N-acetyl-L-leucine-3085 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the N-acetyl-L-leucine-3085 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACRV1 acrosomal vesicle protein 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALOXE3 arachidonate lipoxygenase 3
APAF1 apoptotic peptidase activating factor 1
APOE apolipoprotein E
ATAT1 alpha tubulin acetyltransferase 1
BCAS3 breast carcinoma amplified sequence 3
BGLAP bone gamma-carboxyglutamate (gla) protein
CACTIN cactin, spliceosome C complex subunit
CCR9 chemokine (C-C motif) receptor 9
CD1E CD1e molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFAP70 cilia and flagella associated protein 70
CLDN3 claudin 3
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL7A1 collagen, type VII, alpha 1
COLEC10 collectin sub-family member 10 (C-type lectin)
CRX cone-rod homeobox
CRYM crystallin, mu
CSNK1E casein kinase 1, epsilon
DLX2 distal-less homeobox 2
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EPHA1 EPH receptor A1
FABP3 fatty acid binding protein 3, muscle and heart
FBP1 fructose-1,6-bisphosphatase 1
FER1L4 fer-1-like family member 4, pseudogene (functional)
FGF6 fibroblast growth factor 6
FOXE3 forkhead box E3
FST follistatin
FUT2 fucosyltransferase 2 (secretor status included)
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR107 G protein-coupled receptor 107
HEMK1 HemK methyltransferase family member 1
HHLA1 HERV-H LTR-associating 1
HIST1H3G histone cluster 1, H3g
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HNF1A HNF1 homeobox A
HOXA2 homeobox A2
HOXC11 homeobox C11
HOXD11 homeobox D11
ICAM1 intercellular adhesion molecule 1
IFT27 intraflagellar transport 27
ITGB1BP2 integrin beta 1 binding protein (melusin) 2
IZUMO4 IZUMO family member 4
JRK Jrk homolog (mouse)
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KIDINS220 kinase D-interacting substrate, 220kDa
KLHL18 kelch-like family member 18
LARGE like-glycosyltransferase
LIG3 ligase III, DNA, ATP-dependent
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MCHR1 melanin-concentrating hormone receptor 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NCR2 natural cytotoxicity triggering receptor 2
NEBL nebulette
NFIB nuclear factor I/B
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NUP50 nucleoporin 50kDa
OMG oligodendrocyte myelin glycoprotein
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PADI2 peptidyl arginine deiminase, type II
PCDH12 protocadherin 12
PGAP3 post-GPI attachment to proteins 3
PLAC4 placenta-specific 4
POFUT1 protein O-fucosyltransferase 1
POU2F2 POU class 2 homeobox 2
POU3F4 POU class 3 homeobox 4
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PRKCE protein kinase C, epsilon
PROSC proline synthetase co-transcribed homolog (bacterial)
PRPH peripherin
RAD52 RAD52 homolog (S. cerevisiae)
SCN5A sodium channel, voltage gated, type V alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SH2D4A SH2 domain containing 4A
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A16 solute carrier family 6, member 16
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SLMO1 slowmo homolog 1 (Drosophila)
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNAI2 snail family zinc finger 2
SNCG synuclein, gamma (breast cancer-specific protein 1)
STK38 serine/threonine kinase 38
T T, brachyury homolog (mouse)
TDO2 tryptophan 2,3-dioxygenase
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNPO3 transportin 3
TRIM15 tripartite motif containing 15
VAV2 vav 2 guanine nucleotide exchange factor
VSIG10 V-set and immunoglobulin domain containing 10
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF185 zinc finger protein 185 (LIM domain)
ZNF219 zinc finger protein 219

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
AGBL5 ATP/GTP binding protein-like 5
AKTIP AKT interacting protein
AP1B1 adaptor-related protein complex 1, beta 1 subunit
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARMC7 armadillo repeat containing 7
ASB7 ankyrin repeat and SOCS box containing 7
BAG4 BCL2-associated athanogene 4
BAHCC1 BAH domain and coiled-coil containing 1
BBS1 Bardet-Biedl syndrome 1
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BTBD2 BTB (POZ) domain containing 2
C7ORF43 chromosome 7 open reading frame 43
CBR1 carbonyl reductase 1
CRIP1 cysteine-rich protein 1 (intestinal)
CSF3R colony stimulating factor 3 receptor (granulocyte)
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DEPDC1 DEP domain containing 1
FAM127B family with sequence similarity 127, member B
FES FES proto-oncogene, tyrosine kinase
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GRAMD1B GRAM domain containing 1B
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIRA histone cell cycle regulator
HIST1H2AJ histone cluster 1, H2aj
HIST1H4E histone cluster 1, H4e
HPS6 Hermansky-Pudlak syndrome 6
IDI2-AS1 IDI2 antisense RNA 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IREB2 iron-responsive element binding protein 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KCTD7 potassium channel tetramerization domain containing 7
KPNA5 karyopherin alpha 5 (importin alpha 6)
KPTN kaptin (actin binding protein)
LINC00339 long intergenic non-protein coding RNA 339
LPAR4 lysophosphatidic acid receptor 4
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MECR mitochondrial trans-2-enoyl-CoA reductase
METTL8 methyltransferase like 8
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MYO5C myosin VC
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NABP2 nucleic acid binding protein 2
NDE1 nudE neurodevelopment protein 1
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NPDC1 neural proliferation, differentiation and control, 1
NRGN neurogranin (protein kinase C substrate, RC3)
NT5C 5', 3'-nucleotidase, cytosolic
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCSK7 proprotein convertase subtilisin/kexin type 7
PDZD7 PDZ domain containing 7
PIAS3 protein inhibitor of activated STAT, 3
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PMFBP1 polyamine modulated factor 1 binding protein 1
POLM polymerase (DNA directed), mu
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PRAF2 PRA1 domain family, member 2
RAB8B RAB8B, member RAS oncogene family
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF122 ring finger protein 122
RPA4 replication protein A4, 30kDa
SCRIB scribbled planar cell polarity protein
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SPAG4 sperm associated antigen 4
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STEAP3 STEAP family member 3, metalloreductase
STRN striatin, calmodulin binding protein
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I
TBX19 T-box 19
TESK2 testis-specific kinase 2
TGM5 transglutaminase 5
TMEM159 transmembrane protein 159
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TPST2 tyrosylprotein sulfotransferase 2
TRIM5 tripartite motif containing 5
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TTC33 tetratricopeptide repeat domain 33
TUFT1 tuftelin 1
UNKL unkempt family zinc finger-like
USP18 ubiquitin specific peptidase 18
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WDR46 WD repeat domain 46
YY2 YY2 transcription factor
ZC2HC1A zinc finger, C2HC-type containing 1A
ZC3H12A zinc finger CCCH-type containing 12A
ZMYM3 zinc finger, MYM-type 3