Mycophenolic acid Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/446541
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Genes

198 proteins with high or low expression in Mycophenolic acid relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
TP53I3 tumor protein p53 inducible protein 3 4.29
TP53 tumor protein p53 3.12
LAMA3 laminin, alpha 3 2.9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.52
EPN3 epsin 3 2.33
SULF2 sulfatase 2 2.29
ATF3 activating transcription factor 3 2.14
TCEA3 transcription elongation factor A (SII), 3 2.01
POLH polymerase (DNA directed), eta 1.9
FAS Fas cell surface death receptor 1.87
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 1.85
CES2 carboxylesterase 2 1.83
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.72
DDB2 damage-specific DNA binding protein 2, 48kDa 1.65
CDCA3 cell division cycle associated 3 1.65
SGO1 shugoshin 1 1.64
DGKA diacylglycerol kinase, alpha 80kDa 1.6
SMTN smoothelin 1.58
CPA4 carboxypeptidase A4 1.57
SDC4 syndecan 4 1.52
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 1.49
KANK3 KN motif and ankyrin repeat domains 3 1.46
CSRP2 cysteine and glycine-rich protein 2 1.44
CKAP2 cytoskeleton associated protein 2 1.41
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 1.35
RINL Ras and Rab interactor-like 1.34
CCN2 cellular communication network factor 2 1.32
E2F7 E2F transcription factor 7 1.31
GVINP1 GTPase, very large interferon inducible pseudogene 1 1.3
MARCHF7 membrane associated ring-CH-type finger 7 1.29
LMO7 LIM domain 7 1.28
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.27
TROAP trophinin associated protein 1.23
IKBIP IKBKB interacting protein 1.23
JUN jun proto-oncogene 1.21
EPM2AIP1 EPM2A (laforin) interacting protein 1 1.21
ANLN anillin, actin binding protein 1.2
FDXR ferredoxin reductase 1.16
SLC16A6 solute carrier family 16, member 6 1.16
ZNF503 zinc finger protein 503 1.15
ADGRG1 adhesion G protein-coupled receptor G1 1.15
CCN1 cellular communication network factor 1 1.14
ELL3 elongation factor RNA polymerase II-like 3 1.13
NIPSNAP3A nipsnap homolog 3A (C. elegans) 1.13
COQ8A coenzyme Q8A 1.13
ENC1 ectodermal-neural cortex 1 (with BTB domain) 1.12
CA2 carbonic anhydrase II 1.11
LAMC2 laminin, gamma 2 1.11
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) 1.11
RAET1G retinoic acid early transcript 1G 1.11
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 1.11
FAM210B family with sequence similarity 210, member B 1.1
PHLDB3 pleckstrin homology-like domain, family B, member 3 1.1
APOL2 apolipoprotein L, 2 1.09
RASAL1 RAS protein activator like 1 (GAP1 like) 1.09
CDCA5 cell division cycle associated 5 1.08
LAMB3 laminin, beta 3 1.08
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 1.07
CRLF1 cytokine receptor-like factor 1 1.07
GTSE1 G-2 and S-phase expressed 1 1.06
TGM2 transglutaminase 2 1.06
ESAM endothelial cell adhesion molecule 1.06
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 1.05
RIN1 Ras and Rab interactor 1 1.04
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 1.04
PCLAF PCNA clamp associated factor 1.04
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 1.03
GGT1 gamma-glutamyltransferase 1 1.03
PML promyelocytic leukemia 1.02
MACC1 metastasis associated in colon cancer 1 1.01
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 1.01
RHOD ras homolog family member D 1.01
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 1.0
CLSPN claspin 0.99
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.99
SFN stratifin 0.99
ISG15 ISG15 ubiquitin-like modifier 0.99
RRM2 ribonucleotide reductase M2 0.98
PIMREG PICALM interacting mitotic regulator 0.98
CKAP2L cytoskeleton associated protein 2-like 0.98
TK1 thymidine kinase 1, soluble 0.98
NLRX1 NLR family member X1 0.98
MPZL2 myelin protein zero-like 2 0.98
TRIAP1 TP53 regulated inhibitor of apoptosis 1 0.98
TPX2 TPX2, microtubule-associated 0.96
IER5 immediate early response 5 0.96
TP53I11 tumor protein p53 inducible protein 11 0.96
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 0.96
ARG2 arginase 2 0.95
CRYBG2 crystallin beta-gamma domain containing 2 0.95
PDLIM3 PDZ and LIM domain 3 0.95
ISYNA1 inositol-3-phosphate synthase 1 0.95
ANGPTL4 angiopoietin-like 4 0.95
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 0.94
LTBP3 latent transforming growth factor beta binding protein 3 0.93
EPS8L2 EPS8-like 2 0.93
INCENP inner centromere protein antigens 135/155kDa 0.93
DENND3 DENN/MADD domain containing 3 0.93

low expression

Symbol Name Standardized Value
FAM207A family with sequence similarity 207, member A -3.41
RSL1D1 ribosomal L1 domain containing 1 -2.95
UTP11 UTP11 small subunit processome component -2.78
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -2.72
WDR46 WD repeat domain 46 -2.65
RPS19BP1 ribosomal protein S19 binding protein 1 -2.63
FCF1 FCF1 rRNA-processing protein -2.58
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) -2.56
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -2.56
RRP36 ribosomal RNA processing 36 homolog (S. cerevisiae) -2.56
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -2.46
TPGS1 tubulin polyglutamylase complex subunit 1 -2.4
CCDC59 coiled-coil domain containing 59 -2.4
SLC19A1 solute carrier family 19 (folate transporter), member 1 -2.36
SURF6 surfeit 6 -2.34
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) -2.25
PDCD11 programmed cell death 11 -2.24
CCDC137 coiled-coil domain containing 137 -2.24
RPF1 ribosome production factor 1 homolog (S. cerevisiae) -2.18
PSRC1 proline/serine-rich coiled-coil 1 -2.14
DCAF13 DDB1 and CUL4 associated factor 13 -2.13
RHEB Ras homolog enriched in brain -2.09
SAPCD2 suppressor APC domain containing 2 -2.09
KDM4B lysine (K)-specific demethylase 4B -2.07
ARL5B ADP-ribosylation factor-like 5B -2.04
RPL7L1 ribosomal protein L7-like 1 -2.04
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) -2.03
PUM3 pumilio RNA binding family member 3 -2.01
NOP53 NOP53 ribosome biogenesis factor -1.98
RXRG retinoid X receptor, gamma -1.94
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -1.93
RAB38 RAB38, member RAS oncogene family -1.91
RPUSD1 RNA pseudouridylate synthase domain containing 1 -1.89
CDT1 chromatin licensing and DNA replication factor 1 -1.89
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 -1.86
BMS1 BMS1 ribosome biogenesis factor -1.85
BYSL bystin-like -1.84
RIOK2 RIO kinase 2 -1.79
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 -1.79
NOL7 nucleolar protein 7, 27kDa -1.77
RBM19 RNA binding motif protein 19 -1.76
ZNF142 zinc finger protein 142 -1.76
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) -1.75
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -1.74
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 -1.74
GLI4 GLI family zinc finger 4 -1.73
MYBBP1A MYB binding protein (P160) 1a -1.71
BRIX1 BRX1, biogenesis of ribosomes -1.69
ZCCHC9 zinc finger, CCHC domain containing 9 -1.69
KMT5A lysine methyltransferase 5A -1.69
AXIN1 axin 1 -1.69
SKI SKI proto-oncogene -1.69
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -1.68
SCD stearoyl-CoA desaturase (delta-9-desaturase) -1.68
PNO1 partner of NOB1 homolog (S. cerevisiae) -1.67
GIN1 gypsy retrotransposon integrase 1 -1.66
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -1.65
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae) -1.62
C1ORF131 chromosome 1 open reading frame 131 -1.6
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -1.59
NOL6 nucleolar protein 6 (RNA-associated) -1.58
WDR74 WD repeat domain 74 -1.56
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -1.55
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) -1.52
CCDC170 coiled-coil domain containing 170 -1.51
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2 -1.51
LTV1 LTV1 ribosome biogenesis factor -1.47
RAB20 RAB20, member RAS oncogene family -1.47
EREG epiregulin -1.46
NOP14 NOP14 nucleolar protein -1.45
ARHGAP39 Rho GTPase activating protein 39 -1.44
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 -1.44
NIFK nucleolar protein interacting with the FHA domain of MKI67 -1.44
FAM117B family with sequence similarity 117, member B -1.43
RBM28 RNA binding motif protein 28 -1.42
EBNA1BP2 EBNA1 binding protein 2 -1.42
HDAC4 histone deacetylase 4 -1.42
RBM34 RNA binding motif protein 34 -1.4
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -1.39
NECTIN3 nectin cell adhesion molecule 3 -1.36
RNF166 ring finger protein 166 -1.36
SREBF1 sterol regulatory element binding transcription factor 1 -1.36
RTN4R reticulon 4 receptor -1.35
ARFRP1 ADP-ribosylation factor related protein 1 -1.35
RXRA retinoid X receptor, alpha -1.35
RCL1 RNA terminal phosphate cyclase-like 1 -1.34
EDF1 endothelial differentiation-related factor 1 -1.34
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) -1.32
MCRIP2 MAPK regulated corepressor interacting protein 2 -1.32
NOP16 NOP16 nucleolar protein -1.32
CMIP c-Maf inducing protein -1.3
ZNF580 zinc finger protein 580 -1.3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -1.3
LMO4 LIM domain only 4 -1.29
KCTD5 potassium channel tetramerization domain containing 5 -1.29
TMEM129 transmembrane protein 129, E3 ubiquitin protein ligase -1.28
PWWP3A PWWP domain containing 3A, DNA repair factor -1.28
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -1.27
H1-3 H1.3 linker histone, cluster member -1.27
NKIRAS1 NFKB inhibitor interacting Ras-like 1 -1.26