Myofibril Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores 2025
Category structural or functional annotations
Type cellular component
Description The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. (Gene Ontology, GO_0030016)
External Link http://amigo.geneontology.org/amigo/term/GO:0030016
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Genes

173 proteins localized to the Myofibril cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 5.0
FMNL3 formin-like 3 5.0
MYBPHL myosin binding protein H-like 5.0
CFL2 cofilin 2 (muscle) 5.0
TNNC2 troponin C type 2 (fast) 5.0
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 5.0
ACTA1 actin, alpha 1, skeletal muscle 5.0
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 5.0
SYNM synemin, intermediate filament protein 5.0
MYH13 myosin, heavy chain 13, skeletal muscle 5.0
SYNE2 spectrin repeat containing, nuclear envelope 2 5.0
SYNE1 spectrin repeat containing, nuclear envelope 1 5.0
MYH15 myosin, heavy chain 15 5.0
SCO2 SCO2 cytochrome c oxidase assembly protein 5.0
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 5.0
SVIL supervillin 5.0
VCL vinculin 5.0
NEB nebulin 5.0
SIMC1 SUMO-interacting motifs containing 1 5.0
TPM3 tropomyosin 3 5.0
PDLIM1 PDZ and LIM domain 1 5.0
ANK1 ankyrin 1, erythrocytic 5.0
SCN5A sodium channel, voltage gated, type V alpha subunit 5.0
TNNT3 troponin T type 3 (skeletal, fast) 5.0
FLNB filamin B, beta 5.0
TNNI2 troponin I type 2 (skeletal, fast) 5.0
PGM5 phosphoglucomutase 5 5.0
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 5.0
MYOT myotilin 5.0
PALLD palladin, cytoskeletal associated protein 5.0
SCO1 SCO1 cytochrome c oxidase assembly protein 5.0
LDB3 LIM domain binding 3 5.0
SORBS2 sorbin and SH3 domain containing 2 5.0
PARVB parvin, beta 5.0
ACTN2 actinin, alpha 2 5.0
MYH1 myosin, heavy chain 1, skeletal muscle, adult 5.0
ACTN1 actinin, alpha 1 5.0
TNNT1 troponin T type 1 (skeletal, slow) 5.0
SYNPO2 synaptopodin 2 5.0
TMOD1 tropomodulin 1 5.0
KRT19 keratin 19, type I 5.0
PCNX4 pecanex 4 5.0
DST dystonin 5.0
NEBL nebulette 5.0
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 5.0
MYO18B myosin XVIIIB 5.0
MYOM3 myomesin 3 4.0
MYOM1 myomesin 1 4.0
CAPN3 calpain 3, (p94) 4.0
MYL1 myosin, light chain 1, alkali; skeletal, fast 4.0
PKN1 protein kinase N1 4.0
TPM1 tropomyosin 1 (alpha) 4.0
TPM2 tropomyosin 2 (beta) 4.0
LOC112694756 uncharaterized LOC112694756 4.0
KY kyphoscoliosis peptidase 4.0
PDE4DIP phosphodiesterase 4D interacting protein 4.0
TPM4 tropomyosin 4 4.0
ADPRHL1 ADP-ribosylhydrolase like 1 4.0
TNNT2 troponin T type 2 (cardiac) 4.0
MYPN myopalladin 4.0
ASB2 ankyrin repeat and SOCS box containing 2 4.0
MYZAP myocardial zonula adherens protein 4.0
BMP10 bone morphogenetic protein 10 4.0
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 4.0
SRI sorcin 4.0
HABP4 hyaluronan binding protein 4 4.0
MYH4 myosin, heavy chain 4, skeletal muscle 4.0
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 4.0
PLEC plectin 4.0
MYH2 myosin, heavy chain 2, skeletal muscle, adult 4.0
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 4.0
NEXN nexilin (F actin binding protein) 4.0
MYH7 myosin, heavy chain 7, cardiac muscle, beta 4.0
RTN2 reticulon 2 4.0
TTR transthyretin 4.0
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 4.0
KLHL41 kelch-like family member 41 4.0
ACTC1 actin, alpha, cardiac muscle 1 4.0
PPP1R12A protein phosphatase 1, regulatory subunit 12A 4.0
FKBP1A FK506 binding protein 1A, 12kDa 4.0
FKBP1B FK506 binding protein 1B, 12.6 kDa 4.0
PPP1R12B protein phosphatase 1, regulatory subunit 12B 4.0
HRC histidine rich calcium binding protein 4.0
FLNC filamin C, gamma 4.0
RYR2 ryanodine receptor 2 (cardiac) 4.0
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 4.0
OBSL1 obscurin-like 1 4.0
CALM3 calmodulin 3 (phosphorylase kinase, delta) 4.0
CALM1 calmodulin 1 (phosphorylase kinase, delta) 4.0
CALM2 calmodulin 2 (phosphorylase kinase, delta) 4.0
GGPS1 geranylgeranyl diphosphate synthase 1 4.0
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 4.0
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 4.0
DES desmin 4.0
LMOD1 leiomodin 1 (smooth muscle) 3.0
LMOD3 leiomodin 3 (fetal) 3.0
SYNPO synaptopodin 3.0
LMOD2 leiomodin 2 (cardiac) 3.0
FHL2 four and a half LIM domains 2 3.0
KLHL40 kelch-like family member 40 3.0
AHNAK AHNAK nucleoprotein 3.0
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 3.0
BIN1 bridging integrator 1 3.0
DMD dystrophin 3.0
POLR2M polymerase (RNA) II (DNA directed) polypeptide M 3.0
SYNC syncoilin, intermediate filament protein 3.0
FLNA filamin A, alpha 3.0
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 3.0
SMPX small muscle protein, X-linked 3.0
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 3.0
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 3.0
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 3.0
LRRC27 leucine rich repeat containing 27 3.0
PDE4B phosphodiesterase 4B, cAMP-specific 3.0
TMOD4 tropomodulin 4 (muscle) 3.0
TMOD3 tropomodulin 3 (ubiquitous) 3.0
TMOD2 tropomodulin 2 (neuronal) 3.0
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 3.0
CASQ2 calsequestrin 2 (cardiac muscle) 3.0
AHNAK2 AHNAK nucleoprotein 2 3.0
ACTL8 actin-like 8 3.0
SCN1A sodium channel, voltage gated, type I alpha subunit 3.0
TCAP titin-cap 3.0
MYLK2 myosin light chain kinase 2 3.0
ACTN4 actinin, alpha 4 3.0
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 3.0
ACTN3 actinin, alpha 3 (gene/pseudogene) 3.0
PVALEF parvalbumin like EF-hand containing 3.0
MYL9 myosin, light chain 9, regulatory 3.0
MYOZ3 myozenin 3 3.0
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 3.0
NOL6 nucleolar protein 6 (RNA-associated) 3.0
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 3.0
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 3.0
MYBPC3 myosin binding protein C, cardiac 3.0
MYBPC2 myosin binding protein C, fast type 3.0
MYBPC1 myosin binding protein C, slow type 3.0
SYNPO2L synaptopodin 2-like 3.0
MYOM2 myomesin 2 3.0
MYOZ1 myozenin 1 3.0
MYL2 myosin, light chain 2, regulatory, cardiac, slow 3.0
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 3.0
MYL4 myosin, light chain 4, alkali; atrial, embryonic 3.0
MYL7 myosin, light chain 7, regulatory 3.0
SCN8A sodium channel, voltage gated, type VIII alpha subunit 3.0
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.0
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 3.0
FHL5 four and a half LIM domains 5 3.0
ABRA actin binding Rho activating protein 3.0
UNC13D unc-13 homolog D (C. elegans) 3.0
MYOZ2 myozenin 2 3.0
PDLIM4 PDZ and LIM domain 4 3.0
SCN3B sodium channel, voltage gated, type III beta subunit 3.0
CSRP1 cysteine and glycine-rich protein 1 3.0
TWF2 twinfilin actin binding protein 2 3.0
CSRP2 cysteine and glycine-rich protein 2 3.0
TWF1 twinfilin actin binding protein 1 3.0
RYR1 ryanodine receptor 1 (skeletal) 3.0
RYR3 ryanodine receptor 3 3.0
MYL12B myosin, light chain 12B, regulatory 3.0
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 3.0
MYBPH myosin binding protein H 3.0
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 3.0
PDLIM5 PDZ and LIM domain 5 3.0
PDLIM7 PDZ and LIM domain 7 (enigma) 3.0
ANK2 ankyrin 2, neuronal 3.0
PDLIM2 PDZ and LIM domain 2 (mystique) 3.0
PDLIM3 PDZ and LIM domain 3 3.0
TNNI3 troponin I type 3 (cardiac) 3.0
TNNI1 troponin I type 1 (skeletal, slow) 3.0
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 3.0
PRICKLE4 prickle homolog 4 (Drosophila) 3.0
LRRC10 leucine rich repeat containing 10 3.0