Myelofibrosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A myeloma that is located_in the bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue. (Human Disease Ontology, DOID_4971)
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Genes

719 genes co-occuring with the disease Myelofibrosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
JAK2 Janus kinase 2 3.991
CALR calreticulin 3.655
JAK1 Janus kinase 1 3.5
MPL MPL proto-oncogene, thrombopoietin receptor 3.371
ASXL1 additional sex combs like transcriptional regulator 1 3.346
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 3.315
SRSF2 serine/arginine-rich splicing factor 2 3.123
THPO thrombopoietin 3.093
TET2 tet methylcytosine dioxygenase 2 3.083
BCR breakpoint cluster region 3.063
CD34 CD34 molecule 2.996
U2AF1 U2 small nuclear RNA auxiliary factor 1 2.958
JAK3 Janus kinase 3 2.864
EPO erythropoietin 2.854
FLT3 fms-related tyrosine kinase 3 2.792
TYK2 tyrosine kinase 2 2.772
STAT5B signal transducer and activator of transcription 5B 2.768
SH2B3 SH2B adaptor protein 3 2.763
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.746
STAT5A signal transducer and activator of transcription 5A 2.734
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.68
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.649
RUNX1 runt-related transcription factor 1 2.645
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 2.613
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.608
IFNA1 interferon, alpha 1 2.594
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.579
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.537
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 2.528
EPOR erythropoietin receptor 2.522
IFNA2 interferon, alpha 2 2.521
SETBP1 SET binding protein 1 2.509
IL6 interleukin 6 2.506
IL3 interleukin 3 2.489
NBEAL2 neurobeachin-like 2 2.463
TGFB1 transforming growth factor, beta 1 2.462
CSF3 colony stimulating factor 3 (granulocyte) 2.46
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.43
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 2.413
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.412
IFNA17 interferon, alpha 17 2.394
IFNA14 interferon, alpha 14 2.393
IFNA16 interferon, alpha 16 2.392
IFNA10 interferon, alpha 10 2.392
IFNA7 interferon, alpha 7 2.392
IFNA8 interferon, alpha 8 2.391
IFNA6 interferon, alpha 6 2.391
IFNA21 interferon, alpha 21 2.391
IFNA5 interferon, alpha 5 2.391
IFNA13 interferon, alpha 13 2.39
IFNA4 interferon, alpha 4 2.388
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 2.385
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 2.368
TP53 tumor protein p53 2.354
ETV6 ets variant 6 2.337
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 2.297
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 2.285
CD33 CD33 molecule 2.273
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 2.266
PTPRC protein tyrosine phosphatase, receptor type, C 2.261
STAT1 signal transducer and activator of transcription 1, 91kDa 2.258
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 2.24
MATK megakaryocyte-associated tyrosine kinase 2.238
PDGFRB platelet-derived growth factor receptor, beta polypeptide 2.235
IFNG interferon, gamma 2.229
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.204
CD38 CD38 molecule 2.172
FEN1 flap structure-specific endonuclease 1 2.169
TNF tumor necrosis factor 2.166
KITLG KIT ligand 2.163
ACVR1 activin A receptor, type I 2.163
FIP1L1 factor interacting with PAPOLA and CPSF1 2.162
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.159
IL1B interleukin 1, beta 2.155
BCL2L1 BCL2-like 1 2.151
MPO myeloperoxidase 2.142
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 2.132
PF4 platelet factor 4 2.128
CD19 CD19 molecule 2.111
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.108
CXCL12 chemokine (C-X-C motif) ligand 12 2.107
CD8A CD8a molecule 2.106
CD4 CD4 molecule 2.104
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 2.104
GATA2 GATA binding protein 2 2.102
PTPN11 protein tyrosine phosphatase, non-receptor type 11 2.096
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.091
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 2.091
ANPEP alanyl (membrane) aminopeptidase 2.077
IL2 interleukin 2 2.069
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2.058
LCK LCK proto-oncogene, Src family tyrosine kinase 2.047
IL7 interleukin 7 2.046
BCL2 B-cell CLL/lymphoma 2 2.039
HAMP hepcidin antimicrobial peptide 2.037
FGFR1 fibroblast growth factor receptor 1 2.027
MTOR mechanistic target of rapamycin (serine/threonine kinase) 2.025
IL15 interleukin 15 2.022
VWF von Willebrand factor 2.02
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.012
CRP C-reactive protein, pentraxin-related 2.012
IL3RA interleukin 3 receptor, alpha (low affinity) 1.995
IL1A interleukin 1, alpha 1.995
STAG2 stromal antigen 2 1.994
CXCR4 chemokine (C-X-C motif) receptor 4 1.994
SETD2 SET domain containing 2 1.99
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 1.988
KRAS Kirsten rat sarcoma viral oncogene homolog 1.987
CXCL8 chemokine (C-X-C motif) ligand 8 1.983
BTK Bruton agammaglobulinemia tyrosine kinase 1.982
IL10 interleukin 10 1.977
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.956
GLI1 GLI family zinc finger 1 1.953
NFE2 nuclear factor, erythroid 2 1.952
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 1.952
FN1 fibronectin 1 1.95
IL11 interleukin 11 1.949
APCS amyloid P component, serum 1.939
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.937
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 1.935
IRAK1 interleukin-1 receptor-associated kinase 1 1.931
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.929
CD7 CD7 molecule 1.926
SLAMF1 signaling lymphocytic activation molecule family member 1 1.925
TFRC transferrin receptor 1.915
NCAM1 neural cell adhesion molecule 1 1.904
BRD4 bromodomain containing 4 1.903
GYPA glycophorin A (MNS blood group) 1.899
IL4 interleukin 4 1.89
WT1 Wilms tumor 1 1.885
FGF2 fibroblast growth factor 2 (basic) 1.88
ZNF77 zinc finger protein 77 1.873
AAK1 AP2 associated kinase 1 1.872
GFI1B growth factor independent 1B transcription repressor 1.869
CD5 CD5 molecule 1.863
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.862
CISH cytokine inducible SH2-containing protein 1.861
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.859
SOCS3 suppressor of cytokine signaling 3 1.855
RARA retinoic acid receptor, alpha 1.852
ETNK1 ethanolamine kinase 1 1.85
IL2RA interleukin 2 receptor, alpha 1.844
MECOM MDS1 and EVI1 complex locus 1.84
SOCS1 suppressor of cytokine signaling 1 1.84
IL17A interleukin 17A 1.838
KDM1A lysine (K)-specific demethylase 1A 1.837
MCL1 myeloid cell leukemia 1 1.833
PTH parathyroid hormone 1.821
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.811
CD177 CD177 molecule 1.81
CCL3 chemokine (C-C motif) ligand 3 1.808
ALB albumin 1.806
STAT2 signal transducer and activator of transcription 2, 113kDa 1.801
LOXL2 lysyl oxidase-like 2 1.8
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 1.798
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 1.798
HDAC9 histone deacetylase 9 1.794
TERT telomerase reverse transcriptase 1.791
CXCL10 chemokine (C-X-C motif) ligand 10 1.781
SYK spleen tyrosine kinase 1.775
KMT2A lysine (K)-specific methyltransferase 2A 1.765
H3C13 H3 clustered histone 13 1.764
H3C12 H3 clustered histone 12 1.763
H3-3B H3.3 histone B 1.76
H3-4 H3.4 histone, cluster member 1.76
H3-5 H3.5 histone 1.76
CUX1 cut-like homeobox 1 1.755
PHF6 PHD finger protein 6 1.752
LYN LYN proto-oncogene, Src family tyrosine kinase 1.744
AURKA aurora kinase A 1.743
CD274 CD274 molecule 1.741
FLT3LG fms-related tyrosine kinase 3 ligand 1.735
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.729
IL13 interleukin 13 1.728
EGFR epidermal growth factor receptor 1.727
CD48 CD48 molecule 1.725
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.72
IL9 interleukin 9 1.719
SUZ12 SUZ12 polycomb repressive complex 2 subunit 1.712
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.711
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 1.707
CCL2 chemokine (C-C motif) ligand 2 1.704
F2 coagulation factor II (thrombin) 1.701
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 1.701
LOX lysyl oxidase 1.701
F3 coagulation factor III (thromboplastin, tissue factor) 1.698
MYB v-myb avian myeloblastosis viral oncogene homolog 1.692
CSF1R colony stimulating factor 1 receptor 1.692
MME membrane metallo-endopeptidase 1.685
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.682
SPN sialophorin 1.682
CHP1 calcineurin-like EF-hand protein 1 1.681
CD2 CD2 molecule 1.68
MAPRE2 microtubule-associated protein, RP/EB family, member 2 1.678
IL5 interleukin 5 1.674
BCORL1 BCL6 corepressor-like 1 1.669
MAPK3 mitogen-activated protein kinase 3 1.666
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.665
CD68 CD68 molecule 1.659
CCND1 cyclin D1 1.657
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.656
EVPL envoplakin 1.656
CCL4 chemokine (C-C motif) ligand 4 1.654
LOC102723407 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 1.653
CRLF2 cytokine receptor-like factor 2 1.649
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 1.646
LEPR leptin receptor 1.645
THY1 Thy-1 cell surface antigen 1.643
RDX radixin 1.639
EGF epidermal growth factor 1.63
VAV1 vav 1 guanine nucleotide exchange factor 1.63
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.628
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.627
IL6R interleukin 6 receptor 1.626
SSBP2 single-stranded DNA binding protein 2 1.622
HOXA9 homeobox A9 1.613
PRMT5 protein arginine methyltransferase 5 1.61
PF4V1 platelet factor 4 variant 1 1.61
NES nestin 1.608
OSM oncostatin M 1.604
NUP98 nucleoporin 98kDa 1.598
MSN moesin 1.597
GAK cyclin G associated kinase 1.594
JARID2 jumonji, AT rich interactive domain 2 1.594
IFNB1 interferon, beta 1, fibroblast 1.589
MX1 MX dynamin-like GTPase 1 1.589
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.587
SLCO2A1 solute carrier organic anion transporter family, member 2A1 1.587
ANKRD26 ankyrin repeat domain 26 1.585
GOLGA4 golgin A4 1.582
ALK anaplastic lymphoma receptor tyrosine kinase 1.582
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.582
BRD2 bromodomain containing 2 1.58
CCL5 chemokine (C-C motif) ligand 5 1.577
VCAM1 vascular cell adhesion molecule 1 1.575
ENG endoglin 1.575
CSF1 colony stimulating factor 1 (macrophage) 1.574
IL7R interleukin 7 receptor 1.574
SDC1 syndecan 1 1.572
BCL2L2 BCL2-like 2 1.571
PAX5 paired box 5 1.57
ANXA5 annexin A5 1.569
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.568
BRDT bromodomain, testis-specific 1.563
IL2RG interleukin 2 receptor, gamma 1.559
SF3B1 splicing factor 3b, subunit 1, 155kDa 1.559
FGF4 fibroblast growth factor 4 1.557
SPI1 Spi-1 proto-oncogene 1.557
CD22 CD22 molecule 1.556
NF1 neurofibromin 1 1.553
MYH11 myosin, heavy chain 11, smooth muscle 1.55
CXCL9 chemokine (C-X-C motif) ligand 9 1.549
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.547
RPS14 ribosomal protein S14 1.546
IL18 interleukin 18 1.545
B2M beta-2-microglobulin 1.545
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.544
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 1.54
PECAM1 platelet/endothelial cell adhesion molecule 1 1.538
GSKIP GSK3B interacting protein 1.535
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.535
VPS33B vacuolar protein sorting 33 homolog B (yeast) 1.534
PXDNL peroxidasin-like 1.53
NOTCH1 notch 1 1.529
PXDN peroxidasin 1.529
EZR ezrin 1.527
STAT4 signal transducer and activator of transcription 4 1.526
BRD3 bromodomain containing 3 1.525
CD44 CD44 molecule (Indian blood group) 1.524
FGF3 fibroblast growth factor 3 1.524
IFNAR1 interferon (alpha, beta and omega) receptor 1 1.522
FGF6 fibroblast growth factor 6 1.519
FGF22 fibroblast growth factor 22 1.518
KLF1 Kruppel-like factor 1 (erythroid) 1.518
HMGA2 high mobility group AT-hook 2 1.518
CDKN2A cyclin-dependent kinase inhibitor 2A 1.517
FGF7 fibroblast growth factor 7 1.516
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog 1.516
FGF16 fibroblast growth factor 16 1.516
FGF5 fibroblast growth factor 5 1.515
FGF17 fibroblast growth factor 17 1.515
FGF20 fibroblast growth factor 20 1.513
FGF9 fibroblast growth factor 9 1.513
FGF18 fibroblast growth factor 18 1.511
PCM1 pericentriolar material 1 1.509
SMAD2 SMAD family member 2 1.508
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 1.506
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.505
FGF8 fibroblast growth factor 8 (androgen-induced) 1.5
FGF10 fibroblast growth factor 10 1.499
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 1.499
HLA-A major histocompatibility complex, class I, A 1.498
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 1.497
EPB41 erythrocyte membrane protein band 4.1 1.49
DIABLO diablo, IAP-binding mitochondrial protein 1.489
FOXP3 forkhead box P3 1.489
GP6 glycoprotein VI (platelet) 1.488
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.486
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 1.486
IL22 interleukin 22 1.486
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 1.485
SPP1 secreted phosphoprotein 1 1.484
COL1A1 collagen, type I, alpha 1 1.481
ZFPM1 zinc finger protein, FOG family member 1 1.48
MYD88 myeloid differentiation primary response 88 1.467
PARP1 poly (ADP-ribose) polymerase 1 1.464
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.464
CD79A CD79a molecule, immunoglobulin-associated alpha 1.46
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 1.459
ACTB actin, beta 1.459
KDR kinase insert domain receptor 1.458
BCL6 B-cell CLL/lymphoma 6 1.456
MMP9 matrix metallopeptidase 9 1.453
ATM ATM serine/threonine kinase 1.453
SOCS2 suppressor of cytokine signaling 2 1.452
KDM6A lysine (K)-specific demethylase 6A 1.451
MRTFA myocardin related transcription factor A 1.449
ERBB2 erb-b2 receptor tyrosine kinase 2 1.449
CD1C CD1c molecule 1.44
JUN jun proto-oncogene 1.437
CHIC2 cysteine-rich hydrophobic domain 2 1.436
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.434
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.431
TIMP1 TIMP metallopeptidase inhibitor 1 1.428
CBFB core-binding factor, beta subunit 1.422
ACP5 acid phosphatase 5, tartrate resistant 1.42
MAP2K1 mitogen-activated protein kinase kinase 1 1.42
DNTT DNA nucleotidylexotransferase 1.418
RUNX2 runt-related transcription factor 2 1.418
TLR4 toll-like receptor 4 1.414
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 1.414
PTEN phosphatase and tensin homolog 1.413
CD47 CD47 molecule 1.409
TAL1 T-cell acute lymphocytic leukemia 1 1.408
IRAK4 interleukin-1 receptor-associated kinase 4 1.406
FER fer (fps/fes related) tyrosine kinase 1.404
CDK4 cyclin-dependent kinase 4 1.398
TGFBR1 transforming growth factor, beta receptor 1 1.396
RET ret proto-oncogene 1.393
PDGFA platelet-derived growth factor alpha polypeptide 1.393
EED embryonic ectoderm development 1.39
CDC42 cell division cycle 42 1.388
MEIS1 Meis homeobox 1 1.388
LMO2 LIM domain only 2 (rhombotin-like 1) 1.387
PIM2 Pim-2 proto-oncogene, serine/threonine kinase 1.387
CD59 CD59 molecule, complement regulatory protein 1.387
SLAMF7 SLAM family member 7 1.386
IFNAR2 interferon (alpha, beta and omega) receptor 2 1.385
ZMYM2 zinc finger, MYM-type 2 1.384
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 1.384
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.383
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 1.383
SMAD3 SMAD family member 3 1.382
DOT1L DOT1-like histone H3K79 methyltransferase 1.381
CRBN cereblon 1.38
CD1A CD1a molecule 1.379
CD52 CD52 molecule 1.378
ANGPT1 angiopoietin 1 1.378
LIF leukemia inhibitory factor 1.377
NUP214 nucleoporin 214kDa 1.377
IL1R1 interleukin 1 receptor, type I 1.373
THBS1 thrombospondin 1 1.37
CD1E CD1e molecule 1.369
HP haptoglobin 1.368
TGFB3 transforming growth factor, beta 3 1.368
CD28 CD28 molecule 1.365
TEK TEK tyrosine kinase, endothelial 1.364
SMC3 structural maintenance of chromosomes 3 1.364
GP9 glycoprotein IX (platelet) 1.361
TET1 tet methylcytosine dioxygenase 1 1.36
AGO2 argonaute RISC catalytic component 2 1.359
CD1B CD1b molecule 1.358
IRF9 interferon regulatory factor 9 1.356
IGF1 insulin-like growth factor 1 (somatomedin C) 1.354
EP300 E1A binding protein p300 1.353
BIRC5 baculoviral IAP repeat containing 5 1.351
KDM4C lysine (K)-specific demethylase 4C 1.351
CD1D CD1d molecule 1.351
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 1.35
AFF1 AF4/FMR2 family, member 1 1.346
CDK6 cyclin-dependent kinase 6 1.343
NLRP3 NLR family, pyrin domain containing 3 1.341
CCR2 chemokine (C-C motif) receptor 2 1.338
CD36 CD36 molecule (thrombospondin receptor) 1.335
ASXL2 additional sex combs like transcriptional regulator 2 1.334
CXCR1 chemokine (C-X-C motif) receptor 1 1.332
LCN2 lipocalin 2 1.33
CD27 CD27 molecule 1.327
CD163 CD163 molecule 1.325
ACE2 angiotensin I converting enzyme 2 1.324
BAX BCL2-associated X protein 1.323
SP7 Sp7 transcription factor 1.32
PLEK pleckstrin 1.318
ACE angiotensin I converting enzyme 1.318
SIRPA signal-regulatory protein alpha 1.317
SCARB2 scavenger receptor class B, member 2 1.314
AURKB aurora kinase B 1.31
BMP4 bone morphogenetic protein 4 1.309
ITGAV integrin, alpha V 1.309
CXCR2 chemokine (C-X-C motif) receptor 2 1.308
IL31 interleukin 31 1.306
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.303
CD86 CD86 molecule 1.303
PIAS3 protein inhibitor of activated STAT, 3 1.302
THBD thrombomodulin 1.302
FASLG Fas ligand (TNF superfamily, member 6) 1.301
TSLP thymic stromal lymphopoietin 1.301
FGR FGR proto-oncogene, Src family tyrosine kinase 1.301
CD40LG CD40 ligand 1.301
PLEK2 pleckstrin 2 1.3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.298
FLT1 fms-related tyrosine kinase 1 1.296
CLEC1B C-type lectin domain family 1, member B 1.296
SMO smoothened, frizzled class receptor 1.296
JAG1 jagged 1 1.295
RAD21 RAD21 homolog (S. pombe) 1.293
SCARB1 scavenger receptor class B, member 1 1.292
MYOM2 myomesin 2 1.291
RBM15 RNA binding motif protein 15 1.291
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.289
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 1.287
ICAM1 intercellular adhesion molecule 1 1.287
ELN elastin 1.286
ITK IL2-inducible T-cell kinase 1.285
TGFB2 transforming growth factor, beta 2 1.284
RHOA ras homolog family member A 1.284
NT5E 5'-nucleotidase, ecto (CD73) 1.284
GNAS GNAS complex locus 1.283
PROM1 prominin 1 1.281
CD80 CD80 molecule 1.28
HDAC6 histone deacetylase 6 1.28
HBS1L HBS1-like translational GTPase 1.278
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.278
KLRK1 killer cell lectin-like receptor subfamily K, member 1 1.277
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 1.274
PTCH1 patched 1 1.272
LEP leptin 1.272
PDCD1 programmed cell death 1 1.271
BGLAP bone gamma-carboxyglutamate (gla) protein 1.271
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.27
POSTN periostin, osteoblast specific factor 1.27
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 1.269
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.264
SOCS4 suppressor of cytokine signaling 4 1.264
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 1.262
CHEK2 checkpoint kinase 2 1.259
CD9 CD9 molecule 1.258
HEXIM1 hexamethylene bis-acetamide inducible 1 1.258
IFI27 interferon, alpha-inducible protein 27 1.257
SHH sonic hedgehog 1.254
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 1.253
ELANE elastase, neutrophil expressed 1.251
NGFR nerve growth factor receptor 1.248
CXCR3 chemokine (C-X-C motif) receptor 3 1.247
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.246
CDK9 cyclin-dependent kinase 9 1.244
LOXL1 lysyl oxidase-like 1 1.244
HAVCR2 hepatitis A virus cellular receptor 2 1.242
SMAD4 SMAD family member 4 1.241
TET3 tet methylcytosine dioxygenase 3 1.239
SELPLG selectin P ligand 1.239
PRF1 perforin 1 (pore forming protein) 1.239
DEK DEK proto-oncogene 1.238
CREBBP CREB binding protein 1.233
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.232
LOXL3 lysyl oxidase-like 3 1.229
GP1BB glycoprotein Ib (platelet), beta polypeptide 1.229
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.229
BMI1 BMI1 proto-oncogene, polycomb ring finger 1.229
IL4R interleukin 4 receptor 1.227
KDM5A lysine (K)-specific demethylase 5A 1.227
COMMD3-BMI1 COMMD3-BMI1 readthrough 1.227
TBK1 TANK-binding kinase 1 1.226
MMP2 matrix metallopeptidase 2 1.225
MYH9 myosin, heavy chain 9, non-muscle 1.223
ATG2B autophagy related 2B 1.222
IFNGR1 interferon gamma receptor 1 1.221
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.22
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.216
IRF1 interferon regulatory factor 1 1.216
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.213
BMP7 bone morphogenetic protein 7 1.21
EPB42 erythrocyte membrane protein band 4.2 1.208
PKM pyruvate kinase, muscle 1.208
ACVR2A activin A receptor, type IIA 1.206
ALAS2 5'-aminolevulinate synthase 2 1.206
SEC31A SEC31 homolog A (S. cerevisiae) 1.205
IDO1 indoleamine 2,3-dioxygenase 1 1.204
GLIS2 GLIS family zinc finger 2 1.203
BRCA1 breast cancer 1, early onset 1.203
BMP6 bone morphogenetic protein 6 1.202
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.202
ESR1 estrogen receptor 1 1.201
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.2
IRF3 interferon regulatory factor 3 1.2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.2
CDH5 cadherin 5, type 2 (vascular endothelium) 1.196
HRAS Harvey rat sarcoma viral oncogene homolog 1.195
PRL prolactin 1.194
IRF4 interferon regulatory factor 4 1.192
SELE selectin E 1.192
SMC1A structural maintenance of chromosomes 1A 1.191
FKBP4 FK506 binding protein 4, 59kDa 1.191
MCAM melanoma cell adhesion molecule 1.189
XPO1 exportin 1 1.189
PDGFB platelet-derived growth factor beta polypeptide 1.188
PIM3 Pim-3 proto-oncogene, serine/threonine kinase 1.187
SELL selectin L 1.187
EBF1 early B-cell factor 1 1.186
ASPG asparaginase 1.185
IGF1R insulin-like growth factor 1 receptor 1.185
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.185
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.184
FGF23 fibroblast growth factor 23 1.183
CCL11 chemokine (C-C motif) ligand 11 1.182
IL6ST interleukin 6 signal transducer 1.182
SOX2 SRY (sex determining region Y)-box 2 1.18
HDAC1 histone deacetylase 1 1.179
COL3A1 collagen, type III, alpha 1 1.179
HCK HCK proto-oncogene, Src family tyrosine kinase 1.178
GFI1 growth factor independent 1 transcription repressor 1.177
CCN2 cellular communication network factor 2 1.176
PCGF1 polycomb group ring finger 1 1.176
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.175
GSK3B glycogen synthase kinase 3 beta 1.175
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 1.174
IRF7 interferon regulatory factor 7 1.17
AXL AXL receptor tyrosine kinase 1.168
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 1.167
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 1.167
TUBB tubulin, beta class I 1.166
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 1.166
PTS 6-pyruvoyltetrahydropterin synthase 1.164
AR androgen receptor 1.163
PDCD1LG2 programmed cell death 1 ligand 2 1.163
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 1.162
B3GAT1 beta-1,3-glucuronyltransferase 1 1.16
BMP1 bone morphogenetic protein 1 1.159
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.158
EGR1 early growth response 1 1.158
SOCS7 suppressor of cytokine signaling 7 1.157
BMP2 bone morphogenetic protein 2 1.155
GDF11 growth differentiation factor 11 1.154
CHEK1 checkpoint kinase 1 1.152
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.152
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 1.15
RBBP6 retinoblastoma binding protein 6 1.15
CD40 CD40 molecule, TNF receptor superfamily member 5 1.148
PRPF8 pre-mRNA processing factor 8 1.148
LOXL4 lysyl oxidase-like 4 1.147
SOCS6 suppressor of cytokine signaling 6 1.147
FYN FYN proto-oncogene, Src family tyrosine kinase 1.147
KLF4 Kruppel-like factor 4 (gut) 1.146
CDK2 cyclin-dependent kinase 2 1.144
GRB2 growth factor receptor-bound protein 2 1.142
INSL6 insulin-like 6 1.142
AIM2 absent in melanoma 2 1.142
CDK1 cyclin-dependent kinase 1 1.141
GAB2 GRB2-associated binding protein 2 1.141
SBDS Shwachman-Bodian-Diamond syndrome 1.139
BCL2A1 BCL2-related protein A1 1.139
PTPN6 protein tyrosine phosphatase, non-receptor type 6 1.138
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 1.138
CTF1 cardiotrophin 1 1.137
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 1.137
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 1.136
TBX21 T-box 21 1.133
PBX1 pre-B-cell leukemia homeobox 1 1.133
INSL4 insulin-like 4 (placenta) 1.132
DEFA4 defensin, alpha 4, corticostatin 1.13
TLR3 toll-like receptor 3 1.129
SOST sclerostin 1.129
PTPN2 protein tyrosine phosphatase, non-receptor type 2 1.128
GLI2 GLI family zinc finger 2 1.128
CYCS cytochrome c, somatic 1.128
IL19 interleukin 19 1.128
FOS FBJ murine osteosarcoma viral oncogene homolog 1.128
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 1.127
PLG plasminogen 1.125
IL33 interleukin 33 1.125
DKK1 dickkopf WNT signaling pathway inhibitor 1 1.125
TMPRSS2 transmembrane protease, serine 2 1.123
PLK1 polo-like kinase 1 1.122
MET MET proto-oncogene, receptor tyrosine kinase 1.121
HSPA4 heat shock 70kDa protein 4 1.118
INS insulin 1.117
STIM1 stromal interaction molecule 1 1.116
CD63 CD63 molecule 1.114
LUC7L2 LUC7-like 2 (S. cerevisiae) 1.113
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.113
ISG15 ISG15 ubiquitin-like modifier 1.112
KMT2C lysine (K)-specific methyltransferase 2C 1.112
IL1RAP interleukin 1 receptor accessory protein 1.109
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.109
COL1A2 collagen, type I, alpha 2 1.108
FOXO3 forkhead box O3 1.107
CSNK1A1 casein kinase 1, alpha 1 1.105
RAG2 recombination activating gene 2 1.105
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 1.104
SF3A1 splicing factor 3a, subunit 1, 120kDa 1.103
FGF13 fibroblast growth factor 13 1.102
F7 coagulation factor VII (serum prothrombin conversion accelerator) 1.1
TCF3 transcription factor 3 1.1
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 1.1
F8 coagulation factor VIII, procoagulant component 1.098
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.098
FGFR3 fibroblast growth factor receptor 3 1.097
CR2 complement component (3d/Epstein Barr virus) receptor 2 1.097
ARG1 arginase 1 1.096
TLR7 toll-like receptor 7 1.096
OSMR oncostatin M receptor 1.096
MDM4 MDM4, p53 regulator 1.095
NSD1 nuclear receptor binding SET domain protein 1 1.094
HOXB4 homeobox B4 1.093
KAT6A K(lysine) acetyltransferase 6A 1.093
CTSG cathepsin G 1.092
POU5F1 POU class 5 homeobox 1 1.09
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 1.09
DPP4 dipeptidyl-peptidase 4 1.089
IKZF3 IKAROS family zinc finger 3 (Aiolos) 1.089
USB1 U6 snRNA biogenesis 1 1.086
PI3 peptidase inhibitor 3, skin-derived 1.086
IKZF5 IKAROS family zinc finger 5 (Pegasus) 1.083
MPND MPN domain containing 1.082
PPARG peroxisome proliferator-activated receptor gamma 1.082
CALML3 calmodulin-like 3 1.082
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 1.08
PTX3 pentraxin 3, long 1.077
CALML6 calmodulin-like 6 1.076
TLR9 toll-like receptor 9 1.076
CALML4 calmodulin-like 4 1.076
NAAA N-acylethanolamine acid amidase 1.075
PTPN1 protein tyrosine phosphatase, non-receptor type 1 1.075
CALML5 calmodulin-like 5 1.073
CSK c-src tyrosine kinase 1.072
PRTN3 proteinase 3 1.07
KMT2D lysine (K)-specific methyltransferase 2D 1.07
EPAS1 endothelial PAS domain protein 1 1.069
LIFR leukemia inhibitory factor receptor alpha 1.069
NOTCH2 notch 2 1.069
BIRC2 baculoviral IAP repeat containing 2 1.068
FMC1-LUC7L2 FMC1-LUC7L2 readthrough 1.067
F2R coagulation factor II (thrombin) receptor 1.067
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.066
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 1.066
CLEC12A C-type lectin domain family 12, member A 1.065
CCND2 cyclin D2 1.064
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.064
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 1.062
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.062
CD69 CD69 molecule 1.061
CXCL5 chemokine (C-X-C motif) ligand 5 1.06
BPGM 2,3-bisphosphoglycerate mutase 1.057
FKBP5 FK506 binding protein 5 1.056
CD164 CD164 molecule, sialomucin 1.055
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 1.055
EGLN1 egl-9 family hypoxia-inducible factor 1 1.054
H2AC20 H2A clustered histone 20 1.053
IRF8 interferon regulatory factor 8 1.053
H2AC18 H2A clustered histone 18 1.052
PCGF2 polycomb group ring finger 2 1.052
FAS Fas cell surface death receptor 1.052
PROCR protein C receptor, endothelial 1.052
U2AF2 U2 small nuclear RNA auxiliary factor 2 1.051
KLRC1 killer cell lectin-like receptor subfamily C, member 1 1.05
CXCL2 chemokine (C-X-C motif) ligand 2 1.048
RARG retinoic acid receptor, gamma 1.047
HDAC11 histone deacetylase 11 1.047
SAA2 serum amyloid A2 1.047
CD24 CD24 molecule 1.046
UBA1 ubiquitin-like modifier activating enzyme 1 1.044
CEP70 centrosomal protein 70kDa 1.044
DIAPH1 diaphanous-related formin 1 1.042
KDM2B lysine (K)-specific demethylase 2B 1.041
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.039
CD79B CD79b molecule, immunoglobulin-associated beta 1.039
ERVW-1 endogenous retrovirus group W, member 1 1.039
PDIA3 protein disulfide isomerase family A, member 3 1.037
GATA3 GATA binding protein 3 1.035
PTK2 protein tyrosine kinase 2 1.035
ATRX alpha thalassemia/mental retardation syndrome X-linked 1.035
H4C6 H4 clustered histone 6 1.035
DLL4 delta-like 4 (Drosophila) 1.034
MAPK1 mitogen-activated protein kinase 1 1.033
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.032
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.031
PRDM1 PR domain containing 1, with ZNF domain 1.03
HJV hemojuvelin BMP co-receptor 1.029
DICER1 dicer 1, ribonuclease type III 1.029
CBX5 chromobox homolog 5 1.027
H4C7 H4 clustered histone 7 1.027
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.025
SAA1 serum amyloid A1 1.025
EDN1 endothelin 1 1.025
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1.024
FLT4 fms-related tyrosine kinase 4 1.024
ACVR2B activin A receptor, type IIB 1.023
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) 1.02
NOG noggin 1.017
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.017
SMAD7 SMAD family member 7 1.016
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 1.015
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.012
IL10RA interleukin 10 receptor, alpha 1.012
IL13RA1 interleukin 13 receptor, alpha 1 1.01
TLR2 toll-like receptor 2 1.01
PRKDC protein kinase, DNA-activated, catalytic polypeptide 1.01
CCR7 chemokine (C-C motif) receptor 7 1.01
ERV3-1 endogenous retrovirus group 3, member 1 1.01
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 1.009
MAPK14 mitogen-activated protein kinase 14 1.008
KAT2B K(lysine) acetyltransferase 2B 1.007
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 1.007
NANOG Nanog homeobox 1.004
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.003
BRCA2 breast cancer 2, early onset 1.003
LYST lysosomal trafficking regulator 1.002
DUSP3 dual specificity phosphatase 3 1.002
IL12RB1 interleukin 12 receptor, beta 1 1.001