N-acetyl-L-leucine-4622 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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193 genes differentially expressed following the N-acetyl-L-leucine-4622 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
AFF2 AF4/FMR2 family, member 2
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AMBN ameloblastin (enamel matrix protein)
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARTN artemin
ATG10 autophagy related 10
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL6 B-cell CLL/lymphoma 6
C11ORF63 chromosome 11 open reading frame 63
C17ORF59 chromosome 17 open reading frame 59
CA5B carbonic anhydrase VB, mitochondrial
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CC2D1A coiled-coil and C2 domain containing 1A
CDC14A cell division cycle 14A
COL14A1 collagen, type XIV, alpha 1
CRH corticotropin releasing hormone
CYBRD1 cytochrome b reductase 1
DBP D site of albumin promoter (albumin D-box) binding protein
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DGKA diacylglycerol kinase, alpha 80kDa
DNAI2 dynein, axonemal, intermediate chain 2
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ELOVL5 ELOVL fatty acid elongase 5
EXO5 exonuclease 5
FBXO22 F-box protein 22
FCAR Fc fragment of IgA receptor
FOXD3 forkhead box D3
FUZ fuzzy planar cell polarity protein
GAGE1 G antigen 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPR75 G protein-coupled receptor 75
GRM1 glutamate receptor, metabotropic 1
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HAPLN1 hyaluronan and proteoglycan link protein 1
HEG1 heart development protein with EGF-like domains 1
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HMGN5 high mobility group nucleosome binding domain 5
HOXD1 homeobox D1
INSR insulin receptor
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KSR1 kinase suppressor of ras 1
KYNU kynureninase
LGALS9 lectin, galactoside-binding, soluble, 9
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LTC4S leukotriene C4 synthase
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MBD2 methyl-CpG binding domain protein 2
MLXIP MLX interacting protein
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NUP214 nucleoporin 214kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OTOF otoferlin
PAPOLB poly(A) polymerase beta (testis specific)
PCM1 pericentriolar material 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PDLIM3 PDZ and LIM domain 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PML promyelocytic leukemia
PPP1R37 protein phosphatase 1, regulatory subunit 37
PRB1 proline-rich protein BstNI subfamily 1
PRB4 proline-rich protein BstNI subfamily 4
RAB31 RAB31, member RAS oncogene family
RAB6B RAB6B, member RAS oncogene family
RAI2 retinoic acid induced 2
RGS12 regulator of G-protein signaling 12
RIF1 replication timing regulatory factor 1
RIN3 Ras and Rab interactor 3
RNF126P1 ring finger protein 126 pseudogene 1
RPH3AL rabphilin 3A-like (without C2 domains)
RPL18 ribosomal protein L18
RPL23AP32 ribosomal protein L23a pseudogene 32
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SPRR1A small proline-rich protein 1A
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STRN3 striatin, calmodulin binding protein 3
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
THY1 Thy-1 cell surface antigen
TLR4 toll-like receptor 4
TMOD1 tropomodulin 1
TRAPPC13 trafficking protein particle complex 13
TSSK2 testis-specific serine kinase 2
VAC14 Vac14 homolog (S. cerevisiae)
ZNF407 zinc finger protein 407
ZNF440 zinc finger protein 440

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD17B abhydrolase domain containing 17B
ACADSB acyl-CoA dehydrogenase, short/branched chain
AFAP1 actin filament associated protein 1
AMT aminomethyltransferase
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
BAG4 BCL2-associated athanogene 4
C11ORF30 chromosome 11 open reading frame 30
C22ORF46 chromosome 22 open reading frame 46
C5ORF45 chromosome 5 open reading frame 45
C7ORF43 chromosome 7 open reading frame 43
CCNA1 cyclin A1
CEP112 centrosomal protein 112kDa
CGA glycoprotein hormones, alpha polypeptide
CLCN2 chloride channel, voltage-sensitive 2
CLDN15 claudin 15
CNR2 cannabinoid receptor 2 (macrophage)
CNTLN centlein, centrosomal protein
DCAF4 DDB1 and CUL4 associated factor 4
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DEF6 differentially expressed in FDCP 6 homolog (mouse)
EPN3 epsin 3
EVPL envoplakin
FAM110B family with sequence similarity 110, member B
FBXO2 F-box protein 2
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FILIP1L filamin A interacting protein 1-like
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GMPR guanosine monophosphate reductase
GPR3 G protein-coupled receptor 3
GRAMD1C GRAM domain containing 1C
GSTA3 glutathione S-transferase alpha 3
HIST1H2AJ histone cluster 1, H2aj
HIST2H2AA3 histone cluster 2, H2aa3
HRH2 histamine receptor H2
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KDM5C lysine (K)-specific demethylase 5C
LMNB1 lamin B1
LOC100127972 uncharacterized LOC100127972
LOC100129648 uncharacterized LOC100129648
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC257152 uncharacterized LOC257152
LY6D lymphocyte antigen 6 complex, locus D
MAGEF1 melanoma antigen family F1
MAST3 microtubule associated serine/threonine kinase 3
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MMP2 matrix metallopeptidase 2
MRPL41 mitochondrial ribosomal protein L41
NCS1 neuronal calcium sensor 1
NME3 NME/NM23 nucleoside diphosphate kinase 3
NOL12 nucleolar protein 12
NPFFR1 neuropeptide FF receptor 1
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OR1G1 olfactory receptor, family 1, subfamily G, member 1
PALMD palmdelphin
PCOLCE procollagen C-endopeptidase enhancer
PER3 period circadian clock 3
PEX26 peroxisomal biogenesis factor 26
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PODXL2 podocalyxin-like 2
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PRPH peripherin
PRSS8 protease, serine, 8
RAPSN receptor-associated protein of the synapse
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS17 regulator of G-protein signaling 17
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RIN1 Ras and Rab interactor 1
SAYSD1 SAYSVFN motif domain containing 1
SCAI suppressor of cancer cell invasion
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMR3A submaxillary gland androgen regulated protein 3A
SOX30 SRY (sex determining region Y)-box 30
ST5 suppression of tumorigenicity 5
STAG3 stromal antigen 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TBX19 T-box 19
TESK1 testis-specific kinase 1
TGFB3 transforming growth factor, beta 3
TMEM242 transmembrane protein 242
TMEM53 transmembrane protein 53
TRIM58 tripartite motif containing 58
TSPAN2 tetraspanin 2
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR19 WD repeat domain 19
WDR76 WD repeat domain 76
WDR91 WD repeat domain 91
XYLT2 xylosyltransferase II
ZC3H12A zinc finger CCCH-type containing 12A
ZFP30 ZFP30 zinc finger protein
ZNF273 zinc finger protein 273
ZNF721 zinc finger protein 721
ZSCAN26 zinc finger and SCAN domain containing 26