Myelofibrosis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A myeloma that is located_in the bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue. (Human Disease Ontology, DOID_4971)
External Link https://www.disgenet.org/browser/0/1/0/C0026987
Similar Terms
Downloads & Tools

Genes

168 genes associated with the disease Myelofibrosis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKR1C4 aldo-keto reductase family 1, member C4
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALPI alkaline phosphatase, intestinal
ALPP alkaline phosphatase, placental
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ASXL1 additional sex combs like transcriptional regulator 1
ATN1 atrophin 1
AURKA aurora kinase A
BCR breakpoint cluster region
BMF Bcl2 modifying factor
BMP6 bone morphogenetic protein 6
BORA bora, aurora kinase A activator
C6ORF25 chromosome 6 open reading frame 25
CALR calreticulin
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CD177 CD177 molecule
CD34 CD34 molecule
CD47 CD47 molecule
CDK2 cyclin-dependent kinase 2
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIT1 chitinase 1 (chitotriosidase)
CIP2A cellular inhibitor of PP2A
CRP C-reactive protein, pentraxin-related
CSF3 colony stimulating factor 3 (granulocyte)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUX1 cut-like homeobox 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
DAPK1 death-associated protein kinase 1
DERL1 derlin 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EBI3 Epstein-Barr virus induced 3
EDA ectodysplasin A
ELN elastin
EPO erythropoietin
ETV6 ets variant 6
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FGF2 fibroblast growth factor 2 (basic)
FGF3 fibroblast growth factor 3
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FN1 fibronectin 1
FXYD5 FXYD domain containing ion transport regulator 5
FZD2 frizzled class receptor 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GATA1 GATA binding protein 1 (globin transcription factor 1)
GFI1B growth factor independent 1B transcription repressor
GLI1 GLI family zinc finger 1
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMGXB3 HMG box domain containing 3
HP haptoglobin
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB1 heat shock 27kDa protein 1
HSPB2 heat shock 27kDa protein 2
HSPB3 heat shock 27kDa protein 3
IAPP islet amyloid polypeptide
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNA2 interferon, alpha 2
IFNG interferon, gamma
IL18R1 interleukin 18 receptor 1
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2RA interleukin 2 receptor, alpha
INTS1 integrator complex subunit 1
INTS2 integrator complex subunit 2
IRAK1 interleukin-1 receptor-associated kinase 1
JAK1 Janus kinase 1
JAK2 Janus kinase 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT7 keratin 7, type II
LEP leptin
LEPR leptin receptor
LIG3 ligase III, DNA, ATP-dependent
LOX lysyl oxidase
MAGT1 magnesium transporter 1
MAPK8 mitogen-activated protein kinase 8
MMP8 matrix metallopeptidase 8
MMRN1 multimerin 1
MPL MPL proto-oncogene, thrombopoietin receptor
MRPL28 mitochondrial ribosomal protein L28
MVD mevalonate (diphospho) decarboxylase
MYB v-myb avian myeloblastosis viral oncogene homolog
MYOM2 myomesin 2
NBEAL2 neurobeachin-like 2
NCOR2 nuclear receptor corepressor 2
NFE2 nuclear factor, erythroid 2
NFE2L2 nuclear factor, erythroid 2-like 2
NOG noggin
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NXT1 nuclear transport factor 2-like export factor 1
PAEP progestagen-associated endometrial protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLK1 polo-like kinase 1
PRB1 proline-rich protein BstNI subfamily 1
PRSS27 protease, serine 27
PTH parathyroid hormone
PTHLH parathyroid hormone-like hormone
PYCARD PYD and CARD domain containing
RARB retinoic acid receptor, beta
RARS1 arginyl-tRNA synthetase 1
RPS14 ribosomal protein S14
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SCLY selenocysteine lyase
SCT secretin
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SETBP1 SET binding protein 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SGSM3 small G protein signaling modulator 3
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SNRPF small nuclear ribonucleoprotein polypeptide F
SOAT1 sterol O-acyltransferase 1
SOCS3 suppressor of cytokine signaling 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
SRSF2 serine/arginine-rich splicing factor 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STS steroid sulfatase (microsomal), isozyme S
SUB1 SUB1 homolog (S. cerevisiae)
TAC1 tachykinin, precursor 1
TAL1 T-cell acute lymphocytic leukemia 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBK1 TANK-binding kinase 1
TET2 tet methylcytosine dioxygenase 2
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THPO thrombopoietin
THY1 Thy-1 cell surface antigen
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TP53 tumor protein p53
TPO thyroid peroxidase
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)
WNT1 wingless-type MMTV integration site family, member 1
WT1 Wilms tumor 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZMYM2 zinc finger, MYM-type 2