Mutism Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A speech disorder that involves a complete inability to speak. (Human Disease Ontology, DOID_4189)
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Genes

137 genes co-occuring with the disease Mutism in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
CNTNAP2 contactin associated protein-like 2 2.444
LGI1 leucine-rich, glioma inactivated 1 2.329
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 2.257
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.115
PRNP prion protein 2.076
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 2.069
PNMA2 paraneoplastic Ma antigen 2 2.036
MAPT microtubule-associated protein tau 2.012
TXNDC9 thioredoxin domain containing 9 1.941
TARDBP TAR DNA binding protein 1.936
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.908
GRN granulin 1.9
CHMP2B charged multivesicular body protein 2B 1.895
AMPH amphiphysin 1.888
DPP10 dipeptidyl-peptidase 10 (non-functional) 1.886
C9ORF72 chromosome 9 open reading frame 72 1.855
DPP6 dipeptidyl-peptidase 6 1.849
IGLON5 IgLON family member 5 1.816
CKM creatine kinase, muscle 1.795
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.794
CKMT1B creatine kinase, mitochondrial 1B 1.793
CKB creatine kinase, brain 1.79
SHH sonic hedgehog 1.786
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 1.77
BIN1 bridging integrator 1 1.763
FMR1 fragile X mental retardation 1 1.736
DPYSL5 dihydropyrimidinase-like 5 1.735
LINS1 lines homolog 1 1.72
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 1.683
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 1.671
ZIC4 Zic family member 4 1.629
SOX1 SRY (sex determining region Y)-box 1 1.571
FUS FUS RNA binding protein 1.569
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.557
GJB2 gap junction protein, beta 2, 26kDa 1.526
CRP C-reactive protein, pentraxin-related 1.52
VCP valosin containing protein 1.519
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) 1.517
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.506
RD3 retinal degeneration 3 1.502
TG thyroglobulin 1.495
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 1.488
NRXN1 neurexin 1 1.486
DNER delta/notch-like EGF repeat containing 1.485
GRM5 glutamate receptor, metabotropic 5 1.481
APP amyloid beta (A4) precursor protein 1.479
SLC26A4 solute carrier family 26 (anion exchanger), member 4 1.475
SHANK3 SH3 and multiple ankyrin repeat domains 3 1.471
NRXN2 neurexin 2 1.469
FOXP2 forkhead box P2 1.461
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.456
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.432
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 1.432
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.43
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.412
DRD2 dopamine receptor D2 1.399
TPO thyroid peroxidase 1.399
PSEN1 presenilin 1 1.397
NEFL neurofilament, light polypeptide 1.385
BDNF brain-derived neurotrophic factor 1.371
CRYGN crystallin, gamma N 1.348
OTX2 orthodenticle homeobox 2 1.324
PSEN2 presenilin 2 1.309
CP ceruloplasmin (ferroxidase) 1.308
MB myoglobin 1.303
OXT oxytocin/neurophysin I prepropeptide 1.302
GFAP glial fibrillary acidic protein 1.283
MAOA monoamine oxidase A 1.282
BCHE butyrylcholinesterase 1.282
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) 1.281
GRM1 glutamate receptor, metabotropic 1 1.281
CNTNAP1 contactin associated protein 1 1.277
ZBTB38 zinc finger and BTB domain containing 38 1.272
UBQLN2 ubiquilin 2 1.267
POMC proopiomelanocortin 1.264
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 1.263
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 1.259
MOG myelin oligodendrocyte glycoprotein 1.255
TRH thyrotropin-releasing hormone 1.251
SUFU suppressor of fused homolog (Drosophila) 1.242
IL6 interleukin 6 1.242
ELAVL4 ELAV like neuron-specific RNA binding protein 4 1.228
RASA2 RAS p21 protein activator 2 1.22
PRR12 proline rich 12 1.219
MBP myelin basic protein 1.218
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.216
PRDM8 PR domain containing 8 1.213
EDN3 endothelin 3 1.206
ARSA arylsulfatase A 1.198
PTCH1 patched 1 1.192
TRAPPC12 trafficking protein particle complex 12 1.187
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.187
CRH corticotropin releasing hormone 1.184
TBCD tubulin folding cofactor D 1.183
OSTF1 osteoclast stimulating factor 1 1.18
ENO2 enolase 2 (gamma, neuronal) 1.179
TMEM106B transmembrane protein 106B 1.168
GLI2 GLI family zinc finger 2 1.161
GJD3 gap junction protein, delta 3, 31.9kDa 1.161
APOE apolipoprotein E 1.16
TBP TATA box binding protein 1.16
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 1.156
S100B S100 calcium binding protein B 1.152
ADAM22 ADAM metallopeptidase domain 22 1.146
DNAH8 dynein, axonemal, heavy chain 8 1.143
MAOB monoamine oxidase B 1.132
CNTN4 contactin 4 1.13
NOVA2 neuro-oncological ventral antigen 2 1.129
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 1.128
AVP arginine vasopressin 1.128
ALB albumin 1.125
TSPEAR thrombospondin-type laminin G domain and EAR repeats 1.114
LAS1L LAS1-like (S. cerevisiae) 1.114
CNTN2 contactin 2 (axonal) 1.095
NIPBL Nipped-B homolog (Drosophila) 1.085
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 1.079
NF1 neurofibromin 1 1.079
ATP13A2 ATPase type 13A2 1.072
PRR29 proline rich 29 1.072
RBM8A RNA binding motif protein 8A 1.07
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.065
GOLGA8G golgin A8 family, member G 1.062
SOX10 SRY (sex determining region Y)-box 10 1.061
PLAT plasminogen activator, tissue 1.056
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.055
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.041
SHANK2 SH3 and multiple ankyrin repeat domains 2 1.041
SMC3 structural maintenance of chromosomes 3 1.039
FGA fibrinogen alpha chain 1.038
SMC1A structural maintenance of chromosomes 1A 1.029
THRB thyroid hormone receptor, beta 1.029
ATP7B ATPase, Cu++ transporting, beta polypeptide 1.021
SYP synaptophysin 1.019
PAX3 paired box 3 1.019
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 1.012
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 1.012
AK5 adenylate kinase 5 1.0