NCK1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description NCK adaptor protein 1|The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 4690)
External Link http://www.ncbi.nlm.nih.gov/gene/4690
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341 interacting proteins for NCK1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ABI1 abl-interactor 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ADAM15 ADAM metallopeptidase domain 15
ADGRL2 adhesion G protein-coupled receptor L2
AFF2 AF4/FMR2 family, member 2
AGER advanced glycosylation end product-specific receptor
AIRE autoimmune regulator
AKAP2 A kinase (PRKA) anchor protein 2
AKAP6 A kinase (PRKA) anchor protein 6
ANGPT1 angiopoietin 1
ANGPT4 angiopoietin 4
ANK2 ankyrin 2, neuronal
APOL5 apolipoprotein L, 5
ARF6 ADP-ribosylation factor 6
ARHGAP32 Rho GTPase activating protein 32
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASB16 ankyrin repeat and SOCS box containing 16
ASXL1 additional sex combs like transcriptional regulator 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCAR1 breast cancer anti-estrogen resistance 1
BLNK B-cell linker
BRCA1 breast cancer 1, early onset
BRD4 bromodomain containing 4
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
BRPF3 bromodomain and PHD finger containing, 3
BTK Bruton agammaglobulinemia tyrosine kinase
C20ORF57 chromosome 20 open reading frame 57
C6 complement component 6
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAST calpastatin
CAV2 caveolin 2
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCKBR cholecystokinin B receptor
CCR10 chemokine (C-C motif) receptor 10
CD247 CD247 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CDC27 cell division cycle 27
CDC42 cell division cycle 42
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHRD chordin
CKAP5 cytoskeleton associated protein 5
CNTFR ciliary neurotrophic factor receptor
CNTNAP1 contactin associated protein 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSDE1 cold shock domain containing E1, RNA-binding
CSMD2 CUB and Sushi multiple domains 2
CSNK1G2 casein kinase 1, gamma 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCC DCC netrin 1 receptor
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DLGAP2 discs, large (Drosophila) homolog-associated protein 2
DLGAP3 discs, large (Drosophila) homolog-associated protein 3
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DLX4 distal-less homeobox 4
DNM1 dynamin 1
DNM2 dynamin 2
DOCK1 dedicator of cytokinesis 1
DOCK3 dedicator of cytokinesis 3
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DROSHA drosha, ribonuclease type III
DTNBP1 dystrobrevin binding protein 1
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
ECT2 epithelial cell transforming 2
EFS embryonal Fyn-associated substrate
EGFR epidermal growth factor receptor
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPS15 epidermal growth factor receptor pathway substrate 15
EPX eosinophil peroxidase
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
F2RL2 coagulation factor II (thrombin) receptor-like 2
FAM110A family with sequence similarity 110, member A
FANCA Fanconi anemia, complementation group A
FASLG Fas ligand (TNF superfamily, member 6)
FASN fatty acid synthase
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FER fer (fps/fes related) tyrosine kinase
FGFR1 fibroblast growth factor receptor 1
FLNB filamin B, beta
FLNC filamin C, gamma
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FOXH1 forkhead box H1
FRS2 fibroblast growth factor receptor substrate 2
FYB FYN binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GHR growth hormone receptor
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNS glucosamine (N-acetyl)-6-sulfatase
GOPC golgi-associated PDZ and coiled-coil motif containing
GPR45 G protein-coupled receptor 45
GRAP2 GRB2-related adaptor protein 2
GRB2 growth factor receptor-bound protein 2
GSTZ1 glutathione S-transferase zeta 1
HIST1H1E histone cluster 1, H1e
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPR heterogeneous nuclear ribonucleoprotein R
HOXC8 homeobox C8
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA1B heat shock 70kDa protein 1B
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLC1 immunoglobulin lambda constant 1 (Mcg marker)
IGLC2 immunoglobulin lambda constant 2 (Kern-Oz- marker)
IGLC3 immunoglobulin lambda constant 3 (Kern-Oz+ marker)
IGLC6 immunoglobulin lambda constant 6 (Kern+Oz- marker, gene/pseudogene)
IL3RA interleukin 3 receptor, alpha (low affinity)
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INPP5J inositol polyphosphate-5-phosphatase J
INPP5K inositol polyphosphate-5-phosphatase K
INPPL1 inositol polyphosphate phosphatase-like 1
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITK IL2-inducible T-cell kinase
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAK2 Janus kinase 2
KDR kinase insert domain receptor
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA1522 KIAA1522
KIF13A kinesin family member 13A
KIFC2 kinesin family member C2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KMT2B lysine (K)-specific methyltransferase 2B
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRRC3 leucine rich repeat containing 3
MAP4 microtubule-associated protein 4
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MED14 mediator complex subunit 14
MEPE matrix extracellular phosphoglycoprotein
MET MET proto-oncogene, receptor tyrosine kinase
MINK1 misshapen-like kinase 1
MPDZ multiple PDZ domain protein
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MYLK myosin light chain kinase
MYRIP myosin VIIA and Rab interacting protein
NCK2 NCK adaptor protein 2
NCKAP1 NCK-associated protein 1
NCKAP5 NCK-associated protein 5
NCKIPSD NCK interacting protein with SH3 domain
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEK8 NIMA-related kinase 8
NELFB negative elongation factor complex member B
NFASC neurofascin
NKX2-1 NK2 homeobox 1
NOTCH3 notch 3
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPVF neuropeptide VF precursor
NR5A1 nuclear receptor subfamily 5, group A, member 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NXPH3 neurexophilin 3
OXT oxytocin/neurophysin I prepropeptide
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAX3 paired box 3
PAX7 paired box 7
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDIA2 protein disulfide isomerase family A, member 2
PFN1 profilin 1
PHACTR2 phosphatase and actin regulator 2
PHC2 polyhomeotic homolog 2 (Drosophila)
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PKN2 protein kinase N2
PLCG1 phospholipase C, gamma 1
PNMA2 paraneoplastic Ma antigen 2
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRICKLE3 prickle homolog 3 (Drosophila)
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRMT1 protein arginine methyltransferase 1
PRX periaxin
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PXN paxillin
RAB11B RAB11B, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAG1 recombination activating gene 1
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RELN reelin
RERG RAS-like, estrogen-regulated, growth inhibitor
RHOU ras homolog family member U
RIMS1 regulating synaptic membrane exocytosis 1
RIMS2 regulating synaptic membrane exocytosis 2
RIN3 Ras and Rab interactor 3
RP1L1 retinitis pigmentosa 1-like 1
RPL13 ribosomal protein L13
RPP38 ribonuclease P/MRP 38kDa subunit
RRAS related RAS viral (r-ras) oncogene homolog
RYR1 ryanodine receptor 1 (skeletal)
SASH1 SAM and SH3 domain containing 1
SCARF2 scavenger receptor class F, member 2
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SEPN1 selenoprotein N, 1
SF3B4 splicing factor 3b, subunit 4, 49kDa
SH3KBP1 SH3-domain kinase binding protein 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHANK3 SH3 and multiple ankyrin repeat domains 3
SHROOM2 shroom family member 2
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SNX12 sorting nexin 12
SNX17 sorting nexin 17
SNX27 sorting nexin family member 27
SNX3 sorting nexin 3
SNX7 sorting nexin 7
SNX8 sorting nexin 8
SOCS1 suppressor of cytokine signaling 1
SOCS7 suppressor of cytokine signaling 7
SORBS2 sorbin and SH3 domain containing 2
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SP1 Sp1 transcription factor
SPEN spen family transcriptional repressor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SYK spleen tyrosine kinase
SYNJ1 synaptojanin 1
SYNJ2 synaptojanin 2
SYNPO synaptopodin
TBK1 TANK-binding kinase 1
TEK TEK tyrosine kinase, endothelial
TGDS TDP-glucose 4,6-dehydratase
TGOLN2 trans-golgi network protein 2
TLR9 toll-like receptor 9
TMPO thymopoietin
TNIK TRAF2 and NCK interacting kinase
TNK2 tyrosine kinase, non-receptor, 2
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TPX2 TPX2, microtubule-associated
TRAIP TRAF interacting protein
TRIM39 tripartite motif containing 39
TRIO trio Rho guanine nucleotide exchange factor
TUBA1A tubulin, alpha 1a
TULP1 tubby like protein 1
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBASH3B ubiquitin associated and SH3 domain containing B
UBC ubiquitin C
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
UTRN utrophin
VAV1 vav 1 guanine nucleotide exchange factor
VLDLR very low density lipoprotein receptor
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
WAS Wiskott-Aldrich syndrome
WASF1 WAS protein family, member 1
WASL Wiskott-Aldrich syndrome-like
WIPF1 WAS/WASL interacting protein family, member 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta