Myositis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An inflammatory process affecting the skeletal muscles. Causes include infections, injuries, and autoimmune disorders.|Inflammation of a muscle or muscle tissue. (Experimental Factor Ontology, EFO_0000783)
External Link https://www.disgenet.org/browser/0/1/0/C0027121
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Genes

240 genes associated with the disease Myositis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
AARS1 alanyl-tRNA synthetase 1
AARS2 alanyl-tRNA synthetase 2, mitochondrial
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACTB actin, beta
ACTN3 actinin, alpha 3 (gene/pseudogene)
ADAM17 ADAM metallopeptidase domain 17
ADAR adenosine deaminase, RNA-specific
ADIPOQ adiponectin, C1Q and collagen domain containing
AGER advanced glycosylation end product-specific receptor
AIF1 allograft inflammatory factor 1
ALOX5 arachidonate 5-lipoxygenase
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA2 annexin A2
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ARSF arylsulfatase F
ATG5 autophagy related 5
ATN1 atrophin 1
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BCL2 B-cell CLL/lymphoma 2
BEST1 bestrophin 1
BICD2 bicaudal D homolog 2 (Drosophila)
C1QA complement component 1, q subcomponent, A chain
C1R complement component 1, r subcomponent
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
CA14 carbonic anhydrase XIV
CABIN1 calcineurin binding protein 1
CAMP cathelicidin antimicrobial peptide
CAPN3 calpain 3, (p94)
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle)
CAV3 caveolin 3
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CCR1 chemokine (C-C motif) receptor 1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR7 chemokine (C-C motif) receptor 7
CD163 CD163 molecule
CD177 CD177 molecule
CD274 CD274 molecule
CD34 CD34 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD68 CD68 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD83 CD83 molecule
CETN1 centrin, EF-hand protein, 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRM3 cholinergic receptor, muscarinic 3
CKLF chemokine-like factor
CLEC4C C-type lectin domain family 4, member C
CNN3 calponin 3, acidic
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRP C-reactive protein, pentraxin-related
CTNNA3 catenin (cadherin-associated protein), alpha 3
CTSS cathepsin S
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCPS decapping enzyme, scavenger
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DGKQ diacylglycerol kinase, theta 110kDa
DMD dystrophin
DNASE1L3 deoxyribonuclease I-like 3
DPP4 dipeptidyl-peptidase 4
DYSF dysferlin
ELANE elastase, neutrophil expressed
EMD emerin
ERAP1 endoplasmic reticulum aminopeptidase 1
F2R coagulation factor II (thrombin) receptor
FAM111B family with sequence similarity 111, member B
FAS Fas cell surface death receptor
FBXO32 F-box protein 32
FGF21 fibroblast growth factor 21
FHL1 four and a half LIM domains 1
FKRP fukutin related protein
FOXP3 forkhead box P3
GALNS galactosamine (N-acetyl)-6-sulfatase
GARS glycyl-tRNA synthetase
GAST gastrin
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HARS1 histidyl-tRNA synthetase 1
HARS2 histidyl-tRNA synthetase 2, mitochondrial
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-G major histocompatibility complex, class I, G
HMGB1 high mobility group box 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFIH1 interferon induced with helicase C domain 1
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNL1 interferon, lambda 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFALS insulin-like growth factor binding protein, acid labile subunit
IL10 interleukin 10
IL12A interleukin 12A
IL12RB2 interleukin 12 receptor, beta 2
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL23R interleukin 23 receptor
IL37 interleukin 37
IL4 interleukin 4
IL5 interleukin 5
IL6 interleukin 6
IRAK1 interleukin-1 receptor-associated kinase 1
IRF5 interferon regulatory factor 5
KL klotho
KLRC4 killer cell lectin-like receptor subfamily C, member 4
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KNTC1 kinetochore associated 1
LAMA2 laminin, alpha 2
LAMP1 lysosomal-associated membrane protein 1
LMNA lamin A/C
MBL2 mannose-binding lectin (protein C) 2, soluble
MEFV Mediterranean fever
MICB MHC class I polypeptide-related sequence B
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
MORC3 MORC family CW-type zinc finger 3
MRC1 mannose receptor, C type 1
MSTN myostatin
MUC1 mucin 1, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYD88 myeloid differentiation primary response 88
MYH1 myosin, heavy chain 1, skeletal muscle, adult
NCF2 neutrophil cytosolic factor 2
NEB nebulin
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NLRP3 NLR family, pyrin domain containing 3
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NT5C1A 5'-nucleotidase, cytosolic IA
OPA1 optic atrophy 1 (autosomal dominant)
PAGR1 PAXIP1 associated glutamate-rich protein 1
PDCD1 programmed cell death 1
PKM pyruvate kinase, muscle
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRH1 proline-rich protein HaeIII subfamily 1
PRH2 proline-rich protein HaeIII subfamily 2
PRR12 proline rich 12
PRTN3 proteinase 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PUF60 poly-U binding splicing factor 60KDa
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBBP8 retinoblastoma binding protein 8
RBM45 RNA binding motif protein 45
RGS6 regulator of G-protein signaling 6
RNASEH2A ribonuclease H2, subunit A
RNASEH2B ribonuclease H2, subunit B
RNASEH2C ribonuclease H2, subunit C
RO60 Ro60, Y RNA binding protein
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
S100A11 S100 calcium binding protein A11
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
SAE1 SUMO1 activating enzyme subunit 1
SAMHD1 SAM domain and HD domain 1
SDF4 stromal cell derived factor 4
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLURP1 secreted LY6/PLAUR domain containing 1
SMG7 SMG7 nonsense mediated mRNA decay factor
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SOD1 superoxide dismutase 1, soluble
SPP1 secreted phosphoprotein 1
SRSF1 serine/arginine-rich splicing factor 1
SRSF5 serine/arginine-rich splicing factor 5
STAT4 signal transducer and activator of transcription 4
TAC1 tachykinin, precursor 1
TARDBP TAR DNA binding protein
TARS threonyl-tRNA synthetase
TGFB1 transforming growth factor, beta 1
TGM2 transglutaminase 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNIP1 TNFAIP3 interacting protein 1
TNPO3 transportin 3
TPO thyroid peroxidase
TREX1 three prime repair exonuclease 1
TRIM21 tripartite motif containing 21
TRIM24 tripartite motif containing 24
TRIM33 tripartite motif containing 33
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase
TSHR thyroid stimulating hormone receptor
TSPO translocator protein (18kDa)
TTN titin
TUBB6 tubulin, beta 6 class V
TYK2 tyrosine kinase 2
UBA2 ubiquitin-like modifier activating enzyme 2
UBAC2 UBA domain containing 2
UBB ubiquitin B
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein