN guanine nucleotide release factor
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
RYR3 ryanodine receptor 3
SCN10A sodium channel, voltage gated, type X alpha subunit
SCN11A sodium channel, voltage gated, type XI alpha subunit
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN1B sodium channel, voltage gated, type I beta subunit
SCN2A sodium channel, voltage gated, type II alpha subunit
SCN2B sodium channel, voltage gated, type II beta subunit
SCN3A sodium channel, voltage gated, type III alpha subunit
SCN3B sodium channel, voltage gated, type III beta subunit
SCN4A sodium channel, voltage gated, type IV alpha subunit
SCN4B sodium channel, voltage gated, type IV beta subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SCN7A sodium channel, voltage gated, type VII alpha subunit
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SCN9A sodium channel, voltage gated, type IX alpha subunit
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3
SLN sarcolipin
SORBS1 sorbin and SH3 domain containing 1
SORBS3 sorbin and SH3 domain containing 3
SRI sorcin
STIM1 stromal interaction molecule 1
TBX5 T-box 5
TCAP titin-cap
TLN1 talin 1
TMOD1 tropomodulin 1
TMOD2 tropomodulin 2 (neuronal)
TMOD3 tropomodulin 3 (ubiquitous)
TMOD4 tropomodulin 4 (muscle)
TNNC1 troponin C type 1 (slow)
TNNC2 troponin C type 2 (fast)
TNNI1 troponin I type 1 (skeletal, slow)
TNNI2 troponin I type 2 (skeletal, fast)
TNNI3 troponin I type 3 (cardiac)
TNNT1 troponin T type 1 (skeletal, slow)
TNNT2 troponin T type 2 (cardiac)
TNNT3 troponin T type 3 (skeletal, fast)
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPM3 tropomyosin 3
TPM4 tropomyosin 4
TRDN triadin
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TTN titin
VCL vinculin
VIM vimentin
WWTR1 WW domain containing transcription regulator 1