NBI-74330 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/45784923
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Genes

199 proteins with high or low expression in NBI-74330 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
ANKRD20A4 ankyrin repeat domain 20 family, member A4 0.96
FAN1 FANCD2/FANCI-associated nuclease 1 0.71
PRELID3B PRELI domain containing 3B 0.63
TPGS2 tubulin polyglutamylase complex subunit 2 0.63
EXO1 exonuclease 1 0.61
H3C1 H3 clustered histone 1 0.59
C7 complement component 7 0.56
ZNF672 zinc finger protein 672 0.55
SYTL3 synaptotagmin-like 3 0.53
RNF115 ring finger protein 115 0.51
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.49
RRM2 ribonucleotide reductase M2 0.49
CDCA7 cell division cycle associated 7 0.48
TRAK2 trafficking protein, kinesin binding 2 0.46
SCARA3 scavenger receptor class A, member 3 0.46
DUOX1 dual oxidase 1 0.45
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.45
SPATA7 spermatogenesis associated 7 0.43
HELLS helicase, lymphoid-specific 0.43
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 0.43
COL11A1 collagen, type XI, alpha 1 0.43
PCLAF PCNA clamp associated factor 0.42
ALAS1 5'-aminolevulinate synthase 1 0.42
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.41
CCDC138 coiled-coil domain containing 138 0.41
FLNA filamin A, alpha 0.4
ERVMER34-1 endogenous retrovirus group MER34, member 1 0.4
SP100 SP100 nuclear antigen 0.4
IFFO1 intermediate filament family orphan 1 0.4
ATE1 arginyltransferase 1 0.4
CDK18 cyclin-dependent kinase 18 0.39
CCDC84 coiled-coil domain containing 84 0.39
GEM GTP binding protein overexpressed in skeletal muscle 0.39
TRAF3 TNF receptor-associated factor 3 0.38
OBI1 ORC ubiquitin ligase 1 0.38
EPN3 epsin 3 0.37
ZUP1 zinc finger containing ubiquitin peptidase 1 0.37
RNF4 ring finger protein 4 0.37
THAP1 THAP domain containing, apoptosis associated protein 1 0.36
PRELID1 PRELI domain containing 1 0.36
GREB1 growth regulation by estrogen in breast cancer 1 0.35
WNT10B wingless-type MMTV integration site family, member 10B 0.35
FOXO1 forkhead box O1 0.35
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.35
ZNF320 zinc finger protein 320 0.35
DONSON downstream neighbor of SON 0.34
RBIS ribosomal biogenesis factor 0.34
PUM2 pumilio RNA-binding family member 2 0.34
IVNS1ABP influenza virus NS1A binding protein 0.34
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2 0.34
ALMS1 Alstrom syndrome protein 1 0.34
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 0.34
DCLK2 doublecortin-like kinase 2 0.34
RAD51 RAD51 recombinase 0.33
CENPM centromere protein M 0.33
TENT4A terminal nucleotidyltransferase 4A 0.33
RAD51B RAD51 paralog B 0.33
LRRK1 leucine-rich repeat kinase 1 0.33
CDC25B cell division cycle 25B 0.33
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.33
CTNND2 catenin (cadherin-associated protein), delta 2 0.32
PTTG1 pituitary tumor-transforming 1 0.32
ATAD5 ATPase family, AAA domain containing 5 0.32
BARD1 BRCA1 associated RING domain 1 0.31
EVL Enah/Vasp-like 0.31
ASNSD1 asparagine synthetase domain containing 1 0.3
E2F8 E2F transcription factor 8 0.3
FOXP1 forkhead box P1 0.3
TCF12 transcription factor 12 0.3
ALDOA aldolase A, fructose-bisphosphate 0.3
SKA2 spindle and kinetochore associated complex subunit 2 0.3
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.3
PER2 period circadian clock 2 0.3
IFFO2 intermediate filament family orphan 2 0.29
FNIP1 folliculin interacting protein 1 0.29
IFT22 intraflagellar transport 22 0.29
BBS7 Bardet-Biedl syndrome 7 0.29
TOP2A topoisomerase (DNA) II alpha 170kDa 0.29
PHF1 PHD finger protein 1 0.29
RAD51AP1 RAD51 associated protein 1 0.29
HAUS7 HAUS augmin-like complex, subunit 7 0.29
JPH1 junctophilin 1 0.29
PRICKLE3 prickle homolog 3 (Drosophila) 0.29
ZCCHC2 zinc finger, CCHC domain containing 2 0.29
CDCA7L cell division cycle associated 7-like 0.29
CADPS Ca++-dependent secretion activator 0.29
UCK1 uridine-cytidine kinase 1 0.29
CENPQ centromere protein Q 0.28
MELK maternal embryonic leucine zipper kinase 0.28
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 0.28
CCNF cyclin F 0.28
UCK2 uridine-cytidine kinase 2 0.28
AMD1 adenosylmethionine decarboxylase 1 0.28
PRIM1 primase, DNA, polypeptide 1 (49kDa) 0.28
FBXO5 F-box protein 5 0.28
DIAPH3 diaphanous-related formin 3 0.28
CCDC170 coiled-coil domain containing 170 0.27
CCNA1 cyclin A1 0.27
CDC6 cell division cycle 6 0.27

low expression

Symbol Name Standardized Value
KMT2C lysine (K)-specific methyltransferase 2C -1.06
LRP10 low density lipoprotein receptor-related protein 10 -1.06
ATF3 activating transcription factor 3 -0.97
KSR2 kinase suppressor of ras 2 -0.78
APOE apolipoprotein E -0.76
FADS1 fatty acid desaturase 1 -0.74
LAPTM4A lysosomal protein transmembrane 4 alpha -0.73
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.71
F10 coagulation factor X -0.69
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) -0.68
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 -0.66
RAD9A RAD9 homolog A (S. pombe) -0.66
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -0.65
SLC16A6 solute carrier family 16, member 6 -0.64
TP53 tumor protein p53 -0.63
HBA1 hemoglobin, alpha 1 -0.62
TSKU tsukushi, small leucine rich proteoglycan -0.61
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.6
CBR1 carbonyl reductase 1 -0.6
MAGEF1 melanoma antigen family F1 -0.59
MT-CO1 cytochrome c oxidase subunit I -0.58
ATP5IF1 ATP synthase inhibitory factor subunit 1 -0.57
TTLL4 tubulin tyrosine ligase-like family member 4 -0.55
RNF181 ring finger protein 181 -0.55
VGF VGF nerve growth factor inducible -0.54
DDAH2 dimethylarginine dimethylaminohydrolase 2 -0.53
MXRA7 matrix-remodelling associated 7 -0.51
RARG retinoic acid receptor, gamma -0.5
CALU calumenin -0.5
RNF13 ring finger protein 13 -0.5
NRBF2 nuclear receptor binding factor 2 -0.5
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -0.5
GJB3 gap junction protein, beta 3, 31kDa -0.49
FGFBP1 fibroblast growth factor binding protein 1 -0.49
APOB apolipoprotein B -0.49
HSPG2 heparan sulfate proteoglycan 2 -0.48
ZNF611 zinc finger protein 611 -0.48
RABAC1 Rab acceptor 1 (prenylated) -0.48
ARG2 arginase 2 -0.47
F5 coagulation factor V (proaccelerin, labile factor) -0.47
C17ORF53 chromosome 17 open reading frame 53 -0.47
NCOA4 nuclear receptor coactivator 4 -0.46
FN1 fibronectin 1 -0.46
GLRX glutaredoxin (thioltransferase) -0.46
VTN vitronectin -0.45
APOLTP apolipoprotein lipid transfer particle homolog -0.45
CCDC158 coiled-coil domain containing 158 -0.45
HSH2D hematopoietic SH2 domain containing -0.45
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) -0.45
TMEM59 transmembrane protein 59 -0.44
GSTA1 glutathione S-transferase alpha 1 -0.44
DPY30 dpy-30 homolog (C. elegans) -0.44
C12ORF57 chromosome 12 open reading frame 57 -0.43
KIAA1107 KIAA1107 -0.43
PXMP4 peroxisomal membrane protein 4, 24kDa -0.43
TMEM260 transmembrane protein 260 -0.43
CKM creatine kinase, muscle -0.42
TRMO tRNA methyltransferase O -0.42
HID1 HID1 domain containing -0.42
ABAT 4-aminobutyrate aminotransferase -0.42
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 -0.41
TPM4 tropomyosin 4 -0.41
ANKS3 ankyrin repeat and sterile alpha motif domain containing 3 -0.41
KALRN kalirin, RhoGEF kinase -0.4
JAK3 Janus kinase 3 -0.4
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 -0.4
CLDN3 claudin 3 -0.4
ZNF410 zinc finger protein 410 -0.4
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 -0.39
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.39
FBXL8 F-box and leucine-rich repeat protein 8 -0.39
MCFD2 multiple coagulation factor deficiency 2 -0.39
SLC39A3 solute carrier family 39 (zinc transporter), member 3 -0.39
CCPG1 cell cycle progression 1 -0.39
TIMP3 TIMP metallopeptidase inhibitor 3 -0.38
MRPL50 mitochondrial ribosomal protein L50 -0.38
HEATR5A HEAT repeat containing 5A -0.38
SDHAF4 succinate dehydrogenase complex assembly factor 4 -0.38
SLC22A18 solute carrier family 22, member 18 -0.38
CLSTN3 calsyntenin 3 -0.38
PRG4 proteoglycan 4 -0.37
SLC10A4 solute carrier family 10, member 4 -0.37
GVINP1 GTPase, very large interferon inducible pseudogene 1 -0.37
ADGRG1 adhesion G protein-coupled receptor G1 -0.37
PNPLA8 patatin-like phospholipase domain containing 8 -0.37
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.37
CASP9 caspase 9, apoptosis-related cysteine peptidase -0.37
MYPOP Myb-related transcription factor, partner of profilin -0.37
NDFIP2 Nedd4 family interacting protein 2 -0.36
TRAF3IP2 TRAF3 interacting protein 2 -0.36
RCN1 reticulocalbin 1, EF-hand calcium binding domain -0.36
DIPK1B divergent protein kinase domain 1B -0.36
NDFIP1 Nedd4 family interacting protein 1 -0.36
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.36
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.35
ATP7B ATPase, Cu++ transporting, beta polypeptide -0.35
OASL 2'-5'-oligoadenylate synthetase-like -0.35
ZNF503 zinc finger protein 503 -0.35
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) -0.35
ADIRF adipogenesis regulatory factor -0.34