Myoclonus Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Very brief, involuntary random muscular contractions occurring at rest, in response to sensory stimuli, or accompanying voluntary movements. (Human Phenotype Ontology, HP_0001336)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D009207
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Genes

319 genes/proteins associated with the disease Myoclonus from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
MECP2 methyl CpG binding protein 2 2.88009
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.50778
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.49111
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.48811
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.48562
FOS FBJ murine osteosarcoma viral oncogene homolog 2.47949
TNF tumor necrosis factor 2.43691
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.41198
MAPK1 mitogen-activated protein kinase 1 2.39914
BCL2 B-cell CLL/lymphoma 2 2.39232
BDNF brain-derived neurotrophic factor 2.38521
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.37997
MAPK3 mitogen-activated protein kinase 3 2.37876
PRL prolactin 2.36328
CAT catalase 2.30816
BAX BCL2-associated X protein 2.29997
IL6 interleukin 6 2.24756
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.20559
EGR1 early growth response 1 2.19182
NPY neuropeptide Y 2.17039
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 2.16581
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.16465
DRD2 dopamine receptor D2 2.16413
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 2.14088
JUN jun proto-oncogene 2.12749
NOS2 nitric oxide synthase 2, inducible 2.12692
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.08657
IL1B interleukin 1, beta 2.07174
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.06416
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.06355
CREB1 cAMP responsive element binding protein 1 2.05695
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.05345
POMC proopiomelanocortin 2.05118
DRD1 dopamine receptor D1 2.02754
REN renin 2.01472
HMOX1 heme oxygenase 1 2.0101
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.99466
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.9851
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.96551
NUPR1 nuclear protein, transcriptional regulator, 1 1.96254
PENK proenkephalin 1.95858
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 1.95797
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.9539
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.94674
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.91317
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.89375
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.89027
CCL2 chemokine (C-C motif) ligand 2 1.88704
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.87708
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 1.87559
CRH corticotropin releasing hormone 1.87076
AVP arginine vasopressin 1.8634
TP53 tumor protein p53 1.84959
CXCL8 chemokine (C-X-C motif) ligand 8 1.83467
SOD1 superoxide dismutase 1, soluble 1.82708
IL10 interleukin 10 1.81793
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.81055
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.80905
TH tyrosine hydroxylase 1.80756
VEGFA vascular endothelial growth factor A 1.79789
INS insulin 1.79637
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.7874
OPRM1 opioid receptor, mu 1 1.78454
SOD2 superoxide dismutase 2, mitochondrial 1.78283
C10ORF10 chromosome 10 open reading frame 10 1.77859
FGF2 fibroblast growth factor 2 (basic) 1.77686
GSK3B glycogen synthase kinase 3 beta 1.77238
ADRB2 adrenoceptor beta 2, surface 1.76694
MAPK8 mitogen-activated protein kinase 8 1.76675
GSTP1 glutathione S-transferase pi 1 1.76289
ARC activity-regulated cytoskeleton-associated protein 1.75817
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.75241
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.75082
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.73373
INHBE inhibin, beta E 1.73292
ACHE acetylcholinesterase (Yt blood group) 1.72158
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.71952
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.68974
APP amyloid beta (A4) precursor protein 1.68718
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.68443
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.68295
TGFB1 transforming growth factor, beta 1 1.68211
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.68148
GAL galanin/GMAP prepropeptide 1.68084
NGF nerve growth factor (beta polypeptide) 1.66921
JUNB jun B proto-oncogene 1.65797
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.65599
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.65314
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 1.65227
TAGLN transgelin 1.65
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.64708
MPO myeloperoxidase 1.64484
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.64303
IFNG interferon, gamma 1.63072
CNR1 cannabinoid receptor 1 (brain) 1.62199
PARP1 poly (ADP-ribose) polymerase 1 1.61201
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.60804
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.60734
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.60058
TAC1 tachykinin, precursor 1 1.60035
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 1.58983
CCL5 chemokine (C-C motif) ligand 5 1.58983
ADRB1 adrenoceptor beta 1 1.58889
EDN1 endothelin 1 1.58748
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 1.58327
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.58113
FABP1 fatty acid binding protein 1, liver 1.57853
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.57853
FNDC4 fibronectin type III domain containing 4 1.56632
DDIT3 DNA-damage-inducible transcript 3 1.56607
NPPA natriuretic peptide A 1.56337
GFAP glial fibrillary acidic protein 1.56117
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.55698
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.54888
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.54839
DUSP1 dual specificity phosphatase 1 1.53796
FAS Fas cell surface death receptor 1.53748
TRH thyrotropin-releasing hormone 1.53748
BCL2L1 BCL2-like 1 1.53506
IL1A interleukin 1, alpha 1.53234
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 1.52011
ICAM1 intercellular adhesion molecule 1 1.50751
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.49584
HRH1 histamine receptor H1 1.49584
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.49558
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.48916
NFE2L2 nuclear factor, erythroid 2-like 2 1.48761
CYP3A cytochrome P450, family 3, subfamily A 1.48479
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.47966
ADRA2A adrenoceptor alpha 2A 1.47374
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.47348
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.44382
CALCA calcitonin-related polypeptide alpha 1.44246
HPN hepsin 1.43646
IGF1 insulin-like growth factor 1 (somatomedin C) 1.43618
MAOB monoamine oxidase B 1.41965
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.41965
LEP leptin 1.41667
G6PD glucose-6-phosphate dehydrogenase 1.41091
GCLC glutamate-cysteine ligase, catalytic subunit 1.40288
VIM vimentin 1.39952
MMP9 matrix metallopeptidase 9 1.39646
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.39254
CHRM1 cholinergic receptor, muscarinic 1 1.38555
CCND1 cyclin D1 1.37733
GNAS GNAS complex locus 1.37018
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.36218
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 1.35906
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 1.35877
LHB luteinizing hormone beta polypeptide 1.35069
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 1.34955
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.34782
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.34547
HOMER1 homer scaffolding protein 1 1.34489
PDYN prodynorphin 1.3443
CES2 carboxylesterase 2 1.34401
GAP43 growth associated protein 43 1.34082
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.33731
EGFR epidermal growth factor receptor 1.32756
IL4 interleukin 4 1.32518
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.32074
OPRK1 opioid receptor, kappa 1 1.31686
CDK5 cyclin-dependent kinase 5 1.31119
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 1.31
FN1 fibronectin 1 1.30696
MAPK14 mitogen-activated protein kinase 14 1.30543
PRKCD protein kinase C, delta 1.30329
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.30087
DRD3 dopamine receptor D3 1.30026
SREBF1 sterol regulatory element binding transcription factor 1 1.29996
GRIK2 glutamate receptor, ionotropic, kainate 2 1.29936
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.2941
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.29348
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.28919
NOS1 nitric oxide synthase 1 (neuronal) 1.28579
CCND3 cyclin D3 1.28487
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.28456
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.28364
GAST gastrin 1.28149
OXT oxytocin/neurophysin I prepropeptide 1.27224
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 1.26978
MAOA monoamine oxidase A 1.26732
CCK cholecystokinin 1.26236
BMP4 bone morphogenetic protein 4 1.26021
PLCG1 phospholipase C, gamma 1 1.25868
FOSL2 FOS-like antigen 2 1.25494
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.25369
EGR2 early growth response 2 1.25152
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 1.24935
GRM5 glutamate receptor, metabotropic 5 1.24905
ALB albumin 1.24843
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.24244
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 1.23962
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.23169
TLR4 toll-like receptor 4 1.22599
RELN reelin 1.22599
GJA1 gap junction protein, alpha 1, 43kDa 1.22209
GADD45A growth arrest and DNA-damage-inducible, alpha 1.22048
PRKCB protein kinase C, beta 1.21823
VGF VGF nerve growth factor inducible 1.21759
SREBF2 sterol regulatory element binding transcription factor 2 1.21695
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 1.21631
MCL1 myeloid cell leukemia 1 1.20881
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.20784
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.20719
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 1.20558
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.19966
ADORA2A adenosine A2a receptor 1.19639
VCAM1 vascular cell adhesion molecule 1 1.19113
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 1.17761
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.17464
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 1.17464
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.17431
RGS8 regulator of G-protein signaling 8 1.17399
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 1.17399
GRIK5 glutamate receptor, ionotropic, kainate 5 1.17399
POR P450 (cytochrome) oxidoreductase 1.17134
LDLR low density lipoprotein receptor 1.16967
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.16533
PCNA proliferating cell nuclear antigen 1.16302
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.1617
PVALB parvalbumin 1.16137
CXCL2 chemokine (C-X-C motif) ligand 2 1.15831
PPARG peroxisome proliferator-activated receptor gamma 1.15763
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.15627
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.15593
EFNA2 ephrin-A2 1.1529
CCND2 cyclin D2 1.14781
XBP1 X-box binding protein 1 1.14781
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 1.14781
DHFR dihydrofolate reductase 1.14473
MRPS18B mitochondrial ribosomal protein S18B 1.14404
ADORA1 adenosine A1 receptor 1.142
ADRA1A adrenoceptor alpha 1A 1.14098
IL2 interleukin 2 1.13758
ATF4 activating transcription factor 4 1.13621
PLAT plasminogen activator, tissue 1.13415
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 1.13415
PTK2B protein tyrosine kinase 2 beta 1.13381
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 1.13381
GDNF glial cell derived neurotrophic factor 1.13381
CDK2 cyclin-dependent kinase 2 1.13279
JUND jun D proto-oncogene 1.13075
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 1.12357
CLU clusterin 1.12117
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.11707
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 1.11673
RGS2 regulator of G-protein signaling 2 1.11431
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.11431
FOSL1 FOS-like antigen 1 1.11396
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.1136
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.1129
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 1.11186
TEX261 testis expressed 261 1.10942
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 1.10838
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.10734
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.10631
SOS1 son of sevenless homolog 1 (Drosophila) 1.10388
BBC3 BCL2 binding component 3 1.10104
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.10104
PTK2 protein tyrosine kinase 2 1.10104
ODC1 ornithine decarboxylase 1 1.09751
RB1 retinoblastoma 1 1.09681
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.09611
JAK2 Janus kinase 2 1.09332
TGFA transforming growth factor, alpha 1.09332
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 1.09154
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 1.08975
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.08584
CDK4 cyclin-dependent kinase 4 1.08513
CYCS cytochrome c, somatic 1.08478
TSHB thyroid stimulating hormone, beta 1.08337
FASN fatty acid synthase 1.08337
GH1 growth hormone 1 1.08301
TXN thioredoxin 1.08301
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.08301
HSPA1A heat shock 70kDa protein 1A 1.08161
CREM cAMP responsive element modulator 1.08019
FGF21 fibroblast growth factor 21 1.07804
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.07199
COMT catechol-O-methyltransferase 1.07199
TRHR thyrotropin-releasing hormone receptor 1.07163
CCNE1 cyclin E1 1.06625
OPRD1 opioid receptor, delta 1 1.06588
SPP1 secreted phosphoprotein 1 1.0637
PRKCG protein kinase C, gamma 1.06225
NES nestin 1.06188
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 1.05864
PER1 period circadian clock 1 1.05793
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 1.05648
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.0561
CCL3 chemokine (C-C motif) ligand 3 1.05461
INSR insulin receptor 1.05237
FSHB follicle stimulating hormone, beta polypeptide 1.052
ACSL6 acyl-CoA synthetase long-chain family member 6 1.05126
FMO1 flavin containing monooxygenase 1 1.04941
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 1.04647
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.04611
GCLM glutamate-cysteine ligase, modifier subunit 1.04314
TTR transthyretin 1.04201
TXNRD1 thioredoxin reductase 1 1.04126
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 1.04051
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 1.03493
ALAD aminolevulinate dehydratase 1.03493
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.03456
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.03271
IGFBP1 insulin-like growth factor binding protein 1 1.03271
PRKCZ protein kinase C, zeta 1.03084
TTLL11 tubulin tyrosine ligase-like family member 11 1.03009
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 1.02971
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 1.02708
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.02559
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 1.02447
CPT1A carnitine palmitoyltransferase 1A (liver) 1.02336
NTF3 neurotrophin 3 1.02336
S100A9 S100 calcium binding protein A9 1.02077
AKT2 v-akt murine thymoma viral oncogene homolog 2 1.01966
ADRB3 adrenoceptor beta 3 1.01966
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.01249