NACC1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nucleus accumbens associated 1, BEN and BTB (POZ) domain containing|This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Feb 2012] (NCBI Entrez Gene Database, 112939)
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Genes

328 genes differentially expressed following the NACC1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
HRH1 histamine receptor H1 2.7458
XAF1 XIAP associated factor 1 2.7458
GFRA3 GDNF family receptor alpha 3 2.7458
CNTNAP4 contactin associated protein-like 4 2.7458
NOD2 nucleotide-binding oligomerization domain containing 2 2.7458
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 2.7458
AFM afamin 2.7458
ZBTB42 zinc finger and BTB domain containing 42 2.7458
LMO1 LIM domain only 1 (rhombotin 1) 2.7458
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.7458
FBXL8 F-box and leucine-rich repeat protein 8 2.7458
GPR52 G protein-coupled receptor 52 2.7458
TP73 tumor protein p73 2.7458
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.7458
COL20A1 collagen, type XX, alpha 1 2.7458
CD5 CD5 molecule 2.7458
CFAP74 cilia and flagella associated protein 74 2.7458
MYBPHL myosin binding protein H-like 2.7458
RASL10A RAS-like, family 10, member A 2.7458
NAPSA napsin A aspartic peptidase 2.7458
LRRD1 leucine-rich repeats and death domain containing 1 2.7458
NPAP1 nuclear pore associated protein 1 2.7458
DMRTC1B DMRT-like family C1B 2.7458
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.7458
MYL4 myosin, light chain 4, alkali; atrial, embryonic 2.7458
OIT3 oncoprotein induced transcript 3 2.7458
PRDM1 PR domain containing 1, with ZNF domain 2.7458
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 2.7458
FGF4 fibroblast growth factor 4 2.7458
SMCO3 single-pass membrane protein with coiled-coil domains 3 2.7458
SOST sclerostin 2.7458
TPH1 tryptophan hydroxylase 1 2.7458
GRM6 glutamate receptor, metabotropic 6 2.7458
VCX variable charge, X-linked 2.7458
TNNI2 troponin I type 2 (skeletal, fast) 2.7458
TAS2R19 taste receptor, type 2, member 19 2.7458
BIRC3 baculoviral IAP repeat containing 3 2.7458
ASMT acetylserotonin O-methyltransferase 2.7458
GSG1 germ cell associated 1 2.7458
BSX brain-specific homeobox 2.7458
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.7458
TDRD6 tudor domain containing 6 2.7458
POLR3GL polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like 2.7458
NPIPA8 nuclear pore complex interacting protein family, member A8 2.7458
DIO1 deiodinase, iodothyronine, type I 2.7458
ABRA actin binding Rho activating protein 2.7458
GJA4 gap junction protein, alpha 4, 37kDa 2.7458
MAP3K4-AS1 MAP3K4 antisense RNA 1 2.7458
HBG2 hemoglobin, gamma G 2.7458
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 2.7458
RCVRN recoverin 2.7458
SPRR2A small proline-rich protein 2A 2.7458
MYZAP myocardial zonula adherens protein 2.7458
ACSL5 acyl-CoA synthetase long-chain family member 5 2.7458
ZNF441 zinc finger protein 441 2.7458
TSPAN1 tetraspanin 1 2.7458
GPR37L1 G protein-coupled receptor 37 like 1 2.7458
PROP1 PROP paired-like homeobox 1 2.7458
MCHR1 melanin-concentrating hormone receptor 1 2.7458
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 2.7458
CTXND1 cortexin domain containing 1 2.7458
H3C15 H3 clustered histone 15 2.7458
MINAR2 membrane integral NOTCH2 associated receptor 2 2.7458
ELOC elongin C 2.7458
SEPTIN14 septin 14 2.7458
SPATS1 spermatogenesis associated, serine-rich 1 2.7458
OR6N1 olfactory receptor, family 6, subfamily N, member 1 2.7458
PCDHGA9 protocadherin gamma subfamily A, 9 2.7458
ZNF726 zinc finger protein 726 2.7458
MAGIX MAGI family member, X-linked 2.7458
PCDHGC4 protocadherin gamma subfamily C, 4 2.7458
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.7458
TEX101 testis expressed 101 2.7458
CLDN4 claudin 4 2.7458
FAM240C family with sequence similarity 240 member C 2.7458
PCDHB10 protocadherin beta 10 2.7458
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.7458
RS1 retinoschisin 1 2.7458
ERAS ES cell expressed Ras 2.7458
FAM153A family with sequence similarity 153, member A 2.7458
AMBP alpha-1-microglobulin/bikunin precursor 2.7458
CCR6 chemokine (C-C motif) receptor 6 2.7458
ULBP1 UL16 binding protein 1 2.7458
BEST3 bestrophin 3 2.7458
TSPO2 translocator protein 2 2.7458
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.7458
EXOC3L4 exocyst complex component 3-like 4 2.7458
LSP1 lymphocyte-specific protein 1 2.7458
CFAP45 cilia and flagella associated protein 45 2.7458
OVOL3 ovo-like zinc finger 3 2.7458
CXCL11 chemokine (C-X-C motif) ligand 11 2.7458
MSX1 msh homeobox 1 2.7458
TSSK4 testis-specific serine kinase 4 2.7458
GCOM1 GRINL1A complex locus 1 2.7458
TRIM50 tripartite motif containing 50 2.7458
PCDHGA4 protocadherin gamma subfamily A, 4 2.7458
HCAR1 hydroxycarboxylic acid receptor 1 2.7458
FOXO1 forkhead box O1 2.7458
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.7458
BCO1 beta-carotene oxygenase 1 2.7458
PRDM9 PR domain containing 9 2.7458
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.7458
SFRP1 secreted frizzled-related protein 1 2.7458
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.7458
DBX2 developing brain homeobox 2 2.7458
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.7458
PLCD4 phospholipase C, delta 4 2.7458
AGXT2 alanine--glyoxylate aminotransferase 2 2.7458
HUS1B HUS1 checkpoint homolog b (S. pombe) 2.7458
HSPA1L heat shock 70kDa protein 1-like 2.7458
EBLN1 endogenous Bornavirus-like nucleoprotein 1 2.7458
DGCR6 DiGeorge syndrome critical region gene 6 2.7458
TCEA3 transcription elongation factor A (SII), 3 2.7458
KLF2 Kruppel-like factor 2 2.7458
PRM1 protamine 1 2.7458
OR1M1 olfactory receptor, family 1, subfamily M, member 1 2.7458
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 2.7458
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.7458
WFDC9 WAP four-disulfide core domain 9 2.7458
FNDC1 fibronectin type III domain containing 1 2.7458
CBX8 chromobox homolog 8 2.7458
APOD apolipoprotein D 2.7458
PRR35 proline rich 35 2.7458
SLC7A4 solute carrier family 7, member 4 2.7458
LPO lactoperoxidase 2.7458
GREM1 gremlin 1, DAN family BMP antagonist 2.7458
OTP orthopedia homeobox 2.7458
PLA2G5 phospholipase A2, group V 2.7458
ZNF835 zinc finger protein 835 2.7458
MMP10 matrix metallopeptidase 10 2.7458
KRT40 keratin 40, type I 2.7458
SDSL serine dehydratase-like 2.7458
CFP complement factor properdin 2.7458
DNAH1 dynein, axonemal, heavy chain 1 2.7458
SLC36A3 solute carrier family 36, member 3 2.7458
AOC1 amine oxidase, copper containing 1 2.7458
ZNF648 zinc finger protein 648 2.7458
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.7458
TEX36 testis expressed 36 2.7458
GPR149 G protein-coupled receptor 149 2.7458
FITM1 fat storage-inducing transmembrane protein 1 2.7458
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.7458
TF transferrin 2.7458
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.7458
CLPSL1 colipase-like 1 2.7458
TMEM86B transmembrane protein 86B 2.7458
RTN4RL1 reticulon 4 receptor-like 1 2.7458
PNLIP pancreatic lipase 2.7458
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.7458
NYX nyctalopin 2.7458
KIAA0825 KIAA0825 2.74134
PHIP pleckstrin homology domain interacting protein 2.66504
HSH2D hematopoietic SH2 domain containing 2.65514
EGLN2 egl-9 family hypoxia-inducible factor 2 2.64353
DCTN5 dynactin 5 (p25) 2.64353
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 2.63993
NPY1R neuropeptide Y receptor Y1 2.61616
TRIM21 tripartite motif containing 21 2.61079
CNOT7 CCR4-NOT transcription complex, subunit 7 2.56449
CREB3 cAMP responsive element binding protein 3 2.55694
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.50378
EMILIN3 elastin microfibril interfacer 3 2.49181
SH2D3C SH2 domain containing 3C 2.47497
AUH AU RNA binding protein/enoyl-CoA hydratase 2.46196
IDO1 indoleamine 2,3-dioxygenase 1 2.44089
CFAP95 cilia and flagella associated protein 95 2.44089
B3GAT1 beta-1,3-glucuronyltransferase 1 2.40294
CACYBP calcyclin binding protein 2.39165
IP6K1 inositol hexakisphosphate kinase 1 2.38491
LAMB4 laminin, beta 4 2.37948
ARHGAP30 Rho GTPase activating protein 30 2.33412
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae) 2.32577
PTGR2 prostaglandin reductase 2 2.31053
NAE1 NEDD8 activating enzyme E1 subunit 1 2.29886
MCF2L MCF.2 cell line derived transforming sequence-like 2.29696
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 2.26271
BRAF B-Raf proto-oncogene, serine/threonine kinase 2.2494
GNG7 guanine nucleotide binding protein (G protein), gamma 7 2.23631
STIL SCL/TAL1 interrupting locus 2.23473
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 2.22853
NUDT14 nudix (nucleoside diphosphate linked moiety X)-type motif 14 2.22853
WRAP53 WD repeat containing, antisense to TP53 2.21434
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 2.20799
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 2.19719
TTBK2 tau tubulin kinase 2 2.19719
PRKDC protein kinase, DNA-activated, catalytic polypeptide 2.19719
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 2.18203
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.16592
USP24 ubiquitin specific peptidase 24 2.13342
GUF1 GUF1 GTPase homolog (S. cerevisiae) 2.13262
H2AZ1 H2A.Z variant histone 1 2.10465
ASB6 ankyrin repeat and SOCS box containing 6 2.10465
DNAH6 dynein, axonemal, heavy chain 6 2.10465
TMEM168 transmembrane protein 168 2.10465
SNTG2 syntrophin, gamma 2 2.09869
ANGEL2 angel homolog 2 (Drosophila) 2.09703
MAPK9 mitogen-activated protein kinase 9 2.09703
TRIAP1 TP53 regulated inhibitor of apoptosis 1 2.09145
NKAP NFKB activating protein 2.07669
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2.07227
SLC12A9 solute carrier family 12, member 9 2.06539
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.06175
ZNF57 zinc finger protein 57 2.05966
CEP350 centrosomal protein 350kDa 2.05414
RND2 Rho family GTPase 2 2.04815
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.04594
EPHA1 EPH receptor A1 2.03661
TSPYL1 TSPY-like 1 2.03661
TMTC4 transmembrane and tetratricopeptide repeat containing 4 2.03142
AMZ2 archaelysin family metallopeptidase 2 2.02623
NT5C3A 5'-nucleotidase, cytosolic IIIA 2.02252
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 2.01649
ANOS1 anosmin 1 2.01243
RCE1 Ras converting CAAX endopeptidase 1 2.00132
LRRC57 leucine rich repeat containing 57 2.00096

decreased expression

Symbol Name Standardized Value
FHOD3 formin homology 2 domain containing 3 -2.7458
ZNF382 zinc finger protein 382 -2.7458
BCAS4 breast carcinoma amplified sequence 4 -2.7458
C22ORF23 chromosome 22 open reading frame 23 -2.7458
STAB2 stabilin 2 -2.7458
ARHGAP23 Rho GTPase activating protein 23 -2.7458
EMX1 empty spiracles homeobox 1 -2.7458
FZD9 frizzled class receptor 9 -2.7458
RUMY3 RUMY family member 3 -2.7458
LRIF1 ligand dependent nuclear receptor interacting factor 1 -2.7458
FKBP6 FK506 binding protein 6, 36kDa -2.7458
BCL6 B-cell CLL/lymphoma 6 -2.7458
LEKR1 leucine, glutamate and lysine rich 1 -2.7458
ADCY6 adenylate cyclase 6 -2.7458
TMEM147 transmembrane protein 147 -2.72054
IRF3 interferon regulatory factor 3 -2.66504
SLCO1A2 solute carrier organic anion transporter family, member 1A2 -2.64451
WDR64 WD repeat domain 64 -2.64353
RUNX3 runt-related transcription factor 3 -2.64353
LGALS4 lectin, galactoside-binding, soluble, 4 -2.64353
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -2.64353
MMP19 matrix metallopeptidase 19 -2.64353
LRRC38 leucine rich repeat containing 38 -2.64353
FOXP3 forkhead box P3 -2.64353
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 -2.64353
MEIKIN meiotic kinetochore factor -2.64353
CLDN5 claudin 5 -2.64353
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -2.64353
SPEGNB SPEG neighbor -2.64353
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha -2.64353
NANOS3 nanos homolog 3 (Drosophila) -2.64353
HAL histidine ammonia-lyase -2.64353
CD300A CD300a molecule -2.64353
C4ORF50 chromosome 4 open reading frame 50 -2.64353
POSTN periostin, osteoblast specific factor -2.64353
USP50 ubiquitin specific peptidase 50 -2.64353
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -2.64353
ADGB androglobin -2.64353
GAGE10 G antigen 10 -2.64353
CFAP61 cilia and flagella associated protein 61 -2.64353
NGB neuroglobin -2.64353
RGS11 regulator of G-protein signaling 11 -2.64353
MORN5 MORN repeat containing 5 -2.64353
ADGRD1 adhesion G protein-coupled receptor D1 -2.64353
AGR2 anterior gradient 2 -2.64353
FKBP11 FK506 binding protein 11, 19 kDa -2.59775
SCARF1 scavenger receptor class F, member 1 -2.57519
NDNF neuron-derived neurotrophic factor -2.57519
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma -2.56511
H4C6 H4 clustered histone 6 -2.56511
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 -2.56511
KIF18B kinesin family member 18B -2.5611
COLEC11 collectin sub-family member 11 -2.5611
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -2.55694
KCNIP4 Kv channel interacting protein 4 -2.55545
MICU1 mitochondrial calcium uptake 1 -2.55209
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.50891
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa -2.48874
LHFPL1 lipoma HMGIC fusion partner-like 1 -2.44089
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 -2.43548
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 -2.42754
ZBTB40 zinc finger and BTB domain containing 40 -2.41074
ACLY ATP citrate lyase -2.40294
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain -2.39767
CCDC73 coiled-coil domain containing 73 -2.39065
RGS3 regulator of G-protein signaling 3 -2.37178
GRAMD1B GRAM domain containing 1B -2.36466
TUB tubby bipartite transcription factor -2.3215
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 -2.3215
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -2.31053
PRKD2 protein kinase D2 -2.30664
PDE8B phosphodiesterase 8B -2.27249
SNU13 small nuclear ribonucleoprotein 13 -2.27113
ANXA4 annexin A4 -2.23473
CYREN cell cycle regulator of NHEJ -2.22163
DEPDC5 DEP domain containing 5 -2.21955
FZD3 frizzled class receptor 3 -2.21127
PPP1R7 protein phosphatase 1, regulatory subunit 7 -2.21127
MPP1 membrane protein, palmitoylated 1, 55kDa -2.20799
TRIO trio Rho guanine nucleotide exchange factor -2.20619
ANKRD30BL ankyrin repeat domain 30B-like -2.19819
C3ORF62 chromosome 3 open reading frame 62 -2.1914
SUB1 SUB1 homolog (S. cerevisiae) -2.17917
KLHL3 kelch-like family member 3 -2.17917
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -2.17917
ZNF569 zinc finger protein 569 -2.17565
ZIC3 Zic family member 3 -2.15704
RBM25 RNA binding motif protein 25 -2.14575
PANX2 pannexin 2 -2.14227
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) -2.14075
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa -2.13001
AKAP7 A kinase (PRKA) anchor protein 7 -2.13
FBXL12 F-box and leucine-rich repeat protein 12 -2.12959
LEFTY1 left-right determination factor 1 -2.11952
KMT2A lysine (K)-specific methyltransferase 2A -2.11465
STX4 syntaxin 4 -2.11423
ARMC3 armadillo repeat containing 3 -2.11388
CDC16 cell division cycle 16 -2.11388
STRIP1 striatin interacting protein 1 -2.11249
SDCCAG8 serologically defined colon cancer antigen 8 -2.10499
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -2.10465
LOC124902694 uncharacterized LOC124902694 -2.10465
CCDC142 coiled-coil domain containing 142 -2.10465
CIART circadian associated repressor of transcription -2.09703
HARS1 histidyl-tRNA synthetase 1 -2.09078
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -2.08826
HYPK huntingtin interacting protein K -2.05966
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 -2.04594
EPC2 enhancer of polycomb homolog 2 (Drosophila) -2.02623
IFITM2 interferon induced transmembrane protein 2 -2.02361
FAM221A family with sequence similarity 221, member A -2.02361
WASF2 WAS protein family, member 2 -2.0213
TBC1D22B TBC1 domain family, member 22B -2.01212