Myelodysplastic Syndrome Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Myelodysplastic syndromes are a class of syndromes which involve ineffective production (or dysplasia) of the myeloid class of blood cells.|A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001) (Experimental Factor Ontology, EFO_0000198)
External Link https://www.disgenet.org/browser/0/1/0/C1268964
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Genes

47 genes associated with the disease Myelodysplastic Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ANXA5 annexin A5
ARHGAP26 Rho GTPase activating protein 26
ATOX1 antioxidant 1 copper chaperone
ATXN1 ataxin 1
CCR7 chemokine (C-C motif) receptor 7
CD14 CD14 molecule
CD34 CD34 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CSNK1A1 casein kinase 1, alpha 1
EGR1 early growth response 1
EPO erythropoietin
F2R coagulation factor II (thrombin) receptor
FANCB Fanconi anemia, complementation group B
FGF1 fibroblast growth factor 1 (acidic)
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GATA2 GATA binding protein 2
GFM1 G elongation factor, mitochondrial 1
GLRA1 glycine receptor, alpha 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
IL12B interleukin 12B
IL3 interleukin 3
IL5 interleukin 5
IRF1 interferon regulatory factor 1
JAK2 Janus kinase 2
KITLG KIT ligand
KLF1 Kruppel-like factor 1 (erythroid)
KMT2A lysine (K)-specific methyltransferase 2A
LARP1 La ribonucleoprotein domain family, member 1
MECOM MDS1 and EVI1 complex locus
MSX2 msh homeobox 2
MYD88 myeloid differentiation primary response 88
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
RARS1 arginyl-tRNA synthetase 1
RPS14 ribosomal protein S14
RUNX1 runt-related transcription factor 1
S100A8 S100 calcium binding protein A8
SETBP1 SET binding protein 1
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
THOP1 thimet oligopeptidase 1
TP53 tumor protein p53
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase