Myelomeningocele Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A spina bifida characterized by protrusion of the spinal cord through an opening, covered by meningeal membranes. (Human Disease Ontology, DOID_0060326)
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Genes

193 genes co-occuring with the disease Myelomeningocele in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
VANGL1 VANGL planar cell polarity protein 1 2.606
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 2.444
VANGL2 VANGL planar cell polarity protein 2 2.381
PRICKLE1 prickle homolog 1 (Drosophila) 2.269
PRICKLE2 prickle homolog 2 (Drosophila) 2.188
FZD6 frizzled class receptor 6 2.105
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 2.097
GRHL3 grainyhead-like 3 (Drosophila) 2.09
SHROOM3 shroom family member 3 2.075
SCRIB scribbled planar cell polarity protein 2.019
PTK7 protein tyrosine kinase 7 (inactive) 2.003
AFP alpha-fetoprotein 2.002
DVL2 dishevelled segment polarity protein 2 1.981
DVL3 dishevelled segment polarity protein 3 1.916
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 1.872
DVL1 dishevelled segment polarity protein 1 1.857
PRICKLE3 prickle homolog 3 (Drosophila) 1.843
MNX1 motor neuron and pancreas homeobox 1 1.84
FOLR2 folate receptor 2 (fetal) 1.838
SLC19A1 solute carrier family 19 (folate transporter), member 1 1.815
PRICKLE4 prickle homolog 4 (Drosophila) 1.813
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 1.812
ANKRD6 ankyrin repeat domain 6 1.796
C2CD3 C2 calcium-dependent domain containing 3 1.793
PAX3 paired box 3 1.782
FOLR1 folate receptor 1 (adult) 1.767
FAM171B family with sequence similarity 171, member B 1.763
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 1.718
FUZ fuzzy planar cell polarity protein 1.718
SHH sonic hedgehog 1.709
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 1.705
GFAP glial fibrillary acidic protein 1.664
GLDC glycine dehydrogenase (decarboxylating) 1.652
C6ORF118 chromosome 6 open reading frame 118 1.645
ZIC2 Zic family member 2 1.636
PTPRU protein tyrosine phosphatase, receptor type, U 1.626
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 1.623
SLC46A1 solute carrier family 46 (folate transporter), member 1 1.614
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 1.608
TULP3 tubby like protein 3 1.599
CCDC88C coiled-coil domain containing 88C 1.578
FZD3 frizzled class receptor 3 1.554
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 1.542
INTU inturned planar cell polarity protein 1.54
DACT1 dishevelled-binding antagonist of beta-catenin 1 1.533
NKX2-8 NK2 homeobox 8 1.521
BHMT betaine--homocysteine S-methyltransferase 1.516
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 1.512
SEC24B SEC24 family member B 1.508
MPDZ multiple PDZ domain protein 1.505
LRP6 low density lipoprotein receptor-related protein 6 1.505
ERMARD ER membrane-associated RNA degradation 1.484
L1CAM L1 cell adhesion molecule 1.479
NES nestin 1.478
FOLR3 folate receptor 3 (gamma) 1.476
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 1.475
FZD9 frizzled class receptor 9 1.474
CST3 cystatin C 1.448
BHMT2 betaine--homocysteine S-methyltransferase 2 1.446
FREM2 FRAS1 related extracellular matrix protein 2 1.434
ITPK1 inositol-tetrakisphosphate 1-kinase 1.427
AMT aminomethyltransferase 1.423
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 1.419
GLI3 GLI family zinc finger 3 1.418
AS3MT arsenite methyltransferase 1.409
ZC3H6 zinc finger CCCH-type containing 6 1.407
NGF nerve growth factor (beta polypeptide) 1.398
RAB23 RAB23, member RAS oncogene family 1.398
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 1.39
CLDN24 claudin 24 1.38
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 1.379
MEOX2 mesenchyme homeobox 2 1.371
CRABP1 cellular retinoic acid binding protein 1 1.367
PORCN porcupine homolog (Drosophila) 1.365
HOXB7 homeobox B7 1.363
SOX18 SRY (sex determining region Y)-box 18 1.361
GCSH glycine cleavage system protein H (aminomethyl carrier) 1.359
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 1.357
FGF2 fibroblast growth factor 2 (basic) 1.354
TBXT T-box transcription factor T 1.348
CBS cystathionine-beta-synthase 1.337
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 1.336
CECR2 cat eye syndrome chromosome region, candidate 2 1.335
CPLX3 complexin 3 1.335
TNRC6B trinucleotide repeat containing 6B 1.332
ACHE acetylcholinesterase (Yt blood group) 1.331
BDNF brain-derived neurotrophic factor 1.327
TMEM67 transmembrane protein 67 1.32
HES3 hes family bHLH transcription factor 3 1.309
PHACTR4 phosphatase and actin regulator 4 1.308
WNT5A wingless-type MMTV integration site family, member 5A 1.306
DRAXIN dorsal inhibitory axon guidance protein 1.297
PAX6 paired box 6 1.283
CRABP2 cellular retinoic acid binding protein 2 1.277
RAD9B RAD9 homolog B (S. pombe) 1.269
DHFR2 dihydrofolate reductase 2 1.265
MARCKSL1 MARCKS-like 1 1.264
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) 1.258
EML1 echinoderm microtubule associated protein like 1 1.256
GPR161 G protein-coupled receptor 161 1.25
SOX3 SRY (sex determining region Y)-box 3 1.249
DHFR dihydrofolate reductase 1.248
LPP LIM domain containing preferred translocation partner in lipoma 1.241
UPK3A uroplakin 3A 1.24
NOAZFP nucleolar atypical zinc finger 1.231
SHMT1 serine hydroxymethyltransferase 1 (soluble) 1.228
BMP4 bone morphogenetic protein 4 1.226
PITX1 paired-like homeodomain 1 1.223
COPS9 COP9 signalosome subunit 9 1.222
SNED1 sushi, nidogen and EGF-like domains 1 1.205
MAB21L1 mab-21-like 1 (C. elegans) 1.205
PARD3 par-3 family cell polarity regulator 1.203
POC5 POC5 centriolar protein 1.2
HSF2BP heat shock transcription factor 2 binding protein 1.199
GPC5 glypican 5 1.196
WNT3A wingless-type MMTV integration site family, member 3A 1.195
FKBP8 FK506 binding protein 8, 38kDa 1.189
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 1.186
PAPPA pregnancy-associated plasma protein A, pappalysin 1 1.183
RIPPLY2 ripply transcriptional repressor 2 1.182
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.179
TBX4 T-box 4 1.175
RPGRIP1L RPGRIP1-like 1.165
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 1.165
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.163
MALL mal, T-cell differentiation protein-like 1.158
THY1 Thy-1 cell surface antigen 1.156
EPHA7 EPH receptor A7 1.155
SOX2 SRY (sex determining region Y)-box 2 1.152
XXYLT1 xyloside xylosyltransferase 1 1.15
NT5E 5'-nucleotidase, ecto (CD73) 1.15
TMEM253 transmembrane protein 253 1.149
HOXD13 homeobox D13 1.135
FLNA filamin A, alpha 1.13
GPC6 glypican 6 1.13
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 1.129
SNAP25 synaptosomal-associated protein, 25kDa 1.128
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 1.126
GRHL2 grainyhead-like 2 (Drosophila) 1.121
TNNI2 troponin I type 2 (skeletal, fast) 1.111
PTCH1 patched 1 1.108
ENG endoglin 1.108
MYH14 myosin, heavy chain 14, non-muscle 1.104
RARG retinoic acid receptor, gamma 1.104
ACE angiotensin I converting enzyme 1.104
DAAM1 dishevelled associated activator of morphogenesis 1 1.099
COBL cordon-bleu WH2 repeat protein 1.096
CSNK1G2 casein kinase 1, gamma 2 1.086
CNTNAP1 contactin associated protein 1 1.086
ALB albumin 1.079
NOG noggin 1.079
WDPCP WD repeat containing planar cell polarity effector 1.078
EFNA5 ephrin-A5 1.077
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 1.076
ASPN asporin 1.074
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 1.071
HOXC12 homeobox C12 1.068
HOXC13 homeobox C13 1.067
ADRB3 adrenoceptor beta 3 1.067
CCDC33 coiled-coil domain containing 33 1.066
SARDH sarcosine dehydrogenase 1.066
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 1.066
ARID3B AT rich interactive domain 3B (BRIGHT-like) 1.058
ADAT3 adenosine deaminase, tRNA-specific 3 1.057
DEFB107B defensin, beta 107B 1.055
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 1.054
SNAP29 synaptosomal-associated protein, 29kDa 1.052
WDR81 WD repeat domain 81 1.052
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 1.049
MORN1 MORN repeat containing 1 1.043
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.043
INVS inversin 1.042
CRP C-reactive protein, pentraxin-related 1.04
TBX6 T-box 6 1.026
HIRA histone cell cycle regulator 1.025
RIBC2 RIB43A domain with coiled-coils 2 1.024
CC2D2A coiled-coil and C2 domain containing 2A 1.023
SEZ6 seizure related 6 homolog (mouse) 1.023
AIF1 allograft inflammatory factor 1 1.021
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase 1.02
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 1.019
CD34 CD34 molecule 1.016
CRB2 crumbs family member 2 1.013
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 1.013
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 1.012
POU5F1 POU class 5 homeobox 1 1.011
SMTN smoothelin 1.009
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 1.009
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 1.006
GEMIN4 gem (nuclear organelle) associated protein 4 1.005
RPTN repetin 1.003
ZNF790 zinc finger protein 790 1.001
CEP290 centrosomal protein 290kDa 1.0