N-acetyl-L-leucine-5683 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the N-acetyl-L-leucine-5683 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
AEBP1 AE binding protein 1
ALLC allantoicase
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
BIN2 bridging integrator 2
C2ORF72 chromosome 2 open reading frame 72
C6 complement component 6
C8A complement component 8, alpha polypeptide
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CAMK1D calcium/calmodulin-dependent protein kinase ID
CASR calcium-sensing receptor
CD209 CD209 molecule
CD244 CD244 molecule, natural killer cell receptor 2B4
CD36 CD36 molecule (thrombospondin receptor)
CD53 CD53 molecule
CHD5 chromodomain helicase DNA binding protein 5
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CNTNAP2 contactin associated protein-like 2
COL1A2 collagen, type I, alpha 2
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRHR2 corticotropin releasing hormone receptor 2
DFNB31 deafness, autosomal recessive 31
DGCR8 DGCR8 microprocessor complex subunit
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DTX3 deltex 3, E3 ubiquitin ligase
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM63B family with sequence similarity 63, member B
FBLN1 fibulin 1
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GP5 glycoprotein V (platelet)
GPER1 G protein-coupled estrogen receptor 1
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRK4 G protein-coupled receptor kinase 4
GRM1 glutamate receptor, metabotropic 1
GSK3A glycogen synthase kinase 3 alpha
GUK1 guanylate kinase 1
HAP1 huntingtin-associated protein 1
HCRT hypocretin (orexin) neuropeptide precursor
HES2 hes family bHLH transcription factor 2
HIST1H4E histone cluster 1, H4e
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
IDUA iduronidase, alpha-L-
IGF2-AS IGF2 antisense RNA
IGFBP5 insulin-like growth factor binding protein 5
IL18 interleukin 18
IL22 interleukin 22
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD17 potassium channel tetramerization domain containing 17
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT6B keratin 6B, type II
KRTAP9-9 keratin associated protein 9-9
LDB3 LIM domain binding 3
LY86 lymphocyte antigen 86
MAU2 MAU2 sister chromatid cohesion factor
MBD3 methyl-CpG binding domain protein 3
MOXD1 monooxygenase, DBH-like 1
MPO myeloperoxidase
NDRG2 NDRG family member 2
NPFF neuropeptide FF-amide peptide precursor
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)
OR7C1 olfactory receptor, family 7, subfamily C, member 1
PCDH9 protocadherin 9
PCDHB13 protocadherin beta 13
PDPN podoplanin
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLCE1 phospholipase C, epsilon 1
PLP1 proteolipid protein 1
PRDM16 PR domain containing 16
PRKCA protein kinase C, alpha
RB1 retinoblastoma 1
RHBG Rh family, B glycoprotein (gene/pseudogene)
RIMS2 regulating synaptic membrane exocytosis 2
RS1 retinoschisin 1
SCARF1 scavenger receptor class F, member 1
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC43A3 solute carrier family 43, member 3
SMG7-AS1 SMG7 antisense RNA 1
SPAG6 sperm associated antigen 6
SPHK2 sphingosine kinase 2
SRCAP Snf2-related CREBBP activator protein
STXBP5L syntaxin binding protein 5-like
SYT12 synaptotagmin XII
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TAT tyrosine aminotransferase
TBC1D2B TBC1 domain family, member 2B
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM3 tripartite motif containing 3
TSPAN12 tetraspanin 12
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
ZBTB7A zinc finger and BTB domain containing 7A
ZFAND5 zinc finger, AN1-type domain 5
ZNF471 zinc finger protein 471

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AFAP1 actin filament associated protein 1
ARL15 ADP-ribosylation factor-like 15
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP13A2 ATPase type 13A2
AXIN1 axin 1
BCOR BCL6 corepressor
BEX4 brain expressed, X-linked 4
BFSP1 beaded filament structural protein 1, filensin
BPGM 2,3-bisphosphoglycerate mutase
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CAMKMT calmodulin-lysine N-methyltransferase
CAPN5 calpain 5
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDKL3 cyclin-dependent kinase-like 3
CENPQ centromere protein Q
CGA glycoprotein hormones, alpha polypeptide
CLCN2 chloride channel, voltage-sensitive 2
CLGN calmegin
COTL1 coactosin-like F-actin binding protein 1
CTNND2 catenin (cadherin-associated protein), delta 2
DGAT1 diacylglycerol O-acyltransferase 1
ELOVL4 ELOVL fatty acid elongase 4
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
ERI3 ERI1 exoribonuclease family member 3
FAM169A family with sequence similarity 169, member A
FKBP5 FK506 binding protein 5
GBP2 guanylate binding protein 2, interferon-inducible
GLI3 GLI family zinc finger 3
GLS2 glutaminase 2 (liver, mitochondrial)
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GRTP1 growth hormone regulated TBC protein 1
HHLA3 HERV-H LTR-associating 3
HIST1H1D histone cluster 1, H1d
HMHA1 histocompatibility (minor) HA-1
HOXD11 homeobox D11
HSPA1L heat shock 70kDa protein 1-like
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFT81 intraflagellar transport 81
IPP intracisternal A particle-promoted polypeptide
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNK15 potassium channel, two pore domain subfamily K, member 15
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRI1 KRI1 homolog (S. cerevisiae)
LAMA3 laminin, alpha 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MANBA mannosidase, beta A, lysosomal
MAPK12 mitogen-activated protein kinase 12
MBNL3 muscleblind-like splicing regulator 3
MBTD1 mbt domain containing 1
MITF microphthalmia-associated transcription factor
MXD3 MAX dimerization protein 3
MYL5 myosin, light chain 5, regulatory
MYO1D myosin ID
NAT9 N-acetyltransferase 9 (GCN5-related, putative)
NDE1 nudE neurodevelopment protein 1
NECAB3 N-terminal EF-hand calcium binding protein 3
NR1H3 nuclear receptor subfamily 1, group H, member 3
PDE8B phosphodiesterase 8B
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
POLH polymerase (DNA directed), eta
POLL polymerase (DNA directed), lambda
POMZP3 POM121 and ZP3 fusion
PRAF2 PRA1 domain family, member 2
PRPH peripherin
PRSS16 protease, serine, 16 (thymus)
PTK6 protein tyrosine kinase 6
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PTPRU protein tyrosine phosphatase, receptor type, U
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
S100A9 S100 calcium binding protein A9
SCAMP5 secretory carrier membrane protein 5
SETD8 SET domain containing (lysine methyltransferase) 8
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SHARPIN SHANK-associated RH domain interactor
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC41A3 solute carrier family 41, member 3
TDRD1 tudor domain containing 1
TET3 tet methylcytosine dioxygenase 3
THOP1 thimet oligopeptidase 1
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TTC33 tetratricopeptide repeat domain 33
USP20 ubiquitin specific peptidase 20
VASP vasodilator-stimulated phosphoprotein
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
ZBED1 zinc finger, BED-type containing 1
ZFHX3 zinc finger homeobox 3
ZFP69B ZFP69 zinc finger protein B
ZNF250 zinc finger protein 250
ZNF254 zinc finger protein 254
ZNF324 zinc finger protein 324
ZNF329 zinc finger protein 329