NCK1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description NCK adaptor protein 1|The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 4690)
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Genes

338 genes differentially expressed following the NCK1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
USP26 ubiquitin specific peptidase 26 3.14948
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 3.14948
SSTR3 somatostatin receptor 3 3.14948
MYCT1 myc target 1 3.14948
GIMAP4 GTPase, IMAP family member 4 3.14948
SLC39A4 solute carrier family 39 (zinc transporter), member 4 3.14948
TRPV2 transient receptor potential cation channel, subfamily V, member 2 3.14948
BAAT bile acid CoA:amino acid N-acyltransferase 3.14948
BSX brain-specific homeobox 3.14948
C1ORF146 chromosome 1 open reading frame 146 3.14948
MROH2B maestro heat-like repeat family member 2B 3.14948
CEP295NL CEP295 N-terminal like 3.14948
APOA2 apolipoprotein A-II 3.14948
GJA10 gap junction protein, alpha 10, 62kDa 3.14948
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.14948
HEATR9 HEAT repeat containing 9 3.14948
IL22RA1 interleukin 22 receptor, alpha 1 3.14948
PON3 paraoxonase 3 3.14948
PKP1 plakophilin 1 3.14948
ZNF467 zinc finger protein 467 3.14948
IL5RA interleukin 5 receptor, alpha 3.14948
OR10A2 olfactory receptor, family 10, subfamily A, member 2 3.14948
SLC25A41 solute carrier family 25, member 41 3.14948
CABS1 calcium-binding protein, spermatid-specific 1 3.14948
PSCA prostate stem cell antigen 3.14948
LRRIQ4 leucine-rich repeats and IQ motif containing 4 3.14948
CCDC87 coiled-coil domain containing 87 3.14948
CCDC83 coiled-coil domain containing 83 3.14948
BTBD18 BTB (POZ) domain containing 18 3.14948
BTBD19 BTB (POZ) domain containing 19 3.14948
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 3.14948
GALP galanin-like peptide 3.14948
PSD2 pleckstrin and Sec7 domain containing 2 3.14948
LKAAEAR1 LKAAEAR motif containing 1 3.14948
SPINT4 serine peptidase inhibitor, Kunitz type 4 3.14948
NEUROD2 neuronal differentiation 2 3.14948
FGF7 fibroblast growth factor 7 3.14948
NWD2 NACHT and WD repeat domain containing 2 3.14948
RNF39 ring finger protein 39 3.14948
S100A2 S100 calcium binding protein A2 3.14948
COL15A1 collagen, type XV, alpha 1 3.14948
HBZ hemoglobin, zeta 3.14948
CRYGB crystallin, gamma B 3.14948
OXT oxytocin/neurophysin I prepropeptide 3.14948
MMP20 matrix metallopeptidase 20 3.14948
ATOH1 atonal homolog 1 (Drosophila) 3.14948
CORO6 coronin 6 3.14948
MYO1A myosin IA 3.14948
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 3.14948
ASCL5 achaete-scute family bHLH transcription factor 5 3.14948
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 3.14948
TNS1-AS1 TNS1 antisense RNA 1 3.14948
ALX1 ALX homeobox 1 3.14948
DNAAF1 dynein, axonemal, assembly factor 1 3.14948
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 3.14948
SPRR2E small proline-rich protein 2E 3.14948
LMNTD1 lamin tail domain containing 1 3.14948
TMPRSS5 transmembrane protease, serine 5 3.14948
TMPRSS4 transmembrane protease, serine 4 3.14948
GRAP GRB2-related adaptor protein 3.14948
RASD1 RAS, dexamethasone-induced 1 3.14948
OR52E5 olfactory receptor, family 52, subfamily E, member 5 3.14948
CCER2 coiled-coil glutamate-rich protein 2 3.14948
CAPN3 calpain 3, (p94) 3.14948
OPRM1 opioid receptor, mu 1 3.14948
C1ORF232 chromosome 1 open reading frame 230 3.14948
CFAP97D2 CFAP97 domain containing 2 3.14948
SMIM31 small integral membrane protein 31 3.14948
CFAP107 cilia and flagella associated protein 107 3.14948
LOC122539214 Zinc finger protein LOC122539214 3.14948
MYOCOS myocilin opposite strand 3.14948
SMIM41 small integral membrane protein 41 3.14948
ZNF79 zinc finger protein 79 3.14948
TMOD4 tropomodulin 4 (muscle) 3.14948
MCHR2 melanin-concentrating hormone receptor 2 3.14948
MAGIX MAGI family member, X-linked 3.14948
CD70 CD70 molecule 3.14948
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.14948
C5ORF52 chromosome 5 open reading frame 52 3.14948
WDR38 WD repeat domain 38 3.14948
PCDHA6 protocadherin alpha 6 3.14948
LBHD1 LBH domain containing 1 3.14948
SYCP2 synaptonemal complex protein 2 3.14948
TMPRSS11D transmembrane protease, serine 11D 3.14948
HRH4 histamine receptor H4 3.14948
FOXQ1 forkhead box Q1 3.14948
UPK3B uroplakin 3B 3.14948
AMHR2 anti-Mullerian hormone receptor, type II 3.14948
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 3.14948
OR2A12 olfactory receptor, family 2, subfamily A, member 12 3.14948
LAMA4 laminin, alpha 4 3.14948
TUBA4B tubulin, alpha 4b 3.14948
CNGA4 cyclic nucleotide gated channel alpha 4 3.14948
HNF1B HNF1 homeobox B 3.14948
NPIPB8 nuclear pore complex interacting protein family, member B8 3.14948
TAS1R1 taste receptor, type 1, member 1 3.14948
SAMD15 sterile alpha motif domain containing 15 3.14948
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 3.14948
C6ORF118 chromosome 6 open reading frame 118 3.14948
KCNT1 potassium channel, sodium activated subfamily T, member 1 3.14948
ZNF284 zinc finger protein 284 3.14948
DMTN dematin actin binding protein 3.14948
IL21R interleukin 21 receptor 3.14948
WFDC8 WAP four-disulfide core domain 8 3.14948
HPD 4-hydroxyphenylpyruvate dioxygenase 3.14948
CYS1 cystin 1 3.14948
CGB2 chorionic gonadotropin, beta polypeptide 2 3.14948
FAM209A family with sequence similarity 209, member A 3.14948
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 3.14948
GTF2A1L general transcription factor IIA, 1-like 3.14948
ZNF843 zinc finger protein 843 3.14948
KLF2 Kruppel-like factor 2 3.14948
BTNL8 butyrophilin-like 8 3.14948
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 3.14948
PRSS53 protease, serine, 53 3.14948
RUMY3 RUMY family member 3 3.14948
IL12A interleukin 12A 3.14948
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.14948
CPO carboxypeptidase O 3.14948
BLID BH3-like motif containing, cell death inducer 3.14948
NGB neuroglobin 3.14948
MORC1 MORC family CW-type zinc finger 1 3.14948
ZNF703 zinc finger protein 703 3.14948
ASTL astacin-like metallo-endopeptidase (M12 family) 3.14948
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 3.14948
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 3.14948
CALY calcyon neuron-specific vesicular protein 3.14948
MOBP myelin-associated oligodendrocyte basic protein 3.14948
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 3.14948
ADAM18 ADAM metallopeptidase domain 18 3.14948
CNR2 cannabinoid receptor 2 (macrophage) 3.14948
LRRN4 leucine rich repeat neuronal 4 3.14948
TTC22 tetratricopeptide repeat domain 22 3.14948
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.14948
TCAP titin-cap 3.14948
CD27 CD27 molecule 3.14948
LHX5 LIM homeobox 5 3.14948
SAMD7 sterile alpha motif domain containing 7 3.14948
IL9R interleukin 9 receptor 3.14948
MYF5 myogenic factor 5 3.14948
ACSBG2 acyl-CoA synthetase bubblegum family member 2 3.14948
VAV1 vav 1 guanine nucleotide exchange factor 3.14948
GPR62 G protein-coupled receptor 62 3.14948
PRTN3 proteinase 3 3.14948
ATP10B ATPase, class V, type 10B 3.14948
IDI2 isopentenyl-diphosphate delta isomerase 2 3.14948
UPK1A uroplakin 1A 3.14948
CALML6 calmodulin-like 6 3.14948
GCM1 glial cells missing homolog 1 (Drosophila) 3.14948
BPIFC BPI fold containing family C 3.14948
IFNK interferon, kappa 3.14948
ST18 suppression of tumorigenicity 18, zinc finger 3.14948
TEX35 testis expressed 35 3.14948
PHOX2A paired-like homeobox 2a 3.14948
FOXP3 forkhead box P3 3.14948
POTEG POTE ankyrin domain family, member G 3.14948
SLC51B solute carrier family 51, beta subunit 3.14948
PXT1 peroxisomal, testis specific 1 3.14948
CHRM4 cholinergic receptor, muscarinic 4 3.14948
ZNF534 zinc finger protein 534 3.14948
CHAD chondroadherin 3.14948
FGF10 fibroblast growth factor 10 3.14948
SDSL serine dehydratase-like 3.14948
TMIGD2 transmembrane and immunoglobulin domain containing 2 3.14948
OR52I2 olfactory receptor, family 52, subfamily I, member 2 3.14948
SOX30 SRY (sex determining region Y)-box 30 3.14948
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 3.14948
POTEI POTE ankyrin domain family, member I 3.14948
CARD9 caspase recruitment domain family, member 9 3.14948
NKPD1 NTPase, KAP family P-loop domain containing 1 3.14948
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 3.14948
POU3F2 POU class 3 homeobox 2 3.14948
PADI4 peptidyl arginine deiminase, type IV 3.14948
VENTX VENT homeobox 3.06006
MATN4 matrilin 4 2.9989
ZNF692 zinc finger protein 692 2.93042
NTSR1 neurotensin receptor 1 (high affinity) 2.86842
ZNHIT6 zinc finger, HIT-type containing 6 2.86022
RNASEH2C ribonuclease H2, subunit C 2.83645
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 2.83645
CHD3 chromodomain helicase DNA binding protein 3 2.69637
CCNA1 cyclin A1 2.68533
DDIT3 DNA-damage-inducible transcript 3 2.68533
KLHL10 kelch-like family member 10 2.68533
FAM162A family with sequence similarity 162, member A 2.67177
HDAC6 histone deacetylase 6 2.64216
KIF12 kinesin family member 12 2.62515
AFMID arylformamidase 2.62368
TBC1D23 TBC1 domain family, member 23 2.61928
SDHAF2 succinate dehydrogenase complex assembly factor 2 2.60136
FTL ferritin, light polypeptide 2.57794
MYO1D myosin ID 2.56727
CD302 CD302 molecule 2.55964
MLXIPL MLX interacting protein-like 2.5567
SPATA13 spermatogenesis associated 13 2.54614
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa 2.47947
SDHAF4 succinate dehydrogenase complex assembly factor 4 2.46931
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 2.46931
CLEC19A C-type lectin domain family 19, member A 2.40843
RBM38 RNA binding motif protein 38 2.38227
TSC22D2 TSC22 domain family, member 2 2.37193
ADSS1 adenylosuccinate synthase 1 2.37185
NPIPB2 nuclear pore complex interacting protein family member B2 2.37185
SHOC1 shortage in chiasmata 1 2.33976
LLPH LLP homolog, long-term synaptic facilitation (Aplysia) 2.3395
AP4B1 adaptor-related protein complex 4, beta 1 subunit 2.28985
TEK TEK tyrosine kinase, endothelial 2.27475
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 2.22653
CCT7 chaperonin containing TCP1, subunit 7 (eta) 2.21975
PROB1 proline-rich basic protein 1 2.19121
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 2.19121
HPS6 Hermansky-Pudlak syndrome 6 2.19121
ZIC1 Zic family member 1 2.19121
FAM222A family with sequence similarity 222, member A 2.19121
EPSTI1 epithelial stromal interaction 1 (breast) 2.19121
PEX3 peroxisomal biogenesis factor 3 2.19121
WDR44 WD repeat domain 44 2.19103
SEC13 SEC13 homolog (S. cerevisiae) 2.18038
HDAC9 histone deacetylase 9 2.16832
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 2.15521
AFF2 AF4/FMR2 family, member 2 2.14475
SLC39A6 solute carrier family 39 (zinc transporter), member 6 2.13322
IQCB1 IQ motif containing B1 2.12828
DHRS4 dehydrogenase/reductase (SDR family) member 4 2.12615
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.12568
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 2.12541
DCTN1 dynactin 1 2.12094
TMC1 transmembrane channel-like 1 2.10321
GDF11 growth differentiation factor 11 2.08233
KIF13A kinesin family member 13A 2.07319
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.06998
SLCO5A1 solute carrier organic anion transporter family, member 5A1 2.06998
PLAU plasminogen activator, urokinase 2.06631
UXT ubiquitously-expressed, prefoldin-like chaperone 2.05733
MSANTD4 Myb/SANT-like DNA-binding domain containing 4 with coiled-coils 2.05686
SLC2A4RG SLC2A4 regulator 2.04569
PLD2 phospholipase D2 2.01726
ZNF283 zinc finger protein 283 2.00871

decreased expression

Symbol Name Standardized Value
C9ORF43 chromosome 9 open reading frame 43 -3.14948
QSER1 glutamine and serine rich 1 -3.14948
SIRT4 sirtuin 4 -3.14948
TGFB2 transforming growth factor, beta 2 -3.14948
TRIM22 tripartite motif containing 22 -3.14948
TSLIG3C tRNA splicing ligase complex subunit 3C -3.14948
H3C1 H3 clustered histone 1 -3.14948
NOTCH2NLA notch 2 N-terminal like A -3.14948
ZNF597 zinc finger protein 597 -3.14948
RIPOR3 RIPOR family member 3 -3.14948
MATCAP1 microtubule associated tyrosine carboxypeptidase 1 -3.09739
TEF thyrotrophic embryonic factor -3.01614
BTN1A1 butyrophilin, subfamily 1, member A1 -2.9989
BSND barttin CLCNK-type chloride channel accessory beta subunit -2.9989
GNLY granulysin -2.9989
NOS2 nitric oxide synthase 2, inducible -2.9989
LRRC55 leucine rich repeat containing 55 -2.9989
TEX38 testis expressed 38 -2.9989
ZNF804A zinc finger protein 804A -2.9989
DNAH2 dynein, axonemal, heavy chain 2 -2.9989
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa -2.9989
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.9989
PSD4 pleckstrin and Sec7 domain containing 4 -2.9989
GLB1L galactosidase, beta 1-like -2.9989
TNMD tenomodulin -2.9989
CHD5 chromodomain helicase DNA binding protein 5 -2.9989
SHISA3 shisa family member 3 -2.9989
AURKC aurora kinase C -2.9989
FAM167B family with sequence similarity 167, member B -2.9989
IL4I1 interleukin 4 induced 1 -2.9989
DCDC2B doublecortin domain containing 2B -2.9989
CLTRN collectrin, amino acid transport regulator -2.9989
SLCO2B1 solute carrier organic anion transporter family, member 2B1 -2.9989
ARL9 ADP-ribosylation factor-like 9 -2.9989
CCDC198 coiled-coil domain containing 198 -2.9989
INSL6 insulin-like 6 -2.9989
ERVV-2 endogenous retrovirus group V, member 2 -2.9989
DUSP29 dual specificity phosphatase 29 -2.9989
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -2.9989
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 -2.9989
ULBP1 UL16 binding protein 1 -2.9989
KLHL9 kelch-like family member 9 -2.9989
DPRX divergent-paired related homeobox -2.9989
FAM3B family with sequence similarity 3, member B -2.9989
CAMK2A calcium/calmodulin-dependent protein kinase II alpha -2.9989
CRLF2 cytokine receptor-like factor 2 -2.9989
TDRD10 tudor domain containing 10 -2.9989
CD52 CD52 molecule -2.9989
FAM78A family with sequence similarity 78, member A -2.9989
UFSP1 UFM1-specific peptidase 1 (non-functional) -2.9989
CLVS2 clavesin 2 -2.88801
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 -2.83821
SCAPER S-phase cyclin A-associated protein in the ER -2.78042
RSAD1 radical S-adenosyl methionine domain containing 1 -2.76586
ZNF160 zinc finger protein 160 -2.74986
ELF1 E74-like factor 1 (ets domain transcription factor) -2.71446
ZNF256 zinc finger protein 256 -2.68533
PANK4 pantothenate kinase 4 -2.65249
ZNF496 zinc finger protein 496 -2.64392
ACBD7 acyl-CoA binding domain containing 7 -2.62515
PCNX1 pecanex 1 -2.55863
HAS2 hyaluronan synthase 2 -2.54549
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional) -2.49947
TOX3 TOX high mobility group box family member 3 -2.47947
FLRT1 fibronectin leucine rich transmembrane protein 1 -2.46769
LRRC28 leucine rich repeat containing 28 -2.45102
ZNF85 zinc finger protein 85 -2.44508
FBXL5 F-box and leucine-rich repeat protein 5 -2.43412
AKR1C3 aldo-keto reductase family 1, member C3 -2.40854
BEX4 brain expressed, X-linked 4 -2.37645
BCAR3 breast cancer anti-estrogen resistance 3 -2.3395
SCML1 sex comb on midleg-like 1 (Drosophila) -2.3271
CNOT4 CCR4-NOT transcription complex, subunit 4 -2.322
TXNL4B thioredoxin-like 4B -2.322
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 -2.31843
ADGRL1 adhesion G protein-coupled receptor L1 -2.29481
DNAI3 dynein axonemal intermediate chain 3 -2.26758
PLAGL2 pleiomorphic adenoma gene-like 2 -2.26422
DPYSL4 dihydropyrimidinase-like 4 -2.23437
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -2.23201
RETREG3 reticulophagy regulator family member 3 -2.20975
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.19531
ALMS1 Alstrom syndrome protein 1 -2.17526
CHIC1 cysteine-rich hydrophobic domain 1 -2.16783
PPP2R2D protein phosphatase 2, regulatory subunit B, delta -2.16721
CDH13 cadherin 13 -2.14475
TMBIM6 transmembrane BAX inhibitor motif containing 6 -2.14229
TRAPPC9 trafficking protein particle complex 9 -2.13209
NPDC1 neural proliferation, differentiation and control, 1 -2.1293
TMEM187 transmembrane protein 187 -2.1293
PUDP pseudouridine 5'-phosphatase -2.12094
FMN2 formin 2 -2.12094
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 -2.11411
STARD13 StAR-related lipid transfer (START) domain containing 13 -2.08951
LNP1 leukemia NUP98 fusion partner 1 -2.0862
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 -2.08234
RBM5 RNA binding motif protein 5 -2.06441
MYCBP MYC binding protein -2.05907
GLOD4 glyoxalase domain containing 4 -2.04058
ACO2 aconitase 2, mitochondrial -2.03648